-
1
-
-
0346671342
-
Novel immunotherapies for psoriasis: Clinical research delivers new hope for patients and scientific advances
-
Gottlieb, A. B. Novel immunotherapies for psoriasis: clinical research delivers new hope for patients and scientific advances. J. Invest. Dermatol. Symp. Proc. 9, 79-83 (2004).
-
(2004)
J. Invest. Dermatol. Symp. Proc.
, vol.9
, pp. 79-83
-
-
Gottlieb, A.B.1
-
3
-
-
0042625001
-
Methotrexate versus cyclosporine in moderate-to-severe chronic plaque psoriasis
-
Heydendael, V. M. R. et al. Methotrexate versus cyclosporine in moderate-to-severe chronic plaque psoriasis. N. Engl. J. Med. 349, 658-65 (2003).
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 658-665
-
-
Heydendael, V.M.R.1
-
4
-
-
0032872277
-
Psoriasis causes as much disability as other major medical diseases
-
Rapp, S. R., Feldman, S. R., Exum, M. L., Fleischer, A B. & Reboussin, D. M. Psoriasis causes as much disability as other major medical diseases. J. Am. Acad. Dermatol. 41, 401-407 (1999 ).
-
(1999)
J. Am. Acad. Dermatol.
, vol.41
, pp. 401-407
-
-
Rapp, S.R.1
Feldman, S.R.2
Exum, M.L.3
Fleischer, A.B.4
Reboussin, D.M.5
-
5
-
-
0035069606
-
The impact of psoriasis on quality of life: Results of a 1998 National Psoriasis Foundation Patient-Membership Survey
-
Krueger, G. et al. The impact of psoriasis on quality of life: results of a 1998 National Psoriasis Foundation Patient-Membership Survey. Arch. Dermatol. 137, 280-284 (1998).
-
(1998)
Arch. Dermatol.
, vol.137
, pp. 280-284
-
-
Krueger, G.1
-
6
-
-
1842503108
-
Quality of life in patients with psoriasis: A systemic literature review
-
de Korte, J., Sprangers, M. A. G., Members, F. M. C. & Bos, J. D. Quality of life in patients with psoriasis: a systemic literature review. J. Invest. Dermatol. Symp. Proc. 9, 140-147 (2004).
-
(2004)
J. Invest. Dermatol. Symp. Proc.
, vol.9
, pp. 140-147
-
-
de Korte, J.1
Sprangers, M.A.G.2
Members, F.M.C.3
Bos, J.D.4
-
7
-
-
0036453830
-
Diagnosis and management of psoriatic arthritis
-
Brockbank, J. & Gladman, D. Diagnosis and management of psoriatic arthritis. Drugs 62, 2447-2457 (2002).
-
(2002)
Drugs
, vol.62
, pp. 2447-2457
-
-
Brockbank, J.1
Gladman, D.2
-
8
-
-
0038621941
-
Psoriatic arthritis: A guide for dermatology nurses
-
Gottlieb, A. B. Psoriatic arthritis: a guide for dermatology nurses. Dermatol. Nursing 15, 107-118 (2003).
-
(2003)
Dermatol. Nursing
, vol.15
, pp. 107-118
-
-
Gottlieb, A.B.1
-
9
-
-
0016029730
-
Natural history of psoriasis in 61 twin pairs
-
Farber, E. M., Nall, M. L. & Watson, W. Natural history of psoriasis in 61 twin pairs. Arch. Dermatol 109, 207-211 (1974).
-
(1974)
Arch. Dermatol.
, vol.109
, pp. 207-211
-
-
Farber, E.M.1
Nall, M.L.2
Watson, W.3
-
10
-
-
0037453146
-
Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 6,100-element oligonucleotide array
-
Zhou, X. et al. Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 6,100-element oligonucleotide array. Physiol. Genomics 13, 69-78 (2003).
-
(2003)
Physiol. Genomics
, vol.13
, pp. 69-78
-
-
Zhou, X.1
-
11
-
-
0345659216
-
A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with increased susceptibility to psoriasis
-
Helms, C. et al. A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with increased susceptibility to psoriasis. Nature Genet. 35, 349-356 (2003).
-
(2003)
Nature Genet
, vol.35
, pp. 349-356
-
-
Helms, C.1
-
12
-
-
0026013163
-
Cyclosporine for plaque-type psoriasis. Results of a multidose, double-blind trial
-
Ellis, C. N. et al. Cyclosporine for plaque-type psoriasis. Results of a multidose, double-blind trial. N. Engl. J. Med. 324, 277-284 (1991).
-
(1991)
N. Engl. J. Med.
, vol.324
, pp. 277-284
-
-
Ellis, C.N.1
-
13
-
-
0023924555
-
The pathomechanisms of psoriasis: The skin immune system and cyclosporin
-
Bos, J. D. The pathomechanisms of psoriasis: the skin immune system and cyclosporin. Br. J. Dermatol. 118, 141-155 (1988).
-
(1988)
Br. J. Dermatol.
, vol.118
, pp. 141-155
-
-
Bos, J.D.1
-
14
-
-
0026528262
-
Studies of the effect of cyclosporine in psoriasis in vivo: Combined effects on activated T lymphocytes and epidermal regenerative maturation
-
Gottlieb, A. B. et al. Studies of the effect of cyclosporine in psoriasis in vivo: combined effects on activated T lymphocytes and epidermal regenerative maturation. J. Invest. Dermatol. 98, 302-309 (1992).
-
(1992)
J. Invest. Dermatol.
, vol.98
, pp. 302-309
-
-
Gottlieb, A.B.1
-
15
-
-
0021355272
-
Epidermal T lymphocytes and HLA-DR expression in psoriasis
-
Baker, B. S., Swain, A. F., Fry, L. & Valdimarsson, H. Epidermal T lymphocytes and HLA-DR expression in psoriasis. Br. J. Dermatol. 11, 555-564 (1984).
-
(1984)
Br. J. Dermatol.
, vol.11
, pp. 555-564
-
-
Baker, B.S.1
Swain, A.F.2
Fry, L.3
Valdimarsson, H.4
-
16
-
-
0022545287
-
Expression of HLA-DR molecules by keratinocytes and presence of Langerhans cells in the dermal infiltrate of active psoriatic plaques
-
Gottlieb, A. B. et al. Expression of HLA-DR molecules by keratinocytes and presence of Langerhans cells in the dermal infiltrate of active psoriatic plaques. J. Exp. Med. 164, 1013-1028 (1986).
-
(1986)
J. Exp. Med.
, vol.164
, pp. 1013-1028
-
-
Gottlieb, A.B.1
-
17
-
-
1842383350
-
-
(ed. Dubertret, L.) (ISED, Brescie, Italy
-
Gottlieb, A. B. & Krueger, J. G. in Psoriasis (ed. Dubertret, L.) 63-71 (ISED, Brescie, Italy 1994).
-
(1994)
Psoriasis
, pp. 63-71
-
-
Gottlieb, A.B.1
Krueger, J.G.2
-
18
-
-
0034763861
-
Immunopathology and immunomodulation
-
Gottlieb, A. B. Immunopathology and immunomodulation. Med. Dermatol. 19, 649-657 (2001).
-
(2001)
Med. Dermatol.
, vol.19
, pp. 649-657
-
-
Gottlieb, A.B.1
-
19
-
-
0036866646
-
Recombinantly engineered human proteins: Transforming the treatment of psoriasis
-
Gottlieb, A. B. Recombinantly engineered human proteins: transforming the treatment of psoriasis. Clin. Immunol. 105, 105-116 (2002).
-
(2002)
Clin. Immunol.
, vol.105
, pp. 105-116
-
-
Gottlieb, A.B.1
-
20
-
-
0029861579
-
Dermal injection of immunocytes induces psoriasis
-
Wrone-Smith, T. & Nickoloff, B. J. Dermal injection of immunocytes induces psoriasis. J. Clin. Invest. 98, 1878-1887 (1996).
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 1878-1887
-
-
Wrone-Smith, T.1
Nickoloff, B.J.2
-
21
-
-
0030826483
-
T-lymphocyte dependence of psoriatic pathology in human psoriatic, skin grafted to SCID mice
-
Gilhar, A., David, M., Ullmann, Y., Berkutski, T. & Kalish, R. S. T-lymphocyte dependence of psoriatic pathology in human psoriatic, skin grafted to SCID mice. J. Invest Dermatol. 109, 283-288 (1997).
-
(1997)
J. Invest. Dermatol.
, vol.109
, pp. 283-288
-
-
Gilhar, A.1
David, M.2
Ullmann, Y.3
Berkutski, T.4
Kalish, R.S.5
-
22
-
-
0028990380
-
Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis
-
Gottlieb, S. L. et al. Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis. Nature Med. 1, 442-447 (1995).
-
(1995)
Nature Med.
, vol.1
, pp. 442-447
-
-
Gottlieb, S.L.1
-
23
-
-
0031954067
-
Use of the interleukin-2 fusion protein, DAB389IL-2, for the treatment of psoriasis
-
Gottlieb, A. B., Bacha, P., Parker, K. & Strand, V. Use of the interleukin-2 fusion protein, DAB389IL-2, for the treatment of psoriasis. Dermatol. Ther. 5, 48-63 (1998).
-
(1998)
Dermatol. Ther.
, vol.5
, pp. 48-63
-
-
Gottlieb, A.B.1
Bacha, P.2
Parker, K.3
Strand, V.4
-
24
-
-
0033777375
-
Anti-CD4 monoclonal antibody treatment of moderate to severe psoriasis vulgaris: Results of a pilot, multicenter, multiple dose, placebo-controlled study
-
Gottlieb, A. B. et al. Anti-CD4 monoclonal antibody treatment of moderate to severe psoriasis vulgaris: results of a pilot, multicenter, multiple dose, placebo-controlled study. J. Am. Acad. Dermatol 43, 595-604 (2000).
-
(2000)
J. Am. Acad. Dermatol
, vol.43
, pp. 595-604
-
-
Gottlieb, A.B.1
-
25
-
-
0000459983
-
A multiple dose randomized doubleblind pacebo-controlled study to determine the efficacy and safety of a humanized anti-CD4 monoclonal antibody in the treatment of moderate to severe chronic psoriasis vulgaris
-
Gottlieb, A. B. et al. A multiple dose randomized doubleblind pacebo-controlled study to determine the efficacy and safety of a humanized anti-CD4 monoclonal antibody in the treatment of moderate to severe chronic psoriasis vulgaris. J. Invest. Dermatol. 110 678 (1998).
-
(1998)
J. Invest. Dermatol.
, vol.110
, pp. 678
-
-
Gottlieb, A.B.1
-
26
-
-
85047691301
-
Cycloporine in psoriasis treatment: Inhibition of keratinocyte cell-cycle progression in G1 independent of effects on transforming growth factor-α/epidermal growth factor receptor pathways
-
Khandke, L. et al. Cycloporine in psoriasis treatment: inhibition of keratinocyte cell-cycle progression in G1 independent of effects on transforming growth factor-α/epidermal growth factor receptor pathways. Arch. Dermatol. 127, 1172-1179 (1991).
