Efficient retroviral vector targeting of carcinoembryonic antigen-positive tumors

Molecular Therapy

Volumn 9, Issue 1, 2004, Pages 85-92

  Chowdhury, Simon ^a   Chester, Kerry A ^b   Bridgewater, John ^b   Collins, Mary K ^a   Martin, Francisco ^a,c  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c CSIC   (Spain)

Author keywords

CEA; Retroviral vector; Tumor targeting

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; MATRIX METALLOPROTEINASE; PROLINE; RETROVIRUS VECTOR; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURFACE; CELL TRANSFORMATION; COLORECTAL TUMOR; CONTROLLED STUDY; FEMALE; GENE TARGETING; GENE THERAPY; GENETIC RISK; GENETIC TRANSDUCTION; HEMATOPOIETIC CELL; HOST CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; KIDNEY CELL; LIVER CELL; MOUSE; MURINE LEUKEMIA VIRUS; MUTAGENESIS; NONHUMAN; PROTEIN DEGRADATION; SPLEEN CELL; TUMOR XENOGRAFT; VIRAL GENE DELIVERY SYSTEM; VIRUS ENVELOPE;

AMPHOTROPIC MURINE LEUKEMIA VIRUS; ANIMALIA; MURINAE; UNIDENTIFIED RETROVIRUS;

EID: 1142299562     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2003.10.004     Document Type: Article

References (38)

