Nasal eosinophilia and IL-5 mRNA expression in seasonal allergic rhinitis induced by natural allergen exposure: Effect of topical corticosteroids

Journal of Allergy and Clinical Immunology

Volumn 102, Issue 4 II, 1998, Pages 610-617

  Masuyama, Keisuke ^a   Till, Stephen J ^a   Jacobson, Mikila R ^a   Kamil, Asma ^b   Cameron, Lisa ^b   Juliusson, Sigurdur ^c   Lowhagen, Olle ^d   Kay, A Barry ^a   Hamid, Qutayba A ^b   Durham, Stephen R ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b MCGILL UNIVERSITY   (Canada)

^c Sergrein: Hals net ogeymalaekninger   (Iceland)

^d SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Allergy; Corticosteroids; Cytokines; Eosinophils; IL 5; Rhinitis; T cells

Indexed keywords

ALLERGEN; CD3 ANTIGEN; CORTICOSTEROID; FLUTICASONE PROPIONATE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 5; MESSENGER RNA;

ADULT; ALLERGIC RHINITIS; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; EOSINOPHILIA; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; POLLEN ALLERGY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STEROID THERAPY; T LYMPHOCYTE SUBPOPULATION; TOPICAL DRUG ADMINISTRATION;

EID: 18344398783     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0091-6749(98)70277-5     Document Type: Article

References (23)

1. Varney VA, Jacobson MR, Sudderick RM, Robinson DS, Irani AM, Schwartz LB, et al. Immunohistology of the nasal mucosa following allergen-induced rhinitis. Identification of activated T lymphocytes, eosinophils, and neutrophils. Am Rev Respir Dis 1992;146:170-6.
2. Durham SR, Ying S, Varney VA, Jacobson MR, Sudderick RM, Mackay IS, et al. Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia. J Immunol 1992;148:2390-4.
3. Ghaffar O, Laberge S, Jacobson MR, Lowhagen O, Rak S, Durham SR, et al. IL-13 mRNA and immunoreactivity in allergen-induced rhinitis: comparison with IL-4 expression and modulation by topical glucocorticoid therapy. Am J Respir Cell Mol Biol 1997;17:17-24.
4. Durham SR, Gould HJ, Thienes CP, Jacobson MR, Masuyama K, Rak S, et al. Expression of 8 germ-line gene transcripts and mRNA for the 8 heavy chain of IgE in nasal B cells and the effects of topical corticosteroid. Eur J Immunol 1997;27:2899-906.
5. Ying S, Meng Q, Barata LT, Robinson DS, Durham SR, Kay AB. Associations between IL-13 and IL-4 (mRNA and protein), vascular cell adhesion molecule-1 expression, and the infiltration of eosinophils, macrophages, and T cells in allergen-induced late-phase cutaneous reactions in atopic subjects. J Immunol 1997;158:5050-7
6. Lopez AF, Sanderson CJ, Gamble JR, Campbell HD, Young IG, Vadas MA. Recombinant human interleukin 5 is a selective activator of human eosinophil function. J Exp Med 1988;167:219-24.
7. Rothenberg ME, Petersen J, Stevens RL, Silberstein DS, McKenzie DT, Austen KF, et al. IL-5-dependent conversion of normodense human eosinophils to the hypodense phenotype uses 3T3 fibroblasts for enhanced viability, accelerated hypodensity, and sustained antibody-dependent cytotoxicity. J Immunol 1989;143:2311-6.
8. Walsh GM, Hartnell A, Wardlaw AJ, Kurihara K, Sanderson CJ, Kay AB. IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner. Immunology 1990;71:258-65.
9. Collins PD, Marleau S, Griffiths Johnson DA, Jose PJ, Williams TJ. Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J Exp Med 1995;182:1169-74.
10. Schweizer RC, Welmers BA, Raaijmakers JA, Zanen P, Lammers JW, Koenderman L. RANTES- and interleukin-8-induced responses in normal human eosinophils: effects of priming with interleukin-5. Blood 1994;83:3697-704.
11. Mould AW, Matthaei KI, Young IG, Foster PS. Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice. J Clin Invest 1997;99:1064-71.
12. Ying S, Durham SR, Barkans J, Masuyama K, Jacobson M, Rak S, et al. T cells are the principal source of interleukin-5 mRNA in allergen-induced rhinitis. Am J Respir Cell Mol Biol 1993;9:356-60.
13. Fokkens WJ, Vroom TM, Gerritsma V, Rijntjes E. A biopsy method to obtain high quality specimens of nasal mucosa. Rhinology 1988;26:293-5.
14. Moqbel R, Ying S, Barkans J, Newman TM, Kimmitt P, Wakelin M, et al. Identification of messenger RNA for IL-4 in human eosinophils with granule localization and release of the translated product. J Immunol 1995;155:4939-47.
15. Garrelds IM, De Graaf in 't Veld T, Nahori MA, Vargaftig BB, Gerth van Wijk R, Zijlstra FJ. Interleukin-5 and eosinophil cationic protein in nasal lavages of rhinitis patients. Eur J Pharmacol 1995;275:295-300.
16. Kelly EAB, Rodriguez RR, Busse WW, Jarjour NN. The effect of segmental bronchoprovocation with allergen on airway lymphocyte function. Am J Respir Crit Care Med 1997;156:1421-8.
17. Till S, Dickason R, Huston D, Humbert M, Robinson D, Larche M, et al. IL-5 secretion by allergen-stimulated CD4+ T cells in primary culture: relationship to expression of allergic disease. J Allergy Clin Immunol 1997;99:563-9.
18. Robinson DS, Hamid Q, Ying S, Bentley A, Assoufi B, Durham SR, et al. Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression. Am Rev Respir Dis 1993;148:401-6.
19. Masuyama K, Jacobson MR, Rak S, Meng Q, Sudderick RM, Kay AB, et al. Topical glucocorticosteroid (fluticasone propionate) inhibits cells expressing cytokine mRNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis. Immunology 1994;82:192-9.
20. Cameron LA, Durham SR, Jacobson MR, Masuyama K, Juliusson S, Gould HJ, et al. Expression of IL-4, Cε RNA, and Iε RNA in the nasal mucosa of patients with seasonal rhinitis: effect of topical corticosteriods. J Allergy Clin Immunol 1998;101:330-6.
21. Bradding P, Feather IH, Wilson S, Holgate ST, Howarth PH. Cytokine immunoreactivity in seasonal rhinitis: regulation by a topical corticosteroid. Am J Respir Grit Care Med 1995;151:1900-6.
22. Bradding P, Roberts JA, Britten KM, Montefort S, Djukanovic R, Mueller R, et al. Interleukin-4, -5, and -6 and tumor necrosis factor-α in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 1994;10:471-80.
23. Ying S, Humbert M, Barkans J, Corrigan CJ, Pfister R, Menz G, et al. Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (instrinsic) asthmatics. J Immunol 1997;158-3539-44.