메뉴 건너뛰기




Volumn 69, Issue 3, 2005, Pages 425-432

Inhibition of interleukin-12 expression in diltiazem-treated dendritic cells through the reduction of nuclear factor-κB transcriptional activity

Author keywords

CD40L; Dendritic cells; Diltiazem; IL 12; Lipopolysaccharide; NF B

Indexed keywords

DILTIAZEM; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12;

EID: 12144257775     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.10.004     Document Type: Article
Times cited : (12)

References (54)
  • 1
    • 0031906550 scopus 로고    scopus 로고
    • Signal trasduction through NF-κB
    • M. May, and S. Ghosh Signal trasduction through NF-κB Immunol Today 1998 80 88
    • (1998) Immunol Today , pp. 80-88
    • May, M.1    Ghosh, S.2
  • 2
    • 0037247748 scopus 로고    scopus 로고
    • Nuclear factor-kappaB as a therapeutic target in critical care medicine
    • B. Zingarelli, M. Sheehan, and H. Wong Nuclear factor-kappaB as a therapeutic target in critical care medicine Crit Care Med 2003 105 111
    • (2003) Crit Care Med , pp. 105-111
    • Zingarelli, B.1    Sheehan, M.2    Wong, H.3
  • 3
    • 0033571233 scopus 로고    scopus 로고
    • Cyclosporine a inhibits the expression of costimulatory molecules on in vitro-generated dendritic cells: Association with reduced nuclear translocation of nuclear factor kappa B
    • J. Lee, R. Ganster, D. Geller, G. Burckart, A. Thomson, and L. Lu Cyclosporine A inhibits the expression of costimulatory molecules on in vitro-generated dendritic cells: association with reduced nuclear translocation of nuclear factor kappa B Transplantation 1999 1255 1263
    • (1999) Transplantation , pp. 1255-1263
    • Lee, J.1    Ganster, R.2    Geller, D.3    Burckart, G.4    Thomson, A.5    Lu, L.6
  • 4
    • 0033996762 scopus 로고    scopus 로고
    • The I kappa B kinase (IKK) and NF-kappa B: Key elements of proinflammatory signalling
    • M. Karin, and M. Delhase The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling Semin Immunol 2000 85 98
    • (2000) Semin Immunol , pp. 85-98
    • Karin, M.1    Delhase, M.2
  • 5
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • G. Trinchieri Interleukin-12 and the regulation of innate resistance and adaptive immunity Nat Rev Immunol 2003 133 146
    • (2003) Nat Rev Immunol , pp. 133-146
    • Trinchieri, G.1
  • 6
    • 0031943618 scopus 로고    scopus 로고
    • The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
    • M. Gately, L. Renzetti, J. Magram, A. Stern, L. Adorini, and U. Gubler The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses Annu Rev Immunol 1998 495 521
    • (1998) Annu Rev Immunol , pp. 495-521
    • Gately, M.1    Renzetti, L.2    Magram, J.3    Stern, A.4    Adorini, L.5    Gubler, U.6
  • 7
    • 0029812593 scopus 로고    scopus 로고
    • Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
    • M. Cella, D. Scheidegger, K. Palmer-Lehmann, P. Lane, A. Lanzavecchia, and G. Alber Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation J Exp Med 1996 747 752
    • (1996) J Exp Med , pp. 747-752
    • Cella, M.1    Scheidegger, D.2    Palmer-Lehmann, K.3    Lane, P.4    Lanzavecchia, A.5    Alber, G.6
  • 8
    • 0030240073 scopus 로고    scopus 로고
    • IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection: Evidence against a dominant protective role for T helper 2 cytokines in alloimmunity
    • J. Piccotti, S. Chan, R.E. Goodman, J. Magram, E. Eichwald, and D. Bishop IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection: evidence against a dominant protective role for T helper 2 cytokines in alloimmunity J Immunol 1996 1951 1957
    • (1996) J Immunol , pp. 1951-1957
    • Piccotti, J.1    Chan, S.2    Goodman, R.E.3    Magram, J.4    Eichwald, E.5    Bishop, D.6
  • 9
