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Volumn 16, Issue 10, 2003, Pages 637-648

The Pharmaceutical Industry and Research in 2020 and Beyond

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ANTIOBESITY AGENT; ANTITHROMBOCYTIC AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; CHEMOKINE; CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE; DIGITALIS; G PROTEIN COUPLED RECEPTOR; GENERIC DRUG; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTEGRIN; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MONOCLONAL ANTIBODY; NEW DRUG; NORADRENALIN UPTAKE INHIBITOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PROTEIN; QUININE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; SEROTONIN 2 ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; TETRAHYDROLIPSTATIN; TRANSCRIPTION FACTOR; UNINDEXED DRUG; VACCINE;

EID: 1042267278     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2003.16.10.829294     Document Type: Review
Times cited : (7)

References (73)
  • 1
    • 1042274665 scopus 로고    scopus 로고
    • Discovery of new medicines
    • J.P. Griffin and J. O'Grady (Eds.). BMJ Books
    • Dutta, A.S. Discovery of new medicines. In: Textbook of Pharmaceutical Medicine (4th Ed.). J.P. Griffin and J. O'Grady (Eds.). BMJ Books, 2002: 3-95.
    • (2002) Textbook of Pharmaceutical Medicine (4th Ed.) , pp. 3-95
    • Dutta, A.S.1
  • 3
    • 0037010474 scopus 로고    scopus 로고
    • Selected major risk factors and global and regional11 burden of disease
    • Ezzati, M., Lopez, A.D., Rodgers, A., Hoorn, S.V., Murray, C.J.L. and the Comparative Risk Assessment Collaborating Group. Selected major risk factors and global and regional burden of disease. Lancet 2002, 360: 1347-60.
    • (2002) Lancet , vol.360 , pp. 1347-1360
    • Ezzati, M.1    Lopez, A.D.2    Rodgers, A.3    Hoorn, S.V.4    Murray, C.J.L.5
  • 4
    • 0030948838 scopus 로고    scopus 로고
    • Regional patterns of disability-free life expectancy and disability-adjusted life expectancy: Global burden of disease study
    • Murray, C.J.L. and Lopez, A.D. Regional patterns of disability-free life expectancy and disability-adjusted life expectancy: Global burden of disease study. Lancet 1997, 349: 1347-52.
    • (1997) Lancet , vol.349 , pp. 1347-1352
    • Murray, C.J.L.1    Lopez, A.D.2
  • 5
    • 0030996001 scopus 로고    scopus 로고
    • Global mortality, disability, and the contribution of risk factors: Global burden of disease study
    • Murray, C.J.L. and Lopez, A.D. Global mortality, disability, and the contribution of risk factors: Global burden of disease study. Lancet 1997, 349: 1436-42.
    • (1997) Lancet , vol.349 , pp. 1436-1442
    • Murray, C.J.L.1    Lopez, A.D.2
  • 6
    • 0031001720 scopus 로고    scopus 로고
    • Alternative projections of mortality and disability by cause 1990-2020: Global burden of disease study
    • Murray, C.J.L. and Lopez, A.D. Alternative projections of mortality and disability by cause 1990-2020: Global burden of disease study. Lancet 1997, 349: 1498-504.
    • (1997) Lancet , vol.349 , pp. 1498-1504
    • Murray, C.J.L.1    Lopez, A.D.2
  • 7
    • 0037068957 scopus 로고    scopus 로고
    • th century: A period analysis
    • th century: A period analysis. Lancet 2002, 360: 1131-5.
    • (2002) Lancet , vol.360 , pp. 1131-1135
    • Brenner, H.1
  • 8
    • 1042274666 scopus 로고    scopus 로고
    • Rx R&D myths: The case against the drug industry's R&D "scare card"
    • ISBN 1-58231-024-6
    • Rx R&D myths: The case against the drug industry's R&D "scare card". Public Citizen's Congress Watch (ISBN 1-58231-024-6; www.citizen.org).
