Extracellular superoxide dismutase functions as a major repressor of hypoxia-induced erythropoietin gene expression

Endocrinology

Volumn 146, Issue 1, 2005, Pages 332-340

  Zelko, Igor N ^a   Folz, Rodney J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONATE DEHYDRATASE; ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; GENE EXPRESSION; HEMATOCRIT; HUMAN; HUMAN CELL; HYPOXIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RETICULOCYTE; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; WILD TYPE;

ANIMALS; ANOXIA; BLOTTING, WESTERN; DNA; ENZYME-LINKED IMMUNOSORBENT ASSAY; ERYTHROPOIESIS; ERYTHROPOIETIN; GENE EXPRESSION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; KIDNEY; MICE; MICE, KNOCKOUT; RNA, MESSENGER; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTORS;

EID: 11144234845     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-1007     Document Type: Article

References (44)

1. Zhu H, Jackson T, Bunn HF 2002 Detecting and responding to hypoxia. Nephrol Dial Transplant 17(Suppl 1):3-7
2. Michiels C, Minet E, Mottet D, Raes M 2002 Regulation of gene expression by oxygen: NF-κB and HIF-1, two extremes. Free Radic Biol Med 33:1231-1242
3. Huang LE, Bunn HF 2003 Hypoxia-inducible factor and its biomedical relevance. J Biol Chem 278:19575-19578
4. Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, Kriegsheim AV, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ 2001 Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292:468-472
5. Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin Jr WG 2001 HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292:464-468
6. Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ 2001 C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107:43-54
7. Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT 1998 Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA 95:11715-11720
8. Agani FH, Pichiule P, Chavez JC, LaManna JC 2000 The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia. J Biol Chem 275:35863-35867
9. Vaux EC, Metzen E, Yeates KM, Ratcliffe PJ 2001 Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain. Blood 98:296-302
10. Srinivas V, Leshchinsky I, Sang N, King MP, Minchenko A, Caro J 2001 Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway. J Biol Chem 276:21995-21998
11. Ehleben W, Porwol T, Fandrey J, Kummer W, Acker H 1997 Cobalt and desferrioxamine reveal crucial members of the oxygen sensing pathway in HepG2 cells. Kidney Int 51:483-491
12. Fandrey J, Frede S, Ehleben W, Porwol T, Acker H, Jelkmann W 1997 Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species. Kidney Int 51:492-496
13. Fridovich I 1997 Superoxide anion radical (O2-.), superoxide dismutases, and related matters. J Biol Chem 272:18515-18517
14. Zelko IN, Mariani TJ, Folz RJ 2002 Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic Biol Med 33:337-349
15. Marklund SL 1984 Extracellular superoxide dismutase and other superoxide dismutase isoenzymes in tissues from nine mammalian species. Biochem J 222:649-655
16. Carlsson LM, Jonsson J, Edlund T, Marklund SL 1995 Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia. Proc Natl Acad Sci USA 92:6264-6268
17. Suliman HB, Ryan LK, Bishop L, Folz RJ 2001 Prevention of influenza-induced lung injury in mice overexpressing extracellular superoxide dismutase. Am J Physiol Lung Cell Mol Physiol 280:L69-L78
18. Folz RJ, Abushamaa AM, Suliman HB 1999 Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia. J Clin Invest 103:1055-1066
19. Marklund SL 1982 Human copper-containing superoxide dismutase of high molecular weight. Proc Natl Acad Sci USA 79:7634-7638
20. Willems J, Zwijsen A, Siegers H, Nicolai S, Bettadapura J, Raymackers J, Scarcez T 1993 Purification and sequence of rat extracellular superoxide dismutase B secreted by C6 glioma. J Biol Chem 268:24614-24621
21. Folz RJ, Crapo JD 1994 Extracellular superoxide dismutase (SOD3): tissue-specific expression, genomic characterization, and computer-assisted sequence analysis of the human EC SOD gene. Genomics 22:162-171
22. Ookawara T, Imazeki N, Matsubara O, Kizaki T, Oh-Ishi S, Nakao C, Sato Y, Ohno H 1998 Tissue distribution of immunoreactive mouse extracellular superoxide dismutase. Am J Physiol 275:C840-C847
