Anticonflict actions of aqueous extracts of flowers of Achillea millefolium L. vary according to the estrous cycle phases in Wistar rats

Phytotherapy Research

Volumn 18, Issue 11, 2004, Pages 915-920

  Molina Hernandez, M ^a,c   Tellez Alcantara, N P ^a   Diaz, M A ^a   Perez Garcia, J ^a   Olivera Lopez, J I ^b   Jaramillo, M Teresa ^b  

^a UNIVERSIDAD VERACRUZANA   (Mexico)

^b DEPARTAMENTO DE QUÍMICA   (Mexico)

^c NONE   (Mexico)

Author keywords

Achillea millefolium L.; Anxiety like; Conflict behavior; Diazepam; Estrous cycle

Indexed keywords

ACHILLEA MILLEFOLIUM EXTRACT; DIAZEPAM;

ACHILLEA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS SOLUTION; ARTICLE; CONFLICT; CONTROLLED STUDY; DIESTRUS; DRUG EFFECT; DRUG MECHANISM; ESTRUS CYCLE; FEMALE; FLOWER; NONHUMAN; PROESTRUS; PUNISHMENT; RAT; RAT STRAIN; TRANQUILIZING ACTIVITY;

ACHILLEA; AGONISTIC BEHAVIOR; ANIMALS; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; ESTROUS CYCLE; FEMALE; FLOWERS; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR;

ACHILLEA MILLEFOLIUM; RATTUS NORVEGICUS;

EID: 11144222613     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1578     Document Type: Article

References (62)

