Targeting strategy for gene delivery to carcinoembryonic antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody

Human Gene Therapy

Volumn 9, Issue 2, 1998, Pages 235-248

  Konishi, Hiroyasu ^a,b   Ochiya, Takahiro ^a   Chester, Kerry A ^c   Beǵent, Richard H J ^c   Muto, Tetsuichiro ^b   Sugimura, Takashi ^a   Terada, Masaaki ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; BETA GALACTOSIDASE; CARCINOEMBRYONIC ANTIGEN; CHIMERIC PROTEIN; ENVELOPE PROTEIN; THYMIDINE KINASE;

ANIMAL CELL; ARTICLE; CANCER CELL; CONTROLLED STUDY; ESCHERICHIA COLI; EXPRESSION VECTOR; GENE TARGETING; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; MOLONEY LEUKEMIA ONCOVIRUS; MOUSE; NONHUMAN; RETROVIRUS; VIRUS INFECTION; VIRUS PARTICLE;

ANIMALIA; ESCHERICHIA; ESCHERICHIA COLI; HERPES; MOLONEY MURINE LEUKEMIA VIRUS; MURINAE; ONCOVIRINAE; SIMPLEXVIRUS; UNIDENTIFIED RETROVIRUS;

EID: 0032548399     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.2-235     Document Type: Article

References (9)

1. ABBASI, A.M., CHESTER, K.A., MACPHERSON, J.S., BOXER, G.M., BEGENT, R.H.J., and MALCOME, A.D.B. (1992). Localization of CEA messenger RNA by in situ hybridization in normal colonic mucosa and colorectal adenocarcinoma. J. Pathol. 168, 405-411.
2. AGER, S., NILSON, B.H.K., MORLING, F.J., PENG, K.W., COSSET, F.-L., and RUSSELL, S.J. (1996). Retroviral display of antibody fragments; interdomain spacing strongly influences vector infectivity. Hum. Gene Ther. 7, 2157-2164.
3. BEGENT, R.H.J., VERHAAR, M.J., CHESTER, K.A., CASEY, J.L., GREEN, A.J., NAPIER, M.P., HOPE-STONE, L.D., CUSHEN, N., KEEP, P.A., JOHNSON, C.J., HAWKINS, R.E., HILSON, A.J.W., and ROBSON, L. (1996). Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library. Nature Med. 2, 979-984.
4. BENCHIMOL, S., FUKS, A., JOTHY, S., BEAUCHEMIN, N., SHIROTA, K., and STAMMERS, C.P. (1989). Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell 57, 327-334.
5. BURTIN, P., CHAVANEL, G., and HIRSCH-MARIE, H. (1973). Characterization of a second normal antigen that cross-reacts with CEA. J. Immunol. 111, 1926-1928.
6. CHESTER, K.A., BEGENT, R.H.J., ROBSON, L., KEEP, P., PEDLEY, R.B., BODEN, J.A., BOXER, G., GREEN, A., WINTER, G., COCHET, O., and HAWKINS, R.E. (1994). Phage libraries for generation of clinically useful antibodies. Lancet 343, 455-456.
7. CHU, T.-H., and DORNBURG, R. (1997). Toward highly efficient cell-type-specific gene transfer with retroviral vectors displaying single-chain antibodies. J. Virol. 71, 720-725.
8. CHU, T.-H., MARTINEZ, I., SHEAY, W.C., and DORNBURG, R. (1994). Cell targeting with retroviral vector particles containing antibody-envelope fusion proteins. Gene Ther. 1, 292-299.
9. COSSET, F.-L., MORLING, F.J., TAKEUCHI, Y., WEISS, R.A., COLLINS, M.K.L., and RUSSELL, S.J. (1995). Retroviral retargeting by envelopes expressing an N-terminal binding domain. J. Virol. 69, 6314-6322.