A recombinant trimeric surfactant protein D carbohydrate recognition domain inhibits respiratory syncytial virus infection in vitro and in vivo

European Journal of Immunology

Volumn 29, Issue 11, 1999, Pages 3478-3484

  Hickling, Timothy P ^a,b   Bright, Helen ^a   Wing, Kevin ^a   Gower, David ^a   Martin, Steve L ^a   Sim, Robert B ^b   Malhotra, Rajneesh ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Collectin; G protein; Innate immunity; Respiratory syncytial virus; Surfactant protein D

Indexed keywords

EDETIC ACID; GLYCOSYLATED PROTEIN; LECTIN; MANNAN; RECOMBINANT PROTEIN; SURFACTANT PROTEIN D; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INTRANASAL DRUG ADMINISTRATION; LECTIN BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; VIRUS CELL INTERACTION; VIRUS INFECTION; VIRUS INHIBITION;

EID: 0032721616     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199911)29:11<3478::AID-IMMU3478>3.0.CO;2-W     Document Type: Article

References (29)

1. Holmskov, U., Malhotra, R., Sim, R. B. and Jensenius, J. C., Collectins: collagenous C-type lectins of the innate immune defence system, Immunol. Today 1994. 15: 67-74.
2. Malhotra, R., Lu, J., Holmskov, U. and Sim, R. B., Collectins, collectin receptors and the lectin pathway of complement activation. Clin. Exp. Immunol. 1994. 2: 4-9.
3. Sastry, K. and Ezekowitz, R. A., Collectins: pattern recognition molecules involved in first line host defence. Curr. Opin. Immunol. 1993. 5: 59-66.
4. Drickamer, K., Two distinct classes of carbohydrate-recognition domains in animal lectins. J. Biol. Chem. 1988. 263: 9557-9560.
5. Hoppe, H. J. and Reid, K. B., Trimeric C-type lectin domains in host defence. Structure 1994. 2: 1129-1133.
6. Crouch, E., Persson, A., Chang, D. and Heuser, J., Molecular structure of pulmonary surfactant protein D (SP-D). J. Biol. Chem. 1994. 269: 17311-17319.
7. Malhotra, R., Haurum, J., Thiel, S. and Sim, R. B., Binding of human collectins (SP-A and MBP) to influenza virus. Biochem. J. 1994. 304: 455-461.
8. Hartshorn, K., Chang, D., Rust, K., White, M., Heuser, J. and Crouch, E., Interactions of recombinant human pulmonary surfactant protein D and SP-D multimers with influenza A. Am. J. Physiol. 1996. 271: L753-762.
9. Hartshorn, K. L., Crouch, E, White, M. R., Colamussi, M. L., Kakkanatt, A., Tauber, B., Shepherd, V. and Sastry, K. N., Pulmonary surfactant proteins A and D enhance neutrophil uptake of bacteria. Am. J. Physiol. 1998. 274: 1958-969.
10. Glezen, W. P., Taber, L. H., Frank, A. L. and Kasel, J. A., Risk of primary infection and reinfection with respiratory syncytial virus. Am. J. Dis. Child. 1986. 140: 543-546.
11. Meert, K., Heidemann, S., Lieh-Lai, M. and Sarnaik, A. P., Clinical characteristics of respiratory syncytial virus infections in healthy versus previously compromised host. Pediatr. Pulmonol. 1989. 7: 167-170.
12. Bellini, W. J., Rota, P. A. and Anderson, L. J., Paramyxoviruses. In Mahy, B. W. J. and Collier, L. (Eds.) Topley and Wilson's Microbiology and Microbial Infections, 9th edn, Vol. 1: Virology. Arnold, London 1998, pp 435-461.
13. Levine, S., Klaiber-Franco, R. and Paradiso, P. R., Demonstration that glycoprotein G is the attachment protein of respiratory syncytial virus. J. Gen. Virol. 1987. 68: 2521-2524.
14. Walsh, E. E., Brandriss, M. W. and Schlesinger, J. J., Purification and characterization of the respiratory syncytial virus fusion protein. J. Gen. Virol. 1985. 66: 409-415.
