Anxiolytic-like effect of combined extracts of Zingiber officinale and ginkgo biloba in the elevated plus-maze

Pharmacology Biochemistry and Behavior

Volumn 53, Issue 2, 1996, Pages 271-275

  Hasenohrl R U ^a   Nichau, Ch ^a   Frisch, Ch ^a   De Souza Silva, M A ^a   Huston, J P ^a   Mattern, C M ^b   Hacker R ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b Mattern et Partner   (Germany)

Author keywords

5 HT3 receptor; anxiety; anxiogenic drugs; anxiolytics; diazepam; elevated pluz maze; ginger; ginkgo biloba; rat; serotonin

Indexed keywords

ANXIOLYTIC AGENT; DIAZEPAM; GINKGO BILOBA EXTRACT; PLANT EXTRACT; SEROTONIN 3 RECEPTOR; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG; ZINGICOMB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BEHAVIOR; CONTROLLED STUDY; GINGER; INTRAGASTRIC DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; TRANQUILIZING ACTIVITY;

ANIMALIA; GINKGO BILOBA; ZINGIBER OFFICINALE;

EID: 0342313461     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(95)02001-2     Document Type: Article

References (36)

1. 3 receptor antagonist, on cognition in rodents and primates. Pharmacol. Biochem. Behav. 35:955-962; 1990.
2. Briley, M.; Chopin, P.; Moret, C. Effect of serotonergic lesion on "anxious" behaviour measured in the elevated plus-maze test in the rat. Psychopharmacology 101:187-189; 1990.
3. Chatterjee, S. S.; Gabard, B. Studies on the mechanism of action of an extract of ginkgo biloba, a drug used for treatment of ischemic vascular diseases. Naunyn Schmiedebergs Arch. Pharmacol. 321(Suppl. R52):207; 1982.
4. Chugh, Y.; Saha, N.; Sankaranarayanan, A.; Sharma, P. L. Memory enhancing effects of granisetron (BRL 43694) in a passive avoidance task. Eur. J. Pharmacol. 203:121-123; 1991.
5. Cole, J. C.; Rodgers, R. J. Ethological evaluation of the effects of acute and chronic buspirone treatment in the murine elevated plus-maze test: Comparison with haloperidol. Psychopharmacology 114:288-296; 1994.
6. 3 receptor antagonists in the elevated X-maze. J. Psychopharmacol. 3:10P; 1989.
7. 3 receptors. Pharmacol. Ther. 47:181-202; 1990.
8. 2 receptors. Psychopharmacology 93:502-506; 1987.
9. 1A ligands in the elevated X-maze and effects of dorsal raphe lesions. Psychopharmacology 106:484-490; 1992.
10. Cruz, A. P. M.; Frei, F.; Graeff, F. G. Ethopharmacological analysis of rat behavior on the elevated plus-maze. Pharmacol. Biochem. Behav. 49:171-176; 1994.
11. 3 antagonist (BRL 46470A) injected into basolateral amygdala, as opposed to diazepam. Behav. Brain Res. 59:141-145; 1993.
12. File, S. E.; Baldwin, H. A. Changes in anxiety in rats tolerant to, and withdrawn from, benzodiazepines: Behavioural and biochemical studies. In: Tyrer, P., ed. Psychopharmacology of anxiety. Oxford: Oxford University Press; 1989:28-51.
13. 3 receptor antagonists in the social interaction and elevated plus-maze tests of anxiety in the rat. Psychopharmacology 99:248-251; 1989.
14. Frisch, C.; Hasenöhrl, R. U.; Mattern, C. M.; Hacker, R.; Huston, J. P. Blockade of lithium chloride-induced conditioned place aversion as a test for antiemetic agents: Comparison of metoclopramide with combined extracts of zingiber officinale and ginkgo biloba. Pharmacol. Biochem. Behav. 52:321-327; 1995.
