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Volumn 23, Issue 12, 2004, Pages 555-564

Disruption of estrogen-regulated gene expression by dioxin: Downregulation of a gene associated with the onset of non-insulin-dependent diabetes mellitus (type 2 diabetes)

Author keywords

DNA microarray analysis; Endocrine disruptive chemicals; Estrogen antagonist; Real time PCR; TCDD; Type 2 diabetes

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; DIOXIN; DNA; ENDOCRINE DISRUPTOR; ESTRADIOL; FULVESTRANT; INSULIN RECEPTOR SUBSTRATE 1;

EID: 11844273930     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327104ht488oa     Document Type: Article
Times cited : (10)

References (65)
  • 1
    • 0026349338 scopus 로고
    • The steroid receptor superfamily: Mechanisms of diversity
    • Fuller P. The steroid receptor superfamily: mechanisms of diversity. FASEB J 1991; 5: 3092-97.
    • (1991) FASEB J , vol.5 , pp. 3092-3097
    • Fuller, P.1
  • 2
    • 0027249002 scopus 로고
    • Steroid hormone receptors: Interaction with deoxyribonucleic acid and transcription factors
    • Truss M, Beato M. Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endocrinol Rev 1993; 14: 450-79.
    • (1993) Endocrinol Rev , vol.14 , pp. 450-479
    • Truss, M.1    Beato, M.2
  • 3
    • 0030995199 scopus 로고    scopus 로고
    • The estrogen receptor activity cycle: Dependence on multiple protein-protein interaction
    • Lieberman BA. The estrogen receptor activity cycle: dependence on multiple protein-protein interaction. Crit Rec In Endocr Gene Expr 1997; 7: 43-59.
    • (1997) Crit Rec in Endocr Gene Expr , vol.7 , pp. 43-59
    • Lieberman, B.A.1
  • 4
    • 0024997614 scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin, and related halogenated aromatic hydrocarbons: Examination of mechanisms of toxicity
    • Safe S. 2,3,7,8-Tetrachlorodibenzo-p-dioxin, and related halogenated aromatic hydrocarbons: examination of mechanisms of toxicity. Toxicol 1990; 21: 51-88.
    • (1990) Toxicol , vol.21 , pp. 51-88
    • Safe, S.1
  • 5
    • 0016108734 scopus 로고
    • A toxic syndrome associated with the feeding of polybrominated biphenyl-contaminated protein concentrate to dairy cattle
    • Jackson TF, Halbert FL. A toxic syndrome associated with the feeding of polybrominated biphenyl-contaminated protein concentrate to dairy cattle. J Am Vet Med Assn 1974; 165: 437-39.
    • (1974) J Am Vet Med Assn , vol.165 , pp. 437-439
    • Jackson, T.F.1    Halbert, F.L.2
  • 6
    • 0022363974 scopus 로고
    • Reproductive effects of herbicide exposure in Vietnam: Recent studies by the Vietnamese and others
    • Constable JD, Hatch MC. Reproductive effects of herbicide exposure in Vietnam: recent studies by the Vietnamese and others. Terat Carcinogen Mutagen 1985; 5: 231-50.
    • (1985) Terat Carcinogen Mutagen , vol.5 , pp. 231-250
    • Constable, J.D.1    Hatch, M.C.2
  • 7
    • 0006364797 scopus 로고
    • Differences between Yusho and other kinds of poisoning involving only PCBs
    • Waid JS ed. Boca Raton, FL: CRC Press
    • Kashimoto T, Miyata H. Differences between Yusho and other kinds of poisoning involving only PCBs. In Waid JS ed. PCBs and the environment. Boca Raton, FL: CRC Press, 1994.
    • (1994) PCBs and the Environment
    • Kashimoto, T.1    Miyata, H.2
  • 9
    • 0027428381 scopus 로고
    • Developmental effects of endocrine-disruptive chemicals in wildlife and humans
    • Colborn T, Vom Saal FS, Soto AM. Developmental effects of endocrine-disruptive chemicals in wildlife and humans. Environ Health Perspect 1993; 101: 378-83.