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • J. Banchereau, and R. Steinman Dendritic cells and the control of immunity Nature 1998 245 252
    • (1998) Nature , pp. 245-252
    • Banchereau, J.1    Steinman, R.2
  • 10
    • 0031045622 scopus 로고    scopus 로고
    • Origin, maturation, and antigen presenting function of dendritic cells
    • M. Cella, F. Sallusto, and A. Lanzavecchia Origin, maturation, and antigen presenting function of dendritic cells Curr Opin Immunol 1997 10 16
    • (1997) Curr Opin Immunol , pp. 10-16
    • Cella, M.1    Sallusto, F.2    Lanzavecchia, A.3
  • 11
    • 0031058466 scopus 로고    scopus 로고
    • Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo
    • T. Brocker, M. Riedinger, and K. Karjalainen Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo J Exp Med 1997 541 550
    • (1997) J Exp Med , pp. 541-550
    • Brocker, T.1    Riedinger, M.2    Karjalainen, K.3
  • 12
    • 0030586611 scopus 로고    scopus 로고
    • Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion
    • F. Finkelman, A. Lees, R. Birnbaum, W. Gause, and S. Morris Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion J Immunol 1996 1406 1414
    • (1996) J Immunol , pp. 1406-1414
    • Finkelman, F.1    Lees, A.2    Birnbaum, R.3    Gause, W.4    Morris, S.5
  • 14
    • 0036199656 scopus 로고    scopus 로고
    • Dendritic cell development and survival require distinct NF-kappaB subunits
    • F. Ouaaz, J. Arron, Y. Zheng, Y. Choi, and A. Beg Dendritic cell development and survival require distinct NF-kappaB subunits Immunity 2002 257 270
    • (2002) Immunity , pp. 257-270
    • Ouaaz, F.1    Arron, J.2    Zheng, Y.3    Choi, Y.4    Beg, A.5
  • 15
    • 0037080938 scopus 로고    scopus 로고
    • Manipulation of dendritic cells for tolerance induction in transplantation and autoimmune disease
    • L. Lu, and A. Thomson Manipulation of dendritic cells for tolerance induction in transplantation and autoimmune disease Transplantation 2002 S19 S22
    • (2002) Transplantation
    • Lu, L.1    Thomson, A.2
  • 16
    • 0031757934 scopus 로고    scopus 로고
    • Nuclear factor kappa B: Important transcription factor and therapeutic target
    • J. Lee, and G. Burckart Nuclear factor kappa B: important transcription factor and therapeutic target J Clin Pharmacol 1998 981 993
    • (1998) J Clin Pharmacol , pp. 981-993
    • Lee, J.1    Burckart, G.2
  • 17
    • 0025648543 scopus 로고
    • Additive effects of calcium antagonists on cyclosporin A-induced inhibition of T-cell proliferation
    • M. Marx, M. Weber, F. Merkel, K.M.z. Buschenfelde, and H. Kohler Additive effects of calcium antagonists on cyclosporin A-induced inhibition of T-cell proliferation Nephrol Dial Transplant 1990 1038 1044
    • (1990) Nephrol Dial Transplant , pp. 1038-1044
    • Marx, M.1    Weber, M.2    Merkel, F.3    Buschenfelde, K.Z.M.4    Kohler, H.5
  • 18
    • 0023191555 scopus 로고
    • Inhibition of human natural killer (NK) activity by calcium channel modulators and a calmodulin antagonist
    • J. Solovera, M. Alvarez-Mon, J. Casas, J. Carballido, and A. Durantez Inhibition of human natural killer (NK) activity by calcium channel modulators and a calmodulin antagonist J Immunol 1987 876 880
    • (1987) J Immunol , pp. 876-880
    • Solovera, J.1    Alvarez-Mon, M.2    Casas, J.3    Carballido, J.4    Durantez, A.5
  • 19
    • 0027493428 scopus 로고
    • Immunosuppressive properties of calcium channel blockers
    • K. Chitwood, and K. Heim-Duthoy Immunosuppressive properties of calcium channel blockers Pharmacotherapy 1993 447 454
    • (1993) Pharmacotherapy , pp. 447-454
    • Chitwood, K.1    Heim-Duthoy, K.2
  • 20
    • 0030734072 scopus 로고    scopus 로고
    • The modulatory effect of diltiazem on human in vitro alloreactivity when used alone or in combination with cyclosporin a and/or methylprednisolone
