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Volumn 189, Issue 8, 2004, Pages 1528-1539

Delayed clearance of Pneumocystis carinii infection, increased inflammation, and altered nitric oxide metabolism in lungs of surfactant protein-D knockout mice

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; CD4 ANTIGEN; INDUCIBLE NITRIC OXIDE SYNTHASE; LUNG SURFACTANT; NITRIC OXIDE; SURFACTANT PROTEIN D;

EID: 11144354728     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/383130     Document Type: Article
Times cited : (66)

References (59)
  • 1
    • 0030468397 scopus 로고    scopus 로고
    • Pneumocystis carinii
    • Levine SJ. Pneumocystis carinii. Clin Chest Med 1996; 17:665-75.
    • (1996) Clin Chest Med , vol.17 , pp. 665-675
    • Levine, S.J.1
  • 2
    • 0031742823 scopus 로고    scopus 로고
    • Current issues in the epidemiology, transmission, and reactivation of Pneumocystis carinii
    • Hughes WT. Current issues in the epidemiology, transmission, and reactivation of Pneumocystis carinii. Semin Respir Infect 1998; 13:283-8.
    • (1998) Semin Respir Infect , vol.13 , pp. 283-288
    • Hughes, W.T.1
  • 3
    • 0036046406 scopus 로고    scopus 로고
    • Analysis of underlying diseases and prognosis factors associated with Pneumocystis carinii pneumonia in immunocompromised HIV-negative patients
    • Roblot F, Godet C, Le Moal G, et al. Analysis of underlying diseases and prognosis factors associated with Pneumocystis carinii pneumonia in immunocompromised HIV-negative patients. Eur J Clin Microbiol Infect Dis 2002; 21:523-31.
    • (2002) Eur J Clin Microbiol Infect Dis , vol.21 , pp. 523-531
    • Roblot, F.1    Godet, C.2    Le Moal, G.3
  • 4
    • 0035175347 scopus 로고    scopus 로고
    • Pneumocystis carinii pneumonia in patients without HIV infection
    • Russian DA, Levine SJ. Pneumocystis carinii pneumonia in patients without HIV infection. Am J Med Sci 2001; 321:56-65.
    • (2001) Am J Med Sci , vol.321 , pp. 56-65
    • Russian, D.A.1    Levine, S.J.2
  • 5
    • 0031743010 scopus 로고    scopus 로고
    • Alveolar macrophage and glycoprotein responses to Pneumocystis carinii
    • Limper AH. Alveolar macrophage and glycoprotein responses to Pneumocystis carinii. Semin Respir Infect 1998; 13:339-47.
    • (1998) Semin Respir Infect , vol.13 , pp. 339-347
    • Limper, A.H.1
  • 6
    • 0031742908 scopus 로고    scopus 로고
    • Lymphocytes in host defense against Pneumocystis carinii
    • Beck JM, Harmsen AG. Lymphocytes in host defense against Pneumocystis carinii. Semin Respir Infect 1998; 13:330-8.
    • (1998) Semin Respir Infect , vol.13 , pp. 330-338
    • Beck, J.M.1    Harmsen, A.G.2
  • 7
    • 0033962582 scopus 로고    scopus 로고
    • Collecting and pulmonary innate immunity
    • Crouch E, Hartshorn K, Ofek I. Collecting and pulmonary innate immunity. Immunol Rev 2000; 173:52-65.
    • (2000) Immunol Rev , vol.173 , pp. 52-65
    • Crouch, E.1    Hartshorn, K.2    Ofek, I.3
  • 8
    • 0034744529 scopus 로고    scopus 로고
    • Functions of surfactant proteins B and C
    • Weaver TE, Conkright JJ. Functions of surfactant proteins B and C. Annu Rev Physiol 2001; 63:555-78.