    • (1993) Environ Health Perspect , vol.101 , pp. 378-383
    • Colborn, T.1    Vom Saal, F.S.2    Soto, A.M.3
  • 10
    • 0027937244 scopus 로고
    • Interactive regulation of Ah and glucocorticoid receptors in the synergistic induction of cleft palate by TCDD and hydrocortisone
    • Abbott BD, Perdew GH, Buckalew AR, Birnbaum LS. Interactive regulation of Ah and glucocorticoid receptors in the synergistic induction of cleft palate by TCDD and hydrocortisone. Toxicol Appl Pharmacol 1994; 128: 138-50.
    • (1994) Toxicol Appl Pharmacol , vol.128 , pp. 138-150
    • Abbott, B.D.1    Perdew, G.H.2    Buckalew, A.R.3    Birnbaum, L.S.4
  • 11
    • 0034523380 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits luminal cell differentiation and androgen responsiveness of the ventral prostate without inhibiting prostatic 5-dihydrotesterone formation or testicular androgen production in rat offspring
    • Theobald HM, Roman BL, Lin T-M, Ohtani S, Chen S-W, Peterson RE. 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits luminal cell differentiation and androgen responsiveness of the ventral prostate without inhibiting prostatic 5-dihydrotesterone formation or testicular androgen production in rat offspring. Toxicol Sci 2000; 58: 324-38.
    • (2000) Toxicol Sci , vol.58 , pp. 324-338
    • Theobald, H.M.1    Roman, B.L.2    Lin, T.-M.3    Ohtani, S.4    Chen, S.-W.5    Peterson, R.E.6
  • 12
    • 0034521058 scopus 로고    scopus 로고
    • The plasticizer diethylphthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat
    • Parks LG, Ostby JS, Lambright CR, Abbott BD, Klinefelter GR, Barlow NJ, Gray LE Jr. The plasticizer diethylphthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol Sci 2000; 58: 339-49.
    • (2000) Toxicol Sci , vol.58 , pp. 339-349
    • Parks, L.G.1    Ostby, J.S.2    Lambright, C.R.3    Abbott, B.D.4    Klinefelter, G.R.5    Barlow, N.J.6    Gray Jr., L.E.7
  • 13
    • 0034352920 scopus 로고    scopus 로고
    • The effects of atrazine of female Wistar rats: An evaluation of the protocol for assessing pubertal development and thyroid function
    • Laws SC, Ferrell JM, Stoker TE, Schmid J, Cooper RL. The effects of atrazine of female Wistar rats: an evaluation of the protocol for assessing pubertal development and thyroid function. Toxicol Sci 2000; 58: 366-76.
    • (2000) Toxicol Sci , vol.58 , pp. 366-376
    • Laws, S.C.1    Ferrell, J.M.2    Stoker, T.E.3    Schmid, J.4    Cooper, R.L.5
  • 15
    • 0033767327 scopus 로고    scopus 로고
    • Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development
    • Colon I, Caro D, Bourdony CJ, Rosario O. Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development. Environ Health Perspect 2000; 108: 895-900.
    • (2000) Environ Health Perspect , vol.108 , pp. 895-900
    • Colon, I.1    Caro, D.2    Bourdony, C.J.3    Rosario, O.4
  • 16
    • 0003173604 scopus 로고
    • PCB poisoning from toxic rice-bran oil in Taiwan
    • Waid JS ed. Boca Raton, FL: CRC Press
    • Chen PH, Hsu ST. PCB poisoning from toxic rice-bran oil in Taiwan. In Waid JS ed. PCBs and the environment, Vol. 3. Boca Raton, FL: CRC Press, 1987.