-
(1991)
Arch. Dermatol.
, vol.127
, pp. 1172-1179
-
-
Khandke, L.1
-
27
-
-
0031914851
-
Treatment of recalcitrant plaque psoriasis with a humanized non-depleting antibody to CD4
-
Bachelez, H. et al. Treatment of recalcitrant plaque psoriasis with a humanized non-depleting antibody to CD4. J. Autoimmun. 11, 53-62 (1998).
-
(1998)
J. Autoimmun.
, vol.11
, pp. 53-62
-
-
Bachelez, H.1
-
28
-
-
0031905892
-
Intraepidermal lymphocytes in psoriatic lesions are GMP-17 (TIA-1)+CD8+CD3+ CTLs as determined by phenotypic analysis
-
Austin, L. M., Coven, T. R., Bhardwaj, N., Steinman, R. & Krueger, J. G. Intraepidermal lymphocytes in psoriatic lesions are GMP-17 (TIA-1)+CD8+CD3+ CTLs as determined by phenotypic analysis. J. Cut. Pathol. 25, 79-88 (1998).
-
(1998)
J. Cut. Pathol.
, vol.25
, pp. 79-88
-
-
Austin, L.M.1
Coven, T.R.2
Bhardwaj, N.3
Steinman, R.4
Krueger, J.G.5
-
29
-
-
0024413413
-
Remission of psoriatic lesions with uromonab-CD3 (Orthoclone OKT3) treatment
-
Weinshenker, B. G., Bass, B. H., Ebers, G. C. & Rice, G. P. A. Remission of psoriatic lesions with uromonab-CD3 (Orthoclone OKT3) treatment. J. Am. Acad Dermatol. 20, 1132-1133 (1989).
-
(1989)
J. Am. Acad. Dermatol.
, vol.20
, pp. 1132-1133
-
-
Weinshenker, B.G.1
Bass, B.H.2
Ebers, G.C.3
Rice, G.P.A.4
-
30
-
-
0036145337
-
The immunologic basis for the treatment of psoriasis with new biologic agents
-
Krueger, J. The immunologic basis for the treatment of psoriasis with new biologic agents. J. Am. Acad. Dermatol. 46 1-23 (2002).
-
(2002)
J. Am. Acad. Dermatol.
, vol.46
, pp. 1-23
-
-
Krueger, J.1
-
31
-
-
0017357411
-
Methotrexate: Diagnosis and treatment drugs five years later
-
Weinstein, G. D. Methotrexate: diagnosis and treatment drugs five years later. Ann. Intern. Med. 86, 199-204 (1977).
-
(1977)
Ann. Intern. Med.
, vol.86
, pp. 199-204
-
-
Weinstein, G.D.1
-
32
-
-
0024788033
-
Use of cyclospoirin in psoriasis
-
Bos, J. D., VanJoost, T., Powles, A. V., Meinardi, M. M. H. M. & Fry, L. Use of cyclospoirin in psoriasis. Lancet 23, 1500-1505 (1989).
-
(1989)
Lancet
, vol.23
, pp. 1500-1505
-
-
Bos, J.D.1
VanJoost, T.2
Powles, A.V.3
Meinardi, M.M.H.M.4
Fry, L.5
-
33
-
-
84944283396
-
Cyclosporine improves psoriasis in a double-blind study
-
Ellis, C. N. et al. Cyclosporine improves psoriasis in a double-blind study. JAMA 256, 3110-3116 (1986).
-
(1986)
JAMA
, vol.256
, pp. 3110-3116
-
-
Ellis, C.N.1
-
34
-
-
1542313881
-
Spontaneous development of psoriasis in a new animal model shows an essential rose for resident T cells and tumor necrosis factor α
-
Boyman, O. et al. Spontaneous development of psoriasis in a new animal model shows an essential rose for resident T cells and tumor necrosis factor α. J. Exp. Med. 199, 731-736 (2004).
-
(2004)
J. Exp. Med.
, vol.199
, pp. 731-736
-
-
Boyman, O.1
-
35
-
-
12144276832
-
Crucial role for intraepidermal T cells expressing the collagen-binding integrin α1β1 in psoriasis
-
Conrad, C. et al. Crucial role for intraepidermal T cells expressing the collagen-binding integrin α1β1 in psoriasis. J. Invest. Dermatol. 122, A14-079 (2004).
-
(2004)
J. Invest. Dermatol.
, vol.122
-
-
Conrad, C.1
-
36
-
-
0023069478
-
The lymphocyte function-associated LFA-1, CD2, and LFA-2 molecules: Cell adhesion receptors of the immune system
-
Springer, T. A. et al. The lymphocyte function-associated LFA-1, CD2, and LFA-2 molecules: cell adhesion receptors of the immune system. Ann. Rev. Immunol. 5, 223-252 (1987).
-
(1987)
Ann. Rev. Immunol.
, vol.5
, pp. 223-252
-
-
Springer, T.A.1
-
37
-
-
0025182959
-
Adhesions receptors of the immune system
-
Springer, T. A. Adhesions receptors of the immune system. Nature 346, 425-434 (1990).
-
(1990)
Nature
, vol.346
, pp. 425-434
-
-
Springer, T.A.1
-
39
-
-
0032482337
-
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer call
-
Ridge, J. P., DiRosa, F. & Matzinger, P. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer call. Nature 393, 474-478 (1998).
-
(1998)
Nature
, vol.393
, pp. 474-478
-
-
Ridge, J.P.1
DiRosa, F.2
Matzinger, P.3
-
40
-
-
0032482474
-
T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
-
Schoenberger, S. P., Toes, R. E. M., VanDerVoort, E. I. H., Offringa, R. & Melief, C. J. M. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393, 480-483 (1998).
-
(1998)
Nature
, vol.393
, pp. 480-483
-
-
Schoenberger, S.P.1
Toes, R.E.M.2
VanDerVoort, E.I.H.3
Offringa, R.4
Melief, C.J.M.5
-
41
-
-
0032482356
-
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
-
Bennett, S. R. M. et al. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393, 478-483 (1998).
-
(1998)
Nature
, vol.393
, pp. 478-483
-
-
Bennett, S.R.M.1
-
42
-
-
0025351406
-
Role of the CD28 receptor in T-cell activation
-
June, C. H., Ledbetter, J. A., Linsley, P. S. & Thompson, C. B. Role of the CD28 receptor in T-cell activation. Immunol. Today 11, 211-216 (1990).
-
(1990)
Immunol. Today
, vol.11
, pp. 211-216
-
-
June, C.H.1
Ledbetter, J.A.2
Linsley, P.S.3
Thompson, C.B.4
-
43
-
-
0033135564
-
CTLA4Ig-mediated blockade of T-cell oostimulation in patients with psoriasis vulgaris
-
Abrams, J. R. et al. CTLA4Ig-mediated blockade of T-cell oostimulation in patients with psoriasis vulgaris. J. Clin. Invest. 103, 1243-1252 (1999).
-
(1999)
J. Clin. Invest.
, vol.103
, pp. 1243-1252
-
-
Abrams, J.R.1
-
44
-
-
0034605033
-
Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells
-
Abrams, J. et al. Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells. J. Exp. Med. 192, 681-94 (2000).
-
(2000)
J. Exp. Med.
, vol.192
, pp. 681-694
-
-
Abrams, J.1
-
45
-
-
0343967064
-
Blockade of T-cell costimulation with CTLA4Ig (BMS-188667) reverses pathologic inflammation and keratinocyte activation in psoriatic plaques
-
Krueger, J. G. et al. Blockade of T-cell costimulation with CTLA4Ig (BMS-188667) reverses pathologic inflammation and keratinocyte activation in psoriatic plaques. J. Invest. Dermatol. 108, 555 (1997).
-
(1997)
J. Invest. Dermatol.
, vol.108
, pp. 555
-
-
Krueger, J.G.1
-
46
-
-
0013600514
-
CTLA4Ig (BMS-188667)-mediated blockade of T cell costimulation in patients with psoriasis vulgaris
-
Lebwohl, M. et al. CTLA4Ig (BMS-188667)-mediated blockade of T cell costimulation in patients with psoriasis vulgaris. J. Invest. Dermatol. 108, 570 (1997).
-
(1997)
J. Invest. Dermatol.
, vol.108
, pp. 570
-
-
Lebwohl, M.1
-
47
-
-
0036828011
-
Clinical and histologic response to single-dose treatment of moderate to severe psoriasis with an anti-CD80 monoclonal antibody
-
Gottlieb, A. B. et al. Clinical and histologic response to single-dose treatment of moderate to severe psoriasis with an anti-CD80 monoclonal antibody. J. Am. Acad. Dermatol. 47, 692-700 (2002).
-
(2002)
J. Am. Acad. Dermatol.
, vol.47
, pp. 692-700
-
-
Gottlieb, A.B.1
-
48
-
-
1842735276
-
Evaluation and safety and clinical activity of multiple doses of the anti-CD80 monoclonal antibody, galiximab, in patients with moderate to severe psoriasis
-
Gottlieb, A. B. et al. Evaluation and safety and clinical activity of multiple doses of the anti-CD80 monoclonal antibody, galiximab, in patients with moderate to severe psoriasis. Clin. Immunol. 111, 28-37 (2004).
-
(2004)
Clin. Immunol.
, vol.111
, pp. 28-37
-
-
Gottlieb, A.B.1
-
49
-
-
0038793719
-
Connections between psoriasis and Crohns disease
-
Najarian, D. J. & Gottlieb, A. B. Connections between psoriasis and Crohns disease. J. Am. Acad. Dermatol. 48, 805-821 (2003).
-
(2003)
J. Am. Acad. Dermatol.
, vol.48
, pp. 805-821
-
-
Najarian, D.J.1
Gottlieb, A.B.2
-
50
-
-
0035832515
-
Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: A randomised trial
-
Chaudhari, U. et al. Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial. Lancet 357, 1842-1847 (2001).
-
(2001)
Lancet
, vol.357
, pp. 1842-1847
-
-
Chaudhari, U.1
-
51
-
-
0037234032
-
Pharmacodynamic and pharmacokinetic response to anti-tumor necrosis factor monoclonal antibody (Infliximab) treatment of moderate to severe psoriasis vulgaris
-
Gottlieb, A. B. et al. Pharmacodynamic and pharmacokinetic response to anti-tumor necrosis factor monoclonal antibody (Infliximab) treatment of moderate to severe psoriasis vulgaris. J. Am. Acad. Dermatol. 48, 68-75 (2002).
-
(2002)
J. Am. Acad. Dermatol.
, vol.48
, pp. 68-75
-
-
Gottlieb, A.B.1
-
52
-
-
0038456045
-
Infliximab monotherapy, provides rapid and sustained benefit for plaque-type psoriasis
-
Gottlieb, A. B. et al. Infliximab monotherapy, provides rapid and sustained benefit for plaque-type psoriasis. J. Am. Acad. Dermatol. 48, 829-835 (2003).