    • Public Citizen's Congress Watch
  • 9
    • 0037027050 scopus 로고    scopus 로고
    • COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease
    • Ray, W.A., Stein, C.M., Daugherty, J.R., Hall, K., Arbogast, P.G. and Griffin, M.R. COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease. Lancet 2003, 60: 1071-3.
    • (2003) Lancet , vol.60 , pp. 1071-1073
    • Ray, W.A.1    Stein, C.M.2    Daugherty, J.R.3    Hall, K.4    Arbogast, P.G.5    Griffin, M.R.6
  • 10
    • 0035706282 scopus 로고    scopus 로고
    • The discovery and synthesis of epinephrine
    • Sneader, W. The discovery and synthesis of epinephrine. Drug News Perspect 2001, 14: 491-4.
    • (2001) Drug News Perspect , vol.14 , pp. 491-494
    • Sneader, W.1
  • 11
    • 0035723726 scopus 로고    scopus 로고
    • Epinephrine analogues
    • Sneader, W. Epinephrine analogues. Drug News Perspect 2001, 14: 539-3.
    • (2001) Drug News Perspect , vol.14 , pp. 539-533
    • Sneader, W.1
  • 12
    • 0035724557 scopus 로고    scopus 로고
    • Histamine and the classic antihistamines
    • Sneader, W. Histamine and the classic antihistamines. Drug News Perspect 2001, 14: 618-24.
    • (2001) Drug News Perspect , vol.14 , pp. 618-624
    • Sneader, W.1
  • 13
    • 0033549840 scopus 로고    scopus 로고
    • Drug therapy: Drug treatment of lipid disorders
    • Knopp, R.H. Drug therapy: Drug treatment of lipid disorders. New Engl J Med 1999, 341: 498-511.
    • (1999) New Engl J Med , vol.341 , pp. 498-511
    • Knopp, R.H.1
  • 14
    • 0037434618 scopus 로고    scopus 로고
    • Drug therapy: Selective estrogen-receptor modulators - Mechanisms of action and application to clinical practice
    • Riggs, B.L. and Hartmann, L.C. Drug therapy: Selective estrogen-receptor modulators - Mechanisms of action and application to clinical practice. New Engl J Med 2003, 348: 618-29.
    • (2003) New Engl J Med , vol.348 , pp. 618-629
    • Riggs, B.L.1    Hartmann, L.C.2
  • 15
    • 0034097996 scopus 로고    scopus 로고
    • Cox-2 selective nonsteroidal anti-inflammatory drugs
    • Jackson, L.M. and Hawkey, C.J. Cox-2 selective nonsteroidal anti-inflammatory drugs. Drugs 2000, 59: 1207-16.
    • (2000) Drugs , vol.59 , pp. 1207-1216
    • Jackson, L.M.1    Hawkey, C.J.2
  • 16
    • 0035210592 scopus 로고    scopus 로고
    • 6 receptors in memory formation
    • 6 receptors in memory formation. Drug News Perspect 2001, 14: 396-400.
    • (2001) Drug News Perspect , vol.14 , pp. 396-400
    • Meneses, A.1
  • 17
    • 0037697840 scopus 로고    scopus 로고
    • N-myristoyltransferase inhibitors as potential antifungal drugs
    • Ohtsuo, T. and Aoki, Y. N-myristoyltransferase inhibitors as potential antifungal drugs. Drugs Future 2003, 28: 143-52.
    • (2003) Drugs Future , vol.28 , pp. 143-152
    • Ohtsuo, T.1    Aoki, Y.2
  • 19
    • 0027240552 scopus 로고
    • Zoladex: Discovery, pharmacodynamics and fonnulation
    • Dutta, A.S., Furr, B.J.A. and Hutchinson, F.G. Zoladex: Discovery, pharmacodynamics and fonnulation. Drug News Perspect 1993, 6: 325-32.
