Regulation of TIMP-1 expression by hypoxia in kidney fibroblasts

Annals of the New York Academy of Sciences

Volumn 878, Issue , 1999, Pages 503-505

  Norman, Jill T ^a,c   Clark, Ian M ^b   Garcia, Patricia L ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TISSUE INHIBITOR OF METALLOPROTEINASE 1;

CELL HYPOXIA; CONFERENCE PAPER; ENZYME REGULATION; FIBROBLAST; KIDNEY;

EID: 0032816128     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb07709.x     Document Type: Conference Paper

References (6)

1. 1. Eddy, A. 1996. Molecular insights into renal fibrosis. J. Am. Soc. Nephrol. 7: 2495-2508.
2. 2. Fine, L.G., C. Orphanides & J. Norman. 1998. Progressive renal disease: The chronic hypoxia hypothesis. Kidney. Int. 53 Suppl. 65: S74-S78.
3. 3. Norman, J. 1997. Mechanisms of hypoxia induced changes in collagen-I (coll-I) and tissue inhibitor of metalloproteinase-1 (TIMP-1) gene expression in human renal fibroblasts [abstract]. J. Am. Soc. Nephrol. 8: 523.
4. 4. Bunn, H.F. & R. Poynton. 1996. Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev. 76: 839-885.
5. 5. Clark, I.M., A.D. Rowan, D.R. Edwards et al. 1997. Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1. Biochem J. 324: 611-617.
6. 6. Wood, S.M. & P. Ratcliffe. 1997. Mammalian oxygen sensing and hypoxia-inducible factor 1. Int. J. Biochem. Cell. Biol. 29: 1419-1432.