-
(2003)
J. Am. Acad. Dermatol.
, vol.48
, pp. 829-835
-
-
Gottlieb, A.B.1
-
53
-
-
12144260368
-
Efficacy and safety of ENBREL (etanercept) in patients with psoriasis: Results of a phase III study
-
Leonardi, C., Gottlieb, A. & Zitnik, R. Efficacy and safety of ENBREL (etanercept) in patients with psoriasis: results of a phase III study. J. Invest. Dermatol. 121, 409 (2003).
-
(2003)
J. Invest. Dermatol.
, vol.121
, pp. 409
-
-
Leonardi, C.1
Gottlieb, A.2
Zitnik, R.3
-
54
-
-
10744221697
-
A randomized trial of etanercept as monotherapy for psoriasis
-
Gottlieb, A. B. et al. A randomized trial of etanercept as monotherapy for psoriasis. Arch. Dermatol. 139, 1627-1632 (2003).
-
(2003)
Arch. Dermatol.
, vol.139
, pp. 1627-1632
-
-
Gottlieb, A.B.1
-
55
-
-
4644327125
-
Infliximab induction therapy in patients with severe plaque-type psoriasis: A randomized, doubleblind, placbo-controlled trial
-
(in the press)
-
Gottlieb, A. B. et al. Infliximab induction therapy in patients with severe plaque-type psoriasis: A randomized, doubleblind, placbo-controlled trial. J. Am. Acad. Dermatol. (in the press)
-
J. Am. Acad. Dermatol.
-
-
Gottlieb, A.B.1
-
56
-
-
0024353404
-
Decreased growth inhibition by recombinant γ-interferon is associated with increased transforming growth factor-α production in keratinocytes cultured from psoriatic lesions
-
Nickoloff, B. J., Mitra, R. S., Elder, J. T., Fisher, G. J. & Voorhees, J. J. Decreased growth inhibition by recombinant γ -interferon is associated with increased transforming growth factor-α production in keratinocytes cultured from psoriatic lesions. Br. J. Dermatol. 121, 161-174 (1989).
-
(1989)
Br. J. Dermatol.
, vol.121
, pp. 161-174
-
-
Nickoloff, B.J.1
Mitra, R.S.2
Elder, J.T.3
Fisher, G.J.4
Voorhees, J.J.5
-
57
-
-
0343019918
-
Interleukin-6 (IL-6) is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes
-
Grossman, R. M. et al. Interleukin-6 (IL-6) is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc. Natl Acad Sci. USA 86, 6367-6371 (1989).
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 6367-6371
-
-
Grossman, R.M.1
-
58
-
-
0023716350
-
Keratinocyte growth regulation by the products of immune cells
-
Hancock, G. E., Kaplan, G. &Cohn, Z. A. Keratinocyte growth regulation by the products of immune cells. J. Exp. Med. 168, 1395-1402 (1988).
-
(1988)
J. Exp. Med.
, vol.168
, pp. 1395-1402
-
-
Hancock, G.E.1
Kaplan, G.2
Cohn, Z.A.3
-
59
-
-
0028126761
-
GM-CSF activates regenerative epidermal growth and stimulates keratinocyte proliferation in human skin in vivo
-
Braunstein, S. et al. GM-CSF activates regenerative epidermal growth and stimulates keratinocyte proliferation in human skin in vivo. J. Invest. Dermatol. 103, 601-604 (1994).
-
(1994)
J. Invest. Dermatol.
, vol.103
, pp. 601-604
-
-
Braunstein, S.1
-
60
-
-
0035838332
-
Cytokines: IL-20 - A new effector in skin inflammation
-
Rich, B. & Kupper, T. Cytokines: IL-20 - a new effector in skin inflammation. Curr. Biol. 11, R531-R534 (2001).
-
(2001)
Curr. Biol.
, vol.11
-
-
Rich, B.1
Kupper, T.2
-
61
-
-
0346364791
-
Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriol
-
Romer, J. et al. Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriol. J. Invest. Dermatol. 121, 1306-1311 (2003).
-
(2003)
J. Invest. Dermatol.
, vol.121
, pp. 1306-1311
-
-
Romer, J.1
-
62
-
-
0022543721
-
Significance and pathogenesis of basal keratinocyte herniations in psoriasis
-
Heng, M., Kloss, S., Kuehn, C. & Chase, D. Significance and pathogenesis of basal keratinocyte herniations in psoriasis. J. Invest. Dermatol. 87, 362-366 (1986).
-
(1986)
J. Invest. Dermatol.
, vol.87
, pp. 362-366
-
-
Heng, M.1
Kloss, S.2
Kuehn, C.3
Chase, D.4
-
63
-
-
0032845971
-
The dermoepidermal junction in psoriatic skin as revealed by scanning electron microscopy
-
Vaccaro, M. et al. The dermoepidermal junction in psoriatic skin as revealed by scanning electron microscopy. Arch. Dermatol. Res. 291, 369-396 (1999).
-
(1999)
Arch. Dermatol. Res.
, vol.291
, pp. 369-396
-
-
Vaccaro, M.1
-
64
-
-
0028916476
-
A subset of macrophages located along the basement membrane ('lining cells') is a characteristic histopathological feature of psoriasis
-
Boehncke, W.-H., Wortmann, S., Kaufmann, R., Mielke, V. & Sterry, W. A subset of macrophages located along the basement membrane ('lining cells') is a characteristic histopathological feature of psoriasis. Am. J. Dermatopathol. 17, 139-144 (1995).
-
(1995)
Am. J. Dermatopathol.
, vol.17
, pp. 139-144
-
-
Boehncke, W.-H.1
Wortmann, S.2
Kaufmann, R.3
Mielke, V.4
Sterry, W.5
-
65
-
-
0023181424
-
Changes in keratinocyte maturation during wound healing
-
Mansbridge, J. N. & Knapp, A. M. Changes in keratinocyte maturation during wound healing. J. Invest Dermatol. 89, 253-263 (1987).
-
(1987)
J. Invest. Dermatol.
, vol.89
, pp. 253-263
-
-
Mansbridge, J.N.1
Knapp, A.M.2
-
66
-
-
0025166474
-
Recessive dystrophic epidermolysis bullosa skin displays a chronic growth-activated immunophenotype
-
Smoller, B. A. et al. Recessive dystrophic epidermolysis bullosa skin displays a chronic growth-activated immunophenotype. Arch. Dermatol. 126, 78-83 (1990).
-
(1990)
Arch. Dermatol.
, vol.126
, pp. 78-83
-
-
Smoller, B.A.1
-
67
-
-
0012184206
-
Psoriasis-related subpopulations of memory CD4+ and CD8+ T cells are selectively reduced by Alefacept
-
Krueger, J. G., Gilleaudeau, P., Kikuchi, T. & Lee, E. Psoriasis-related subpopulations of memory CD4+ and CD8+ T cells are selectively reduced by Alefacept. J. Invest Dermatol. 119, 345 (2002).
-
(2002)
J. Invest. Dermatol.
, vol.119
, pp. 345
-
-
Krueger, J.G.1
Gilleaudeau, P.2
Kikuchi, T.3
Lee, E.4
-
68
-
-
0028210091
-
E-selectin and vascular cell adhesion molecule-1 are critical for initial trafficking of helper-inducer/memory T cells in psoriatic, plaques
-
Wakita, H. & Takigawa, M. E-selectin and vascular cell adhesion molecule-1 are critical for initial trafficking of helper-inducer/memory T cells in psoriatic, plaques. Arch. Dermatol 130, 457-463 (1994).
-
(1994)
Arch. Dermatol.
, vol.130
, pp. 457-463
-
-
Wakita, H.1
Takigawa, M.2
-
69
-
-
0036569218
-
Alefacept, an immunomodulatory recombinant LFA-3/IgG1 fusion protein, induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2+ cells
-
daSilva, A. J. et al. Alefacept, an immunomodulatory recombinant LFA-3/IgG1 fusion protein, induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2+ cells. J. Immunol. 168, 4462-4471 (2002).
-
(2002)
J. Immunol.
, vol.168
, pp. 4462-4471
-
-
daSilva, A.J.1
-
70
-
-
0035954670
-
Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes
-
Ellis, C. N., Krueger, G. G. & Group, A. C. S. Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes. N. Engl. J. Med. 345, 248-255 (2001).
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 248-255
-
-
Ellis, C.N.1
Krueger, G.G.2
Group, A.C.S.3
-
71
-
-
0036895587
-
Alefacept Clinical Study Group. A randomized, double-blind, placebo-controlled phase III study evaluating efficacy an dtolerability of 2 courses of alefacept in patients with chronic plaque psoriasis
-
Krueger, G. G. et al. Alefacept Clinical Study Group. A randomized, double-blind, placebo-controlled phase III study evaluating efficacy an dtolerability of 2 courses of alefacept in patients with chronic plaque psoriasis. J. Am. Acad Dermatol. 47, 821-833 (2002).
-
(2002)
J. Am. Acad. Dermatol.
, vol.47
, pp. 821-833
-
-
Krueger, G.G.1
-
72
-
-
0038385972
-
An international, randomized, doubleblind, placebo-controlled phase 3 trial of intramuscular all in patients with chronic plaque psoriasis
-
Lebwohl, M. et al. An international, randomized, doubleblind, placebo-controlled phase 3 trial of intramuscular all in patients with chronic plaque psoriasis. Arch. Dermatol. 139, 719-727 (2003).
-
(2003)
Arch. Dermatol.
, vol.139
, pp. 719-727
-
-
Lebwohl, M.1
-
73
-
-
0142182716
-
CD4+ T-cell-directed antibody responses are maintained in patients with psoriasis receiving alefacept: Results of a randomized study
-
Gottlieb, A. B. et al. CD4+ T-cell-directed antibody responses are maintained in patients with psoriasis receiving alefacept: results of a randomized study J. Am. Acad. Dermatol. 49, 816-825 (2003).
-
(2003)
J. Am. Acad. Dermatol.
, vol.49
, pp. 816-825
-
-
Gottlieb, A.B.1
-
74
-
-
12944283147
-
Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis
-
Gottlieb, A. et al. Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis. J. Am. Acad. Dermatol. 42, 428-435 (2000).
-
(2000)
J. Am. Acad. Dermatol.
, vol.42
, pp. 428-435
-
-
Gottlieb, A.1
-
75
-
-
0036822279
-
Alefacept treatment in psoriatic, arthritis: Reduction of the effector T cell population in peripheral blood and synovial tissue is associated with improvement of clinical signs of arthritis
-
Kraan, M. C. et al. Alefacept treatment in psoriatic, arthritis: reduction of the effector T cell population in peripheral blood and synovial tissue is associated with improvement of clinical signs of arthritis. Arthritis Rheum. 46, 2776-2784 (2002).
-
(2002)
Arthritis Rheum.
, vol.46
, pp. 2776-2784
-
-
Kraan, M.C.1
-
76
-
-
0036578664
-
Psoriasis as a model for T-cell-mediated disease: Immunobiologic and clinical effects of treatment with multiple doses of efalizumab, an anti-CD11a monoclonal antibody
-
Gottlieb, A. B. et al. Psoriasis as a model for T-cell-mediated disease: Immunobiologic and clinical effects of treatment with multiple doses of efalizumab, an anti-CD11a monoclonal antibody. Arch. Derm. 138, 591-600 (2002).
