메뉴 건너뛰기




Volumn 58, Issue 1, 2004, Pages 2-9

Mapping genes for common diseases: The case for genetic (LD) maps

Author keywords

Haplotype block; HapMap project; Linkage disequilibrium map; Linkage map; Recombination hot spot

Indexed keywords

DNA POLYMORPHISM; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENE MAPPING; GENETIC RECOMBINATION; GENOME ANALYSIS; HAPLOTYPE; HUMAN; REVIEW; THEORETICAL MODEL;

EID: 10844228016     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000081451     Document Type: Review
Times cited : (28)

References (45)
  • 2
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch N, Merikangas K: The future of genetic studies of complex human diseases. Science 1996;273:1516-1517.
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 3
    • 0037173639 scopus 로고    scopus 로고
    • Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
    • Van Eerdewegh P, et al: Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 2002;418:426-439.
    • (2002) Nature , vol.418 , pp. 426-439
    • Van Eerdewegh, P.1
  • 4
    • 0033624575 scopus 로고    scopus 로고
    • The common PPAR gamma Pro12A1a polymorphism is associated with decreased risk of type 2 diabetes
    • Altshuler D, et al: The common PPAR gamma Pro12A1a polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000;26:76-80.
    • (2000) Nat Genet , vol.26 , pp. 76-80
    • Altshuler, D.1
  • 5
    • 0013375948 scopus 로고    scopus 로고
    • Neuregulin 1 and susceptibility to schizophrenia
    • Stefansson H, et al: Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 2002;71:877-892.
    • (2002) Am J Hum Genet , vol.71 , pp. 877-892
    • Stefansson, H.1
  • 6
    • 0034785352 scopus 로고    scopus 로고
    • Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease
    • Rioux JD, et al: Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat Genet 2001;29:223-228.
    • (2001) Nat Genet , vol.29 , pp. 223-228
    • Rioux, J.D.1
  • 8
    • 0034969437 scopus 로고    scopus 로고
    • Are rare variants responsible for susceptibility to complex diseases?
    • Pritchard JK: Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet 2001;69:124-137.
    • (2001) Am J Hum Genet , vol.69 , pp. 124-137
    • Pritchard, J.K.1
  • 9
    • 0029805706 scopus 로고    scopus 로고
    • The new genomics: Global views of biology
    • Lander ES: The new genomics: global views of biology. Science 1996;274:536-539.
    • (1996) Science , vol.274 , pp. 536-539
    • Lander, E.S.1
  • 10
    • 0033573934 scopus 로고    scopus 로고
    • Genetic isolates: Separate but equal?
    • Kruglyak L: Genetic isolates: Separate but equal? Proc Natl Acad Sci USA 1999;96:1170-1172.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1170-1172
    • Kruglyak, L.1
  • 11
    • 0033039497 scopus 로고    scopus 로고
    • Prospects for whole-genome linkage disequilibrium mapping of common disease genes
    • Kruglyak L: Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet 1999;22:139-144.
    • (1999) Nat Genet , vol.22 , pp. 139-144
    • Kruglyak, L.1
  • 13
    • 0033592988 scopus 로고    scopus 로고
    • Genetic epidemiology of single nucleotide polymorphisms
    • Collins A, Lonjou C, Morton NE: Genetic epidemiology of single nucleotide polymorphisms. Proc Natl Acad Sci USA 1999;96:15173-15177.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 15173-15177
    • Collins, A.1    Lonjou, C.2    Morton, N.E.3
  • 14
    • 0035283148 scopus 로고    scopus 로고
    • The genome-wide distribution of background linkage disequilibrium in a population isolate
    • Service SK, Ophoff RA, Freimer NB: The genome-wide distribution of background linkage disequilibrium in a population isolate. Hum Mol Genet 2001;10:545-551
    • (2001) Hum Mol Genet , vol.10 , pp. 545-551
    • Service, S.K.1    Ophoff, R.A.2    Freimer, N.B.3
  • 18
    • 79959503826 scopus 로고    scopus 로고
    • The International HapMap project
    • The International HapMap Consortium: The International HapMap project. Nature 2003;426:789-796.
    • (2003) Nature , vol.426 , pp. 789-796
  • 19
    • 0034789532 scopus 로고    scopus 로고
    • Haplotype tagging for the identification of common disease genes
    • Johnson GCL, et al: Haplotype tagging for the identification of common disease genes. Nature Genet 2001;29:233-237.
    • (2001) Nature Genet , vol.29 , pp. 233-237
    • Johnson, G.C.L.1
  • 20
    • 18444369013 scopus 로고    scopus 로고
    • The structure of haplotype blocks in the human genome
    • Gabriel SB, et al: The structure of haplotype blocks in the human genome. Science 2002;296:2225-2229.
    • (2002) Science , vol.296 , pp. 2225-2229
    • Gabriel, S.B.1
  • 21
    • 0037373275 scopus 로고    scopus 로고
    • Discovering genotypes underlying human phenotypes: Past successes for mendelian disease, future approaches for complex disease