    • (1987) PCBs and the Environment , vol.3
    • Chen, P.H.1    Hsu, S.T.2
  • 17
    • 0342293624 scopus 로고
    • Recent studies of the human immunotoxic effects of 2,3,7,8- tetrachlorodibenzo-p-dioxin
    • Newcombe DS, Rose NR, Bloom JC eds. New York: Raven Press
    • Hoffman RE. Recent studies of the human immunotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin. In Newcombe DS, Rose NR, Bloom JC eds. Clinical immunotoxicology. New York: Raven Press, 1992; 339-48.
    • (1992) Clinical Immunotoxicology , pp. 339-348
    • Hoffman, R.E.1
  • 18
    • 0027183561 scopus 로고
    • Mitogen and antigen induced B and T cell responses of peripheral blood mononuclear cells from the harbour seal (Phoca vitulina)
    • De Swart RI, Kluten RMG, Huizing CJ, Vedder EJ, Reijnders PJH et al. Mitogen and antigen induced B and T cell responses of peripheral blood mononuclear cells from the harbour seal (Phoca vitulina). Vet Immunol & Immunopath 1993; 37: 217-30.
    • (1993) Vet Immunol & Immunopath , vol.37 , pp. 217-230
    • De Swart, R.I.1    Kluten, R.M.G.2    Huizing, C.J.3    Vedder, E.J.4    Reijnders, P.J.H.5
  • 21
    • 0029923149 scopus 로고    scopus 로고
    • Reduction in penis size and plasma testosterone concentrations in juvenile alligators living in a contaminated environment
    • Guillette LJ, Pickford DB, Crain DA, Rooney AA, Percival HF. Reduction in penis size and plasma testosterone concentrations in juvenile alligators living in a contaminated environment. Gen Comp Endocrinol 1996; 101: 32-42.
    • (1996) Gen Comp Endocrinol , vol.101 , pp. 32-42
    • Guillette, L.J.1    Pickford, D.B.2    Crain, D.A.3    Rooney, A.A.4    Percival, H.F.5
  • 22
    • 0032135591 scopus 로고    scopus 로고
    • A pharmacodynamic analysis of TCDD-induced cytochrome P450 gene expression in multiple tissues: Dose-and time-dependent effects
    • Santostefano MJ, Wang X, Richardson VM, Ross DG, DeVito MJ, Birnbaum LS. A pharmacodynamic analysis of TCDD-induced cytochrome P450 gene expression in multiple tissues: dose-and time-dependent effects. Toxicol Applied Pharmacol 1998; 151: 294-310.
    • (1998) Toxicol Applied Pharmacol , vol.151 , pp. 294-310
    • Santostefano, M.J.1    Wang, X.2    Richardson, V.M.3    Ross, D.G.4    DeVito, M.J.5    Birnbaum, L.S.6
  • 23
    • 0032104188 scopus 로고    scopus 로고
    • In utero and lactational exposure of the male rat to 2,3,7,8- tetrachlorodibenzo-p-dioxin impairs prostate development: Effects on gene expression
    • Roman BL, Peterson RE. In utero and lactational exposure of the male rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs prostate development: effects on gene expression. Toxicol Appl Pharmacol 1998; 150: 240-53.
    • (1998) Toxicol Appl Pharmacol , vol.150 , pp. 240-253
    • Roman, B.L.1    Peterson, R.E.2
  • 24
    • 0010473981 scopus 로고    scopus 로고
    • In utero and lactational exposure of the male rat to 2,3,7,8- tetrachlorodibenzo-p-dioxin impairs prostate development: Effects on growth and cytodifferentiation
    • Roman BL, Timms BG, Prins GS, Peterson RE. In utero and lactational exposure of the male rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs prostate development: effects on growth and cytodifferentiation. Toxicol Appl Pharmacol 1998; 150: 254-70.
    • (1998) Toxicol Appl Pharmacol , vol.150 , pp. 254-270
    • Roman, B.L.1    Timms, B.G.2    Prins, G.S.3    Peterson, R.E.4
  • 25
    • 0024532233 scopus 로고
    • Relation between cytochrome P4501A1 expression and estrogen receptor content of human breast cancer cells
    • Vickers PJ, Dufresne MJ, Cowan KH. Relation between cytochrome P4501A1 expression and estrogen receptor content of human breast cancer cells. Mol Endo 1989; 3: 157-64.