-
(2002)
Arch. Derm.
, vol.138
, pp. 591-600
-
-
Gottlieb, A.B.1
-
77
-
-
0037825762
-
Subcutaneously administered efalizumab (antiCD11a) improves signs and symptoms of moderate to severe plaque psoriasis
-
Gottlieb, A. G. et al. Subcutaneously administered efalizumab (antiCD11a) improves signs and symptoms of moderate to severe plaque psoriasis. J. Cut. Med. Surg. 7, 198-207 (2003).
-
(2003)
J. Cut. Med. Surg.
, vol.7
, pp. 198-207
-
-
Gottlieb, A.G.1
-
78
-
-
0345107256
-
A Novel targeted T-cell modulator, efalizumab, for plaque psoriasis
-
Lebwohl, M. et al. A Novel targeted T-cell modulator, efalizumab, for plaque psoriasis. N. Engl J. Med. 349, 2004-2013 (2003)
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 2004-2013
-
-
Lebwohl, M.1
-
79
-
-
17944381053
-
The treatment of moderate to severe psoriasis with a new anti-CD11a monoclonal antibody
-
Papp K., B. R. et al. The treatment of moderate to severe psoriasis with a new anti-CD11a monoclonal antibody. J. Am. Acad Dermatol. 45, 665-674 (2001).
-
(2001)
J. Am. Acad. Dermatol.
, vol.45
, pp. 665-674
-
-
Papp, K.B.R.1
-
80
-
-
12144277869
-
The pharmacokinetics and pharmacodynamics of efalizumab following 12 weeks of subcutaneous treatment in subjects with moderate to severe plaque psoriasis in a phase I, open-label, multi-center study
-
Motensen, D. et al. The pharmacokinetics and pharmacodynamics of efalizumab following 12 weeks of subcutaneous treatment in subjects with moderate to severe plaque psoriasis in a phase I, open-label, multi-center study. J. Invest Dermatol. 121, 379 (2003).
-
(2003)
J. Invest Dermatol.
, vol.121
, pp. 379
-
-
Motensen, D.1
-
81
-
-
12144276043
-
Presence of 'inflammatory' dendritic cells in psoriasis vulgaris lesions and modulation by efalizumab (anti-CD11a)
-
Chamian, F. et al. Presence of 'inflammatory' dendritic cells in psoriasis vulgaris lesions and modulation by efalizumab (anti-CD11a). J. Invest, Dermatol. 122, A41-A245 (2004).
-
(2004)
J. Invest. Dermatol.
, vol.122
-
-
Chamian, F.1
-
82
-
-
0346515709
-
Efalizumab for patients with moderate to severe plaque psoriasis: A randomized controlled trial
-
Gordon, K. B. et al. Efalizumab for patients with moderate to severe plaque psoriasis: a randomized controlled trial. JAMA 290, 3073-3080 (2004).
-
(2004)
JAMA
, vol.290
, pp. 3073-3080
-
-
Gordon, K.B.1
-
83
-
-
12144254336
-
Efficacy and safety outcomes of long-term efalizumab therapy in patients with moderate to severe plaque psoriasis: An update
-
Gottlieb, A. B., Hamilton, T. K., Caro, I. & Gordon, K. B. Efficacy and safety outcomes of long-term efalizumab therapy in patients with moderate to severe plaque psoriasis: an update. J. Invest. Dermatol. 122, A57-A341 (2004).
-
(2004)
J. Invest. Dermatol.
, vol.122
-
-
Gottlieb, A.B.1
Hamilton, T.K.2
Caro, I.3
Gordon, K.B.4
-
84
-
-
0003198906
-
Intracellular TNF-α, IFN-γ, and IL-2 identify TC1 and TH1 effector populations in psoriasis vulgaris plaque lymphocytes: Single-cell analysis by flow cytometry
-
Austin, L., Ozawa, M., Kikuchi, T. & Krueger, G. Intracellular TNF-α, IFN-γ, and IL-2 identify TC1 and TH1 effector populations in psoriasis vulgaris plaque lymphocytes: single-cell analysis by flow cytometry. J. Invest Dermatol. 110, 649 (1998).
-
(1998)
J. Invest. Dermatol.
, vol.110
, pp. 649
-
-
Austin, L.1
Ozawa, M.2
Kikuchi, T.3
Krueger, G.4
-
85
-
-
0028233818
-
Elevated tumour necrosis factor-α (TNF-α) biological activity in psoriatic skin lesions
-
Ettehadi, P., Greaves, M. W., Wallach, D., Aderka, D. & Camp, R. D. R. Elevated tumour necrosis factor-α (TNF-α) biological activity in psoriatic skin lesions. Clin. Exp. Immunol. 96, 146-151 (1994).
-
(1994)
Clin. Exp. Immunol.
, vol.96
, pp. 146-151
-
-
Ettehadi, P.1
Greaves, M.W.2
Wallach, D.3
Aderka, D.4
Camp, R.D.R.5
-
86
-
-
0037364369
-
Mechanisms of TNF-α- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis
-
Ritchlin, C. T., Haas-Smith, S. A., Li, P., Hicks, D. G., Schwarz, E. M. Mechanisms of TNF-α- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. J. Clin. Invest. 111, 821-831 (2003).
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 821-831
-
-
Ritchlin, C.T.1
Haas-Smith, S.A.2
Li, P.3
Hicks, D.G.4
Schwarz, E.M.5
-
87
-
-
0037234032
-
Pharmacodynamic and pharmacokinetic response to anti-tumor necrosis factor-α monoclonal antibody (infliximab) treatment of moderate to severe psoriasis vulgaris
-
Gottlieb, A. B. et al. Pharmacodynamic and pharmacokinetic response to anti-tumor necrosis factor-α monoclonal antibody (infliximab) treatment of moderate to severe psoriasis vulgaris. J. Am. Acad. Dermatol. 48, 68-75 (2003).
-
(2003)
J. Am. Acad. Dermatol.
, vol.48
, pp. 68-75
-
-
Gottlieb, A.B.1
-
88
-
-
0032847323
-
The immunologic and genetic basis of psoriasis
-
Nickoloff, B. J. The immunologic and genetic basis of psoriasis. Arch. Dermatol. 135, 1104-1110 (1999).
-
(1999)
Arch. Dermatol.
, vol.135
, pp. 1104-1110
-
-
Nickoloff, B.J.1
-
89
-
-
0037269890
-
Clinical research helps elucidate the role of tumor necrosis factor-α in the pathogeesis of T1-mediated immune disorders: Use of targeted immunotherapeutics as pathogenic probes
-
Gottlieb, A. G. Clinical research helps elucidate the role of tumor necrosis factor-α in the pathogeesis of T1-mediated immune disorders: use of targeted immunotherapeutics as pathogenic probes. Lupus 12, 192-196 (2003).
-
(2003)
Lupus
, vol.12
, pp. 192-196
-
-
Gottlieb, A.G.1
-
90
-
-
0041568189
-
The role of apoptosis in human epidermal keratinocytes
-
Weisfelner, M. E. & Gottlieb, A. B. The role of apoptosis in human epidermal keratinocytes. J. Drugs. Dermatol. 2, 385-391 (2003).
-
(2003)
J. Drugs. Dermatol.
, vol.2
, pp. 385-391
-
-
Weisfelner, M.E.1
Gottlieb, A.B.2
-
91
-
-
0034729950
-
Etanercept in the treatment of psoriatic arthritis and psoriasis: A randomised trial
-
Mease, P. J. et al. Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial. Lancet 356, 385-390 (2000).
-
(2000)
Lancet
, vol.356
, pp. 385-390
-
-
Mease, P.J.1
-
92
-
-
0030707785
-
Inflammatory infiltrate and interleukin-8 expression in the synovium of psoriatic arthritis - An immunohistochemical and mRNA analysis
-
Konig, A. et al. Inflammatory infiltrate and interleukin-8 expression in the synovium of psoriatic arthritis - an immunohistochemical and mRNA analysis. Rheumatol. Int. 17, 159-168 (1997).
-
(1997)
Rheumatol. Int.
, vol.17
, pp. 159-168
-
-
Konig, A.1
-
93
-
-
0027998659
-
Immunohistochemical markers for arthritis in psoriasis
-
Veale, D., Barnes, L., Rogers, S. & Fitz, G. O. Immunohistochemical markers for arthritis in psoriasis. Ann. Rheum. Dis. 53, 450-454 (1994).
-
(1994)
Ann. Rheum. Dis.
, vol.53
, pp. 450-454
-
-
Veale, D.1
Barnes, L.2
Rogers, S.3
Fitz, G.O.4
-
94
-
-
0030766567
-
A TNF-α promoter polymorphism is associated with juvenile onset psoriasis and psoriatic arthritis
-
Hohler, T et al. A TNF-α promoter polymorphism is associated with juvenile onset psoriasis and psoriatic arthritis. J. Invest. Dermatol. 109, 562-565 (1997).
-
(1997)
J. Invest. Dermatol.
, vol.109
, pp. 562-565
-
-
Hohler, T.1
-
95
-
-
0038047689
-
Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohns Disease
-
VanDenBrande, J. M. H. et al. Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohns Disease. Gastroenterology 124, 1774-1785 (2003).
-
(2003)
Gastroenterology
, vol.124
, pp. 1774-1785
-
-
VanDenBrande, J.M.H.1
-
96
-
-
0036229932
-
Binding and functional comparisons of two types of tumor necrosis factor antagonists
-
Scallon, B. et al. Binding and functional comparisons of two types of tumor necrosis factor antagonists. J. Pharmacol. Exp. Ther. 301, 418-426 (2002).
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.301
, pp. 418-426
-
-
Scallon, B.1
-
97
-
-
0029004771
-
Chimeric anti-TNF-α monoclonal anti-body cA2 binds recombinant transmembrane TNF-α and activates immune effector functions
-
Scallon, B. J., Moore, M. A., Trinh, H., Knight, D. M. & Ghrayeb, J. Chimeric anti-TNF-α monoclonal anti-body cA2 binds recombinant transmembrane TNF-α and activates immune effector functions. Cytokine 7, 251-259 (1995).
-
(1995)
Cytokine
, vol.7
, pp. 251-259
-
-
Scallon, B.J.1
Moore, M.A.2
Trinh, H.3
Knight, D.M.4
Ghrayeb, J.5
-
98
-
-
0036151047
-
Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease
-
tenHove, T., vanMontfrans, C., Peppelenbosch, M. P. & vanDeventer, S. J. Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease. Gut 50, 206-211 (2002).
-
(2002)
Gut
, vol.50
, pp. 206-211
-
-
tenHove, T.1
vanMontfrans, C.2
Peppelenbosch, M.P.3
vanDeventer, S.J.4
-
99
-
-
0033524159
-
Infliximab (chimeric anti-tumour necrosis factor-α monoclonal antibody) versus placebo in theumatoid arthritis patients receiving concomitant methotrexate: A randomised phase III trial
-
Maini, R. et al. Infliximab (chimeric anti-tumour necrosis factor-α monoclonal antibody) versus placebo in theumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. Lancet 354, 1932-1939 (1999).
