Reduced interferon-γ production and mutations of the interleukin-12 receptor β2 chain gene in atopic subjects

International Archives of Allergy and Immunology

Volumn 124, Issue 1-3, 2001, Pages 117-120

  Kondo, Naomi ^a   Matsui, Eiko ^a   Kaneko, Hideo ^a   Fukao, Toshiyuki ^a   Teramoto, Takahide ^a   Inoue, Ryosuke ^a   Watanabe, Mizuho ^a   Kasahara, Kimiko ^a   Morimoto, Naoko ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Atopic gene; IgE; Interferon ; Interleukin 12; Interleukin 12 receptor 1 and 2; Mutation of IL 12R 2 chain gene

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR;

ATOPY; CONFERENCE PAPER; GENE MUTATION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; IMMUNOREGULATION; INTERFERON PRODUCTION; MONONUCLEAR CELL; PRIORITY JOURNAL;

CELLS, CULTURED; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; INTERFERON TYPE II; INTERLEUKIN-12; LEUKOCYTES, MONONUCLEAR; MODELS, IMMUNOLOGICAL; MUTATION; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; SIGNAL TRANSDUCTION;

EID: 0035044914     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000053687     Document Type: Conference Paper

References (11)

1. IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2
2. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
3. Serum IgE level is negatively correlated with the ability of peripheral mononuclear cells to produce interferon gamma (IFN-γ): Evidence of reduced expression of IFN-γ mRNA in atopic patients
4. Relationship between interferon-γ, interleukin-4 and IgE production of lymphocytes from hen's egg-sensitive patients
5. 2 (chain gene)in atopic subjects
6. A functional interleukin 12 receptor comlex is composed of two β-type cytokine receptor subunits
7. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
8. IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses
9. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
10. Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients
11. Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor