Genetic heterogeneity of autoimmune diabetes: Age of presentation in adults is influenced by HLA DRB1 and DQB1 genotypes (UKPDS 43)

Diabetologia

Volumn 42, Issue 5, 1999, Pages 608-616

  Horton, V ^a   Stratton, I ^a   Bottazzo, G F ^b   Shattock, M ^b   Mackay, I ^d   Zimmet, P ^c   Manley, S ^a   Holman, R ^a   Turner, R ^a  

^a RADCLIFFE INFIRMARY   (United Kingdom)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^c BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^d NONE

Author keywords

DQB1 genotype; DRB1 genotype; HLA genotypes; Type I diabetes; Type II diabetes

Indexed keywords

AUTOANTIBODY; GLUTAMATE DECARBOXYLASE; HLA DQ ANTIGEN; HLA DR ANTIGEN; INSULIN; METFORMIN; ORAL ANTIDIABETIC AGENT; PANCREAS ISLET CELL ANTIBODY; SULFONYLUREA DERIVATIVE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC HETEROGENEITY; GENOTYPE; HUMAN; INSULIN TREATMENT; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ONSET AGE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ADULT; AGED; AGING; AUTOANTIBODIES; AUTOIMMUNE DISEASES; DIABETES MELLITUS, TYPE 1; GENOTYPE; GLUTAMATE DECARBOXYLASE; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; INSULIN; ISLETS OF LANGERHANS; MIDDLE AGED; RANDOM ALLOCATION; RISK FACTORS;

EID: 0032967848     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051202     Document Type: Article

References (42)