-
(1999)
Lancet
, vol.354
, pp. 1932-1939
-
-
Maini, R.1
-
100
-
-
0030954732
-
A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor-α for Crohns disease
-
Targan, S. R. et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor-α for Crohns disease. N. Engl. J. Med. 337, 1029-1035 (1997).
-
(1997)
N. Engl. J. Med.
, vol.337
, pp. 1029-1035
-
-
Targan, S.R.1
-
101
-
-
0033529049
-
Infliximab for the treatment of fistulas in patients with Crohn's disease
-
Present, D. H. et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N. Engl. J. Med. 340 1398-1401 (1999).
-
(1999)
N. Engl. J. Med.
, vol.340
, pp. 1398-1401
-
-
Present, D.H.1
-
102
-
-
0029751983
-
Increased MRI activity and immune activation in two multiple sclerosis patients treated with monoclonal anti-tumor necrosis factor antibody CA2
-
VanOosten, B. W. et al. Increased MRI activity and immune activation in two multiple sclerosis patients treated with monoclonal anti-tumor necrosis factor antibody CA2. Neurology 47 1531-1534 (1996).
-
(1996)
Neurology
, vol.47
, pp. 1531-1534
-
-
VanOosten, B.W.1
-
103
-
-
0034023433
-
Treatment with anti-tumor necrosis factor-α (TNF-α) monoclonal antibody dramatically decreases the clinical activity of psoriasis lesions
-
Oh, C. J., Des, K. M. & Gottlieb, A. B. Treatment with anti-tumor necrosis factor-α (TNF-α) monoclonal antibody dramatically decreases the clinical activity of psoriasis lesions. J. Am. Acad. Dermatol. 42, 829-830 (2000).
-
(2000)
J. Am. Acad. Dermatol.
, vol.42
, pp. 829-830
-
-
Oh, C.J.1
Des, K.M.2
Gottlieb, A.B.3
-
104
-
-
4644327125
-
Infliximab induction therapy for patients with severe plaque-type psoriasis: A randomized, doubleblind, placebo-controlled trial
-
Gottlieb, A. B. et al. Infliximab induction therapy for patients with severe plaque-type psoriasis: A randomized, doubleblind, placebo-controlled trial. J. Am. Acad. Dermatol. 51, 534-542 (2004).
-
(2004)
J. Am. Acad. Dermatol.
, vol.51
, pp. 534-542
-
-
Gottlieb, A.B.1
-
105
-
-
0000568957
-
The Infliximab Multinational Psoriatic Arthritis Controlled Trial (IMPACT)
-
Antoni, C. et al. The Infliximab Multinational Psoriatic Arthritis Controlled Trial (IMPACT). Arthritis Rheum. 46, S381 (2002).
-
(2002)
Arthritis Rheum.
, vol.46
-
-
Antoni, C.1
-
106
-
-
1242336428
-
The one year results of the infliximab multinational psoriatic arthritis controlled trial (IMPACT)
-
Antoni, C. et al. The one year results of the infliximab multinational psoriatic arthritis controlled trial (IMPACT). Arthritis Rheum. 48, S285 (2003).
-
(2003)
Arthritis Rheum.
, vol.48
-
-
Antoni, C.1
-
107
-
-
3042649266
-
Etanercept treatment of psoriatic arthritis: Safety, efficacy, and the effect on disease progression
-
Mease, P. et al. Etanercept treatment of psoriatic arthritis: safety, efficacy, and the effect on disease progression. Arthritis Rheum. 50, 2264-2272 (2004).
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 2264-2272
-
-
Mease, P.1
-
108
-
-
0034673697
-
Etanercept in children with polyarticular juvenile rheumatoid arthritis
-
Lovell, D. et al. Etanercept in children with polyarticular juvenile rheumatoid arthritis. N. Engl J. Med. 342 763-769 (2000).
-
(2000)
N. Engl. J. Med.
, vol.342
, pp. 763-769
-
-
Lovell, D.1
-
109
-
-
0034743750
-
Longterm Safety and Efficacy of Etanercept in Patients with Rheumatoid Arthritis
-
Moreland, I. W. et al. Longterm Safety and Efficacy of Etanercept in Patients with Rheumatoid Arthritis. J. Rheumatol. 28, 1238-1244 (2001).
-
(2001)
J. Rheumatol.
, vol.28
, pp. 1238-1244
-
-
Moreland, I.W.1
-
110
-
-
0242411795
-
Recombinant human tumor necrosis factor receptor (etanercept) for treating ankylosing spondylitis
-
Davis, J. C. et al. Recombinant human tumor necrosis factor receptor (etanercept) for treating ankylosing spondylitis. Arthritis Rheum. 48, 3230-3236 (2003).
-
(2003)
Arthritis Rheum.
, vol.48
, pp. 3230-3236
-
-
Davis, J.C.1
-
111
-
-
0344926414
-
Etanercept as monotherapy in patients with psoriasis
-
Leonardi, C. L. et al. Etanercept as monotherapy in patients with psoriasis. N. Engl. J. Med. 349, 2014-2022 (2003).
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 2014-2022
-
-
Leonardi, C.L.1
-
112
-
-
12144271562
-
Durability of treatment response following withdrawal from etanercept in psoriasis patients
-
Gottlieb, A. B., Gordon, K. B., Wang, A. & Zitnik, R. Durability of treatment response following withdrawal from etanercept in psoriasis patients. J. Invest. Dermatol. 122, A51-306 (2004).
-
(2004)
J. Invest. Dermatol.
, vol.122
-
-
Gottlieb, A.B.1
Gordon, K.B.2
Wang, A.3
Zitnik, R.4
-
113
-
-
12144276831
-
Efficacy of etanercept in an integrated multistudy database of patients with psoriasis
-
Gordon, K. B. et al. Efficacy of etanercept in an integrated multistudy database of patients with psoriasis. J. Invest Dermatol. 122, A54-321 (2004).
-
(2004)
J. Invest. Dermatol.
, vol.122
-
-
Gordon, K.B.1
-
114
-
-
0037116867
-
Adverse reactions to TNF-α inhibitors in rheumatoid arthritis
-
Day, R. Adverse reactions to TNF-α inhibitors in rheumatoid arthritis. Lancet 359, 540-541 (2002).
-
(2002)
Lancet
, vol.359
, pp. 540-541
-
-
Day, R.1
-
115
-
-
2342658406
-
Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy
-
Keystone, E. et al. Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy. Arthritis Rheum. 50, 1400-1411 (2004).
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 1400-1411
-
-
Keystone, E.1
-
116
-
-
0242410494
-
Infections and anti-tumor necrosis factor α therapy
-
Ellerin, T., Rubin, R. H. & Weinblatt, M. Infections and anti-tumor necrosis factor α therapy. Arthritis Rheum. 48, 3013-3022 (2003).
-
(2003)
Arthritis Rheum.
, vol.48
, pp. 3013-3022
-
-
Ellerin, T.1
Rubin, R.H.2
Weinblatt, M.3
-
117
-
-
0347285359
-
Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris
-
Lee, E. et al. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J. Exp. Med. 199, 125-130 (2004).
-
(2004)
J. Exp. Med.
, vol.199
, pp. 125-130
-
-
Lee, E.1
-
118
-
-
12144272384
-
Treatment of moderate-to-severe psoriasis with human monoclonal antibody to human IL-12
-
Kauffman, C. L. et al. Treatment of moderate-to-severe psoriasis with human monoclonal antibody to human IL-12. J. Invest Dermatol. 121, 353 (2003).
-
(2003)
J. Invest. Dermatol.
, vol.121
, pp. 353
-
-
Kauffman, C.L.1
-
119
-
-
9744265704
-
A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis
-
Kauffman, C. L. et al. A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis. J. Invest Dermatol. 123, 1037-1044 (2004).
-
(2004)
J. Invest. Dermatol.
, vol.123
, pp. 1037-1044
-
-
Kauffman, C.L.1
-
120
-
-
0023867476
-
Granulocyte/macrophage colony-stimulating factor and interleukin 1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells
-
Heufler, C., Koch, F. & Schuler, G. Granulocyte/macrophage colony-stimulating factor and interleukin 1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells. J. Exp. Med. 167, 700-705 (1988).
-
(1988)
J. Exp. Med.
, vol.167
, pp. 700-705
-
-
Heufler, C.1
Koch, F.2
Schuler, G.3
-
121
-
-
0023622463
-
Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells
-
Witmer-Pack, M. D., Olivier, W., Valinsky, J., Schuler, G. & Steinman, R. M. Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells. J. Exp. Med. 166, 1484-1498 (1987).
-
(1987)
J. Exp. Med.
, vol.166
, pp. 1484-1498
-
-
Witmer-Pack, M.D.1
Olivier, W.2
Valinsky, J.3
Schuler, G.4
Steinman, R.M.5
-
122
-
-
3042747086
-
Cytokines and chemokines in the initiation and regulation of epidermal Langerhans cell mobilization
-
Kimber, I., Cumberbatch, M., Dearman, R. J., Bhushan, M. & Griffiths, C. E. M. Cytokines and chemokines in the initiation and regulation of epidermal Langerhans cell mobilization. Br. J. Dermatol. 142, 401-412 (2000).
-
(2000)
Br. J. Dermatol.
, vol.142
, pp. 401-412
-
-
Kimber, I.1
Cumberbatch, M.2
Dearman, R.J.3
Bhushan, M.4
Griffiths, C.E.M.5
-
123
-
-
0034944039
-
Interleukin-18: A novel cytokine in inflammatory rheumatic disease
-
McInnes, I. B., Gracie, J. A. & Liew, F. Y. Interleukin-18: a novel cytokine in inflammatory rheumatic disease. Arthritis. Rheum. 44, 1481-1483 (2001).
-
(2001)
Arthritis. Rheum.
, vol.44
, pp. 1481-1483
-
-
McInnes, I.B.1
Gracie, J.A.2
Liew, F.Y.3
-
124
-
-
2542527670
-
The roles of interleukin-18 in collagen-induced arthriis in the BB rat
-
Ye, X. J., Tang, B., Kang, A. H., Myers, L. K. & Cremer, M. A. The roles of interleukin-18 in collagen-induced arthriis in the BB rat. Clin. Exp. Immunol. 136, 1365-2249 (2004).
-
(2004)
Clin. Exp. Immunol.
, vol.136
, pp. 1365-2249
-
-
Ye, X.J.1
Tang, B.2
Kang, A.H.3
Myers, L.K.4
Cremer, M.A.5
-
125
-
-
0034795561
-
Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-γ and TNF-α production
-
Siegmund, B. et al. Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-γ and TNF-α production. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 R1264-R1273 (2001).
-
(2001)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.281
-
-
Siegmund, B.1
-
126
-
-
0036672918
-
Maintaining the norm: T-cell homeostasis
-
Jameson, S. C. Maintaining the norm: T-cell homeostasis. Nature Rev. Immunol. 2 547-555 (2002).
-
(2002)
Nature Rev. Immunol.