1. Bhattacharya SK. 1994. Behavioral studies on BR-16A (Mentat), a herbal psychotropic formulation. Indian J Exp Biol 32: 37-43.
2. Bhattacharya SK, Mitra SK. 1991, Anxiolytic activity of Panax ginseng roots: an experimental study. J Ethnopharmacol 34: 87-92.
3. Bitran D, Dowd JA. 1996. Ovarian steroids modify the behavioral and neurochemical responses of the central benzodiazepine receptor. Psychopharmacology 125: 65-73.
4. Bitran D, Hilvers RJ, Kellogg CK. 1991. Anxiolytic effects of 3 aipha-5 alpha [beta]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABA-A receptor. Brain Res 561: 157-161.
5. Bitran D, Purdy RH, Kellogg CK. 1993. Anxiolytic effect of progesterone is associated with increases in cortical allopregnanolone and GABA-A receptor function. Pharmacol Biochem Behav 45: 423-428.
6. Bitran D, Shiekh M, McLeod M. 1995. Anxiolytic effect of progesterone is mediated by the neurosteroid allopregnanolone at brain GABA-A receptors. J Neuroendocrinol 7: 171-177.
7. Bless EP, McGinnis KA, Mitchell AL, Hartwell A, Mitchell JB. 1997. The effects of gonadal steroids on brain stimulation reward in female rats. Behav Brain Res 82: 235-244.
8. Cano L. 1997. Flora medicinal de Veracruz. I. Inventario etnobotánico. Universidad Veracruzana: Xalapa, Veracruz, Mexico.
9. Canonaco M, Tavolaro R, Maggi A. 1993. Steroid hormones and receptors of the GABA-A supramolecular complex. II. Progesterone and estrogen inhibitory effects on the chloride ion channel receptor in different forebrain areas of the female rat. Neuroendocrinology 57: 974-984.
10. Castleman M. 1997. Hierbas Curativas. Editorial Diana: México, 364-367.
11. Crammer JL. 1986. Premenstrual depression, cortisol and estradiol treatment. Psychol Med 16: 451-455.
12. Fernández-Guasti A, Picazo O. 1990. The actions of diazepam and serotonergic anxiolytics vary according to the gender and the estrous cycle phase. Pharm Biochem Behav 37: 77-81.
13. Fernández-Guasti A, Picazo O. 1992. Changes in anxiety along the various phases of the oestrus cycle: effect of oestrogen and progesterone. Psychoneuroendocrinology 17: 681-689.
14. Fernandez-Guasti A, Picazo O. 1995. Flumazenil blocks the anxiolytic actions of allopregnanolone. Eur J Pharmacol 281: 113-115.
15. Fernandez-Guasti A, Picazo O. 1997. Anxiolytic actions of diazepam, but not of buspirone, are influenced by gender and the endocrine stage. Behav Brain Res 88: 213-218.
16. Fink G, Summer BW, Mcqueen JK, Wilson H, Rosie R. 1998. Sex steroid control of mood, mental state and memory. Clin Exp Pharmacol Physiol 25: 764-775.
17. Freeman ME. 1988. The ovarian cycle of the rat. In The Physiology of Reproduction, Knobil E, de Neil J (eds). Raven Press: New York, 1893-1928.
18. Grattan DR, Rocca MS, Strauss KI, Sagrillo CA, Selmanoff M, McCarthy MM. 1996. GABAergic neuronal activity and mRNA levels for both forms of glutarnic acid decarboxylase (GAD65 and GAD67) are reduced in the diagonal band of Broca during the afternoon of proestrus. Brain Res 733: 46-55.
19. Halbreich U, Lemus CZ, Liebeman JA, Parry B, Schiavi RC. 1990. Gonadal hormones, sex and behavior. Pharmacol Bull 26: 297-301.
20. Hascöet M, Bourin M, Todd KG, Coüetoux Du Terre A. 1994. Anti-conflict effect of 5HT-1A agonists in rats: A new model for evaluating anxiolytic-like activity. J Psychopharmacol 8: 227-237.
21. Hascöet M, Bourin M. 1997. Anticonflict effect of alpidem as compared with the benzodiazepine alprazolam in rats. Pharmacol Biochem Behav 56: 317-324.
22. Hasenöhrl RV, Nichau CH, Frisch CH, et al. 1996. Anxiolytic-like effect of combined extracts of Zingiber officinale and Ginkgo biloba in the elevated plus-maze. Pharmacol Biochem Behav 53: 271-275.
23. Hlatky MA, Boothroyd D, Vittinghoff E, Sharp P, Whooley MA. 2002. Quality-of-life and depressive symptoms in postmenopausal women after receiving hormone therapy. Results from the heart and estrogen/progestin replacement study (HERS) trial. JAMA 287: 591-597.
24. Hogervorst E, Williams J, Budge M, Riedel W, Jolles J. 2000. The nature of the effect of female gonadal hormone replacement therapy on cognitive function in post-menopausal women: a meta-analysis. Neuroscience 101: 485-512.
25. Huber TJ, Nickel V, Troger M, Schneider U, Husstedt H, Emrich HM 1999. A syndrome of psychosis following discontinuation of an estrogen-progestogen contraceptive and improvement following replacement: A case report. Neuropsychobiology 40: 75-77.
26. Hurwitz HM, Davis H. 1983. Depriving rats of food: a reappraisal of two techniques. J Exp Anal Behav 40: 211-213.
27. Jaiswal AK, Bhattacharya SK, Acharya SS. 1994. Anxiolytic activity of Azadirachta indica leaf extract in rats. Indian J Exp Biol 32: 489-491.
28. Kroboth P, McAuley JW. 1997. Progesterone: Does it affect response to drug? Psychopharmacol Bull 33: 297-301.
29. Lambert JJ, Belelli D, Hill-Venning C, Peters JA. 1995. Neurosteroids and GABA-A receptor function. Trends Pharmacol Sci 16: 295-303.
30. Leer MN, Bradbury A, Maloney JC, Stewart CN. 1988. Elevated shock threshold in sexually receptive female rats. Physiol Behav 42: 617-620.
