A comparison of in vitro and in vivo stability in mice of two morpholino duplexes differing in chain length

Bioconjugate Chemistry

Volumn 14, Issue 5, 2003, Pages 1018-1023

  He, Jiang ^a   Liu, Guozheng ^a   Zhang, Surong ^a   Vanderheyden, Jean Luc ^a   Liu, Ning ^a   Liu, Changbin ^a   Zhang, Yumin ^a   Gupta, Suresh ^a   Rusckowski, Mary ^a   Hnatowich, Donald J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CHAIN LENGTH; CHAINS; MAMMALS; STABILITY;

AFFINITY CONSTANTS; BIODISTRIBUTIONS; CHAINS LENGTH; HETERODUPLEX; HOMODUPLEXES; HYBRIDISATION; IN-VITRO; RESONANCE ANALYSIS; SURFACE-PLASMON RESONANCE; VITRO AND IN VIVO;

SURFACE PLASMON RESONANCE;

AMINE; DNA; MORPHOLINE DERIVATIVE; PHOSPHORODIAMIDATE MORPHOLINO DERIVATIVE; POLYMER; SODIUM CHLORIDE; TECHNETIUM 99M; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONJUGATE; CONTROLLED STUDY; CULTURE MEDIUM; DISSOCIATION; DRUG CONJUGATION; DRUG DESIGN; DRUG DISTRIBUTION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TISSUE LEVEL; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYBRIDIZATION; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MALE; MEASUREMENT; MOLECULAR WEIGHT; MOUSE; NONHUMAN; RADIOACTIVITY; SERUM; SURFACE PLASMON RESONANCE; URINE;

ANIMALIA;

EID: 10744231527     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0341019     Document Type: Article

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