Effect of population stratification on case-control association studies: I. Elevation in false positive rates and comparison to confounding risk ratios (a simulation study)

Human Heredity

Volumn 58, Issue 1, 2004, Pages 30-39

  Heiman, Gary A ^a,c   Hodge, Susan E ^a,b   Gorroochurn, Prakash ^a   Zhang, Junying ^a   Greenberg, David A ^a,b  

^a New York State Psychiatric Institute   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c Columbia University ^*  (United States)

Author keywords

Bias; Case control studies; Genetic association; Population stratification; Reproducibility of results

Indexed keywords

ANALYTICAL ERROR; ARTICLE; CASE CONTROL STUDY; COMPUTER SIMULATION; DATA BASE; DISEASE MARKER; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC PARAMETERS; MATHEMATICAL MODEL; PATIENT SELECTION; POPULATION STRUCTURE; PREVALENCE; RISK ASSESSMENT;

BIAS (EPIDEMIOLOGY); CASE-CONTROL STUDIES; COMPUTER SIMULATION; CONFOUNDING FACTORS (EPIDEMIOLOGY); GENE FREQUENCY; GENETICS, POPULATION; HUMANS; MODELS, STATISTICAL; ODDS RATIO; PREVALENCE;

EID: 10844267270     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000081454     Document Type: Article

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