, vol.2
, pp. 547-555
-
-
Jameson, S.C.1
-
127
-
-
0034663951
-
Inhibition of keratinocyte apoptosis by IL-15: A new parameter in the pathogenesis of psoriasis?
-
Ruckert, R. et al. Inhibition of keratinocyte apoptosis by IL-15: a new parameter in the pathogenesis of psoriasis? J. Immunol. 165, 2240-2250 (2000).
-
(2000)
J. Immunol.
, vol.165
, pp. 2240-2250
-
-
Ruckert, R.1
-
128
-
-
0242490176
-
The molecular basis of lymphocyte recruitment to the skin: Clues for pathogenesis and selective therapies of inflammatory disorders
-
Schon, M. P., Zollner, T. M. & Henning Boehncke, W. The molecular basis of lymphocyte recruitment to the skin: clues for pathogenesis and selective therapies of inflammatory disorders. J. Invest. Dermatol. 121, 951-962 (2003).
-
(2003)
J. Invest. Dermatol.
, vol.121
, pp. 951-962
-
-
Schon, M.P.1
Zollner, T.M.2
Henning Boehncke, W.3
-
129
-
-
1842413033
-
Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells
-
Fuhlbrigge, R. C., Kieffer, J. D., Armerding, D. & Kupper, T. S. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature 389, 978-981 (1997).
-
(1997)
Nature
, vol.389
, pp. 978-981
-
-
Fuhlbrigge, R.C.1
Kieffer, J.D.2
Armerding, D.3
Kupper, T.S.4
-
130
-
-
0025637676
-
Immune and inflammatory processes in cutaneous tissues. Mechanisms and speculations
-
Kupper, T. S. Immune and inflammatory processes in cutaneous tissues. Mechanisms and speculations. J. Clin. Invest. 86, 1783-1789 (1990).
-
(1990)
J. Clin. Invest.
, vol.86
, pp. 1783-1789
-
-
Kupper, T.S.1
-
131
-
-
0345504168
-
Inflammatory skin diseases, T cells, and immune surveillance
-
Robert, C. & Kupper, T. S. Inflammatory skin diseases, T cells, and immune surveillance. Mech. Disease 341, 1817-1828 (1999).
-
(1999)
Mech. Disease
, vol.341
, pp. 1817-1828
-
-
Robert, C.1
Kupper, T.S.2
-
132
-
-
0036117531
-
Efomycine M. a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation
-
Schon, M. P. et al. Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation. Nature Med 8, 366-372 (2002).
-
(2002)
Nature Med.
, vol.8
, pp. 366-372
-
-
Schon, M.P.1
-
133
-
-
0035210705
-
Therapeutic potential of a novel synthetic selectin blocker, J-R9188 in allergic dermatitis
-
Ikegami-Kuzuhara, A. Y., T., Ohmoto, H. Inoue, Y. Saito, T. Therapeutic potential of a novel synthetic selectin blocker, J-R9188 in allergic dermatitis. J. Pharmacol. 134, 1498-1504 (2001).
-
(2001)
J. Pharmacol.
, vol.134
, pp. 1498-1504
-
-
Ikegami-Kuzuhara, A.Y.T.1
Ohmoto, H.2
Inoue, Y.3
Saito, T.4
-
134
-
-
0038141739
-
Potential therapeutic role for cytokine or adhesion molecule manipulation in Crohn's disease in the shadow of infliximab?
-
Shand, A. F. A. Potential therapeutic role for cytokine or adhesion molecule manipulation in Crohn's disease in the shadow of infliximab? Int. J. Colorectal. Dis. 18, 1-11 (2003).
-
(2003)
Int. J. Colorectal. Dis.
, vol.18
, pp. 1-11
-
-
Shand, A.F.A.1
-
135
-
-
0037413468
-
Natilizumab for active Crohn's disease
-
Ghosh, S. et al. Natilizumab for active Crohn's disease. N. Engl. J. Med. 348, 24-32 (2003).
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 24-32
-
-
Ghosh, S.1
-
136
-
-
0028335730
-
Increased expression of adhesion receptors in both lesional and non-lesional psoriatic skin
-
De Boer, O. et al. Increased expression of adhesion receptors in both lesional and non-lesional psoriatic skin. Arch. Dermatol. Res. 286, 304-311 (1994).
-
(1994)
Arch. Dermatol. Res.
, vol.286
, pp. 304-311
-
-
De Boer, O.1
-
137
-
-
0028237388
-
Cellular interactions and adhesion molecules in psoriatic skin
-
deBoer, O., Verhagen, C., Visser, A., Bos, J. & Das, P. Cellular interactions and adhesion molecules in psoriatic skin. Acta Derm. Venereol. Suppl. (Stockh.) 186, 15-18 (1994).
-
(1994)
Acta Derm. Venereol. (Stockh.)
, vol.186
, Issue.SUPPL.
, pp. 15-18
-
-
deBoer, O.1
Verhagen, C.2
Visser, A.3
Bos, J.4
Das, P.5
-
138
-
-
0024477696
-
Characterization of intercellular adhesion molecule-1 and HLA-DR expression in normal and inflamed skin: Modulation by recombinant γ interferon and tumor necrosis factor
-
Griffiths, C. E. M., Voorhees, J. J. & Nickoloff, B. J. Characterization of intercellular adhesion molecule-1 and HLA-DR expression in normal and inflamed skin: modulation by recombinant γ interferon and tumor necrosis factor. J. Am. Acad. Dermatol. 20 617-629 (1989).
-
(1989)
J. Am. Acad. Dermatol.
, vol.20
, pp. 617-629
-
-
Griffiths, C.E.M.1
Voorhees, J.J.2
Nickoloff, B.J.3
-
139
-
-
0024591397
-
Intercellular adhesion molecule-I (ICAM-I) expression correlated to inflammation
-
Lisby, S., Ralfkiaer, E., Rothlein, R. & Vejlsgaard, G. L. Intercellular adhesion molecule-I (ICAM-I) expression correlated to inflammation. Br. J. Dermatol. 120, 479-484 (1989).
-
(1989)
Br. J. Dermatol.
, vol.120
, pp. 479-484
-
-
Lisby, S.1
Ralfkiaer, E.2
Rothlein, R.3
Vejlsgaard, G.L.4
-
140
-
-
0028234474
-
Immunohistochemical studies of infiltrating cells in early and chronic lesions of psoriasis
-
Onuma, S. Immunohistochemical studies of infiltrating cells in early and chronic lesions of psoriasis. J. Dermatol. 21, 223-232 (1994).
-
(1994)
J. Dermatol.
, vol.21
, pp. 223-232
-
-
Onuma, S.1
-
141
-
-
0034740860
-
Role of integrin αE(CD103)β7 for tissue-specific epidermal localization of CD8+ T lymphocytes
-
Pauls, K. et al. Role of integrin αE(CD103)β7 for tissue-specific epidermal localization of CD8+ T lymphocytes. J. Invest. Dermatol. 117, 569-575 (2002).
-
(2002)
J. Invest. Dermatol.
, vol.117
, pp. 569-575
-
-
Pauls, K.1
-
142
-
-
0036887172
-
Preferential expression of αEβ7 integrin (CD103) on CD8+ T cells in the psoriatic epidermis: Regulation by interleukins 4 and 12 and transforming growth factor-β
-
Teraki, Y. & Shiohara, T. Preferential expression of αEβ7 integrin (CD103) on CD8+ T cells in the psoriatic epidermis: regulation by interleukins 4 and 12 and transforming growth factor-β. J. Invest Dermatol. 147, 1118-1126 (2002).
-
(2002)
J. Invest. Dermatol.
, vol.147
, pp. 1118-1126
-
-
Teraki, Y.1
Shiohara, T.2
-
143
-
-
0024207304
-
Role of interferon-γ in cutaneous trafficking of lymphocytes with emphasis on molecular and cellular adhesion events
-
Nickoloff, B. J. Role of interferon-γ in cutaneous trafficking of lymphocytes with emphasis on molecular and cellular adhesion events. Arch. Dermatol. 124, 1835-1845 (1988).
-
(1988)
Arch. Dermatol.
, vol.124
, pp. 1835-1845
-
-
Nickoloff, B.J.1
-
144
-
-
12144254944
-
IL-7 promotes Th1 cell differentiation
-
Rich, B. IL-7 promotes Th1 cell differentiation. J. Invest Dermatol. 122, A124-753 (2004).
-
(2004)
J. Invest. Dermatol.
, vol.122
-
-
Rich, B.1
-
145
-
-
12144251556
-
CXCR6 and its logand are consecutively expressed in skin
-
Ferenczi, K., Murphy, J., Krzysiek, R. & Kupper, T. S. CXCR6 and its logand are consecutively expressed in skin. J. Invest. Dermatol. 122, A130-777 (2004).
-
(2004)
J. Invest. Dermatol.
, vol.122
-
-
Ferenczi, K.1
Murphy, J.2
Krzysiek, R.3
Kupper, T.S.4
-
146
-
-
0038644624
-
Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis
-
Xia, Y. P. et al. Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis. Blood 102, 161-168 (2003).
-
(2003)
Blood
, vol.102
, pp. 161-168
-
-
Xia, Y.P.1
-
147
-
-
1642534521
-
Evidence for vascular endothelial growth factor (VEGF) as a modifier gene in psoriasis
-
Detmar, M. Evidence for vascular endothelial growth factor (VEGF) as a modifier gene in psoriasis. J. Invest. Dermatol. 122 XIV-XV (2004).
-
(2004)
J. Invest. Dermatol.
, vol.122
, pp. 14-15
-
-
Detmar, M.1
-
148
-
-
1642575255
-
Single-nucleotide polymorphisms of vascular endothelial growth factor in psoriasis of early onset
-
Young, H. S., Summers, A. M., Bhushan, M., Brenchley, P. E. C. & Griffiths, C. E. Single-nucleotide polymorphisms of vascular endothelial growth factor in psoriasis of early onset. J. Invest. Dermatol. 122, 209-215 (2004).
-
(2004)
J. Invest. Dermatol.
, vol.122
, pp. 209-215
-
-
Young, H.S.1
Summers, A.M.2
Bhushan, M.3
Brenchley, P.E.C.4
Griffiths, C.E.5
-
149
-
-
0032729645
-
The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-γ, interleukin-2, and tumor necrosis factor-α, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: A type 1 differentiation bias is also measured in circulating blood T cells in psoriatic, patients
-
Austin, L., Ozawa, M., Kikuchi, T., Walters, I. & Krueger, J. The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-γ, interleukin-2, and tumor necrosis factor-α, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic, patients. J. Invest. Dermatol. 113, 752-759 (1999).
-
(1999)
J. Invest. Dermatol.
, vol.113
, pp. 752-759
-
-
Austin, L.1
Ozawa, M.2
Kikuchi, T.3
Walters, I.4
Krueger, J.5
-
150
-
-
0023792898
-
Detection of a γ-interferon-induced protein (IP-10) in psoriatic plaques
-
Gottlieb, A. B., Luster, A D., Posnett, D. N. & Carter, D. M. Detection of a γ-interferon-induced protein (IP-10) in psoriatic plaques. J. Exp. Med. 168, 941-948 (1988).