    • (1989) Mol Endo , vol.3 , pp. 157-164
    • Vickers, P.J.1    Dufresne, M.J.2    Cowan, K.H.3
  • 26
    • 0028285855 scopus 로고
    • Antiestrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17 β-estradiol-induced pS2 expression
    • Zacharewski TR, Bondy KL, McDonell P, Wu ZF. Antiestrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17 β-estradiol-induced pS2 expression. Can Res 1994; 54: 2707-13.
    • (1994) Can Res , vol.54 , pp. 2707-2713
    • Zacharewski, T.R.1    Bondy, K.L.2    McDonell, P.3    Wu, Z.F.4
  • 27
    • 0028824818 scopus 로고
    • Immunoresponsiveness in endometriosis: Implications of estrogenic toxicants
    • Rier SE, Martin DC, Bowman RE, Becker JL. Immunoresponsiveness in endometriosis: implications of estrogenic toxicants. Env Health Perspec 1995; 103 (Suppl 7): 151-56.
    • (1995) Env Health Perspec , vol.103 , Issue.SUPPL. 7 , pp. 151-156
    • Rier, S.E.1    Martin, D.C.2    Bowman, R.E.3    Becker, J.L.4
  • 28
    • 0032103386 scopus 로고    scopus 로고
    • Reproductive toxicity and tissue concentrations of low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male offspring rats exposed throughout pregnancy and lactation
    • Faqi AS, Dalsenter PR, Merker H-J, Chahoud I. Reproductive toxicity and tissue concentrations of low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male offspring rats exposed throughout pregnancy and lactation. Toxicol Appl Pharmacol 1998; 150: 383-92.
    • (1998) Toxicol Appl Pharmacol , vol.150 , pp. 383-392
    • Faqi, A.S.1    Dalsenter, P.R.2    Merker, H.-J.3    Chahoud, I.4
  • 29
    • 0019941478 scopus 로고
    • Transplancental transfer of PCBs and chlorinated hydrocarbon pesticides from the pregnant striped dolphin (Stenella coeruleoalba) to her fetus
    • Tanabe S, Tatsukawa R, Maruyama K, Miyazaki N. Transplancental transfer of PCBs and chlorinated hydrocarbon pesticides from the pregnant striped dolphin (Stenella coeruleoalba) to her fetus. Agric Biol Chem 1982; 46: 1249-54.
    • (1982) Agric Biol Chem , vol.46 , pp. 1249-1254
    • Tanabe, S.1    Tatsukawa, R.2    Maruyama, K.3    Miyazaki, N.4
  • 30
    • 0028990832 scopus 로고
    • Residue levels of several organochlorines in Tursiops truncatus milk collected at varied stages of lactation
    • Ridgway S, Reddy M. Residue levels of several organochlorines in Tursiops truncatus milk collected at varied stages of lactation. Mar Poll Bull 1995; 30: 609-14.
    • (1995) Mar Poll Bull , vol.30 , pp. 609-614
    • Ridgway, S.1    Reddy, M.2
  • 32
    • 0037240630 scopus 로고    scopus 로고
    • Quantification of human intestinal gene expression profiles using exfoliated colonocytes: A pilot study
    • Davidson LA, Lupton JR, Miskovsky E, Fields AP and Chapkin RS. Quantification of human intestinal gene expression profiles using exfoliated colonocytes: a pilot study. Biomarkers 2003; 8: 51-61.
