Neutralizing epitopes on the extracellular interferon γ receptor (IFNγR) α-chain characterized by homolog scanning mutagenesis and X-ray crystal structure of the A6 Fab-1FNγR1-108 complex

Journal of Molecular Biology

Volumn 273, Issue 4, 1997, Pages 882-897

  Sogabe, Satoshi ^b   Stuart, Fiona ^a   Henke, Christoph ^a   Bridges, Angela ^a   Williams, Geoffrey ^a   Birch, Ashley ^a   Winkler, Fritz K ^b   Robinson, John A ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Antibody Fab fragment; Cytokine; Induced fit; Molecular recognition; Surface plasmon resonance biosensor

Indexed keywords

EPITOPE; FIBRONECTIN; GAMMA INTERFERON; IMMUNOGLOBULIN F(AB) FRAGMENT; INTERFERON RECEPTOR;

AMINO TERMINAL SEQUENCE; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; EXTRACELLULAR SPACE; HUMAN; HYDROGEN BOND; MOLECULAR RECOGNITION; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR BINDING; STEREOCHEMISTRY; X RAY DIFFRACTION;

EID: 0031558771     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1336     Document Type: Article

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