Therapeutic potential of a novel synthetic selectin blocker, OJ-R9188, in allergic dermatitis

British Journal of Pharmacology

Volumn 134, Issue 7, 2001, Pages 1498-1504

  Ikegami Kuzuhara, Akemi ^a   Yoshinaka, Tsuyoshi ^a   Ohmoto, Hiroshi ^a   Inoue, Yoshimasa ^a   Saito, Tadayuki ^a  

^a Nippon Organon KK   (Japan)

Author keywords

Atopic dermatitis; Cell adhesion; Selectin; Skin inflammation

Indexed keywords

CARBOHYDRATE DERIVATIVE; OJ R 9188; SELECTIN; SELECTIN BLOCKING AGENT; THIOGLYCOLIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOPIC DERMATITIS; CELL INFILTRATION; CONTROLLED STUDY; IC 50; MOUSE; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; SKIN ALLERGY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BINDING, COMPETITIVE; DEOXYGUANOSINE; DERMATITIS; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; E-SELECTIN; FREE RADICAL SCAVENGERS; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNOGLOBULIN G; L-SELECTIN; MALE; MICE; MICE, INBRED BALB C; OLIGOSACCHARIDES; P-SELECTIN; PERITONITIS; PICRYL CHLORIDE; POLYSACCHARIDES; RECOMBINANT FUSION PROTEINS; SELECTINS; THIOGLYCOLATES;

EID: 0035210705     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704397     Document Type: Article

References (48)

1. Selectin blockade prevents antigen-induced late bronchial responses and airway hyperresponsiveness in allergic sheep
2. The synergy between naive and memory T cells during activation
3. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-dependent mice
4. The cutaneous lymphocyte antigen is a skin lymphocyte homing, receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1
5. Endothelial leukocyte adhesion molecule 1: An inducible receptor for neutrophils related to complement regulatory proteins and lectins
6. Selectins
7. PADCAM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells
8. Only simultaneous blocking of the L- and P-selectin completely inhibits neutrophil migration into mouse peritoneum
9. Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker
10. Structure/activity studies of anti-inflammatory peptides based on a conserved peptide region of the lectin domein of E-, L- and P-selectin
11. Leukocyte-endothelial cell adhesion as an asctive, multi-step process: A combinatorial mechanism for specificity and diversity in leukocyte targeting
12. The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl Lewis (x) oligosaccharide
13. Lesional expression of interferon-g in atopic eczema
14. Analysis of the cytokine pattern expressed in situ in inhalant allergen patch-test reactions of atopic dermatitis patients
15. Endothelial leucocyte adhesion molecule-1 (ELAM-1) expressin in cutaneous inflammation
16. Differential in situ cytokine gene expression in acue versus chronic atopic dermatitis
17. Studies on selectin blockers 6: Discovery of homological sugar unit of Fucose necessary for E-selectin binding
18. Topographic distribution of a granule membrane protein (GMP-140) that is expressed on the platelet surface after activation: An immunogold-surface replica study
19. + T cells
20. A highly practical synthesis of the sialyl Lewis X pentasaccharide and an investigation of binding to E-, P- and L-selectins
21. Novel synthetic inhibitors of selectin-mediated cell adhesion: Synthesis of 1,6-bis [3-(3-carboxymethylphenyl)-4-(2-α-D-mannopyranosyloxy) phenyl]hexane (TBC1269)
22. Characterization of E-selectin-deficient mice: Demonstration of overlapping function of the endothelial selectins
23. Selectins: Interpreters of cell-specific carbohydrate information during inflammation
24. An endothelial ligand for L-selectin is a novel mucin-like molecule
25. Expression of endothelial-leukocyte adhesion molecule-1 in elicited late phase allergic reactions
26. GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies
27. An immunopharmacological study of the biphasic allergic skin reaction in mice
28. Fucoidin, a potent inhibitor of L-selectin function, reduces contact hypersensitivity reaction in mice
29. Characterization of a specific ligand for P-selectin on myeloid cells. A minor glycoprotein with sialylated O-linked oligosaccharides
30. Inflammatory roles of P-selectin
31. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice
32. Studies on selectin blocker. I. Structure-activity relationships of sialyl Lewis X analogs
33. ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialil-Lex
34. ELAM-1 is an adhesion molecule for skin-homing T cells
35. Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue-selective homing receptor for skin-homing T cells
36. Cell surface lectins in the immune system
37. Fucoidin, a potent inhibitor of leukocyte rolling, prevents neutrophil influx into phorbolester-induced inflammatory sites in rabbit lungs
38. GMP-140 binding to neutrophils is inhibited by sulfated glycans
39. Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin
40. A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation
41. Detection of eosinophils using an eosinophil peroxidase assay. Its use as an assay for eosinophil differentiation factors
42. Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice
43. Eosinophil adhesion to nasal polyp endothelium is P-selectin-dependent
44. Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: An immunocytochemical study
45. Selection ligands
46. Role of selectins on IgE-mediated skin reaction
47. Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells
48. A crucial effect of ligand clustering on the inhibition of binding by L-selectin in intercellular adhesion