    • (1993) Drug News Perspect , vol.6 , pp. 325-332
    • Dutta, A.S.1    Furr, B.J.A.2    Hutchinson, F.G.3
  • 20
    • 0028789199 scopus 로고
    • Drug development in gastroenterology: The changing view of industry
    • Parsons, M.E. and Garner, A. Drug development in gastroenterology: The changing view of industry. Aliment Pharmacol Ther 1995, 9: 457-63.
    • (1995) Aliment Pharmacol Ther , vol.9 , pp. 457-463
    • Parsons, M.E.1    Garner, A.2
  • 21
    • 0030448099 scopus 로고    scopus 로고
    • 1976 and all that! - 20 Years of antisecretory therapy
    • Garner, A., Fadlallah, H. and Parsons, M.E. 1976 and all that! - 20 years of antisecretory therapy. Gut 1996, 39: 784-6.
    • (1996) Gut , vol.39 , pp. 784-786
    • Garner, A.1    Fadlallah, H.2    Parsons, M.E.3
  • 23
    • 0037096223 scopus 로고    scopus 로고
    • Therapeutic vaccines: Realities of today and hopes for the future
    • Sela, M., Arnon, R. and Schechter, B. Therapeutic vaccines: Realities of today and hopes for the future. Drug Discov Today 2002, 7: 664-73.
    • (2002) Drug Discov Today , vol.7 , pp. 664-673
    • Sela, M.1    Arnon, R.2    Schechter, B.3
  • 24
    • 0032505102 scopus 로고    scopus 로고
    • Drug therapy: Thrombopoietin
    • Kaushansky, K. Drug therapy: Thrombopoietin. New Engl J Med 1998, 339: 746-54.
    • (1998) New Engl J Med , vol.339 , pp. 746-754
    • Kaushansky, K.1
  • 26
    • 0037413467 scopus 로고    scopus 로고
    • A controlled trial of natalizumab for relapsing multiple sclerosis
    • Miller, D.H., Khan, O.A., Sheremata, W.A. et al. A controlled trial of natalizumab for relapsing multiple sclerosis. New Engl J Med 2003, 348: 15-23.
    • (2003) New Engl J Med , vol.348 , pp. 15-23
    • Miller, D.H.1    Khan, O.A.2    Sheremata, W.A.3
  • 27
    • 0036558205 scopus 로고    scopus 로고
    • Prioritising the proteome: Identifying pharmaceutically relevant targets
    • Swindells, M.B. and Overington, J.P. Prioritising the proteome: Identifying pharmaceutically relevant targets. Drug Discov Today 2002, 7: 516-21.
    • (2002) Drug Discov Today , vol.7 , pp. 516-521
    • Swindells, M.B.1    Overington, J.P.2
  • 28
    • 0037417220 scopus 로고    scopus 로고
    • Mechanisms of disease: Apoptosis and caspases in neurodegenerative diseases
    • Friedlander, R.M. Mechanisms of disease: Apoptosis and caspases in neurodegenerative diseases. New Engl J Med 2003, 348: 1365-75.
    • (2003) New Engl J Med , vol.348 , pp. 1365-1375
    • Friedlander, R.M.1
  • 29
    • 0032504237 scopus 로고    scopus 로고
    • G protein-coupled receptors I. Diversity of receptor-ligand interactions
    • Ji, T.H., Grossmann, M. and Ji, I. G protein-coupled receptors I. Diversity of receptor-ligand interactions. J Biol Chem 1998, 273: 17299-302.
    • (1998) J Biol Chem , vol.273 , pp. 17299-17302
    • Ji, T.H.1    Grossmann, M.2    Ji, I.3
  • 30
    • 0032541084 scopus 로고    scopus 로고
    • G Protein-coupled receptors - II. Mechanism of agonist activation
    • Gether, U. and Kobilka, B.K. G Protein-coupled receptors - II. Mechanism of agonist activation. J Biol Chem 1998, 273: 17979-82.