15. 3 receptor antagonists: A critical update on therapeutic potential. Trends Pharmacol. Sci. 14:265-269; 1993.
16. Guinot, P.; Caffrey, E.; Lambe, R.; Darragh, A. Inhibition der PAF-induzierten Thrombozyten-Aggregation durch Rökan. In: Kemper, F. H.; Schmid-Schönbein, H.; eds. Rökan-Ginkgo biloba EGb 761, vol. 1.: Pharmakologie. Berlin: Springer; 1991:63-67.
17. Handley, S. L.; McBlane, J. W. 5-HT drugs in animal models of anxiety. Psychopharmacology 112:13-20; 1993.
18. Handley, S. L.; Mithani, S. Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of "fear"-motivated behaviour. Naunyn Schmiedebergs Arch. Pharmacol. 327:1-5; 1984.
19. Handley, S. L.; McBlane, J. W.; Critchley, M. A. E.; Njung'e, K. Multiple serotonin mechanisms in animal models of anxiety: Environmental, emotional and cognitive factors. Behav. Brain Res. 58:203-210; 1993.
20. 3 receptor antagonists. Psychopharmacology 104:545-551; 1991.
21. 3 effect of galanolactone, diterpenoid isolated from ginger. Chem. Pharm. Bull. 39:397-399; 1991.
22. Iversen, S. D. 5-HT and anxiety. Neuropharmacology 23:1553-1560; 1984.
23. Krieglstein, J.; Beck, T.; Seibert, A. Influence of an extract of ginkgo biloba on cerebral blood flow and metabolism. Life Sci. 39:2327-2334; 1986.
24. Lister, R. G. The amnesic action of benzodiazepines in man. Neurosci. Biobehav. Rev. 9:87-94; 1985.
25. Marsden, C. A. 5-Hydroxytryptamine receptor subtypes and new anxiolytic drugs: An appraisal. In: Tyrer, P., ed. Psychopharmacology of anxiety. Oxford: Oxford University Press; 1989:3-27.
26. Mitchelson, F. Pharmacological agents affecting emesis. A review (Part I). Drugs 43:295-315; 1992.
27. Mitchelson, F. Pharmacological agents affecting emesis. A review (Part II). Drugs 43:443-463; 1992.
28. Nevins, M. E.; Anthony, E. W. Antagonists at the serotonin-3 receptor can reduce the fear-potentiated startle response in the rat: Evidence for different types of anxiolytic activity? J. Pharmacol. Exp. Ther. 268:248-254; 1994.
29. Pellow, S.; File, S. E. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat. Pharmacol. Biochem. Behav. 24:525-529; 1986.
30. Pellow, S.; Chopin, P.; File, S. E.; Briley, M. Validation of openxlosed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods 14:149-167; 1985.
31. Stein, L.; Wise, C. D.; Betluzzi, J. D. Effects of benzodiazepines on central serotonergic mechanisms. In: Costa, E.; Greengard, P., eds, Mechanism of action of benzodiazepines. New York: Raven Press; 1975:29-44.
32. Thiebot, M.-H. Some evidence for amnesic-like effects of benzodiazepines in animals. Neurosci. Biobehav. Rev. 9:95-100; 1985.
33. Treit, D.; Menard, J.; Royan, C. Anxiogenic stimuli in the elevated plus-maze. Pharmacol. Biochem. Behav. 44:463-469; 1993.
34. Venault, P.; Chapouthier, G.; Prado de Carvalho, L.; Simiand, J.; Morre, M.; Dodd, R. H.; Rossier, J. Benzodiazepine impairs and #-carboline enhances performance in learning and memory tasks. Nature 321:864-866; 1986.
35. Wright, I. K.; Heaton, M.; Upton, N.; Marsden, C. A. Comparison of acute and chronic treatment of various serotonergic agents with those of diazepam and idazoxan in the rat elevated X-maze. Psychopharmacology 107:405-414; 1992.
36. Yamahara, J.; Rong, H. Q.; Iwamato, M.; Kobayashi, G.; Matsuda, H.; Fujimura, H. Active components of ginger exhibiting antiserotonergic action. Phytother. Res. 3:70-71; 1989.