23. Oury TD, Day BJ, Crapo JD1996 Extracellular superoxide dismutase in vessels and airways of humans and baboons. Free Radic Biol Med 20:957-965
24. Folz RJ, Guan J, Seldin MF, Oury TD, Enghild JJ, Crapo JD 1997 Mouse extracellular superoxide dismutase: primary structure, tissue-specific gene expression, chromosomal localization, and lung in situ hybridization. Am J Respir Cell Mol Biol 17:393-403
25. Chikuma M, Masuda S, Kobayashi T, Nagao M, Sasaki R 2000 Tissue-specific regulation of erythropoietin production in the murine kidney, brain, and uterus. Am J Physiol Endocrinol Metab 279:E1242-E1248
26. Mylrea KC, Abbrecht PH 1970 Hematologic responses of mice subjected to continuous hypoxia. Am J Physiol 218:1145-1149
27. Sonna LA, Cullivan ML, Sheldon HK, Pratt RE, Lilly CM 2003 Effect of hypoxia on gene expression by human hepatocytes (HepG2). Physiol Genom 12:195-207
28. Wykoff CC, Beasley NJ, Watson PH, Turner KJ, Pastorek J, Sibtain A, Wilson GD, Tuiley H, Talks KL, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL 2000 Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res 60:7075-7083
29. Koury ST, Bondurant MC, Koury MJ 1988 Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. Blood 71:524-527
30. Lacombe C, Da Silva JL, Bruneval P, Fournier JG, Wendling F, Casadevall N, Camilleri JP, Bariety J, Varet B, Tambourin P 1988 Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney. J Clin Invest 81:620-623
31. Shanks JH, Hill CM, Lappin TR, Maxwell AP 1996 Localization of erythropoietin gene expression in proximal renal tubular cells detected by digoxigenin-labelled oligonucleotide probes. J Pathol 179:283-287
32. Maxwell AP, Lappin TR, Johnston CF, Bridges JM, McGeown MG 1990 Erythropoietin production in kidney tubular cells. Br J Haematol 74:535-539
33. Loya F, Yang Y, Lin H, Goldwasser E, Albitar M 1994 Transgenic mice carrying the erythropoietin gene promoter linked to lacZ express the reporter in proximal convoluted tubule cells after hypoxia. Blood 84:1831-1836
34. Liu Y, Christou H, Morita T, Laughner E, Semenza GL, Kourembanas S 1998 Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5′ enhancer. J Biol Chem 273:15257-15262
35. Huang LE, Willmore WG, Gu J, Goldberg MA, Bunn HF 1999 Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling. J Biol Chem 274:9038-9044
36. Sogawa K, Numayama-Tsuruta K, Ema M, Abe M, Abe H, Fujii-Kuriyama Y 1998 Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia. Proc Natl Acad Sci USA 95:7368-7373
37. Palmer LA, Gaston B, Johns RA 2000 Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides. Mol Pharmacol 58:1197-1203
38. Ortega Mateo A, Amaya Aleixandre de Artinano 2000 Nitric oxide reactivity and mechanisms involved in its biological effects. Pharmacol Res 42:421-427
39. Huang LE, Arany Z, Livingston DM, Bunn HF 1996 Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit. J Biol Chem 271:32253-32259
40. Leist M, Ghezzi P, Grasso G, Bianchi R, Villa P, Fratelli M, Savino C, Bianchi M, Nielsen J, Gerwien J, Kallunki P, Larsen AK, Helboe L, Christensen S, Pedersen LO, Nielsen M, Torup L, Sager T, Sfacteria A, Erbayraktar S, Erbayraktar Z, Gokmen N, Yilmaz O, Cerami-Hand C, Xie QW, Coleman T, Cerami A, Brines M 2004 Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science 305:239-242
41. Brines ML, Ghezzi P, Keenan S, Agnello D, de Lanerolle NC, Cerami C, Itri LM, Cerami A 2000 Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci USA 97:10526-10531
42. Siren AL, Fratelli M, Brines M, Goemans C, Casagrande S, Lewczuk P, Keenan S, Gleiter C, Pasquali C, Capobianco A, Mennini T, Heumann R, Cerami A, Ehrenreich H, Ghezzi P 2001 Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci USA 98:4044-4049
43. Grimm C, Wenzel A, Groszer M, Mayser H, Seeliger M, Samardzija M, Bauer C, Gassmann M, Reme CE 2002 HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration. Nat Med 8:718-724
44. Parsa CJ, Matsumoto A, Kim J, Riel RU, Pascal LS, Walton GB, Thompson RB, Petrofski JA, Annex BH, Stamler JS, Koch WJ 2003 A novel protective effect of erythropoietin in the infarcted heart. J Clin Invest 112:999-1007