    • (2003) Biomarkers , vol.8 , pp. 51-61
    • Davidson, L.A.1    Lupton, J.R.2    Miskovsky, E.3    Fields, A.P.4    Chapkin, R.S.5
  • 33
    • 0034022356 scopus 로고    scopus 로고
    • A rapid and sensitive reporter gene system using green fluorescent protein expression to detect chemicals with estrogenic activity
    • Miller S, Kennedy D, Thomson J, Han F, Smith R, Ing N, Piedrahita J, Busbee D. A rapid and sensitive reporter gene system using green fluorescent protein expression to detect chemicals with estrogenic activity. Toxicol Sci 2000; 55: 69-77.
    • (2000) Toxicol Sci , vol.55 , pp. 69-77
    • Miller, S.1    Kennedy, D.2    Thomson, J.3    Han, F.4    Smith, R.5    Ing, N.6    Piedrahita, J.7    Busbee, D.8
  • 34
    • 0026042049 scopus 로고
    • p-nonylphenol: An estrogenic xenobiotic released from 'modified' polystyrene
    • Soto AM, Justicia H, Wray JW, Sonnenschein C. p-Nonylphenol: an estrogenic xenobiotic released from 'modified' polystyrene. Environ Health Persp 1991; 92: 167-73.
    • (1991) Environ Health Persp , vol.92 , pp. 167-173
    • Soto, A.M.1    Justicia, H.2    Wray, J.W.3    Sonnenschein, C.4
  • 36
    • 0034490361 scopus 로고    scopus 로고
    • Estradiol receptors in dolphin kidney endothelial cells: Detection and comparison with estrogen receptors from MCF7 cells
    • Miller S, Han F, Prado J, Busbee D. Estradiol receptors in dolphin kidney endothelial cells: detection and comparison with estrogen receptors from MCF7 cells. In Vitro & Molecular Toxicology 2000; 13: 199-211.
    • (2000) In Vitro & Molecular Toxicology , vol.13 , pp. 199-211
    • Miller, S.1    Han, F.2    Prado, J.3    Busbee, D.4
  • 37
    • 0034523473 scopus 로고    scopus 로고
    • Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat
    • Gray LE Jr, Ostby J, Furr J, Price M, Veeramachaneni DNR, Parks L. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol Sci 2000; 58: 350-65.
    • (2000) Toxicol Sci , vol.58 , pp. 350-365
    • Gray Jr., L.E.1    Ostby, J.2    Furr, J.3    Price, M.4    Veeramachaneni, D.N.R.5    Parks, L.6
  • 38
    • 0027507755 scopus 로고
    • IRS-1: Essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells
    • Wang L-M, Myers MG Jr, Sun X-J, Aaronson MW, Pierce JH. IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells. Science 1993; 261: 1591-95.
    • (1993) Science , vol.261 , pp. 1591-1595
    • Wang, L.-M.1    Myers Jr., M.G.2    Sun, X.-J.3    Aaronson, M.W.4    Pierce, J.H.5
  • 39
    • 0031172739 scopus 로고    scopus 로고
    • Hydroxylated polychlorinated biphenyl metabolites are anti-estrogenic in a stably transfected human breast adenocarcinoma (MCF-7) cell line
    • Kramer V, Helferich W, Bergman A, Klasson-Wehler E, Giesy JP. Hydroxylated polychlorinated biphenyl metabolites are anti-estrogenic in a stably transfected human breast adenocarcinoma (MCF-7) cell line. Tox Appl Pharmacol 1997; 144: 363-76.
    • (1997) Tox Appl Pharmacol , vol.144 , pp. 363-376
    • Kramer, V.1    Helferich, W.2    Bergman, A.3    Klasson-Wehler, E.4    Giesy, J.P.5
  • 40
    • 0029918651 scopus 로고    scopus 로고
    • Antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin are mediated by direct transcriptional interference with the liganded estrogen receptor
    • Kharat I, Saatcioglu F. Antiestrogenic effects of 2,3,7,8- tetrachlorodibenzo-p-dioxin are mediated by direct transcriptional interference with the liganded estrogen receptor. J Biol Chem 1996; 271: 10533-37.
