Over-expression of TGF-β1 in Smad4-deficient human oral carcinoma cells causes tumour regression in vivo by mechanisms that sensitize cells to apoptosis

Journal of Pathology

Volumn 205, Issue 1, 2005, Pages 14-20

  Thavaraj, Selvam ^a   Paterson, Ian C ^a   Hague, Angela ^a   Prime, Stephen S ^a,b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b BRISTOL DENTAL HOSPITAL   (United Kingdom)

Author keywords

Cancer; Human keratinocytes; Regression; Transforming growth factor

Indexed keywords

CISPLATIN; FAS ANTIGEN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; DNA BINDING PROTEIN; RECOMBINANT PROTEIN; SMAD4 PROTEIN, HUMAN; TGFB1 PROTEIN, HUMAN; TGFB1 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL PROLIFERATION; CELL TRANSPLANTATION; CONTROLLED STUDY; ENZYME MECHANISM; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; MITOCHONDRION; MOUSE; MOUTH CARCINOMA; NONHUMAN; NUDE MOUSE; ORTHOTOPIC TRANSPLANTATION; PRIORITY JOURNAL; SENSITIZATION; SIGNAL TRANSDUCTION; TUMOR REGRESSION; ANIMAL; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CELL CULTURE; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; MOUTH TUMOR; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; XENOGRAFT;

ANIMALS; APOPTOSIS; CISPLATIN; DNA-BINDING PROTEINS; DRUG SYNERGISM; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MOUTH NEOPLASMS; NEOPLASM PROTEINS; NEOPLASM REGRESSION, SPONTANEOUS; NEOPLASM TRANSPLANTATION; RECOMBINANT PROTEINS; SMAD4 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 11144255284     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1683     Document Type: Article

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