31. Leonard LG. 1998. Depression and anxiety disorders during multiple pregnancy and parenthood. J Obstet Gynecol Neonatal Nurs 27: 329-337.
32. Maggi A, Perez J. 1984. Progesterone and estrogens in rat brain: Modulation of GABA (gamma-amino butyric acid) receptor activity. Eur J Pharmacol 103: 165-168.
33. Martínez M. 1996. Las Plantas Medicinales de México. Ed. Botas, México. 223.
34. MacArthur C. 1999. What does postnatal care do for women's health? Lancet 353: 353-354.
35. Mahesh VB, Brann D, Hendry LB. 1996. Diverse modes of action of progesterone and its metabolites. J Steroid Biochem Molec Biol 56: 209-219.
36. Molina M, Contreras M, Téllez NP. 2001. Diazepam increases the number of punished responses in a conflict-operant paradigm during late proestrus and estrus in the Wistar rat. Neuropsychobiology 43: 29-33.
37. Molina M, Contreras M, Tellez P, Rodriguez F. 1999. Sedative actions of Ternstroemia sylvatica in the male rat. Phytomedicine 6: 115-118.
38. Molina M, Perez J, Olivera L. 2002. Female Wistar rats tested during late proestrus or during pregnancy and ovariectomized rats tested after receive progesterone or allopregnanolone displayed reduced conflict behavior. Progr Neuropsychopharmacol Biol Psychiatry 26: 839-844.
39. Molina M, Téllez NP. 2001. Estrus variation in anticonflict effects of midazolam microinjected into septal nuclei in female Wistar rats. Pharmacol Biochem Behav 68: 531-537.
40. Molina M, Tellez P, Martínez E. 2000. Agastache mexicana may produce anxiogenic-like actions in the male rat. Phytomedicine 7: 199-203.
41. Mora S, Dussaubat N, Diaz-Veliz G. 1996. Effects of the estrous cycle and ovarian hormones on behavioral indices of anxiety in female rats. Psychoneuroendocrinology 21: 609-620.
42. National Institutes Of Health, 1996. Guide for the Care and Use of Laboratory Animals. National Institutes of Health. National Academy Press: Washington, DC.
43. Pahlow M. 1979. El Gran Libro de las Plantas Medicinales. Editorial Everest SA: Madrid, 258-260.
44. Pearlstein TB. 1995. Hormones and depression: what are the facts about premenstrual syndrome, menopause, and hormone replacement therapy? Am J Obstet Gynecol 173: 646-653.
45. Picazo O, Femández-Guasti A. 1993. Changes in experimental anxiety along pregnancy and lactation. Physiol Behav 54: 295-299.
46. Picazo O, Femández-Guasti A. 1995. Anti-anxiety effects of progesterone and some of its reduced metabolites: An evaluation using the burying behavior test. Brain Res 680: 135-141.
47. Rodríguez JF, Howard JL, Pollard GT, Hendricks SE. 1984. Effect of ovarian hormones on conflict behaviour. Psychoneuroendocrinology 9: 293-300.
48. Rodriguez JF, Hagley MT, Hendricks SE. 1986. Anxiolytic effects of progesterone are sexually dimorphic. Life Sci 38: 1841-1845.
49. Schmidt PJ, Rubinow DR. 1997. Neuroregulatory role of gonadal steroids in humans. Psychopharmacol Bull 33: 219-220.
50. Sellal F. 1995. L'action amnésiante des benzodiazépines chez l'homme. Synthese 11: 1519-1523.
51. Smith S, Waterhourse D, Chapin JK, Woodward DJ. 1987. Progesterone alters GABA and glutamate responsiveness: A possible mechanism for its anxiolytic action. Brain Res 400: 353-359.
52. Steimer T, Driscoll P, Schulz E. 1997. Brain metabolism of progesterone, coping behavior and emotional reactivity in male rats from two psychogenetically selected lines. J Neuroendocrinol 9: 169-175.
53. Stuart S, Couser G, Schilder K, Ohara MW, Gorman L. 1998. Postpartum anxiety depression: Onset and comorbidity in a community sample. J Nervous Mental Disord 186: 420-424.
54. Thongsaard W, Deachapunya C, Pongsakom S, Boyd E, Bennett G, Marsden A. 1996. Barakol: A potential anxiolytic extracted from Cassia siamea. Pharmacol Biochem Behav 53: 753-758.
55. Twyman RE, MacDonald RL. 1992. Neurosteroid regulation of GABA-A receptor single channel kinetic properties of mouse spinal cord neurons in culture. Physiol Behav 456: 215-245.
56. Van Goozen SHM, Frijda NH, Wiegant VM, Endert E, Van de Poli NE. 1996. The premenstrual phase and reactions to aversive events: a study of hormonal influences on emotionality. Psychoneuroendocrinology 21: 479-497.
57. Viola H, Wolfman C, Levi De Stein M, et al. 1994. Isolation of pharmacologically active benzodiazepine receptor ligands from Tilia tormentosa (Tiliaceae). J Ethnopharmacol 44: 47-53.
58. Viola H, Wasowski C, Levi De Stein M, et al. 1995. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptor-ligand with anxiolytic effects. Planta Med 61: 213-216.
59. Wagner KD, Berenson AB. 1994. Norplant-associated major depression and panic disorder. J Clin Psychiatry 55: 478-480.
60. Wieland S, Lan NC, Mirasedeghi S, Gee KW. 1991. Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-OH-20-one. Brain Res 565: 263-268.
61. Wiklund IK, Mattsson LA, Lindgren R, Limoni C. 1999. Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. Int J Clin Pharm Res XIX: 89-99.
62. Wolfman C, Viola H, Paladini AC, Dajas F, Medina JH. 1994. Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea. Pharmacol Biochem Behav 47: 1-4.