-
(1988)
J. Exp. Med.
, vol.168
, pp. 941-948
-
-
Gottlieb, A.B.1
Luster, A.D.2
Posnett, D.N.3
Carter, D.M.4
-
151
-
-
0025205121
-
Immunologic mechanisms in psoriasis
-
Gottlieb, A. B. Immunologic mechanisms in psoriasis. J. Invest. Dermatol. 95, 18S-19S (1990).
-
(1990)
J. Invest. Dermatol.
, vol.95
-
-
Gottlieb, A.B.1
-
152
-
-
0024453281
-
In situ localization of interferons in psoriatic lesions
-
Livden, J. K., Nilsen, R., Bjerke, J. R. & Matre, R. In situ localization of interferons in psoriatic lesions. Arch. Dermatol. Res. 281, 392-397 (1989).
-
(1989)
Arch. Dermatol. Res.
, vol.281
, pp. 392-397
-
-
Livden, J.K.1
Nilsen, R.2
Bjerke, J.R.3
Matre, R.4
-
153
-
-
9144271239
-
Increased levels of an interleukin-1 inhibitor block interleukin-1 activity but not immunoreactivity of mRNA expression of interleukin-1β in psoriasis skin
-
Cooper, K. D. et al. Increased levels of an interleukin-1 inhibitor block interleukin-1 activity but not immunoreactivity of mRNA expression of interleukin-1β in psoriasis skin. J. Invest. Dermatol. 90, 552 (1988).
-
(1988)
J. Invest. Dermatol.
, vol.90
, pp. 552
-
-
Cooper, K.D.1
-
154
-
-
0037291745
-
Thalidomide: A review of approved and investigational uses
-
Matthews, S. J. & McCoy, C. Thalidomide: a review of approved and investigational uses. Clin. Ther. 25, 342-395 (2003).
-
(2003)
Clin. Ther.
, vol.25
, pp. 342-395
-
-
Matthews, S.J.1
McCoy, C.2
-
155
-
-
0142026209
-
p38 MAP kinases: Key signalling molecules as therapeutic targets for inflammatory diseases
-
Kumar, S., Broehm, J. & Lee, J. C. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nature Rev. Drug Discov. 2, 717-726 (2003).
-
(2003)
Nature Rev. Drug Discov.
, vol.2
, pp. 717-726
-
-
Kumar, S.1
Broehm, J.2
Lee, J.C.3
-
156
-
-
0002979775
-
IL-4-induced immune deviation as therapy of psoriasis
-
Thomas, P. IL-4-induced immune deviation as therapy of psoriasis. Arch. Derm. Res. 293, 30 (2001).
-
(2001)
Arch. Derm. Res.
, vol.293
, pp. 30
-
-
Thomas, P.1
-
157
-
-
0032519956
-
IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: A new therapeutic approach
-
Asadullah, K. et al. IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: a new therapeutic approach. J. Clin. Invest 101, 783-794 (1998).
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 783-794
-
-
Asadullah, K.1
-
158
-
-
0000119099
-
IL-11 is an immune-modulatory cytokine which downregulates IL-12, Type 1 cytokines, and multiple inflammation-associated genes in patients with psoriasis
-
Trepicchio, W. et al. IL-11 is an immune-modulatory cytokine which downregulates IL-12, Type 1 cytokines, and multiple inflammation-associated genes in patients with psoriasis. J. Invest. Dermatol. 112 598 (1999).
-
(1999)
J. Invest. Dermatol.
, vol.112
, pp. 598
-
-
Trepicchio, W.1
-
159
-
-
0033857240
-
Successful in vivo blockade of CD25 (high-affinity iryterleukin 2 receptor) on T cells by administration of humanized anti-Tac antibody to patients with psoriasis
-
Krueger, J. G. et al. Successful in vivo blockade of CD25 (high-affinity iryterleukin 2 receptor) on T cells by administration of humanized anti-Tac antibody to patients with psoriasis. J. Am. Acad. Dermatol. 43, 448-458 (2000).
-
(2000)
J. Am. Acad. Dermatol.
, vol.43
, pp. 448-458
-
-
Krueger, J.G.1
-
160
-
-
20244383720
-
Antipsoriatic effect of fumaric acid derivatives
-
Altmeyer, P. et al. Antipsoriatic effect of fumaric acid derivatives. J. Am. Acad. Dermatol. 30, 977-981 (1994 ).
-
(1994)
J. Am. Acad. Dermatol.
, vol.30
, pp. 977-981
-
-
Altmeyer, P.1
-
161
-
-
0042413498
-
Longterm safety aspects of systemic therapy with fumaric acid esters in severe psoriasis
-
Hoefnagel, J., Thio, H., Willemze, R. & Bavinck, J. Longterm safety aspects of systemic therapy with fumaric acid esters in severe psoriasis. Br. J. Dermatol. 149, 363-369 (2003).
-
(2003)
Br. J. Dermatol.
, vol.149
, pp. 363-369
-
-
Hoefnagel, J.1
Thio, H.2
Willemze, R.3
Bavinck, J.4
-
162
-
-
2642687679
-
Fumaric acid esters suppress peripheral CD4- and CD8-positive lymphocytes in psoriasis
-
Hoxtermann, S., Nuchel, C. & Altmeyer, P. Fumaric acid esters suppress peripheral CD4- and CD8-positive lymphocytes in psoriasis. Dermatology 196, 223-230 (1998).
-
(1998)
Dermatology
, vol.196
, pp. 223-230
-
-
Hoxtermann, S.1
Nuchel, C.2
Altmeyer, P.3
-
163
-
-
0037364080
-
Beneficial effects of fumarate therapy in psoriasis vulgaris patients coincide with downregulation of type 1 cytokines
-
Litjens, N. H. R. et al. Beneficial effects of fumarate therapy in psoriasis vulgaris patients coincide with downregulation of type 1 cytokines. Br. J. Dermatol. 148, 444-451 (2003).
-
(2003)
Br. J. Dermatol.
, vol.148
, pp. 444-451
-
-
Litjens, N.H.R.1
-
164
-
-
0035675207
-
Dimethylfumarate inhibits tumor-necrosis-factor-induced CD62E Expression in an NF-κB-dependent manner
-
Loewe, R. et al. Dimethylfumarate inhibits tumor-necrosis-factor-induced CD62E Expression in an NF-κ B-dependent manner. J. Invest. Dermatol. 117, 1363-1368 (2001).
-
(2001)
J. Invest. Dermatol.
, vol.117
, pp. 1363-1368
-
-
Loewe, R.1
-
165
-
-
0031896129
-
Treatment of psoriasis with fumaric acid esters: Results of a prospective multicentre study
-
Mrowietz, U., Christophers, E. & Altmeyer, P. Treatment of psoriasis with fumaric acid esters: results of a prospective multicentre study. Br. J. Dermatol. 138, 456-460 (1998).
-
(1998)
Br. J. Dermatol.
, vol.138
, pp. 456-460
-
-
Mrowietz, U.1
Christophers, E.2
Altmeyer, P.3
-
166
-
-
0031661686
-
The antipsoriatic agent dimethylfumarate immunomodulates T-cell cytokine secretion and inhibits cytokines of the asoriatic cytokine network
-
Ockenfels, H., Schultewolter, T., Ockenfels, G., Funk, R. & Goos, M. The antipsoriatic agent dimethylfumarate immunomodulates T-cell cytokine secretion and inhibits cytokines of the asoriatic cytokine network. Br. J. Dermatol. 139, 390-395 (1998).
-
(1998)
Br. J. Dermatol.
, vol.139
, pp. 390-395
-
-
Ockenfels, H.1
Schultewolter, T.2
Ockenfels, G.3
Funk, R.4
Goos, M.5
-
167
-
-
0028817466
-
Long-term systemic therapy with dimethylfumarate and monoethylfumarate (Fumaderm) in psoriasis
-
Thio, H., van der Schroeff, J., Nugteren-Huying, W. & Vermeer, B. Long-term systemic therapy with dimethylfumarate and monoethylfumarate (Fumaderm) in psoriasis. J. Eur. Acad. Dermatol. Venereol. 4, 35-40 (1995).
-
(1995)
J. Eur. Acad. Dermatol. Venereol.
, vol.4
, pp. 35-40
-
-
Thio, H.1
van der Schroeff, J.2
Nugteren-Huying, W.3
Vermeer, B.4
-
168
-
-
0035113357
-
Inhibition of dendritic cell differentiation by fumaric acid esters
-
Zhu, K. & Mrowietz, U. Inhibition of dendritic cell differentiation by fumaric acid esters. J. Invest. Dermatol. 116 203-208 (2001).
-
(2001)
J. Invest. Dermatol.
, vol.116
, pp. 203-208
-
-
Zhu, K.1
Mrowietz, U.2
-
169
-
-
0345732760
-
Dimethylfumarate is a potent inducer of apoptosis in human T cells
-
Treumer, F., Zhu, K., Glaser, R. & Mrowietz, U. Dimethylfumarate is a potent inducer of apoptosis in human T cells. J. Invest. Dermatol. 121, 1383-1388 (2003).
-
(2003)
J. Invest. Dermatol.
, vol.121
, pp. 1383-1388
-
-
Treumer, F.1
Zhu, K.2
Glaser, R.3
Mrowietz, U.4
-
170
-
-
0016752588
-
Treatment of psoriasis with oral mycophenolic, acid
-
Jones, E. L., Epinette, W. W., Hackney, V. C., Menendez, L. & Frost, P. Treatment of psoriasis with oral mycophenolic, acid. J. Invest. Dermatol. 65, 537-542 (1975).
-
(1975)
J. Invest. Dermatol.
, vol.65
, pp. 537-542
-
-
Jones, E.L.1
Epinette, W.W.2
Hackney, V.C.3
Menendez, L.4
Frost, P.5
-
171
-
-
10344247417
-
Treatment with oral pimecrolimus significantly improves psoriasis with a clear dose-response effect
-
Griffiths, D. L. & Gottlieb, A. Treatment with oral pimecrolimus significantly improves psoriasis with a clear dose-response effect. J. Invest Dermatol. 121, 391 (2003).
-
(2003)
J. Invest. Dermatol.
, vol.121
, pp. 391
-
-
Griffiths, D.L.1
Gottlieb, A.2
-
172
-
-
2942701931
-
Oral tazarotene and oral pimecrolimus: Novel oral therapies in development for psoriasis
-
Singh, F. & Weinberg, J. M. Oral tazarotene and oral pimecrolimus: novel oral therapies in development for psoriasis. J. Drugs Dermatol. 3, 141-143 (2004).
-
(2004)
J. Drugs Dermatol.
, vol.3
, pp. 141-143
-
-
Singh, F.1
Weinberg, J.M.2
-
173
-
-
0035313701
-
The Stat family in cytokine signaling
-
Ihle, J. N. The Stat family in cytokine signaling. Curr. Opin. Cell. Biol. 13, 211-217 (2001).
-
(2001)
Curr. Opin. Cell. Biol.
, vol.13
, pp. 211-217
-
-
Ihle, J.N.1
-
174
-
-
0038004740
-
Targeting JNK for therapeutic benefit; from junk to gold?
