Barakol: A potential anxiolytic extracted from Cassia siamea

Pharmacology Biochemistry and Behavior

Volumn 53, Issue 3, 1996, Pages 753-758

  Thongsaard, W ^a,b,c   Deachapunya, C ^a   Pongsakorn, S ^a   Boyd, E A ^b   Bennett, G W ^c   Marsden, C A ^c  

^a SRINAKHARINWIROT UNIVERSITY   (Thailand)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

Anxiolytic; Barakol; Cassia siamea; Diazepam; Elevated plus maze

Indexed keywords

ANXIOLYTIC AGENT; BARAKOL; CASSIA EXTRACT; CASSIA SIAMEA EXTRACT; DIAZEPAM; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; EXPLORATORY BEHAVIOR; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; MAZE TEST; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; THAILAND; TRADITIONAL MEDICINE; TRANQUILIZING ACTIVITY;

ANIMALIA; CASSIA; SENNA SIAMEA;

EID: 0029986763     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(95)02088-8     Document Type: Article

References (21)

1. Arunlakshana, O. Pharmacological study of the leaves of Cassia siamea. Siriraj Hosp. Gaz. 1:434-444; 1949.
2. Barnett, S. A. The rat: A study in behaviour. Chicago, IL: Aldine; 1966.
3. Bycroft, B. W.; Hassanali-Walji, A.; Johnson, A. W.; King, T. J. The structure and synthesis of barakol: A novel dioxaphenalene derivative from Cassia siamea. J. Chem. Soc. 12:1686-1689; 1970.
4. Chaichantipyuth, C. A phytochemical study of the leaves of Cassia siamea and Cassia spectabilis. Thesis submitted for the degree of Master of Science in Pharmacy, Chulalongkorn University, Bangkok; 1979.
5. Colpaert, F. C.; Meert, T. F.; Niemegeers, C. J. E.; Janssen, P. A. J. Behavioural and 5-HT antagonist effects of ritanserin: A pure and selective antagonist of LSD discrimination in rat. Psychopharmacology. 86:45-54; 1985.
6. File, S. E. The contribution of behavioural studies to the neuropharmacology of anxiety. Neuropharmacology 26:877-886; 1987.
7. 2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)2-aminopropane analogues. J. Med. Chem. 29: 194-199; 1986.
8. Haefely, W. The role of GABA in anxiolytic/antidepressant drug action. In: Elliott, J. M.; Heal, D. J.; Marsden, C. A., eds. Experimental approaches to anxiety and depression. Chichester: John Wiley; 1992:151-168.
9. Handley, S. L.; Mithani, S. Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of 'fear'-motivated behaviour. Naunyn-Schmied. Arch. Pharmacol. 327: 1-5; 1984.
10. Harris, T. M.; Wittek, P. J. Biogenetic-type syntheses of polycyclic polyketide metabolites using partially protected β-hexa- and β-heptaketones: 6-hydroxymusizin, barakol, emodin, and eleutherinol. J. Am. Chem. Soc. 97:3270-3271; 1975.
11. Hassanali-Walji, A.; King, T. J.; Wallwork, S. C. Barakol, a novel dioxaphenalene derivative from Cassia siamea. J. Chem. Soc. Chem. Commun. 12:678; 1969.
12. Jantarayota, P. Effects of barakol extracted from leaves of Cassia siamea on the central nervous system. Thesis submitted for the degree of Master of Science in Pharmacy, Chulalingkorn University, Bangkok; 1987.
13. Kinghorn, A. D.; Balandrin, M. F. Human medicinal agents from plants. Washington, DC: American Chemical Society; 1992.
14. Mokasmit, M. Hypertensive effects of Thai medicinal plants. Newsletter of National Research Council of Thailand. 22:3-4; 1981.
15. Montgomery, K. C. The relation between fear induced by novel stimulation and exploratory behaviour. J. Comp. Physiol. Psychol. 48:254-260; 1955.
16. Pellow, S.; Chopin, P.; Briley, M.; File, S, E. The validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci Methods 14:149-167; 1985.
17. Pellow, S.; File, S. E. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat. Pharmacol. Biochem. Behav. 24:525-529; 1986.
18. Satyavati, G. V.; Raina, M. K.; Sharma, M. Medicinal plants of India. New Delhi: Indian Council of Medical Research; 1979.
19. Thongsaard, W.; Deachapunya, C.; Pongsakorn, S.; Boyd, E. A.; Bennett, G. W.; Marsden, C. A. The dioxaphenalene derivative barakol extracted from Cassia siamea: A natural anxiolytic? Br. J. Pharmacol. 114:284P; 1995.
20. Tongroach, P.; Jantarayota, P.; Tantisira, B.; Kanluan, P.; Tongroach, C.; Chaichantipyuth, C. Barakol, a neuroactive compound from Cassia siamea. Proceedings of the First JSPS-NRCT Joint Seminar in Pharmaceutical Sciences: Advances in Research on Pharmacologically Active Substances from Natural Sources, Chiangmai, Thailand; 1992:OP21.
21. Wright, I. K.; Heaton, M.; Upton, N.; Marsden, C. A. Comparison of acute and chronic treatment of various serotonergic agents with those of diazepam and idazoxan in the rat elevated x-maze. Psychopharmacology 107:405-414; 1992.