    • (2001) Annu Rev Physiol , vol.63 , pp. 555-578
    • Weaver, T.E.1    Conkright, J.J.2
  • 9
    • 0035051057 scopus 로고    scopus 로고
    • The pulmonary collectins and surfactant metabolism
    • Hawgood S, Poulain FR. The pulmonary collectins and surfactant metabolism. Annu Rev Physiol 2001; 63:495-519.
    • (2001) Annu Rev Physiol , vol.63 , pp. 495-519
    • Hawgood, S.1    Poulain, F.R.2
  • 10
    • 0035048532 scopus 로고    scopus 로고
    • Surfactant proteins A and D and pulmonary host defense
    • Crouch EC, Wright JR. Surfactant proteins A and D and pulmonary host defense. Annu Rev Physiol 2001; 63:521-54.
    • (2001) Annu Rev Physiol , vol.63 , pp. 521-554
    • Crouch, E.C.1    Wright, J.R.2
  • 11
    • 0036068402 scopus 로고    scopus 로고
    • Tissue distribution of surfactant proteins A and D in the mouse
    • Akiyama J, Hoffman A, Brown C, et al. Tissue distribution of surfactant proteins A and D in the mouse. J Histochem Cytochem 2002; 50:993-6.
    • (2002) J Histochem Cytochem , vol.50 , pp. 993-996
    • Akiyama, J.1    Hoffman, A.2    Brown, C.3
  • 12
    • 0031795751 scopus 로고    scopus 로고
    • Structure, biologic properties, and expression of surfactant protein D (SP-D)
    • Crouch EC. Structure, biologic properties, and expression of surfactant protein D (SP-D). Biochimica et Biophysica Acta 1998; 1408:278-89.
    • (1998) Biochimica et Biophysica Acta , vol.1408 , pp. 278-289
    • Crouch, E.C.1
  • 13
    • 13144282686 scopus 로고    scopus 로고
    • Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D
    • Botas C, Poulain F, Akiyama J, et al. Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D. Proc Natl Acad Sci USA 1998; 95:11869-74.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11869-11874
    • Botas, C.1    Poulain, F.2    Akiyama, J.3
  • 14
    • 15144352324 scopus 로고    scopus 로고
    • Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo
    • Korfhagen TR, Sheftelyevich V, Burhans MS, et al. Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo. J Biol Chem 1998; 273:28438-43.
    • (1998) J Biol Chem , vol.273 , pp. 28438-28443
    • Korfhagen, T.R.1    Sheftelyevich, V.2    Burhans, M.S.3
  • 15
    • 0030758115 scopus 로고    scopus 로고
    • Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages
    • Madan T, Eggleton P, Kishore U, et al. Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages. Infect Immun 1997; 65:3171-9.
    • (1997) Infect Immun , vol.65 , pp. 3171-3179
    • Madan, T.1    Eggleton, P.2    Kishore, U.3
  • 16
    • 0032212269 scopus 로고    scopus 로고
    • Recombinant rat surfactant-associated protein D inhibits human T lymphocyte proliferation and IL-2 production
    • Borron PJ, Crouch EC, Lewis JF, Wright JR, Possmayer F, Fraher LJ. Recombinant rat surfactant-associated protein D inhibits human T lymphocyte proliferation and IL-2 production. J Immunol 1998; 161: 4599-603.
    • (1998) J Immunol , vol.161 , pp. 4599-4603
    • Borron, P.J.1    Crouch, E.C.2    Lewis, J.F.3    Wright, J.R.4    Possmayer, F.5    Fraher, L.J.6
  • 17
    • 0035877211 scopus 로고    scopus 로고
    • Surfactant protein D regulates NF-κB and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways
    • Yoshida M, Korfhagen TR, Whitsett JA. Surfactant protein D regulates NF-κB and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways. J Immunol 2001; 166:7514-9.