    • A. D'Ambrosio, G. Segoloni, and F. Quintieri The modulatory effect of diltiazem on human in vitro alloreactivity when used alone or in combination with cyclosporin A and/or methylprednisolone Transplant Int 1997 426 431
    • (1997) Transplant Int , pp. 426-431
    • D'Ambrosio, A.1    Segoloni, G.2    Quintieri, F.3
  • 24
  • 26
    • 19244387277 scopus 로고    scopus 로고
    • Mycophenolate mofetil inhibits differentiation, maturation and allostimulatory function of human monocyte-derived dendritic cells
    • M. Colic, Z. Stojic-Vukanic, B. Pavlovic, D. Jandric, and I. Stefanoska Mycophenolate mofetil inhibits differentiation, maturation and allostimulatory function of human monocyte-derived dendritic cells Clin Exp Immunol 2003 63 69
    • (2003) Clin Exp Immunol , pp. 63-69
    • Colic, M.1    Stojic-Vukanic, Z.2    Pavlovic, B.3    Jandric, D.4    Stefanoska, I.5
  • 27
    • 0035877017 scopus 로고    scopus 로고
    • Infection of human macrophages and dendritic cells with Mycobacterium tuberculosis induces a differential cytokine gene expression that modulates T cell response
    • E. Giacomini, E. Iona, L. Ferroni, M. Miettinen, L. Fattorini, and G. Orefici Infection of human macrophages and dendritic cells with Mycobacterium tuberculosis induces a differential cytokine gene expression that modulates T cell response J Immunol 2001 7033 7041
    • (2001) J Immunol , pp. 7033-7041
    • Giacomini, E.1    Iona, E.2    Ferroni, L.3    Miettinen, M.4    Fattorini, L.5    Orefici, G.6
  • 28
    • 0036644594 scopus 로고    scopus 로고
    • Selective expression of type I IFN genes in human dendritic cells infected with Mycobacterium tuberculosis
    • M. Remoli, E. Giacomini, G. Lutfalla, E. Dondi, G. Orefici, and A. Battistini Selective expression of type I IFN genes in human dendritic cells infected with Mycobacterium tuberculosis J Immunol 2002 366 374
    • (2002) J Immunol , pp. 366-374
    • Remoli, M.1    Giacomini, E.2    Lutfalla, G.3    Dondi, E.4    Orefici, G.5    Battistini, A.6
  • 29
    • 0033525511 scopus 로고    scopus 로고
    • Interleukin-12 induces expression of interferon regulatory factor-1 via signal transducer and activator of transcription-4 in human T helper type 1 cells
    • E.N.P. Coccia, A. Battistini, C. Pini, F. Sinigaglia, and L. Rogge Interleukin-12 induces expression of interferon regulatory factor-1 via signal transducer and activator of transcription-4 in human T helper type 1 cells J Biol Chem 1999 6698 6703
    • (1999) J Biol Chem , pp. 6698-6703
    • Coccia, E.N.P.1    Battistini, A.2    Pini, C.3    Sinigaglia, F.4    Rogge, L.5
  • 30
    • 0142156744 scopus 로고    scopus 로고
    • Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1
    • J. Liu, S. Cao, L. Herman, and X. Ma Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1 J Exp Med 2003 1265 1276
    • (2003) J Exp Med , pp. 1265-1276
    • Liu, J.1    Cao, S.2    Herman, L.3    Ma, X.4
  • 31
    • 0035451798 scopus 로고    scopus 로고
    • Regulation of IL-12 p40 promoter activity in primary human monocytes: Roles of NF-kappaB, CCAAT/enhancer-binding protein beta, and PU.1 and identification of a novel repressor element (GA-12) that responds to IL-4 and prostaglandin E(2)
    • C. Becker, S. Wirtz, X. Ma, M. Blessing, P. Galle, and M. Neurath Regulation of IL-12 p40 promoter activity in primary human monocytes: roles of NF-kappaB, CCAAT/enhancer-binding protein beta, and PU.1 and identification of a novel repressor element (GA-12) that responds to IL-4 and prostaglandin E(2) J Immunol 2001 2608 2618
    • (2001) J Immunol , pp. 2608-2618
    • Becker, C.1    Wirtz, S.2    Ma, X.3    Blessing, M.4    Galle, P.5    Neurath, M.6
  • 33
    • 0029146930 scopus 로고
    • Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway
    • Z. Chen, J. Hagler, V. Palombella, F. Melandri, D. Scherer, and D. Ballard Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway Genes Dev 1995 1586 1597
    • (1995) Genes Dev , pp. 1586-1597
    • Chen, Z.1    Hagler, J.2    Palombella, V.3    Melandri, F.4    Scherer, D.5    Ballard, D.6
  • 34
    • 0028978032 scopus 로고
    • Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli
    • E. Traenckner, H. Pahl, T. Henkel, K. Schmidt, S. Wilk, and P. Baeuerle Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli EMBO J 1995 2876 2883
    • (1995) EMBO J , pp. 2876-2883
    • Traenckner, E.1    Pahl, H.2    Henkel, T.3    Schmidt, K.4    Wilk, S.5    Baeuerle, P.6
  • 35
    • 0028929371 scopus 로고
    • Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation
    • J. Brockman, D. Scherer, T. McKinsey, S. Hall, X. Qi, and W. Lee Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation Mol Cell Biol 1995 2809 2818
    • (1995) Mol Cell Biol , pp. 2809-2818
    • Brockman, J.1    Scherer, D.2    McKinsey, T.3    Hall, S.4    Qi, X.5    Lee, W.6
  • 36
    • 0030610907 scopus 로고    scopus 로고
    • The signal response of IkappaB alpha is regulated by transferable N- and C-terminal domains
    • K. Brown, G. Franzoso, L. Baldi, L. Carlson, L. Mills, and Y. Lin The signal response of IkappaB alpha is regulated by transferable N- and C-terminal domains Mol Cell Biol 1997 3017 3021
    • (1997) Mol Cell Biol , pp. 3017-3021
    • Brown, K.1    Franzoso, G.2    Baldi, L.3    Carlson, L.4    Mills, L.5    Lin, Y.6
  • 37
    • 0030611595 scopus 로고    scopus 로고
    • IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK
    • J. Woronicz, X. Gao, Z. Cao, M. Rothe, and D.V. Goeddel IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK Science 1997 866 869
    • (1997) Science , pp. 866-869
    • Woronicz, J.1    Gao, X.2    Cao, Z.3    Rothe, M.4    Goeddel, D.V.5
  • 38
    • 0030610362 scopus 로고    scopus 로고
    • A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
    • J. DiDonato, M. Hayakawa, D. Rothwarf, E. Zandi, and M. Karin A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB Nature 1997 548 554
    • (1997) Nature , pp. 548-554
    • Didonato, J.1    Hayakawa, M.2    Rothwarf, D.3    Zandi, E.4    Karin, M.5
  • 39
    • 0031586174 scopus 로고    scopus 로고
    • Identification and characterization of an IkappaB kinase
    • C. Regnier, H. Song, X. Gao, D. Goeddel, Z. Cao, and M. Rothe Identification and characterization of an IkappaB kinase Cell 1997 373 383
    • (1997) Cell , pp. 373-383
    • Regnier, C.1    Song, H.2    Gao, X.3    Goeddel, D.4    Cao, Z.5    Rothe, M.6
  • 40
    • 0030613551 scopus 로고    scopus 로고
    • The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
    • E. Zandi, D. Rothwarf, M. Delhase, M. Hayakawa, and M. Karin The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation Cell 1997 243 252
    • (1997) Cell , pp. 243-252
    • Zandi, E.1    Rothwarf, D.2    Delhase, M.3    Hayakawa, M.4    Karin, M.5
  • 41
    • 0028972488 scopus 로고
    • Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination
    • D. Scherer, J. Brockman, Z. Chen, T. Maniatis, and D. Ballard Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination Proc Natl Acad Sci USA 1995 11259 11263
    • (1995) Proc Natl Acad Sci USA , pp. 11259-11263
    • Scherer, D.1    Brockman, J.2    Chen, Z.3    Maniatis, T.4    Ballard, D.5
  • 42
    • 0032826292 scopus 로고    scopus 로고
    • Expression of the RelB transcription factor correlates with the activation of human dendritic cells
    • G.J. Clark, S. Gunningham, A. Troy, S. Vuckovic, and D. Hart Expression of the RelB transcription factor correlates with the activation of human dendritic cells Immunology Today 1999 189 196