1. Ram, Z., et al. (1997). Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nat. Med. 3: 1354-1361.
2. Roth, J. A., et al. (1996). Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nat. Med. 2: 985-991.
3. Kohn, D. B., Sadelain, M., and Glorioso, J. C. (2003). Occurrence of leukaemia following gene therapy of X-linked SCID. Nat. Rev. Cancer 3: 477-488.
4. Rosenberg, N., and Joliceur, P. (1997). Retroviral pathogenesis. In Retroviruses (J. M. Coffin, H. S. H., and H. E. Varmus. Eds.). pp. 475-587. New York: Cold Spring Harbor Laboratory Press.
5. Gordon, E. M., et al. (2001). Systemic administration of a matrix-targeted retroviral vector is efficacious for cancer gene therapy in mice. Hum. Gene Ther. 12: 193-204.
6. Martin, F., Chowdhury, S., Neil, S., Phillipps, N., and Collins, M. K. (2002). Envelope-targeted retrovirus vectors transduce melanoma xenografts but not spleen or liver. Mol. Ther. 5: 269-274.
7. Peng, K. W., Vile, R., Cosset, F. L., and Russell, S. (1999). Selective transduction of protease-rich tumors by matrix-metalloproteinase-targeted retroviral vectors. Gene Ther. 6: 1552-1557.
8. Peng, K. W., et al. (2001). Organ distribution of gene expression after intravenous infusion of targeted and untargeted lentiviral vectors. Gene Ther. 8: 1456-1463.
9. Martin, F., Neil, S., Kupsch, J., Maurice, M., Cosset, F., and Collins, M. (1999). Retrovirus targeting by tropism restriction to melanoma cells. J. Virol. 73: 6923-6929.
10. Hammarstrom, S. (1999). The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin. Cancer Biol. 9: 67-81.
11. Chester, K. A., et al. (1994). Phage libraries for generation of clinically useful antibodies. Lancet 343: 455-456.
12. Begent, R. H., et al. (1996). Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library. Nat. Med. 2: 979-984.
13. Peng, K. W., Morling, F. J., Cosset, F. L., Murphy, G., and Russell, S. J. (1997). A gene delivery system activatable by disease-associated matrix metallo-proteinases. Hum. Gene Ther. 8: 729-738.
14. Ye, Q. Z., Johnson, L. L., Yu, A. E., and Hupe, D. (1995). Reconstructed 19 kDa catalytic domain of gelatinase A is an active proteinase. Biochemistry 34: 4702-4708.
15. Cosset, F. L., Takeuchi, Y., Battini, J. L., Weiss, R. A., and Collins, M. K. (1995). High-titer packaging cells producing recombinant retroviruses resistant to human serum. J. Virol. 69: 7430-7436.
16. Martin, F., Chowdhury, S., Neil, S. J., Chester, K. A., Cosset, F. L., and Collins, M. K. (2003). Targeted retroviral infection of tumor cells by receptor cooperation. J. Virol. 77 2753-2756.
17. Takeuchi, Y., Cosset, F. L., Lachmann, P. J., Okada, H., Weiss, R. A., and Collins, M. K. (1994). Type C retrovirus inactivation by human complement is determined by both the viral genome and the producer cell. J. Virol. 68: 8001-8007.
18. Jobbagy, Z., Garfield, S., Baptiste, L., Eiden, M. V., and Anderson, W. B. (2000). Subcellular redistribution of Pit-2 P(i) transporter/amphotropic leukemia virus (A-MuLV) receptor in A-MuLV-infected NIH 3T3 fibroblasts: involvement in super-infection interference. J. Virol. 74: 2847-2854.
19. Lam, J. S., Reeves, M. E., Cowherd, R., Rosenberg, S. A., and Hwu, P. (1996). Improved gene transfer into human lymphocytes using retroviruses with the gibbon ape leukemia virus envelope. Hum. Gene Ther. 7: 1415-1422.
20. Chonn, A., Cullis, P. R., and Devine, D. V. (1991). The role of surface charge in the activation of the classical and alternative pathways of complement by liposomes. J. Immunol. 146: 4234-4241.
21. Baker, E. A., and Leaper, D. J. (2003). The plasminogen activator and matrix metalloproteinase systems in colorectal cancer: relationship to tumour pathology. Eur. J. Cancer 39: 981-988.
22. Pizzato, M., Marlow, S. A., Blair, E. D., and Takeuchi, Y. (1999). Initial binding of murine leukemia virus particles to cells does not require specific Env/receptor interaction. J. Virol. 73: 8599-8611.
23. Pizzato, M., et al. (2001). Evidence for nonspecific adsorption of targeted retrovirus vector particles to cells. Gene Ther. 8: 1088-1096.
24. Porter, C. D. (2002). Rescue of retroviral envelope fusion deficiencies by cationic liposomes. J. Gene Med. 4: 622-633.
25. Walker, S. J., Pizzato, M., Takeuchi, Y., and Devereux, S. (2002). Heparin binds to murine leukemia virus and inhibits Env-independent attachment and infection. J. Virol. 76: 6909-6918.
26. Konishi, H., et al. (1998). Targeting strategy for gene delivery to carcinoembryonic antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody. Hum. Gene Ther. 9: 235-248.
27. Khare, P. D., et al. (2001). Specifically targeted killing of carcinoembryonic antigen (CEA)-expressing cells by a retroviral vector displaying single-chain variable fragmented antibody to CEA and carrying the gene for inducible nitric oxide synthase. Cancer Res. 61: 370-375.
28. Khare, P. D., et al. (2002). Tumor growth suppression by a retroviral vector displaying scFv antibody to CEA and carrying the iNOS gene. Anticancer Res. 22: 2443-2446.
29. Gordon, E. M., et al. (2000). Inhibition of metastatic tumor growth in nude mice by portal vein infusions of matrix-targeted retroviral vectors bearing a cytocidal cyclin G1 construct. Cancer Res. 60: 3343-3347.
30. Hall, F. L., et al. (2000). Molecular engineering of matrix-targeted retroviral vectors incorporating a surveillance function inherent in von Willebrand factor. Hum. Gene Ther. 11: 983-993.
31. Buchholz, C. J., Peng, K. W., Morling, F. J., Zhang, J., Cosset, F. L., and Russell, S. J. (1998). In vivo selection of protease cleavage sites from retrovirus display libraries. Nat. Biotechnol. 16: 951-954.
32. Chester, J., et al. (2002). Tumor antigen-specific induction of transcriptionally targeted retroviral vectors from chimeric immune receptor-modified T cells. Nat. Biotechnol. 20: 256-263.
33. Naldini, L., et al. (1996). In vivo gene delivery and stable transduction of non-dividing cells by a lentiviral vector. Science 272: 263-267.
34. Low, W., Harries, M., Ye, H., Du, M. Q., Boshoff, C., and Collins, M. (2001). Internal ribosome entry site regulates translation of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein. J. Virol. 75: 2938-2945.
35. 6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumor cells. Br. J. Cancer 67: 1299-1302.
36. Chester, K. A., et al. (1994). Production and tumor-binding characterization of a chimeric anti-CEA Fab expressed in Escherichia coli. Int. J. Cancer 57: 67-72.
37. Cosset, F. L., Morling, F. J., Takeuchi, Y., Weiss, R. A., Collins, M. K., and Russell, S. J. (1995). Retroviral retargeting by envelopes expressing an N-terminal binding domain. J. Virol. 69: 6314-6322.
38. Sternlicht, M. D., and Werb, Z. (2001). How matrix metalloproteinases regulate cell behavior. Annu. Rev. Cell Dev. Biol. 17: 463-516.