    • (2001) J Immunol , vol.166 , pp. 7514-7519
    • Yoshida, M.1    Korfhagen, T.R.2    Whitsett, J.A.3
  • 19
    • 0031716582 scopus 로고    scopus 로고
    • Functional roles of the lung surfactant proteins SP-A and SP-D in innate immunity
    • Reid KB. Functional roles of the lung surfactant proteins SP-A and SP-D in innate immunity. Immunobiology 1998; 199:200-7.
    • (1998) Immunobiology , vol.199 , pp. 200-207
    • Reid, K.B.1
  • 20
    • 0035217517 scopus 로고    scopus 로고
    • Surfactant protein D enhances bacterial antigen presentation by bone marrow-derived dendritic cells
    • Brinker KG, Martin E, Borron P, et al. Surfactant protein D enhances bacterial antigen presentation by bone marrow-derived dendritic cells. Am J Physiol Lung Cell Mol Physiol 2001; 281:L1453-63.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.281
    • Brinker, K.G.1    Martin, E.2    Borron, P.3
  • 22
    • 0035044068 scopus 로고    scopus 로고
    • Carbohydrate recognition domain of surfactant protein D mediates interactions with Pneumocystis carinii glycoprotein A
    • Vuk-Pavlovic Z, Standing JE, Crouch EC, Limper AH. Carbohydrate recognition domain of surfactant protein D mediates interactions with Pneumocystis carinii glycoprotein A. Am J Respir Cell Mol Biol 2001; 24: 475-84.
    • (2001) Am J Respir Cell Mol Biol , vol.24 , pp. 475-484
    • Vuk-Pavlovic, Z.1    Standing, J.E.2    Crouch, E.C.3    Limper, A.H.4
  • 24
    • 0029411071 scopus 로고
    • Surfactant protein-D modulates interaction of Pneumocystis carinii with alveolar macrophages
    • Limper AH, Crouch EC, O'Riordan DM, et al. Surfactant protein-D modulates interaction of Pneumocystis carinii with alveolar macrophages. J Lab Clin Med 1995; 126:416-22.
    • (1995) J Lab Clin Med , vol.126 , pp. 416-422
    • Limper, A.H.1    Crouch, E.C.2    O'Riordan, D.M.3
  • 25
    • 0035869184 scopus 로고    scopus 로고
    • Immunosuppressed surfactant protein A - Deficient mice have increased susceptibility to Pneumocystis carinii infection
    • Linke MJ, Harris CE, Korfhagen TR, et al. Immunosuppressed surfactant protein A - deficient mice have increased susceptibility to Pneumocystis carinii infection. J Infect Dis 2001; 183:943-52.
    • (2001) J Infect Dis , vol.183 , pp. 943-952
    • Linke, M.J.1    Harris, C.E.2    Korfhagen, T.R.3
  • 26
    • 0030784825 scopus 로고    scopus 로고
    • Immunomodulatory functions of surfactant
    • Wright JR. Immunomodulatory functions of surfactant. Physiol Rev 1997; 77:931-62.
    • (1997) Physiol Rev , vol.77 , pp. 931-962
    • Wright, J.R.1
  • 27
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly
    • Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. Am J Physiol 1996; 271:C1424-37.
    • (1996) Am J Physiol , vol.271
    • Beckman, J.S.1    Koppenol, W.H.2
  • 29
    • 0032884061 scopus 로고    scopus 로고
    • Oxidant-mediated lung injury in the acute respiratory distress syndrome
    • Matthay MA, Geiser T, Matalon S, Ischiropoulos H. Oxidant-mediated lung injury in the acute respiratory distress syndrome. Crit Care Med 1999; 27:2028-30.
    • (1999) Crit Care Med , vol.27 , pp. 2028-2030
    • Matthay, M.A.1    Geiser, T.2    Matalon, S.3    Ischiropoulos, H.4
  • 30
    • 0031924821 scopus 로고    scopus 로고
    • Plasma 3-nitrotyrosine is elevated in premature infants who develop bronchopulmonary dysplasia
    • Banks BA, Ischiropoulos H, McClelland M, Ballard PL, Ballard RA. Plasma 3-nitrotyrosine is elevated in premature infants who develop bronchopulmonary dysplasia. Pediatrics 1998; 101:870-4.
