A C-Terminal PDZ Motif in NHE3 Binds NHERF-1 and Enhances cAMP Inhibition of Sodium-Hydrogen Exchange

Biochemistry

Volumn 42, Issue 43, 2003, Pages 12662-12668

  Weinman, Edward J ^a,b   Wang, Yu ^a   Wang, Fengying ^a   Greer, Charmaine ^a   Steplock, Deborah ^a   Shenolikar, Shirish ^c  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b BALTIMORE VA MEDICAL CENTER   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; CELLS; HORMONES; HYDROGEN; ION EXCHANGE; PROTEINS; SODIUM;

PROTEIN ADAPTERS;

BIOCHEMISTRY;

8 BROMO CYCLIC AMP; AGAROSE; CYCLIC AMP; FORSKOLIN; HEXAHISTIDINE; HISTIDINE DERIVATIVE; HORMONE; NICKEL; NITRILOTRIACETIC ACID; PDZ PROTEIN; PROTEIN; PROTEIN NHERF 1; SODIUM PROTON EXCHANGE PROTEIN 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; MOLECULAR INTERACTION; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN STABILITY; PROTEIN TRANSPORT; REGULATORY MECHANISM; SEQUENCE TAGGED SITE; SIGNAL TRANSDUCTION; TWO HYBRID SYSTEM; YEAST;

AMINO ACID MOTIFS; ANIMALS; BINDING SITES; CYCLIC AMP; PHOSPHOPROTEINS; RABBITS; SODIUM-HYDROGEN ANTIPORTER;

ANIMALIA;

EID: 0242349774     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035244l     Document Type: Article

References (34)

1. + exchanger, Annu. Rev. Physiol. 55, 289-304.
2. + exchanger NHE3 isoform, J. Biol. Chem. 271, 3590-3599.
3. + exchanger requires a dissociable phosphoprotein cofactor, J. Clin. Invest. 92, 1781-1786.
4. + exchanger, J. Clin. Invest. 95, 2143-2149.
5. + exchanger, NHE3, requires an associated regulatory protein, Proc. Natl. Acad. Sci. U.S.A. 94, 3010-3015.
6. Reczek, D., Berryman, M., and Bretscher, A. (1997) Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family, J. Cell Biol. 139, 169-179.
7. Lamprecht, G., Weinman, E. J., and Yun, C. H. (1998) The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3, J. Biol. Chem. 273, 29972-29978.
8. + exchanger 3 (NHE3) is dependent on the presence but not the phosphorylation of NHERF, J. Biol. Chem. 274, 24753-24758.
9. Weinman, E. J., Steplock, D., Donowitz, M., and Shenolikar, S. (2000) NHERF association with ezrin is essential for cAMP-mediated phosphorylation and inhibition of sodium-hydrogen exchanger isoform 3, Biochemistry 39, 6123-6129.
10. Weinman, E. J., Steplock, D., Tate, K., Hall, R. A., Spurney, R. F., and Shenolikar, S. (1998) Structure-function of the Na/H exchanger regulatory factor (NHE-RF), J. Clin. Invest. 101, 2199-2206.
11. + exchanger isoform 3 in a renal polarized epithelial cell model, J. Biol. Chem. 277, 21480-21488.
12. + exchange, Nature 392, 626-630.
13. Wang, S., Raab, R. W., Schatz, P. J., Guggino, W. B., and Li, M. (1998) Peptide binding consensus of the NHE-RF-PDZ1 domain marches the C-terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR), FEBS Lett. 427, 103-108.
14. Harper, J. F. (1984) Peritz F test: Basic program of a robust multiple comparison test for statistical analysis of all differences among group means, Comput. Biol. Med. 14, 437-445.
15. - cotransporter in BSC-1 cells, J. Biol. Chem. 276, 42339-42346.
16. Lowry, O. H., Rosenbrough, N. J., Farr, A. L., and Randall, R. J. (1951) Protein measurement with the Folin phenol reagent, J. Biol. Chem. 193, 265-275.
17. - salvage mechanisms in model systems and the mouse pancreatic duct, J. Biol. Chem. 276, 17236-17243.
18. Sheng, M., and Sala, C. (2001) PDZ domains and the organization of supramolecular complexes, Annu. Rev. Neurosci. 24, 1-19.
19. + exchangers stably expressed in a fibroblast cell line, J. Biol. Chem. 268, 25527-25535.
20. + exchanger regulatory factor 2 mediates phosphorylation of serum- and glucocorticoid-induced protein kinase 1 by 3-phosphoinositide-dependent protein kinase 1, Biochem. Biophys. Res. Commun. 298, 207-215.
21. Voltz, J. W., Weinman, E. J., and Shenolikar, S. (2001) Expanding the role of NHERF, a PDZ domain-containing adaptor to growth regulation, Oncogene 20, 6309-6314.
22. + exchanger NHE3, J. Biol. Chem. 276, 40761-40708.
23. + exchanger NHE3 and the cytoskeletal protein ezrin, J. Biol. Chem. 273, 25856-25863.
24. Shenolikar, S., Voltz, J. W., Minkoff, C. M., Wade, J. B., and Weinman, E. J. (2002) Targeted disruption of the mouse gene encoding the PDZ domain-containing protein adapter, NHERF-1, promotes internalization of sodium-phosphate cotransporter type IIa and renal phosphate wasting, Proc. Natl. Acad. Sci. U.S.A. 99, 11470-11475.
25. Weinman, E. J., Steplock, D., and Shenolikar, S. (2003) NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes, FEBS Lett. 536, 141-144.
26. + exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signaling, Nature 417, 858-861.
27. Fouassier, L., Yun, C. C., Fitz, J. G., and Doctor, R. B. (2000) Evidence for ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) self-association through PDZ-PDZ interactions, J. Biol. Chem. 275, 25039-25045.
28. Shenolikar, S., Minkoff, C. M., Steplock, D., Chuckeree, C., Liu, M.-Z., and Weinman, E. J. (2001) N-terminal PDZ Domain is required for NHERF dimerization, FEBS Lett. 24559, 1-4.
29. Lau, A. G., and Hall, R. A. (2001) Oligomerization of NHERF-1 and NHERF-2 PDZ domains: Differential regulation by association with receptor carboxyl-termini and by phosphorylation, Biochemistry 40, 8572-8580.
30. + exchanger regulatory factor-1 by Cdc2 kinase, J. Biol. Chem. 276, 41559-41565.
31. 2-adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA, Proc. Natl. Acad. Sci. U.S.A. 100, 342-346.
32. + exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis, J. Biol. Chem. 277, 23714-23724.
33. Raghuram, V., Mak, D. D., and Foskett, J. K. (2001) Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction, Proc. Natl. Acad. Sci. U.S.A. 98, 1300-1305.
34. + exchanger regulatory factor potentiates receptor activity, Mol. Cell. Biol. 20, 8352-8363.