    • (1998) J Biol Chem , vol.273 , pp. 17979-17982
    • Gether, U.1    Kobilka, B.K.2
  • 31
    • 0032875356 scopus 로고    scopus 로고
    • Physiological regulation of G protein-linked signalling
    • Morris, A.J. and Malbon, C.C. Physiological regulation of G protein-linked signalling. Physiol Rev 1999, 79: 1373-430.
    • (1999) Physiol Rev , vol.79 , pp. 1373-1430
    • Morris, A.J.1    Malbon, C.C.2
  • 32
    • 0030671337 scopus 로고    scopus 로고
    • Orphan G protein-coupled receptors: A neglected opportunity for pioneer drug discovery
    • Stadel, J.M., Wilson, S. and Bergsma, D.J. Orphan G protein-coupled receptors: A neglected opportunity for pioneer drug discovery. Trends Pharmacol Sci 1997, 18: 430-7.
    • (1997) Trends Pharmacol Sci , vol.18 , pp. 430-437
    • Stadel, J.M.1    Wilson, S.2    Bergsma, D.J.3
  • 33
    • 0031792950 scopus 로고    scopus 로고
    • Orphan G-protein-coupled receptors - The next generation of drug targets
    • Wilson, S., Bergsma, D.J., Chambers, J.K. et al. Orphan G-protein-coupled receptors - The next generation of drug targets. Br J Pharmacol 1998, 125: 1387-92.
    • (1998) Br J Pharmacol , vol.125 , pp. 1387-1392
    • Wilson, S.1    Bergsma, D.J.2    Chambers, J.K.3
  • 34
    • 0034677966 scopus 로고    scopus 로고
    • Drug discovery: A historical perspective
    • Drews, J. Drug discovery: A historical perspective. Science 2000, 287: 1960-4.
    • (2000) Science , vol.287 , pp. 1960-1964
    • Drews, J.1
  • 36
    • 0033855713 scopus 로고    scopus 로고
    • Selective oestrogen receptor modulators: Structure, function, and clinical use
    • Osborne, C.K., Zhao, H. and Fuqua, S.A.W. Selective oestrogen receptor modulators: Structure, function, and clinical use. J Clin Oncol 2000, 18: 3172-86.
    • (2000) J Clin Oncol , vol.18 , pp. 3172-3186
    • Osborne, C.K.1    Zhao, H.2    Fuqua, S.A.W.3
  • 37
    • 0032921685 scopus 로고    scopus 로고
    • Selective oestrogen receptor modulators
    • Mitlak, B.H. and Cohen, F.J. Selective oestrogen receptor modulators. Drugs 1999, 57: 653-63.
    • (1999) Drugs , vol.57 , pp. 653-663
    • Mitlak, B.H.1    Cohen, F.J.2
  • 38
    • 0034085656 scopus 로고    scopus 로고
    • Selective oestrogen receptor modulators (SERMs): Effects on multiple organ systems
    • Agnusdei, D. and Iori, N. Selective oestrogen receptor modulators (SERMs): Effects on multiple organ systems. Curr Med Chem 2000, 7: 577-84.
    • (2000) Curr Med Chem , vol.7 , pp. 577-584
    • Agnusdei, D.1    Iori, N.2
  • 39
    • 0001418652 scopus 로고    scopus 로고
    • Selective androgen receptor modulators
    • Zhi, L. and Martinborough, E. Selective androgen receptor modulators. Ann Rep Med Chem 2001, 36: 169-80.
    • (2001) Ann Rep Med Chem , vol.36 , pp. 169-180
    • Zhi, L.1    Martinborough, E.2
  • 40
    • 0034048844 scopus 로고    scopus 로고
    • Kinase inhibitors in cancer therapy
    • Sedlacek, H.H. Kinase inhibitors in cancer therapy. Drugs 2000, 59: 435-76.