    • (1998) Pediatrics , vol.101 , pp. 870-874
    • Banks, B.A.1    Ischiropoulos, H.2    McClelland, M.3    Ballard, P.L.4    Ballard, R.A.5
  • 31
    • 0032880537 scopus 로고    scopus 로고
    • Oxidative damage to proteins of bronchoalveolar lavage fluid in patients with acute respiratory distress syndrome: Evidence for neutrophil-mediated hydroxylation, nitration, and chlorination
    • Lamb NJ, Gutteridge JMC, Baker C, Evans TW, Quinlan GJ. Oxidative damage to proteins of bronchoalveolar lavage fluid in patients with acute respiratory distress syndrome: evidence for neutrophil-mediated hydroxylation, nitration, and chlorination. Crit Care Med 1999; 27: 1738-44.
    • (1999) Crit Care Med , vol.27 , pp. 1738-1744
    • Lamb, N.J.1    Gutteridge, J.M.C.2    Baker, C.3    Evans, T.W.4    Quinlan, G.J.5
  • 32
    • 0032825511 scopus 로고    scopus 로고
    • Nitration of proteins in bronchoalveolar lavage fluid from patients with acute respiratory distress syndrome receiving inhaled nitric oxide
    • Lamb NJ, Quinlan GJ, Westerman ST, Gutteridge JMC, Evans TW. Nitration of proteins in bronchoalveolar lavage fluid from patients with acute respiratory distress syndrome receiving inhaled nitric oxide. Am J Respir Crit Care Med 1999; 160:1031-4.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1031-1034
    • Lamb, N.J.1    Quinlan, G.J.2    Westerman, S.T.3    Gutteridge, J.M.C.4    Evans, T.W.5
  • 33
    • 0034073045 scopus 로고    scopus 로고
    • Plasma proteins modified by tyrosine nitration in acute respiratory distress syndrome
    • Gole MD, Souza JM, Choi I, et al. Plasma proteins modified by tyrosine nitration in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol 2000; 278:L961-7.
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.278
    • Gole, M.D.1    Souza, J.M.2    Choi, I.3
  • 34
    • 0026720138 scopus 로고
    • Differential extraction for the rapid purification of bovine surfactant protein B
    • Beers MF, Bates SR, Fisher AB. Differential extraction for the rapid purification of bovine surfactant protein B. Am J Physiol 1992; 262: L773-8.
    • (1992) Am J Physiol , vol.262
    • Beers, M.F.1    Bates, S.R.2    Fisher, A.B.3
  • 35
    • 0027215888 scopus 로고
    • ATP and adenosine 3′,5′-cyclic monophosphate stimulate the synthesis of surfactant protein A in rat lung
    • Wali A, Beers MF, Dodia C, Feinstein SI, Fisher AB. ATP and adenosine 3′,5′-cyclic monophosphate stimulate the synthesis of surfactant protein A in rat lung. Am J Physiol 1993; 264:L431-7.
    • (1993) Am J Physiol , vol.264
    • Wali, A.1    Beers, M.F.2    Dodia, C.3    Feinstein, S.I.4    Fisher, A.B.5
  • 36
    • 0025282012 scopus 로고
    • A new model of Pneumocystis carinii infection in mice selectivity depleted of helper T lymphocytes
    • Shellito JE, Suzara VV, Blumenfeld W, Beck JM, Steger HJ, Ermak TH. A new model of Pneumocystis carinii infection in mice selectivity depleted of helper T lymphocytes. J Clin Invest 1990; 85:1686-93.
