Systemic administration of a matrix-targeted retroviral vector is efficacious for cancer gene therapy in mice

Human Gene Therapy

Volumn 12, Issue 2, 2001, Pages 193-204

  Gordon, E M ^a   Zhen Hai Chen, ^a   Liu, L ^a   Whitley, M ^a   Wei, D ^a,b   Groshen, S ^a,b   Hinton, D R ^a   Anderson, W F ^a,b   Beart Jr , R W ^a,b   Hall, F L ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; CYCLINE; PLACEBO; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER; CANCER THERAPY; CONTROLLED STUDY; GENE CONSTRUCT; GENE TARGETING; GENE THERAPY; HUMAN; HUMAN CELL; MARKER GENE; MOUSE; NONHUMAN; RETROVIRUS; TUMOR GROWTH; TUMOR VASCULARIZATION; TUMOR XENOGRAFT;

ANIMALS; BETA-GALACTOSIDASE; COLLAGEN; CYCLINS; GENE THERAPY; GENETIC VECTORS; HUMANS; IN SITU NICK-END LABELING; INFUSIONS, INTRAVENOUS; MICE; MICE, NUDE; RETROVIRIDAE; SKIN NEOPLASMS; TRANSPLANTATION, HETEROLOGOUS;

ANIMALIA; MUS MUSCULUS; UNIDENTIFIED RETROVIRUS;

EID: 0035915763     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303401750061258     Document Type: Article

References (34)

1. Gene therapy
2. Human gene therapy
3. Retroviral vectors preloaded with a viral receptor-ligand bridge protein are targeted to specific cell types
4. Retroviral vector-mediated transfer of an antisense cyclin G1 construct inhibits osteosarcoma tumor growth in nude mice
5. The resistance of retroviral vectors produced from human cells to serum inactivation in vivo and in vitro is primate species dependent
6. A neutralizable epitope common to the envelope glycoproteins of ecotropic, polytropic, xenotropic, and amphotropic murine leukemia viruses
7. Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution
8. Modulation of the organ microenvironment for treatment of cancer metastasis
9. Angiogenesis in cancer, vascular, rheumatoid and other disease
10. Tumor with VEGF promoter activity in stromal cells
11. Gene therapy using retroviral vectors
12. Inhibition of metastatic tumor growth in nude mice by portal vein infusions of matrix-targeted retroviral vectors bearing a cytocidal cyclin G1 construct
13. Targeting retroviral vectors to vascular lesions by genetic engineering of the Mo-MuLV gp70 envelope protein
14. Molecular engineering of matrix-targeted retroviral vectors incorporating a surveillance function inherent in von Willebrand factor
15. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
16. Intratumoral injection of an antisense cyclin G1 retroviral vector inhibits growth of undifferentiated carcinoma xenografts in nude mice
17. Nonparametric estimation from incomplete observations
18. Tissue-specific targeting of retroviral vectors through ligand-receptor interactions
19. Retroviral vector targeting to melanoma cells by single-chain antibody incorporation in envelope
20. Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection
21. Analysis of the functional and host range-determining regions of the murine ecotropic and amphotropic retrovirus envelope proteins
22. Targeting of retroviral vectors through protease-substrate interactions
23. Viral vector targeting
24. Retroviral vector-mediated gene transfer of antisense cyclin G1 (CYCG1) inhibits proliferation of human osteogenic sarcoma cells
25. The p53-regulated cyclin G Gene promotes cell growth: p53 downstream effectors cyclin G and Gadd45 exert different effects on cisplatin sensitivity
26. Generation of targeted retroviral vectors by using single-chain variable fragment: An approach to in vivo gene delivery
27. A transient three-plasmid expression system for the production of high titer retroviral vectors
28. Cell adhesion and angiogenesis
29. A collagen/gelatin-binding decapeptide derived from bovine propolypeptide of von Willebrand factor
30. Tests for trend in life table analysis
31. Characterization of the proline-rich region of murine leukemia virus envelope protein
32. Molecular cloning of the human CYCGI gene encoding a G-type cyclin: Overexpression in osteosarcoma cells
33. Identification of the block in targeted retroviral-mediated gene transfer
34. Down-regulation of cyclin G1 expression by retrovirus-mediated antisense gene transfer inhibits vascular smooth muscle cell proliferation and neointima formation