    • Botstein D, Risch N: Discovering genotypes underlying human phenotypes: Past successes for mendelian disease, future approaches for complex disease. Nat Genet Suppl 2003;33:228-237.
    • (2003) Nat Genet Suppl , vol.33 , pp. 228-237
    • Botstein, D.1    Risch, N.2
  • 22
    • 0035941029 scopus 로고    scopus 로고
    • Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21
    • Patil N, et al: Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science 2001;294:1719-1723.
    • (2001) Science , vol.294 , pp. 1719-1723
    • Patil, N.1
  • 23
    • 0037188541 scopus 로고    scopus 로고
    • A dynamic programming algorithm for haplotype block partitioning
    • Zhang K, et al: A dynamic programming algorithm for haplotype block partitioning. Proc Natl Acad Sci USA 2002;99:7335-7339.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 7335-7339
    • Zhang, K.1
  • 27
    • 0036844238 scopus 로고    scopus 로고
    • Distribution of recombination crossovers and the origin of haplotype blocks: The interplay of population history, recombination and mutation
    • Wang N, Akey JM, Zhang K, Chakraborty R, Jin L: Distribution of recombination crossovers and the origin of haplotype blocks: The interplay of population history, recombination and mutation. Am J Hum Genet 2002;71:1227-1234.
    • (2002) Am J Hum Genet , vol.71 , pp. 1227-1234
    • Wang, N.1    Akey, J.M.2    Zhang, K.3    Chakraborty, R.4    Jin, L.5
  • 28
    • 0043267974 scopus 로고    scopus 로고
    • Haplotype blocks and linkage disequiulibrium in the human genome
    • Wall JD, Pritchard JK: Haplotype blocks and linkage disequiulibrium in the human genome. Nat Rev Genet 2003;4:587-597.
    • (2003) Nat Rev Genet , vol.4 , pp. 587-597
    • Wall, J.D.1    Pritchard, J.K.2
  • 29
    • 12244297072 scopus 로고    scopus 로고
    • Recombination hotspots rather than population history dominate linkage disequilibrium in the MHC class II region
    • Kauppi L, Sajantila A, Jeffreys AJ: Recombination hotspots rather than population history dominate linkage disequilibrium in the MHC class II region. Hum Mol Genet 2003;12:33-40.
    • (2003) Hum Mol Genet , vol.12 , pp. 33-40
    • Kauppi, L.1    Sajantila, A.2    Jeffreys, A.J.3
  • 33
    • 0032539537 scopus 로고    scopus 로고
    • Mapping a disease locus by allelic association
    • Collins A, Morton NE: Mapping a disease locus by allelic association. Proc Natl Acad Sci USA 1998;95:1741-1745.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 1741-1745
    • Collins, A.1    Morton, N.E.2
  • 34
    • 0141889553 scopus 로고    scopus 로고
    • A note on the optimal measure of allelic association
    • Shete S: A note on the optimal measure of allelic association. Ann Hum Genet 2003;67:189-191.
    • (2003) Ann Hum Genet , vol.67 , pp. 189-191
    • Shete, S.1
  • 35
    • 0029150074 scopus 로고
    • A comparison of linkage disequilibrium measures for fine-scale mapping
    • Devlin B, Risch N: A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics 1995;29:311-322.
    • (1995) Genomics , vol.29 , pp. 311-322
    • Devlin, B.1    Risch, N.2
  • 36
    • 0034795550 scopus 로고    scopus 로고
    • Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex
    • Jeffreys AJ, Kauppi L, Neumann R: Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex, Nat Genet 2001;29:217-222.
    • (2001) Nat Genet , vol.29 , pp. 217-222
    • Jeffreys, A.J.1    Kauppi, L.2    Neumann, R.3
  • 39
    • 18444396271 scopus 로고    scopus 로고
    • A first-generation linkage disequilibrium map of human chromosome 22
    • Dawson E, et al: A first-generation linkage disequilibrium map of human chromosome 22. Nature 2002;418:544-548.
    • (2002) Nature , vol.418 , pp. 544-548
    • Dawson, E.1
  • 40
    • 18544381909 scopus 로고    scopus 로고
    • A high-resolution recombination map of the human genome
    • Kong, et al: A high-resolution recombination map of the human genome. Nature Genet 2002;31:241-247.
    • (2002) Nature Genet , vol.31 , pp. 241-247
    • Kong1
  • 41
    • 0347361674 scopus 로고    scopus 로고
    • Modeling linkage disequilibrium and identifying recombination hotspots using single-nucleotide polymorphism data
    • Li N, Stephens M: Modeling linkage disequilibrium and identifying recombination hotspots using single-nucleotide polymorphism data. Genetics 2003;165:2213-2233.
    • (2003) Genetics , vol.165 , pp. 2213-2233
    • Li, N.1    Stephens, M.2
  • 43
    • 0036959017 scopus 로고    scopus 로고
    • The signature of positive selection at randomly chosen loci
    • Przeworski M: The signature of positive selection at randomly chosen loci. Genetics 2002;162:2053.
    • (2002) Genetics , vol.162 , pp. 2053
    • Przeworski, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.