-
Manning, A. M. & Davis, R. J. Targeting JNK for therapeutic benefit; from junk to gold? Nature Rev. Drug Discov. 2, 554-565 (2003).
-
(2003)
Nature Rev. Drug Discov.
, vol.2
, pp. 554-565
-
-
Manning, A.M.1
Davis, R.J.2
-
175
-
-
0346505340
-
The IKKNF-kappaB system: A treasure trove for drug development
-
Karin, M., Yamamoto, Y., & Wang, Q. M. The IKKNF-kappaB system: a treasure trove for drug development. Nature Rev. Drug Discov. 3, 17-26 (2004).
-
(2004)
Nature Rev. Drug Discov.
, vol.3
, pp. 17-26
-
-
Karin, M.1
Yamamoto, Y.2
Wang, Q.M.3
-
176
-
-
0029962470
-
Modulation of epidermal differentiation, tissue inflammation, and T-lymphocyte infiltration in posoriatic plaques by topical calcitriol
-
Lu, I. et al. Modulation of epidermal differentiation, tissue inflammation, and T-lymphocyte infiltration in posoriatic plaques by topical calcitriol. J. Cutan. Pathol. 23, 419-434 (1996 ).
-
(1996)
J. Cutan. Pathol.
, vol.23
, pp. 419-434
-
-
Lu, I.1
-
177
-
-
0029955912
-
Etretinate promotes keratinocyte terminal differentiation and reduces T-cell infiltration in psoriatic epidermis
-
Gottlieb, S. L. et al. Etretinate promotes keratinocyte terminal differentiation and reduces T-cell infiltration in psoriatic epidermis. J. Cutan. Pathol. 23, 404-418 (1996).
-
(1996)
J. Cutan. Pathol.
, vol.23
, pp. 404-418
-
-
Gottlieb, S.L.1
-
178
-
-
0041743096
-
The National Psoriasis Foundation Psoriasis Score (NPF-PS) system versus the Psoriasis Area Severity Index (PASI) and Physician's Global Assessment (PGA): A comparison
-
Gottlieb, A. B., Chaudhari, U., Baker, D. G., Perate, M. & Dooley, L. T. The National Psoriasis Foundation Psoriasis Score (NPF-PS) system versus the Psoriasis Area Severity Index (PASI) and Physician's Global Assessment (PGA): a comparison. J. Drugs Dermatol. 3, 260-266 (2003).
-
(2003)
J. Drugs Dermatol.
, vol.3
, pp. 260-266
-
-
Gottlieb, A.B.1
Chaudhari, U.2
Baker, D.G.3
Perate, M.4
Dooley, L.T.5
-
179
-
-
0018099294
-
Severe psoriasis oral therapy with a new retinoid
-
Frederiksson, T. & Pettersson, U. Severe psoriasis oral therapy with a new retinoid. Dermatologica 157, 238-244 (1978).
-
(1978)
Dermatologica
, vol.157
, pp. 238-244
-
-
Frederiksson, T.1
Pettersson, U.2
-
180
-
-
0041826789
-
Effectiveness of psoriatic arthritis therapies
-
Gladman, D. D. Effectiveness of psoriatic arthritis therapies. Sem. Arthritis Rheum. 33, 29-37 (2003).
-
(2003)
Sem. Arthritis Rheum.
, vol.33
, pp. 29-37
-
-
Gladman, D.D.1
-
181
-
-
0346458589
-
Assessment of patients with psoriatic arthritis. A review of currently available measures
-
Gladman, D. D. et al. Assessment of patients with psoriatic arthritis. A review of currently available measures. Arthritis Rheum. 50, 24-35 (2004).
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 24-35
-
-
Gladman, D.D.1
-
183
-
-
0028223483
-
PUVA bath therapy strongly suppresses immunological and epidermal activation in psoriasis: A possible cellular basis for remittive therapy
-
Vallat, V. P. et al. PUVA bath therapy strongly suppresses immunological and epidermal activation in psoriasis: a possible cellular basis for remittive therapy. J. Exp. Med. 180 283-296 (1994).
-
(1994)
J. Exp. Med.
, vol.180
, pp. 283-296
-
-
Vallat, V.P.1
-
184
-
-
0033953110
-
CD69, HLA-DR and the IL-2R identify persistently activated T cells in psoriasis vulgaris lesional skin: Blood and skin comparisons by flow cytometry
-
Ferenczi, K., Burack, L., Pope, M., Krueger, J. & Austin, L. CD69, HLA-DR and the IL-2R identify persistently activated T cells in psoriasis vulgaris lesional skin: blood and skin comparisons by flow cytometry. J. Autoimmun. 14, 63-78. (2000).
-
(2000)
J. Autoimmun.
, vol.14
, pp. 63-78
-
-
Ferenczi, K.1
Burack, L.2
Pope, M.3
Krueger, J.4
Austin, L.5
-
185
-
-
0025812824
-
Soluble IL-2 receptor and CD25 cells in psoriasis: Effects of cyclosporin A and PUVA therapy
-
Duncan, J. I. et al. Soluble IL-2 receptor and CD25 cells in psoriasis: effects of cyclosporin A and PUVA therapy. Clin. Exp. Immunol. 85, 293-296 (1991).
-
(1991)
Clin. Exp. Immunol.
, vol.85
, pp. 293-296
-
-
Duncan, J.I.1
-
186
-
-
0028809898
-
Successful ultraviolet B treatment of psoriasis is accompanied by a reversal of keratinocyte pathology and by selective depletion of intraepidermal T cells
-
Krueger, J. G. et al. Successful ultraviolet B treatment of psoriasis is accompanied by a reversal of keratinocyte pathology and by selective depletion of intraepidermal T cells. J. Exp. Med. 182, 2057-2068 (1995).
-
(1995)
J. Exp. Med.
, vol.182
, pp. 2057-2068
-
-
Krueger, J.G.1
-
187
-
-
0041355377
-
Climatotherapy at the Dead Sea is a remittive therapy for psoriasis: Combined effects on epidermal and immunologic activation
-
Hodak, E. et al. Climatotherapy at the Dead Sea is a remittive therapy for psoriasis: combined effects on epidermal and immunologic activation. J. Am. Acad. Dermatol. 49, 451-457 (2003).
-
(2003)
J. Am. Acad. Dermatol.
, vol.49
, pp. 451-457
-
-
Hodak, E.1
-
188
-
-
84943435507
-
γ-Interferon induces different keratinocyte expression of HLA-DR, DQ and intercellular adhesion molecule-1 (ICAM-1) antigens
-
Nickoloff, B. & Griffiths, C. γ-Interferon induces different keratinocyte expression of HLA-DR, DQ and intercellular adhesion molecule-1 (ICAM-1) antigens. J. Invest. Dermatol. 90, 592 (1988).
-
(1988)
J. Invest. Dermatol.
, vol.90
, pp. 592
-
-
Nickoloff, B.1
Griffiths, C.2
-
189
-
-
0344064197
-
Immunologic targets in psoriasis
-
Kupper, T S. Immunologic targets in psoriasis. N. Engl J. Med. 349, 1987-1990 (2003).
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 1987-1990
-
-
Kupper, T.S.1
-
190
-
-
0037269890
-
Clinical research helps elucidate the role of tumor necrosis factor-α (TNF-α) in the pathogenesis of T1 mediated immune disorders: Use of targeted immunotherapeutics as pathogenic probes
-
Gottlieb, A. B. Clinical research helps elucidate the role of tumor necrosis factor-α (TNF-α) in the pathogenesis of T1 mediated immune disorders: use of targeted immunotherapeutics as pathogenic probes. Lupus 12, 192-196 (2003).
-
(2003)
Lupus
, vol.12
, pp. 192-196
-
-
Gottlieb, A.B.1
-
191
-
-
0031908882
-
The C-X-C chemokine Mig is highly expressed in the papillae of psoriatic, lesions
-
Goebeler, M. et al. The C-X-C chemokine Mig is highly expressed in the papillae of psoriatic, lesions. J. Pathol. 184 89-95 (1998).
-
(1998)
J. Pathol.
, vol.184
, pp. 89-95
-
-
Goebeler, M.1
-
192
-
-
0034660183
-
Up-regulation of macrophage inflammatory protein-3 α/CCL20 and CC chemokine receptor 6 in psoriasis
-
Homey, B. et al. Up-regulation of macrophage inflammatory protein-3 α/CCL20 and CC chemokine receptor 6 in psoriasis. J. Immunol. 164, 6621-32 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 6621-6632
-
-
Homey, B.1
-
193
-
-
0028186576
-
Differential expression of ICAM-1, E-selectin and VCAM-1 by endothelial cells in psoriasis and contact dermatitis
-
Das, P. et al. Differential expression of ICAM-1, E-selectin and VCAM-1 by endothelial cells in psoriasis and contact dermatitis. Acta Derm. Venereol. Suppl. (Stockh.) 186, 21-2 (1994).
-
(1994)
Acta Derm. Venereol. (Stockh.)
, vol.186
, Issue.SUPPL.
, pp. 21-22
-
-
Das, P.1
-
194
-
-
0025896576
-
Proliferating cells in psoriatic dermis are comprised primarily of T cells, endothelial cells, and factor XIIIa+ perivascular dendritic cells
-
Morganroth, G. S., Chan, L. S., Weinstein, G. D., Voorhees, J. J. & Cooper, K. D. Proliferating cells in psoriatic dermis are comprised primarily of T cells, endothelial cells, and factor XIIIa+ perivascular dendritic cells. J. Invest. Dermatol. 96, 333-340 (1991).
-
(1991)
J. Invest. Dermatol.
, vol.96
, pp. 333-340
-
-
Morganroth, G.S.1
Chan, L.S.2
Weinstein, G.D.3
Voorhees, J.J.4
Cooper, K.D.5
-
195
-
-
0025222062
-
Lymphocyte trafficking in psoriasis: A new perspective emphasizing the dermal dendrocyte with active dermal recruitment mediated via endothelial cells followed by intra-epidermal T-cell activation
-
Nickoloff, B. J. & Griffiths, C. E. M. Lymphocyte trafficking in psoriasis: a new perspective emphasizing the dermal dendrocyte with active dermal recruitment mediated via endothelial cells followed by intra-epidermal T-cell activation. J. Invest. Dermatol. 95, 35S-37S (1990).
-
(1990)
J. Invest. Dermatol.
, vol.95
-
-
Nickoloff, B.J.1
Griffiths, C.E.M.2
-
196
-
-
0023857710
-
Detection of transforming growth factor α in normal, malignant, and hyperproliferative human keratinocytes
-
Gottlieb, A. B., Chang, C. K., Posnett, D. N., Fanelli, B. & Tam, J. P. Detection of transforming growth factor α in normal, malignant, and hyperproliferative human keratinocytes. J. Exp. Med. 167, 670-675 (1988).
-
(1988)
J. Exp. Med.
, vol.167
, pp. 670-675
-
-
Gottlieb, A.B.1
Chang, C.K.2
Posnett, D.N.3
Fanelli, B.4
Tam, J.P.5
|