Altered tissue expression pattern of cell adhesion molecules, ICAM-1, E-selectin and VCAM-1, in bullous pemphigoid during methotrexate therapy

Experimental Dermatology

Volumn 13, Issue 2, 2004, Pages 65-69

  Dahlman Ghozlan, K ^a,b   Ortome, J P ^a   Heilborn, J D ^b   Stephansson, Eija ^b  

^a INSERM   (France)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Bullous pemphigoid; Cellular adhesion molecules; E selectin; Methotrexate; VCAM 1

Indexed keywords

CELL ADHESION MOLECULE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; METHOTREXATE; VASCULAR CELL ADHESION MOLECULE 1;

AGED; ARTICLE; BULLOUS SKIN DISEASE; CELL INFILTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOTHELIUM CELL; EOSINOPHIL; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; KERATINOCYTE; LOW DRUG DOSE; MICROSCOPY; PEMPHIGOID; PERICYTE; PROTEIN EXPRESSION; SKIN BIOPSY;

AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; BIOPSY; E-SELECTIN; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; INTERCELLULAR ADHESION MOLECULE-1; METHOTREXATE; PEMPHIGOID, BULLOUS; SKIN; VASCULAR CELL ADHESION MOLECULE-1;

EID: 1342326697     PISSN: 09066705     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0906-6705.2004.00113.x     Document Type: Article

References (16)

1. Korman N J. Bullous pemphigoid. Dermatol Clin 1993: 11: 483-498.
2. Morrison Lh, Diaz L A, Anhalt G J. Bullous pemphigoid. In: Wojnarowska F, Briggman R A, eds. Management of Blistering Diseases, 1st edn. London: Chapman & Hall Ltd, 1990: 63-82.
3. Frenette P S, Wagner D D. Adhesion molecules - Part I-II. N Engl J Med 1996: 334-335 (1526-1529): 43-45.
4. Karashima T, Hachisuka H, Okubo K, Sasai Y. Epidermal keratinocytes of bullous pemphigoid express intercellular adhesion molecule-1 (ICAM-1). J Dermatol 1992: 19: 82-86.
5. Rico M J, Benning C, Weingart E S, Streilein R D, Hall R P III Characterization of skin cytokines in bullous pemphigoid and pemphigus vulgaris. Br J Dermatol 1999: 140: 1079-1086.
6. Moqbel R, Levi-Schaffer F, Kay A B. Cytokine generation by eosinophils. J Allergy Clin Immunol 1994: 94: 1183-1188.
7. Springer T A. Adhesion receptors of the immune system. Nature 1990: 346: 425-434.
8. Bochner B S, Schleimer R P. The role of adhesion molecules in human eosinophil and basophil recruitment. J Allergy Clin Immunol 1994: 94: 427-438; quiz 439.
9. Dustin M L, Rothlein R, Bhan A K, Dinarello C A, Springer T A. Induction by IL 1 and interferon-gamma: Tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol 1986: 137: 245-254.
10. Chihara J, Yamamoto T, Kayaba H, et al. Degranulation of eosinophils mediated by intercellular adhesion molecule-1 and its ligands is involved in adhesion molecule expression on endothelial cells-selective induction of VCAM-1. J Allergy Clin Immunol 1999: 103: S452-S456.
11. Chapman P T, Haskard D O. Leukocyte adhesion molecules. Br Med Bull 1995: 51: 296-311.
12. Heilborn J D, Ståhle-Bäckdahl M, Albertioni F, Vassilaki I, Peterson C, Stephansson E. Low-dose oral pulse methotrexate as monotherapy in elderly patients with bullous pemphigoid. J Am Acad Dermatol 1999: 40: 741-749.
13. Dahlman-Ghozlan K, Heilborn J D, Stephansson E. Circulating levels of soluble E-selectin, ICAM-1 and VCAM-1 in bullous pemphigoid during low-dose methotrexate therapy. A prospective study. Exp Dermatol 2000: 9: 336-340.
14. Ståhle-Bäckdahl M, Inoue M, Guidice G J, Parks W C. 92-kD gelatinase is produced by eosinophils at the site of blister formation in bullous pemphigoid and cleaves the extracellular domain of recombinant 180-kD bullous pemphigoid autoantigen. J Clin Invest 1994: 93: 2022-2030.
15. Shrikhande M, Hunziker T, Braathen L R, Pichler W J, Dahinden C A, Yawalkar N. Increased coexpression of eotaxin and interleukin 5 in bullous pemphigoid. Acta Derm Venereol 2000: 80: 277-280.
16. Dahlman-Ghozlan K, Stephansson E, Bahadoran P, Spadafora S, Ortonne J-P. Low-dose oral methotrexate induces apoptosis of the eosinophils in bullous pemfigoid. J Invest Dermatol 2000: 115: 578 (Abstract: 291).