    • (2000) Drugs , vol.59 , pp. 435-476
    • Sedlacek, H.H.1
  • 41
    • 0034084453 scopus 로고    scopus 로고
    • The role of polypeptide growth factors in human carcinomas: New targets for a novel pharmacological approach
    • Favoni, R.E. and De Cupis, A. The role of polypeptide growth factors in human carcinomas: New targets for a novel pharmacological approach. Pharmacol Rev 2000, 52: 179-206.
    • (2000) Pharmacol Rev , vol.52 , pp. 179-206
    • Favoni, R.E.1    De Cupis, A.2
  • 42
    • 0034104525 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors targeted to the epidermal growth factor receptor subfamily
    • Noonberg, S.B. and Benz, C.C. Tyrosine kinase inhibitors targeted to the epidermal growth factor receptor subfamily. Drugs 2000, 59: 753-67.
    • (2000) Drugs , vol.59 , pp. 753-767
    • Noonberg, S.B.1    Benz, C.C.2
  • 43
    • 0032854118 scopus 로고    scopus 로고
    • The structure based design of ATP-site directed protein kinase inhibitors
    • Toledo, L.M., Lydon, N.B. and Elbaum, D. The structure based design of ATP-site directed protein kinase inhibitors. Curr Med Chem 1999, 6: 775-805.
    • (1999) Curr Med Chem , vol.6 , pp. 775-805
    • Toledo, L.M.1    Lydon, N.B.2    Elbaum, D.3
  • 44
    • 0032880746 scopus 로고    scopus 로고
    • The cell cycle and drug discovery: The promise and the hope
    • Brooks, G. and La Thangue, N.B. The cell cycle and drug discovery: The promise and the hope. Drug Discov Today 1999, 4: 455-64.
    • (1999) Drug Discov Today , vol.4 , pp. 455-464
    • Brooks, G.1    La Thangue, N.B.2
  • 45
    • 0034722893 scopus 로고    scopus 로고
    • From oncogene to drug: Development of small molecule tyrosine kinase inhibitors as anti-tumour and anti-angiogenic agents
    • Morin, M.J. From oncogene to drug: Development of small molecule tyrosine kinase inhibitors as anti-tumour and anti-angiogenic agents. Oncogene 2000, 19: 6574-83.
    • (2000) Oncogene , vol.19 , pp. 6574-6583
    • Morin, M.J.1
  • 46
    • 0036660263 scopus 로고    scopus 로고
    • Role of GSK-3beta in Alzheimer's disease pathology
    • Planel, E., Sun, X. and Takashima, A. Role of GSK-3beta in Alzheimer's disease pathology. Drug Dev Res 2002, 56: 491-510.
    • (2002) Drug Dev Res , vol.56 , pp. 491-510
    • Planel, E.1    Sun, X.2    Takashima, A.3
  • 47
    • 0036074697 scopus 로고    scopus 로고
    • Trk neurotrophin receptor activators
    • Pollack, S.J. and Harper, S.J. Trk neurotrophin receptor activators. Drug News Perspect 2002, 15: 268-77.
    • (2002) Drug News Perspect , vol.15 , pp. 268-277
    • Pollack, S.J.1    Harper, S.J.2
  • 48
    • 0035479234 scopus 로고    scopus 로고
    • Tumour angiogenesis as a therapeutic target
    • Matter, A. Tumour angiogenesis as a therapeutic target. Drug Discov Today 2001, 6: 1005-23.
    • (2001) Drug Discov Today , vol.6 , pp. 1005-1023
    • Matter, A.1
  • 49
    • 0037186924 scopus 로고    scopus 로고
    • Drug therapy: Imatinib mesylate - A new oral targeted therapy
    • Savage, D.G. and Antman, K.H. Drug therapy: Imatinib mesylate - A new oral targeted therapy. New Engl J Med 2002, 346: 683-93.
    • (2002) New Engl J Med , vol.346 , pp. 683-693
    • Savage, D.G.1    Antman, K.H.2
  • 50
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon, D.J., Leyland-Jones, B., Shak, S. et. al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. New Engl J Med 2001, 344: 783-92.