    • (1999) Immunology Today , pp. 189-196
    • Clark, G.J.1    Gunningham, S.2    Troy, A.3    Vuckovic, S.4    Hart, D.5
  • 43
    • 0031572428 scopus 로고    scopus 로고
    • Nuclear localization of RelB is associated with effective antigen-presenting cell function
    • A. Pettit, C. Quinn, K. MacDonald, L. Cavanagh, G. Thomas, and W. Townsend Nuclear localization of RelB is associated with effective antigen-presenting cell function J Immunol 1997 3681 3691
    • (1997) J Immunol , pp. 3681-3691
    • Pettit, A.1    Quinn, C.2    MacDonald, K.3    Cavanagh, L.4    Thomas, G.5    Townsend, W.6
  • 45
    • 0025943986 scopus 로고
    • The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B
    • M. Schmitz, and P. Baeuerle The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B EMBO J 1991 3805 3817
    • (1991) EMBO J , pp. 3805-3817
    • Schmitz, M.1    Baeuerle, P.2
  • 46
    • 0027190466 scopus 로고
    • KBF1 (p50 NF-kappa B homodimer) acts as a repressor of H-2κB gene expression in metastatic tumor cells
    • D. Plaksin, P. Baeuerle, and L. Eisenbach KBF1 (p50 NF-kappa B homodimer) acts as a repressor of H-2κB gene expression in metastatic tumor cells J Exp Med 1993 1651 1662
    • (1993) J Exp Med , pp. 1651-1662
    • Plaksin, D.1    Baeuerle, P.2    Eisenbach, L.3
  • 47
    • 0034459681 scopus 로고    scopus 로고
    • Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region
    • I. Udalova, A. Richardson, A. Denys, C. Smith, H. Ackerman, and B. Foxwell Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region Mol Cell Biol 2000 9113 9119
    • (2000) Mol Cell Biol , pp. 9113-9119
    • Udalova, I.1    Richardson, A.2    Denys, A.3    Smith, C.4    Ackerman, H.5    Foxwell, B.6
  • 48
    • 0031437833 scopus 로고    scopus 로고
    • P50 (NF-kappa B1) is upregulated in LPS tolerant P388D1 murine macrophages
    • H. Ziegler-Heitbrock, I. Petersmann, and M. Frankenberger p50 (NF-kappa B1) is upregulated in LPS tolerant P388D1 murine macrophages Immunobiology 1997 73 80
    • (1997) Immunobiology , pp. 73-80
    • Ziegler-Heitbrock, H.1    Petersmann, I.2    Frankenberger, M.3
  • 49
    • 1542319174 scopus 로고    scopus 로고
    • Bcl-3 and NFkappaB p50-p50 homodimers act as transcriptional repressors in tolerant CD4+ T cells
    • S. Grundstrom, P. Anderson, P. Scheipers, and A. Sundstedt Bcl-3 and NFkappaB p50-p50 homodimers act as transcriptional repressors in tolerant CD4+ T cells J Biol Chem 2004 8460 8468
    • (2004) J Biol Chem , pp. 8460-8468
    • Grundstrom, S.1    Anderson, P.2    Scheipers, P.3    Sundstedt, A.4
  • 50
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • B. Oppmann, R. Lesley, B. Blom, J.C. Timans, Y. Xu, and B. Hunte Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Immunity 2000 715 725
    • (2000) Immunity , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3    Timans, J.C.4    Xu, Y.5    Hunte, B.6
  • 51
    • 2942536314 scopus 로고    scopus 로고
    • Memory T cells in transplantation: Generation, function, and potential role in rejection
    • A. Bingaman, and D. Farber Memory T cells in transplantation: generation, function, and potential role in rejection Am J Transplant 2004 846 852
    • (2004) Am J Transplant , pp. 846-852
    • Bingaman, A.1    Farber, D.2
  • 52
    • 0347949510 scopus 로고    scopus 로고
    • Molecular mechanisms of interleukin-10-mediated inhibition of NF-kappaB activity: A role for p50
    • F. Driessler, K. Venstrom, R. Sabat, K. Asadullah, and A. Schottelius Molecular mechanisms of interleukin-10-mediated inhibition of NF-kappaB activity: a role for p50 Clin Exp Immunol 2004 64 67
    • (2004) Clin Exp Immunol , pp. 64-67
    • Driessler, F.1    Venstrom, K.2    Sabat, R.3    Asadullah, K.4    Schottelius, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.