    • (1990) J Clin Invest , vol.85 , pp. 1686-1693
    • Shellito, J.E.1    Suzara, V.V.2    Blumenfeld, W.3    Beck, J.M.4    Steger, H.J.5    Ermak, T.H.6
  • 38
    • 0026072156 scopus 로고
    • Reduction in intensity of Pneumocystis carinii pneumonia in mice by aerosol administration of gamma interferon
    • Beck JM, Liggit HD, Brunette EN, Fuchs HJ, Shellito JE, Debs RJ. Reduction in intensity of Pneumocystis carinii pneumonia in mice by aerosol administration of gamma interferon. Infect Immun 1991; 59: 3859-62.
    • (1991) Infect Immun , vol.59 , pp. 3859-3862
    • Beck, J.M.1    Liggit, H.D.2    Brunette, E.N.3    Fuchs, H.J.4    Shellito, J.E.5    Debs, R.J.6
  • 39
    • 0031858760 scopus 로고    scopus 로고
    • Susceptibility to Pneumocystis carinii in mice is dependent on simultaneous deletion of IFN-γ and type 1 and 2 TNF receptor genes
    • Rudmann DG, Preston AM, Moore MW, Beck JM. Susceptibility to Pneumocystis carinii in mice is dependent on simultaneous deletion of IFN-γ and type 1 and 2 TNF receptor genes. J Immunol 1998; 161: 360-6.
    • (1998) J Immunol , vol.161 , pp. 360-366
    • Rudmann, D.G.1    Preston, A.M.2    Moore, M.W.3    Beck, J.M.4
  • 40
    • 0036783686 scopus 로고    scopus 로고
    • The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice
    • Haczku A, Atochina EN, Tomer Y, et al. The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice. Am J Physiol Lung Cell Mol Physiol 2002; 283:L755-65.
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.283
    • Haczku, A.1    Atochina, E.N.2    Tomer, Y.3
  • 42
    • 0035371281 scopus 로고    scopus 로고
    • Pneumocystis carinii pneumonia alters expression and distribution of lung collectins SP-A and SP-D
    • Atochina EN, Beck JM, Scanlon ST, Preston AM, Beers MF. Pneumocystis carinii pneumonia alters expression and distribution of lung collectins SP-A and SP-D. J Lab Clin Med 2001; 137:429-39.
    • (2001) J Lab Clin Med , vol.137 , pp. 429-439
    • Atochina, E.N.1    Beck, J.M.2    Scanlon, S.T.3    Preston, A.M.4    Beers, M.F.5
  • 43
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72:248-54.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 44
    • 70449246528 scopus 로고
    • Phosphorous assay in column chromatography
    • Bartlett GR. Phosphorous assay in column chromatography. J Biol Chem 1959; 234:466-8.
    • (1959) J Biol Chem , vol.234 , pp. 466-468
    • Bartlett, G.R.1
  • 46
    • 0029884282 scopus 로고    scopus 로고
    • Nitric oxide production and perivascular tyrosine nitration in brain following carbon monoxide poisoning in the rat
    • Ischiropoulos H, Beers MF, Ohnishi ST, Fisher D, Garner S, Thom SR. Nitric oxide production and perivascular tyrosine nitration in brain following carbon monoxide poisoning in the rat. J Clin Invest 1996; 97:2260-7.
    • (1996) J Clin Invest , vol.97 , pp. 2260-2267
    • Ischiropoulos, H.1    Beers, M.F.2    Ohnishi, S.T.3    Fisher, D.4    Garner, S.5    Thom, S.R.6
  • 47
    • 0034094435 scopus 로고    scopus 로고
    • Immunohistochemical localization of protein 3-nitrotyrosine and S-nitrosocysteine in a murine model of inhaled nitric oxide therapy
    • Lorch SA, Foust R, Gow A, et al. Immunohistochemical localization of protein 3-nitrotyrosine and S-nitrosocysteine in a murine model of inhaled nitric oxide therapy. Pediatr Res 2000; 47:798-805.