    • (1996) J Biol Chem , vol.271 , pp. 10533-10537
    • Kharat, I.1    Saatcioglu, F.2
  • 41
    • 0028146850 scopus 로고
    • Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoic acid in MCF-7 human breast cancer cells
    • Lu Y, Wang X, Safe S. Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoic acid in MCF-7 human breast cancer cells. Tox Appl Pharm 1994; 127: 1-8.
    • (1994) Tox Appl Pharm , vol.127 , pp. 1-8
    • Lu, Y.1    Wang, X.2    Safe, S.3
  • 42
    • 0031056329 scopus 로고    scopus 로고
    • In vitro bioassays for assessing estrogenic substances
    • Zacharewski T. In vitro bioassays for assessing estrogenic substances. Env Sci Tech 1997; 31: 613-23.
    • (1997) Env Sci Tech , vol.31 , pp. 613-623
    • Zacharewski, T.1
  • 43
    • 0027494867 scopus 로고
    • Mechanism of 2,3,7,8-tetrachloro-p-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells
    • Wang X, Porter W, Krishnan V, Narasimhan TR, Safe S. Mechanism of 2,3,7,8-tetrachloro-p-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells. Mol Cell Endo 1993; 96: 159-66.
    • (1993) Mol Cell Endo , vol.96 , pp. 159-166
    • Wang, X.1    Porter, W.2    Krishnan, V.3    Narasimhan, T.R.4    Safe, S.5
  • 44
    • 0032420358 scopus 로고    scopus 로고
    • Ah receptor agonists as endocrine disruptors: Antiestrogenic activity and mechanisms
    • Safe S, Wang F, Porter W, Duan R, McDougal A. Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms. Toxicol Lett 1998; 102-103: 343-47.
    • (1998) Toxicol Lett , vol.102-103 , pp. 343-347
    • Safe, S.1    Wang, F.2    Porter, W.3    Duan, R.4    McDougal, A.5
  • 45
    • 0025813375 scopus 로고
    • Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
    • Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA et al. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 1991; 352: 73-77.
    • (1991) Nature , vol.352 , pp. 73-77
    • Sun, X.J.1    Rothenberg, P.2    Kahn, C.R.3    Backer, J.M.4    Araki, E.5    Wilden, P.A.6
  • 46
    • 0027502323 scopus 로고
    • Human insulin receptor substrate-1 gene (IRS1): Chromosomal localization to 2q35-q36.1 and identification of a simple tandem repeat DNA polymorphism
    • Stoffel M, Espinosa R III, Keller SR, Lienhard GE, Le Beau M, Bell GI. Human insulin receptor substrate-1 gene (IRS1): chromosomal localization to 2q35-q36.1 and identification of a simple tandem repeat DNA polymorphism. Diabetologia 1993; 36: 335-37.
    • (1993) Diabetologia , vol.36 , pp. 335-337
    • Stoffel, M.1    Espinosa III, R.2    Keller, S.R.3    Lienhard, G.E.4    Le Beau, M.5    Bell, G.I.6
  • 48
    • 0026343102 scopus 로고
    • Molecular pathways of steroid receptor action
    • O'Malley B, Tsai M-J. Molecular pathways of steroid receptor action. Biol Repro 1992; 46: 163-67.
    • (1992) Biol Repro , vol.46 , pp. 163-167
    • O'Malley, B.1    Tsai, M.-J.2
  • 51
    • 0029893417 scopus 로고    scopus 로고
    • A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling: Evidence from transfection studies
    • Almind K, Inoue G, Pedersen O, Kahn CR. A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling: evidence from transfection studies. J Clin Invest 1996; 97: 2569-75.
    • (1996) J Clin Invest , vol.97 , pp. 2569-2575
    • Almind, K.1    Inoue, G.2    Pedersen, O.3    Kahn, C.R.4
  • 52
    • 0032504257 scopus 로고    scopus 로고
    • Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes
    • Rother KI, Imai Y, Caruso M, Beguinot F, Formissano P, Accili D. Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes. J Biol Chem 1998; 273: 17491-97.
