Basolateral Na+/HCO3- cotransport activity is regulated by the dissociable Na+/H+ exchanger regulatory factor

Journal of Clinical Investigation

Volumn 104, Issue 2, 1999, Pages 195-201

  Bernardo, Angelito A ^a,b,d   Kear, Felicidad T ^a   Santos, Anna V P ^a   Ma, Jianfei ^a   Steplock, Debra ^b,c   Robey, R Brooks ^a,b   Weinman, Edward J ^b,c  

^a UNIVERSITY OF ILLINOIS   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c WEST VIRGINIA UNIVERSITY   (United States)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE; CYCLIC AMP DEPENDENT PROTEIN KINASE; REGULATOR PROTEIN; SODIUM ION;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; BRUSH BORDER; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENETIC ENGINEERING; KIDNEY PROXIMAL TUBULE; NONHUMAN; PRIORITY JOURNAL; RABBIT; REGULATOR GENE; SODIUM TRANSPORT;

EID: 0032711693     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI5344     Document Type: Article

References (30)

1. Alpern, R.J. 1990. Cell mechanisms of proximal tubule acidification. Physiol. Rev. 70:79-114.
2. - cotransporter. Nature. 387:409-413.
3. - cotransporter. J. Biol. Chem. 272:19111-19114.
4. Akiba, T., Rocco, V.K., and Warnock, D.G. 1987. Parallel adaptation of the rabbit renal cortical sodium/proton antiporter and sodium bicarbonate cotransporter in metabolic acidosis and alkalosis. J. Clin. Invest. 80:308-315.
5. 3 cotransporter and Na-H antiporter in chronic respiratory acidosis and alkalosis. Am. J. Physiol. 256:F414-F420.
6. 3 cotransporter in the rabbit proximal tubule. Proc. Natl. Acad. Sci. USA. 87:7917-7920.
7. 3 reabsorption in the rat proximal tubule by stimulating phosphatidyl inositol metabolism and inhibiting base exit. J. Clin. Invest. 89:1485-1489.
8. 3 cotransporter by cyclic AMP and calcium dependent protein kinase. Am. J. Physiol. 256:F560-F565.
9. + exchanger and its regulation by cAMP-dependent protein kinases. J. Membr. Biol. 109:233-241.
10. + exchanger. J. Clin. Invest. 95:2143-2149.
11. Moe, O.W., Amemiya, M., and Yamaji, Y. 1996. Activation of protein kinase A acutely inhibits and phosphorylates Na/H exchanger NHE-3. J. Clin. Invest. 96:2187-2194.
12. Zhao, H., et al. 1999. Acute inhibition of Na/H exchanger NHE-3 by cAMP-role of protein kinase A and NHE-3 and NHE-3 phosphoserine 552 and 605. J. Biol. Chem. 274:3978-3987.
13. + exchanger III: evidence for a regulatory protein in the inhibitory effect of protein kinase A. J. Membr. Biol. 145:67-74.
14. Talor, Z., Richison, G., and Arruda, J.A.L. 1985. High affinity binding sites in luminal and basolateral renal membranes. Am. J. Physiol. 248:F472-F481.
15. - cotransporter I: partial purification and reconstitution. J. Membr. Biol. 140:31-37.
16. + exchanger. J. Membr. Biol. 101:11-18.
17. + cotransporter III: presence and modulation by glucocorticoids in primary cultures of the proximal tubule. Kidney Int. 47:1669-1676.
18. Green, J.A., and Kleeman, C.R. 1992. The role of calcium and cAMP messenger systems in intracellular pH regulation of osteoblastic cells. Am. J. Physiol. 262:C111-C121.
19. Towbin, H., Staehelin, T., and Gordon, J. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. Proc. Natl. Acad. Sci. USA. 76:4350-4354.
20. Jentsch, T.J., Janicke, I., Sorgonfrei, D., Keller, S., and Wiederholdt, M. 1986. The regulation of intracellular pH in monkey kidney epithelial cells (B-SC-1). J. Biol. Chem. 261:12120-12127.
21. + exchanger requires a dissociable phosphoprotein cofactor J. Clin. Invest. 92:1781-1786.
22. Yun, C.H., et al. 1997. cAMP-mediated inhibition of the epithelial brush border Na/H exchanger, NHE3, requires an associated regulatory protein. Proc. Natl. Acad. Sci. USA. 94:3010-3015.
23. Custer, M.B., Spindler, B., Verrey, F., Murer, H., and Biber, J. 1997. Identificaton of a new gene product (Diphor-1) regulated by dietary phosphate. Am. J. Physiol. 273:F801-F806.
24. Morais Cabral, J.H., et al. 1996. Crystal structure of PDZ domain. Nature. 382:649-652.
25. Harrison, S.C. 1996. Peptide surface association: the case of PDZ and PTB domains. Cell. 86:341-343.
26. + exchanger is a common interactor for merlin and ERM (MERM) proteins. J. Biol. Chem. 273:1273-1276.
27. + exchanger NHE3 and rhe cytoskeletal protein ezrin. J. Biol. Chem. 273:25856-25863.
28. Lamprecht, G., Weinman, E.J., and Yun, C.H. 1998. The role of NHE-RF and E3KARP in the cAMP-mediated inhibition of NHE-3 J. Biol. Chem. 273:29972-29978.
29. + exchanger. Nature. 392:626-630.
30. Weinman, E.J., et al. 1998. Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF). J. Clin. Invest. 101:2199-2206.