    • (2000) Pediatr Res , vol.47 , pp. 798-805
    • Lorch, S.A.1    Foust, R.2    Gow, A.3
  • 50
  • 51
    • 0035081547 scopus 로고    scopus 로고
    • Protective role of lung surfactant protein D in a murine model of invasive pulmonary aspergillosis
    • Madan T, Kishore U, Singh M, et al. Protective role of lung surfactant protein D in a murine model of invasive pulmonary aspergillosis. Infect Immun 2001; 69:2728-31.
    • (2001) Infect Immun , vol.69 , pp. 2728-2731
    • Madan, T.1    Kishore, U.2    Singh, M.3
  • 53
    • 0032721616 scopus 로고    scopus 로고
    • A recombinant trimeric surfactant protein D carbohydrate recognition domain inhibits respiratory syncytial virus infection in vitro and in vivo
    • Hickling TP, Bright H, Wing K, et al. A recombinant trimeric surfactant protein D carbohydrate recognition domain inhibits respiratory syncytial virus infection in vitro and in vivo. Eur J Immunol 1999; 29: 3478-84.
    • (1999) Eur J Immunol , vol.29 , pp. 3478-3484
    • Hickling, T.P.1    Bright, H.2    Wing, K.3
  • 54
    • 0032725183 scopus 로고    scopus 로고
    • Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia
    • Wright TW, Gigliotti F, Finkelstein JN, McBride JT, An CL, Harmsen AG. Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia. J Clin Invest 1999; 104:1307-17.
    • (1999) J Clin Invest , vol.104 , pp. 1307-1317
    • Wright, T.W.1    Gigliotti, F.2    Finkelstein, J.N.3    McBride, J.T.4    An, C.L.5    Harmsen, A.G.6
  • 55
    • 0030035056 scopus 로고    scopus 로고
    • Nitric oxide and host defense against Pneumocystis carinii infection in a mouse model
    • Shellito JE, Kolls JK, Olariu R, Beck JM. Nitric oxide and host defense against Pneumocystis carinii infection in a mouse model. J Infect Dis 1996; 173:432-9.
    • (1996) J Infect Dis , vol.173 , pp. 432-439
    • Shellito, J.E.1    Kolls, J.K.2    Olariu, R.3    Beck, J.M.4
  • 56
    • 0031814994 scopus 로고    scopus 로고
    • Interaction of rat Pneumocystis carinii and rat alveolar epithelial cells in vitro
    • Beck JM, Preston AM, Wagner JG, et al. Interaction of rat Pneumocystis carinii and rat alveolar epithelial cells in vitro. Am J Physiol 1998; 275: L118-25.
    • (1998) Am J Physiol , vol.275
    • Beck, J.M.1    Preston, A.M.2    Wagner, J.G.3
  • 58
    • 0032474233 scopus 로고    scopus 로고
    • Bronchodilator S-nitrosothiol deficiency in asthmatic respiratory failure
    • Gaston B, Sears S, Woods J, et al. Bronchodilator S-nitrosothiol deficiency in asthmatic respiratory failure. Lancet 1998; 351:1317-9.
    • (1998) Lancet , vol.351 , pp. 1317-1319
    • Gaston, B.1    Sears, S.2    Woods, J.3
  • 59
    • 0033505556 scopus 로고    scopus 로고
    • Decreased levels of nitrosothiols in the lower airways of patients with cystic fibrosis and normal pulmonary function
    • Grasemann H, Gaston B, Fang KZ, Paul K, Ratjen F. Decreased levels of nitrosothiols in the lower airways of patients with cystic fibrosis and normal pulmonary function. J Pediatr 1999; 135:770-2.
    • (1999) J Pediatr , vol.135 , pp. 770-772
    • Grasemann, H.1    Gaston, B.2    Fang, K.Z.3    Paul, K.4    Ratjen, F.5


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