    • (1998) J Biol Chem , vol.273 , pp. 17491-17497
    • Rother, K.I.1    Imai, Y.2    Caruso, M.3    Beguinot, F.4    Formissano, P.5    Accili, D.6
  • 53
    • 0033028690 scopus 로고    scopus 로고
    • The insulin-sensitive glucose transporter (GLUT4) is involved in early bone growth in control and diabetic mice, but is regulated through the insulin-like growth factor 1 receptor
    • Maor G, Karnieli E. The insulin-sensitive glucose transporter (GLUT4) is involved in early bone growth in control and diabetic mice, but is regulated through the insulin-like growth factor 1 receptor. Endocrinology 1999; 140: 1841-51.
    • (1999) Endocrinology , vol.140 , pp. 1841-1851
    • Maor, G.1    Karnieli, E.2
  • 54
    • 84888885969 scopus 로고    scopus 로고
    • Sites of insulin action on GLUT4 trafficking revealed by ultra-fast digital imaging microscopy
    • Patki V, Tuft R, Corvera S. Sites of insulin action on GLUT4 trafficking revealed by ultra-fast digital imaging microscopy. Diabetes 2000; 50: 593-609.
    • (2000) Diabetes , vol.50 , pp. 593-609
    • Patki, V.1    Tuft, R.2    Corvera, S.3
  • 55
    • 84888928928 scopus 로고    scopus 로고
    • Expression of membrane targeted PO-3 kinase enhances insulin-induced IRS-1 degradation in 3T3-L1 adipocytes
    • Egawa K, Nakashima N, Sharma PM, Maegawa H, Olefsky JM. Expression of membrane targeted PO-3 kinase enhances insulin-induced IRS-1 degradation in 3T3-L1 adipocytes. Diabetes 2000; 48: 328-33.
    • (2000) Diabetes , vol.48 , pp. 328-333
    • Egawa, K.1    Nakashima, N.2    Sharma, P.M.3    Maegawa, H.4    Olefsky, J.M.5
  • 56
    • 0023896248 scopus 로고
    • Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance
    • Kadowaki T, Bevins CL, Cama A, Ojamaa K, Marcus-Samuels B, Kadowaki H et al. Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance. Science 1988; 240: 787-90.
    • (1988) Science , vol.240 , pp. 787-790
    • Kadowaki, T.1    Bevins, C.L.2    Cama, A.3    Ojamaa, K.4    Marcus-Samuels, B.5    Kadowaki, H.6
  • 57
    • 0028032894 scopus 로고
    • Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
    • Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, Hayakawa T et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 1994; 372: 182-86.
    • (1994) Nature , vol.372 , pp. 182-186
    • Tamemoto, H.1    Kadowaki, T.2    Tobe, K.3    Yagi, T.4    Sakura, H.5    Hayakawa, T.6
  • 58
    • 11844260572 scopus 로고    scopus 로고
    • Interaction between insulin receptor and IRS proteins in IR/IRS-[1.sup.+/-] and IR/IRS-[2.sup.+/-] mice
    • Kido Y, Kanno H, Withers DJ, Burks DJ, Accili D. Interaction between insulin receptor and IRS proteins in IR/IRS-[1.sup.+/-] and IR/IRS-[2.sup.+/-] mice. Diabetes 2000; 48: 10-22.
    • (2000) Diabetes , vol.48 , pp. 10-22
    • Kido, Y.1    Kanno, H.2    Withers, D.J.3    Burks, D.J.4    Accili, D.5
  • 59
    • 0026793446 scopus 로고
    • Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study
    • Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet 1992; 340: 925-29.
    • (1992) Lancet , vol.340 , pp. 925-929
    • Martin, B.C.1    Warram, J.H.2    Krolewski, A.S.3    Bergman, R.N.4    Soeldner, J.S.5    Kahn, C.R.6
  • 60
    • 0027367546 scopus 로고
    • Amino acid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus
    • Almind K, Bjorbaek C, Vestergaard H, Hansen T, Echwold S, Pedersen O. Amino acid polymorphisms of insulin receptor substrate-1 in non-insulin- dependent diabetes mellitus. Lancet 1993; 342: 828-33.