    • (2001) New Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 51
    • 0037027771 scopus 로고    scopus 로고
    • Genomic medicine: Genetic testing
    • Burke, W. Genomic medicine: Genetic testing. New Engl J Med 2002, 347: 1867-75.
    • (2002) New Engl J Med , vol.347 , pp. 1867-1875
    • Burke, W.1
  • 52
    • 0037413486 scopus 로고    scopus 로고
    • Genomic medicine: Population screening in the age of genomic medicine
    • Khoury, M.J., McCabe, L.L. and McCabe, E.R.B. Genomic medicine: Population screening in the age of genomic medicine. New Engl J Med 2003, 348: 50-8.
    • (2003) New Engl J Med , vol.348 , pp. 50-58
    • Khoury, M.J.1    McCabe, L.L.2    McCabe, E.R.B.3
  • 53
    • 0037421590 scopus 로고    scopus 로고
    • Drug therapy: Pharmacogenomics - Drug disposition, drug targets, and side effects
    • Evans, W.E. and McLeod, H.L. Drug therapy: Pharmacogenomics - drug disposition, drug targets, and side effects. New Engl J Med 2003, 348: 538-49.
    • (2003) New Engl J Med , vol.348 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2
  • 54
  • 55
    • 0031886030 scopus 로고    scopus 로고
    • The business of pharmacogenomics
    • Persidis, A. The business of pharmacogenomics. Nat Biotechnol 1998, 16: 209-10.
    • (1998) Nat Biotechnol , vol.16 , pp. 209-210
    • Persidis, A.1
  • 56
    • 0037417254 scopus 로고    scopus 로고
    • Genomic medicine: Alzheimer's disease and Parkinson's disease
    • Nussbaum, R.L. and Ellis, C.E. Genomic medicine: Alzheimer's disease and Parkinson's disease. New Engl J Med 2003, 348: 1356-64.
    • (2003) New Engl J Med , vol.348 , pp. 1356-1364
    • Nussbaum, R.L.1    Ellis, C.E.2
  • 58
    • 0037153045 scopus 로고    scopus 로고
    • New players in the genetics of stroke
    • Tournier-Lasserve, E. New players in the genetics of stroke. New Engl J Med 2002, 347: 1711-2.
    • (2002) New Engl J Med , vol.347 , pp. 1711-1712
    • Tournier-Lasserve, E.1
  • 59
    • 0032784646 scopus 로고    scopus 로고
    • Proteomics: Quantitative and physical mapping of cellular proteins
    • Blackstock, W.P. and Weir, M.P. Proteomics: Quantitative and physical mapping of cellular proteins. Trends Biotechnol 1999, 17: 121-7.
    • (1999) Trends Biotechnol , vol.17 , pp. 121-127
    • Blackstock, W.P.1    Weir, M.P.2
  • 60
    • 0037101903 scopus 로고    scopus 로고
    • Function first: A powerful approach to post-genomic drug discovery
    • Betz, S.F., Baxter S.M. and Fetrow, J.S. Function first: A powerful approach to post-genomic drug discovery. Drug Discov Today 2002, 7: 865-71.
    • (2002) Drug Discov Today , vol.7 , pp. 865-871
    • Betz, S.F.1    Baxter, S.M.2    Fetrow, J.S.3
  • 61
    • 0036629266 scopus 로고    scopus 로고
    • High-throughput protein expression for the post-genomic era
    • Chambers, S.P. High-throughput protein expression for the post-genomic era. Drug Discov Today 2002, 7: 759-65.
    • (2002) Drug Discov Today , vol.7 , pp. 759-765
    • Chambers, S.P.1
  • 62
    • 0036462475 scopus 로고    scopus 로고
    • High-throughput crystallization and structure determination in drug discovery
    • Stewart, L., Clark, R. and Behnke, C. High-throughput crystallization and structure determination in drug discovery. Drug Discov Today 2002, 7: 187-96.