1. Bottazzo GF (1993) On the honey disease. A dialogue with Socrates. Diabetes 42: 778-800
2. Rahier J, Goebbels RM, Henquin JC (1983) Cellular composition of the human diabetic pancreas. Diabetologia 24: 366-371
3. Bonifacio E, Genovese S, Braghi S et al. (1995) Islet autoantibody markers in IDDM: risk assessment strategies yielding high sensitivity. Diabetologia 38: 816-822
4. Verge CF, Howard NJ, Rowley MJ et al. (1994) Antiglutamate decarboxylase and other antibodies at the onset of childhood IDDM: a population-based study. Diabetologia 37: 1113-1120
5. Groop LC, Bottazzo GF, Doniach D (1986) Islet cell antibodies identify latent type 1 diabetes in patients aged 35-37 years at diagnosis. Diabetes 35: 237-241
6. Zimmer PZ, Tuomi T, Mackay IR et al. (1994) Latent autoimmune diabetes mellitus in adults (LADA): the role of antibodies to glutamic acid decarboxylase in diagnosis and prediction of insulin dependency. Diabet Med 11: 299-303
7. Tuomi T, Groop LC, Zimmer PZ, Rowley MJ, Knowles W, Mackay IR (1993) Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease. Diabetes 42: 359-362
8. UKPDS Group (1997) UKPDS 25: Clinical value of ICA and GADA in predicting insulin requirement in patients with newly diagnosed NIDDM at different ages. Lancet 350: 1288-1293
9. Davies JL, Kawaguichi Y, Bennett ST et al. (1994) A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371: 130-136
10. Thomson G, Robinson WP, Kuhner MK et al. (1988) Genetic heterogeneity: modes of inheritance and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus. Am J Hum Genet 43: 799-816
11. Todd JA, Bell JI, McDevitt HO (1987) HLA-DQβ gene contributes to susceptibitity and resistance to insulin-dependent diabetes mellitus. Nature 329: 599-604
12. Nepom BS, Palmer J, Kim SJ, Hansen JA, Holbeck SL, Nepom GT (1986) Specific genomic markers for the HLA-DQ subregion discriminate between DR4 + insulin-dependent diabetes mellitus and DR4 + seropositive juvenile rheumatoid arthritis. J Exp Med 164: 345-350
13. Kahlil I, Deschamps I, Lepage V, Al-Daccak R, Degos L, Hors J (1992) Dose effect of cis- and trans-encoded HLA-DQab heterodimers in IDDM susceptibility. Diabetes 41: 378-384
14. Pugliese A, Gianini R, Moromisato R et al. (1995) HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDM. Diabetes 44: 608-613
15. Lucassen AM, Julier C, Beressi JP et al. (1993) Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR. Nat Genet 4: 305-310
16. Nistico L, Buzzetti R, Pritchard LE et al. (1996) The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, Type 1 diabetes. Hum Mol Gen 5: 1075-1080
17. Groop L, Miettinen A, Groop P-H, Meri S, Koskimies, Bottazzo GF (1988) Organ-specific autoimmunity and HLA-DR antigens as markers for B-cell destruction in patients with Type 2 diabetes. Diabetes 37: 99-103
18. Gleichmann H, Zorcher B, Greulich B et al. (1984) Correlation of islet cell antibodies and HLA-DR phenotypes with diabetes mellitus in adults. Diabetologia 27: 90-92
19. UKPDS Group (1991) UK Prospective Diabetes Study VIII: Study design, progress and performance. Diabetologia 34: 877-890
20. Horton VA, Bunce M, Davies DR, Turner RC, Lo YM (1995) HLA typing for DR3 and DR4 using artificial restriction fragment length polymorphism-PCR from DNA using archival materials. J Clin Pathol 48: 33-36
21. Marsh SG, Bodmer JG (1995) HLA class II region nucleotide sequences, 1995. Tissue Antigens 46: 258-280
22. Doherty DG, Vaughan RW, Donaldson PT, Mowat AP (1992) HLA, DQA, DQB and DRB genotyping by oligonucleotide analysis: distribution of alleles and haplotypes in British caucasoids. Hum Immunol 34: 53-63
23. Patel P, Lo Y-MD, Bell JI, Wainscoat JS (1992) Detection of susceptibility alleles to insulin-dependent diabetes mellitus at the DQB1 locus by artificial PCR RFLP. Immunogenetics 36: 264-265
24. Bonifacio E, Bingley PJ, Shattock M et al. (1990) Quantification of islet-cell antibodies and prediction of insulin dependent diabetes. Lancet 335: 147-149
25. Rowley MJ, Mackay IR, Chen QY, Knowles WJ, Zimmet PZ (1992) Antibodies to glutamic acid decarboxylase discriminate major types of diabetes mellitus. Diabetes 41: 548-551
26. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419
27. Todd JA (1995) Genetic analysis of type 1 diabetes using a whole genome approach. Proc Natl Acad Sci USA 92: 8560-8565
28. Caillat-Zucman S, Garchon H, Timsit J et al. (1992) Age-dependent HLA genetic heterogeneity of Type 1 insulin-dependent diabetes mellitus. J Clin Invest 90: 2242-2250
29. Karjalainen J, Salmela P, Ilonen J, Surcel HM, Knip M (1989) A comparison of childhood and adult type 1 diabetes mellitus. N Engl J Med 320: 881-886
30. Dubois-Laforgue D, Timsit J, Djilali-Saiah I, Bitard C, Caillet-Fulman S (1997) Insulin dependent diabetes mellitus in nonDR3/nonDR4 subjects. Hum Immunol 57: 107-109
31. Oldstone MBA, Nerenberg M, Southern P, Price J, Lewicki H (1991) Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell 65: 319-332
32. Zimmer PZ, Rowley MJ, Mackay IR et al. (1993) The ethnic distribution of antibodies to glutamic acid decarboxylase: presence and levels in insulin-dependent diabetes mellitus in Europid and Asian subjects. J Diabetes Complications 7: 1-7
33. Nepom GT (1990) A unified hypothesis for the complex interactions of HLA associations with IDDM. Diabetes 39: 1153-1157
34. Cucca F, Todd JA (1996) HLA susceptibility to type 1 diabetes: methods and mechanisms. In: Browning MJ, McMichael AJ (eds) HLA and MHC: genes, molecules and function. BIOS Scientific Publishers, Oxford, pp 383-406
35. She JX (1996) Susceptibility to type I diabetes: HLA-DQ and DR revisted. Immunol Today 17: 323-329
36. Bennett ST, Lucassen AM, Gough SCL et al. (1995) Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene mini-satellite locus. Nat Genet 9: 284-292
37. van der Auwera B, van Waeyenberge C, Schuit F et al. (1995) DRB1*0403 protects against IDDM in Caucasians with the High-Risk heterozygous DQA*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. The Belgian Diabetes Registry. Diabetes 44: 527-530
38. Genovese S, Bonifacio E, McNally JM et al. (1992) Distinct cytoplasmic islet cell antibodies with different risks for type 1 (insulin-dependent) diabetes mellitus. Diabetologia 35: 385-388
39. Bjork E, Velloso L, Kampe O, Karlsson FA (1994) GAD autoantibodies in IDDM, stiff-man syndrome and autoimmune polyendocrine syndrome type 1 recognize different epitopes. Diabetes 43: 161-165
40. Ikenoue H, Okamura K, Kuroda T, Sato K, Yoshinari M, Fujishima M (1988) Thyroid amyloidosis with recurrent subacute thyroiditis-like syndrome. J Clin Endocrinol Metab 67: 41-45
41. 65 antibodies in insulin-dependent diabetes (IDDM), malnutrition-related diabetes (MRDM) and non-insulin dependent diabetes (NIDDM) patients from eastern India. Diabetologia 39: S301, A81
42. Mohan V, Deepa R, Bhatia E et al. (1998) Antibodies to pancreatic islet cell antigens in diabetes seen in southern India with particular reference to fibrocalculous pancreatic diabetes. Diabet Med 15: 156-159