    • (1993) Lancet , vol.342 , pp. 828-833
    • Almind, K.1    Bjorbaek, C.2    Vestergaard, H.3    Hansen, T.4    Echwold, S.5    Pedersen, O.6
  • 61
    • 0032848780 scopus 로고    scopus 로고
    • Variants of the insulin receptor substrate-1 and fatty acid binding protein 2 genes and the risk of type 2 diabetes, obesity, and hyperinsulinemia in African-Americans: The Atherosclerosis Risk in Communities Study
    • Lei H, Coresh J, Shuldiner A, Boerwinkle E, Brancati F. Variants of the insulin receptor substrate-1 and fatty acid binding protein 2 genes and the risk of type 2 diabetes, obesity, and hyperinsulinemia in African-Americans: The Atherosclerosis Risk in Communities Study. Diabetes 1999; 48: 1862-68.
    • (1999) Diabetes , vol.48 , pp. 1862-1868
    • Lei, H.1    Coresh, J.2    Shuldiner, A.3    Boerwinkle, E.4    Brancati, F.5
  • 62
    • 84888890998 scopus 로고    scopus 로고
    • The insulin receptor substrate-1 (IRS-1) Gly972Arg polymorphism is associated with obesity in the Quebec family study (GFS)
    • Weisnagel J, Chagnon YC, Rankinen T, Nadeau A, Chagnon M, Perusse L, Bouchard C. The insulin receptor substrate-1 (IRS-1) Gly972Arg polymorphism is associated with obesity in the Quebec family study (GFS). Diabetes 2000; 49: 199-201.
    • (2000) Diabetes , vol.49 , pp. 199-201
    • Weisnagel, J.1    Chagnon, Y.C.2    Rankinen, T.3    Nadeau, A.4    Chagnon, M.5    Perusse, L.6    Bouchard, C.7
  • 63
    • 0029118510 scopus 로고
    • Insulin resistance: Interactions between obesity and a common variant of insulin receptor substrate-1
    • Clausen JO, Hansen T, Bjorbaek C, Echwald, SM, Urhammer SA, Rasmussen S et al. Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1. Lancet 1995; 346: 397-402.
    • (1995) Lancet , vol.346 , pp. 397-402
    • Clausen, J.O.1    Hansen, T.2    Bjorbaek, C.3    Echwald, S.M.4    Urhammer, S.A.5    Rasmussen, S.6
  • 64
    • 0026547869 scopus 로고
    • Polymorphisms at the GLUT1 (HepG2) and GLUT4 (muscle/adiposite) glucsose transporter genes and non-insulin-dependent diabetes mellitus (NIDDM)
    • Baroni MG, Oelbaum RS, Pozzilli P, Stocks J, Li S-R, Fiore V, Galton DJ. Polymorphisms at the GLUT1 (HepG2) and GLUT4 (muscle/adiposite) glucsose transporter genes and non-insulin-dependent diabetes mellitus (NIDDM). Hum Genet 1992; 88: 557-61.
    • (1992) Hum Genet , vol.88 , pp. 557-561
    • Baroni, M.G.1    Oelbaum, R.S.2    Pozzilli, P.3    Stocks, J.4    Li, S.-R.5    Fiore, V.6    Galton, D.J.7
  • 65
    • 0034351407 scopus 로고    scopus 로고
    • The gly-to-arg(972) amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells
    • Hribal ML, Federici M, Porzio O, Lauro D, Borboni P, Accili D et al. The gly-to-arg(972) amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells. J Clin Endocr Metab 2000; 85: 2004-2013.
    • (2000) J Clin Endocr Metab , vol.85 , pp. 2004-2013
    • Hribal, M.L.1    Federici, M.2    Porzio, O.3    Lauro, D.4    Borboni, P.5    Accili, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.