Detection of YMDD motif mutations in some lamivudine-untreated asymptomatic hepatitis B virus carriers

Journal of Hepatology

Volumn 34, Issue 4, 2001, Pages 584-586

  Kobayashi, Satsuki ^a   Ide, Tatsuya ^b   Sata, Michio ^b  

^a Sumitomo Metal Industries Ltd   (Japan)

^b KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Asymptomatic carriers; Hepatitis B virus; Lamivudine; Mutation

Indexed keywords

ANTIVIRUS AGENT; LAMIVUDINE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GENE SEQUENCE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOLECULAR CLONING; PRIORITY JOURNAL; VIRUS DETECTION; VIRUS MUTATION; VIRUS RESISTANCE;

ADULT; AGED; AMINO ACID MOTIFS; CARRIER STATE; FEMALE; HEPATITIS B VIRUS; HUMANS; LAMIVUDINE; MALE; MIDDLE AGED; MUTATION; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 0035056086     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(00)00023-4     Document Type: Article

References (8)

1. Inhibition of the replication of hepatitis B virus in vitro by 2′,3′-dideoxy-3′thiacytidine and related analogues
2. Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo
3. Identification of four conserved motifs among the RNA-dependent polymerase encoding elements
4. Development of a new method for detecting a mutation in the gene encoding hepatitis B virus reverse transcriptase active site (YMDD motif)
5. Identification and characterization of mutations in hepatitis B virus resistant to lamivudine
6. The M539V polymerase variant of human hepatitis B virus demonstrates resistance to 2′-deoxy-3′-thiacytidine and a reduced ability to synthesize viral DNA
7. YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: A study by in vitro full-length viral DNA transfection
8. Clinical significance of YMDD mutant hepatitis B virus (HBV) in a large cohort of lamivudine-treated hepatits B patients