15. Langedijk, J. P., Schaaper, W. M., Meloen, R. H. and van Oirschot, J. T., Proposed three-dimensional model for the attachment protein G of respiratory syncytial virus. J. Gen. Virol. 1996. 77: 1249-1257.
16. Gruber, C. and Levine, S., Respiratory syncytial virus polypeptides. IV. The oligosaccharides of the glycoproteins. J. Gen. Virol. 1985. 66: 417-432.
17. Wertz, G. W., Krieger, M. and Ball, L. A., Structure and cell surface alteration of the attachment glycoprotein of human respiratory syncytial virus in a cell line deficient O-glycosylation. J. Virol. 1989. 63: 4767-4776.
18. Lambert, D. M., Role of oligosaccharides in the structure and function of respiratory syncytial virus glycoproteins. Virology 1988. 64: 458-466.
19. Malhotra, R. and Sim, R. B., Collectins and viral infection. Trends Microbiol. 1995. 3: 240-243.
20. Hartshorn, K. L., White, M. R., Shepherd, V., Reid, K., Jensenius, J. C. and Crouch, E. C., Mechanisms of anti-influenza activity of surfactant proteins A and D: comparison with serum collectins. Am. J. Physiol. 1997. 273: L1156-1166.
21. Hartshorn, K. L., Reid, K. B., White, M. R., Jensenius, J. C., Morris, S. M., Tauber, A. I. and Crouch, E., Neutrophil deactivation by influenza A viruses: mechanisms of protection after viral opsonization with collectins and hemagglutination-inhibiting antibodies. Blood 1996. 87: 3450-3461.
22. Crowe, J. E., Murphy, B. R., Chanock, R. M., Williamson, R. A., Barbas, C. F. and Burton, D. R., Recombinant human respiratory syncytial virus (RSV) monoclonal antibody Fab is effective therapeutically when introduced directly into the lungs of RSV-infected mice. Proc. Natl. Acad. Sci. USA 1994. 91: 1386-1390.
23. Crowe, J. E., Gilmour, P. S., Murphy, B. R., Chanock, R. M., Duan, L., Pomerantz, R. J. and Pilkington, G. R., Isolation of a second recombinant human respiratory syncytial virus monoclonal antibody fragment (Fab RSVF2-5) that exhibits therapeutic efficacy in vivo. J. Infect. Dis. 1998. 177: 1073-1076.
24. Kerr, M. H. and Paton, J. Y., Surfactant protein levels in severe respiratory syncytial virus infection. Am. J. Respir. Crit. Care Med. 1999. 159: 1115-1118.
25. Postle, A. D., Mander, A., Reid, K. B., Wang, J. Y., Wright, S. M., Moustaki, M. and Warner, J. O., Deficient hydrophilic lung surfactant proteins A and D with normal surfactant phospholipid molecular species in cystic fibrosis. Am. J. Respir. Cell. Mol. Biol. 1999, 20: 90-98.
26. Strong, P., Kishore, U., Morgan, C., Lopez Bernai, A., Singh, M. and Reid, K. B. M., A novel method of purifying lung surfactant proteins A and D from the lung lavage of alveolar proteinosis patients and from pooled amniotic fluid. J. Immunol. Methods. 1998. 220: 139-149.
27. Harlow, E. and Lane, D. (Eds.) Antibiodies: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1988.
28. Kishore, U., Wang, J. Y., Hoppe, H. J. and Reid, K. B., The alpha-helical neck region of human lung surfactant protein D is essential for the binding of the carbohydrate recognition domains to lipopolysaccharides and phospholipids. Biochem. J. 1996. 318: 505-511.
29. Routledge, E. G., Willcocks, M. M., Samson, A. C., Morgan, L, Scott, R., Anderson, J. J. and Toms, G. L., The purification of four respiratory syncytial virus proteins and their evaluation as protective agents against experimental infection in BALB/c mice. J. Gen. Virol. 1988. 69: 293-303.