Vitamin C downregulates interleukin-18 production by increasing reactive oxygen intermediate and mitogen-activated protein kinase signalling in B16F10 murine melanoma cells

Melanoma Research

Volumn 13, Issue 6, 2003, Pages 549-554

  Cho, Daeho ^a   Hahm, Eunsil ^b   Kang, Jae Seung ^b   Kim, Young In ^b   Yang, Yoolhee ^a   Park, Jong Hoon ^a   Kim, Daejin ^b   Kim, Seonghan ^b   Kim, Yeong Seok ^c   Hur, Daeyoung ^c   Park, Hyunjeong ^d   Pang, Saic ^e   Hwang II, Young ^b   Lee, Wang Jae ^b  

^a Sookmyung Women's University   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Inje University College of Medicine   (South Korea)

^d The Catholic University of Korea   (South Korea)

^e Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Interleukin 18; Melanoma; Mitogen activated protein kinase; p38; Reactive oxygen intermediates; Vitamin C

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ANTIOXIDANT; ASCORBIC ACID; INTERLEUKIN 18; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FLOW CYTOMETRY; GENETIC TRANSCRIPTION; IMMUNOREGULATION; INTRACELLULAR SPACE; MELANOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; UPREGULATION;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BLOTTING, WESTERN; CELL LINE, TUMOR; DENSITOMETRY; DOWN-REGULATION; ENZYME INHIBITORS; FLOW CYTOMETRY; IMIDAZOLES; IMMUNOPRECIPITATION; INTERLEUKIN-18; MAP KINASE SIGNALING SYSTEM; MELANOMA; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TIME FACTORS;

EID: 10744229894     PISSN: 09608931     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008390-200312000-00002     Document Type: Article

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