Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins

Diabetes Care

Volumn 20, Issue 6, 1997, Pages 965-970

  Christie, Michael R ^a   Roll, Ursula ^b   Payton, Mark A ^a   Hatfield, Emma C I ^a   Ziegler, Anette G ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b Klinikum Schwabing   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; GLUTAMATE DECARBOXYLASE; INSULIN ANTIBODY; PANCREAS ISLET CELL ANTIBODY; PROTEIN ANTIBODY; PROTEIN TYROSINE PHOSPHATASE;

ADOLESCENT; ADULT; ANTIBODY DETECTION; ARTICLE; AUTOIMMUNITY; CHILD; DIAGNOSTIC VALUE; FEMALE; HIGH RISK PATIENT; HUMAN; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; RELATIVE;

EID: 0030960386     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.20.6.965     Document Type: Article

References (20)

1. Bonifacio E, Bingley PJ, Shattock M, Dean BM, Dunger D, Gale EAM, Bottazzo GF: Quantification of islet cell antibodies and prediction of insulin-dependent diabetes. Lancet 335:147-149, 1990
2. Bingley PJ, Bonifacio E, Shattock M, Gillmor HA, Sawtell PA, Dunger DB, Scott R, Bottazzo GF, Gale E: Can islet cell antibodies predict IDDM in the general population? Diabetes Care 16:45-50, 1993
3. Landin-Olsson M, Palmer JP, Lernmark A, Blom L, Sundkvist G, Nystrom L, Dahlquist G: Predictive value of islet cell and insulin autoantibodies for type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children. Diabetologia 35:1068-1073, 1992
4. Bingley PJ, Christie MR, Bonifacio E, Bonfanti R, Shattock M, Fonte MT, Bottazzo GF, Gale E: Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes 43:1304-1310, 1994
5. Harrison LC: Islet cell autoantigens in insulin-dependent diabetes: Pandora's box revisited. Immunol Today 13:348-352, 1992
6. Christie MR, Vohra G, Champagne P, Daneman D, Delovitch TL: Distinct antibody specificities to a 64-kD islet cell antigen in type 1 diabetes as revealed by trypsin treatment. J Exp Med 172:789-794, 1990
7. Payton M, Hawkes C, Christie M: Relationship of the 37,000-and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). J Clin Invest 96:1506-1511, 1995
8. Roll U, Christie MR, Standl E, Ziegler AG: Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients. Diabetes 43:154-160, 1994
9. Ziegler AG, Bachmann W, Rabl W: Prophylactic insulin treatment in relatives at high risk for type 1 diabetes. Diabetes Metab Rev 9:289-293, 1993
10. Petersen JS, Hejnaes KR, Moody A, Karlsen AE, Marshall MO, HoierMadsen M, Boel E, Michelsen BK, Dyrberg T: Detection of GAD(65) antibodies in diabetes and other autoimmune disease using a simple radioligand assay. Diabetes 43:459-467, 1994
11. Schmidli RS, Colman PG, Bonifacio E, participating laboratories: Disease sensitivity and specificity of 52 assays for glutamic acid decarboxylase antibodies. The Second GADAb Workshop. Diabetes 44:636-640 1995
12. Ziegler AG, Ziegler R, Vardi P, Jackson RA, Soeldner JS, Eisenbarth GS: Life-table analysis of progression to diabetes of antiinsulin autoantibody-positive relatives of individuals with type 1 diabetes. Diabetes 38:1320-1325, 1989
13. Greenbaum CJ, Wilkin TJ, Palmer JP: Fifth International Serum Exchange Workshop for Insulin Autoantibody (IAA) Standardization. Diabetologia 35:798-800, 1992
14. Lu J, Li Q, Xie H, Chen ZJ, Borovitskaya AE, Maclaren NK, Notkins AL, Lan M: Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment. Proc Natl Acad Sci USA 93:2307-2311, 1996
15. Hawkes CJ, Wasmeier C, Christie MR, Hutton JC: Identification of the 37kDa-antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2. Diabetes 45:1187-1192, 1996
16. Seidel D, Ziegler AG: Prediction of type 1 diabetes. Horm Res 45:36-39, 1996
17. Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA, Chase P, Eisenbarth GS: Prediction of type I diabetes in first degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 45:926-933, 1996
18. Roll U, Christie MR, Fuchtenbusch M, Payton MA, Hawkes CJ, Ziegler AG: Perinatal autoimmunity in offspring of diabetic parents: the German multicentre BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes 45:967-973, 1996
19. Genovese S, Bingley PJ, Bonifacio E, Christie MR, Shattock M, Bonfanti R, Foxon R, Gale EAM, Bottazzo GF: Combined analysis of IDDM-related autoantibodies in healthy schoolchildren. Lancet 344:756, 1994
20. Karjalainen J, Salmela P, Ilonen J, Surchel H, Knip M: A comparison of childhood and adult type 1 diabetes mellitus. N Engl J Med 320:881-886, 1989