    • (2002) Drug Discov Today , vol.7 , pp. 187-196
    • Stewart, L.1    Clark, R.2    Behnke, C.3
  • 63
    • 0027489384 scopus 로고
    • Medical progress: Clinical implications of the p53 tumour-suppressor gene
    • Harris, C.C. and Hollstein, M. Medical progress: Clinical implications of the p53 tumour-suppressor gene. New Engl J Med 1993, 329: 1318-27.
    • (1993) New Engl J Med , vol.329 , pp. 1318-1327
    • Harris, C.C.1    Hollstein, M.2
  • 65
    • 0033287914 scopus 로고    scopus 로고
    • Combinatorial chemistry as a tool for drug discovery
    • Floyd, C.D., Leblanc, C. and Whittaker, M. Combinatorial chemistry as a tool for drug discovery. Prog Med Chem 1999, 36: 91-168.
    • (1999) Prog Med Chem , vol.36 , pp. 91-168
    • Floyd, C.D.1    Leblanc, C.2    Whittaker, M.3
  • 66
    • 17744409919 scopus 로고    scopus 로고
    • Application of high-throughput screening techniques to drug discovery
    • Cox, B., Denyer, J.C., Binnie, A. et al. Application of high-throughput screening techniques to drug discovery. Prog Med Chem 2000, 37: 83-133.
    • (2000) Prog Med Chem , vol.37 , pp. 83-133
    • Cox, B.1    Denyer, J.C.2    Binnie, A.3
  • 68
    • 0031472588 scopus 로고    scopus 로고
    • Role of pharmacokinetics and metabolism in drug discovery and metabolism
    • Lin, J.H. and Lu, A.Y.H. Role of pharmacokinetics and metabolism in drug discovery and metabolism. Pharmacol Rev 1997, 49: 403-49.
    • (1997) Pharmacol Rev , vol.49 , pp. 403-449
    • Lin, J.H.1    Lu, A.Y.H.2
  • 69
    • 0037082199 scopus 로고    scopus 로고
    • The emerging importance of predictive ADME simulation in drug discovery
    • Beresford, A.P., Selick H.E. and Tarbit, M.H. The emerging importance of predictive ADME simulation in drug discovery. Drug Discov Today 2002, 7: 109-16.
    • (2002) Drug Discov Today , vol.7 , pp. 109-116
    • Beresford, A.P.1    Selick, H.E.2    Tarbit, M.H.3
  • 70
    • 0032546158 scopus 로고    scopus 로고
    • Medical progress: Imaging the brain
    • Gilman, S. Medical progress: Imaging the brain. New Engl J Med 1998, 338: 812-20, 889-98.
    • (1998) New Engl J Med , vol.338 , pp. 812-820
    • Gilman, S.1
  • 71
    • 0035282803 scopus 로고    scopus 로고
    • In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography
    • Aboagye, E.O., Price, P.M and Jones, T. In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography. Drug Discov Today 2001, 6: 293-302.
    • (2001) Drug Discov Today , vol.6 , pp. 293-302
    • Aboagye, E.O.1    Price, P.M.2    Jones, T.3
  • 72
    • 0037140187 scopus 로고    scopus 로고
    • Effectiveness of positron emission tomography in the pre-operative assessment of patients with suspected non-small cell lung cancer: The PLUS multicentre randomised trial
    • van Tinteren, H. et al. and the PLUS study group. Effectiveness of positron emission tomography in the pre-operative assessment of patients with suspected non-small cell lung cancer: The PLUS multicentre randomised trial. Lancet 2002, 359: 1388-92.
    • (2002) Lancet , vol.359 , pp. 1388-1392
    • Van Tinteren, H.1
  • 73
    • 0037092618 scopus 로고    scopus 로고
    • Whole-animal cellular and molecular imaging to accelerate drug development
    • Contag, P.R. Whole-animal cellular and molecular imaging to accelerate drug development. Drug Discov Today 2002, 7: 555-62.
    • (2002) Drug Discov Today , vol.7 , pp. 555-562
    • Contag, P.R.1


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