High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 74, Issue 4, 1997, Pages 439-442

  Lachman, Herbert M ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Abuse; Cocaine; Dopamine; Opiates; Polymorphism

Indexed keywords

CATECHOL METHYLTRANSFERASE; COCAINE; OPIATE;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SUBSTANCE ABUSE;

ALLELES; CATECHOL O-METHYLTRANSFERASE; CODON; DISEASE SUSCEPTIBILITY; DOPAMINE; GENE FREQUENCY; GENOTYPE; HUMANS; ODDS RATIO; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; REWARD; SUBSTANCE-RELATED DISORDERS;

EID: 0030836682     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19970725)74:4<439::AID-AJMG16>3.0.CO;2-J     Document Type: Article

References (3)

1. Aksoy S, Klener J, Weinshilboum RM (1993): Catechol-O-methyltransferase pharmacogenetics: Photoaffinity labelling and Western blot analysis of human liver samples. Pharmacogenetics 3:116-122.
2. Bennett G (1983): Substance abuse in adulthood. In Bennett G, Vourakis C, Woolf DS (eds). "Substance Abuse: Pharmacological, Developmental, and Clinical Perspectives." New York: John Wiley and Sons. pp. 175-191.
3. Bertocci B, Miggiano V, Da Prada M, Dembric Z, Lahm H-W, Malherbe P (1991): Human catechol-O-methyltransferase: Cloning and expression of the membrance associated form. Proc Natl Acad Sci USA 88:1416-1420.