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Volumn 10, Issue 6, 2004, Pages 1071-1084

Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): Treatment with hsFlt3L inhibits intracranial glioma progression

Author keywords

Adenovirus; Brain; Flt3L; HSV1 TK; Immunology; Tumor

Indexed keywords

ADENOVIRUS VECTOR; CD4 ANTIGEN; CD8 ANTIGEN; FLT3 LIGAND; GLYCOPROTEIN P 15095; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

EID: 10344265483     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.08.025     Document Type: Article
Times cited : (74)

References (53)
  • 1
    • 0037378411 scopus 로고    scopus 로고
    • Current and future strategies for the treatment of malignant brain tumors
    • M.G. Castro et al. Current and future strategies for the treatment of malignant brain tumors Pharmacol. Ther. 98 2003 71-108
    • (2003) Pharmacol. Ther. , vol.98 , pp. 71-108
    • Castro, M.G.1
  • 2
    • 17344371681 scopus 로고    scopus 로고
    • Beta-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses
    • A. Puumalainen et al. Beta-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses Hum. Gene Ther. 9 1998 1769-1774
    • (1998) Hum. Gene Ther. , vol.9 , pp. 1769-1774
    • Puumalainen, A.1
  • 3
    • 0034329438 scopus 로고    scopus 로고
    • Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses
    • A.M. Sandmair et al. Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses Hum. Gene Ther. 11 2000 2197-2205
    • (2000) Hum. Gene Ther. , vol.11 , pp. 2197-2205
    • Sandmair, A.M.1
  • 4
    • 0033007570 scopus 로고    scopus 로고
    • Treatment of intracranial gliomas with bone marrow-derived dendritic cells pulsed with tumor antigens
    • L.M. Liau et al. Treatment of intracranial gliomas with bone marrow-derived dendritic cells pulsed with tumor antigens J. Neurosurg. 90 1999 1115-1124
    • (1999) J. Neurosurg. , vol.90 , pp. 1115-1124
    • Liau, L.M.1
  • 5
    • 2342641762 scopus 로고    scopus 로고
    • Replicative oncolytic herpes simplex viruses in combination cancer therapies
    • D.E. Post G. Fulci E.A. Chiocca E.G. VanMeir Replicative oncolytic herpes simplex viruses in combination cancer therapies Curr. Gene Ther. 4 2004 41-51
    • (2004) Curr. Gene Ther. , vol.4 , pp. 41-51
    • Post, D.E.1    Fulci, G.2    Chiocca, E.A.3    VanMeir, E.G.4
  • 6
    • 1542464964 scopus 로고    scopus 로고
    • Oncolytic viruses for the therapy of brain tumors and other solid malignancies: A review
    • G. Fulci E.A. Chiocca Oncolytic viruses for the therapy of brain tumors and other solid malignancies: A review Front. Biosci. 1 2003 346-360
    • (2003) Front. Biosci. , vol.1 , pp. 346-360
    • Fulci, G.1    Chiocca, E.A.2
  • 7
    • 2442687810 scopus 로고    scopus 로고
    • Glioma tropic neural stem cells consist of astrocytic precursors and their migratory capacity is mediated by CXCR4
    • M. Ehtesham et al. Glioma tropic neural stem cells consist of astrocytic precursors and their migratory capacity is mediated by CXCR4 Neoplasia 6 2004 287-293
    • (2004) Neoplasia , vol.6 , pp. 287-293
    • Ehtesham, M.1
  • 8
    • 3142692559 scopus 로고    scopus 로고
    • Vaccination with tumor lysate-pulsed dendritic cells elicits antigen specific cytotoxic T-cells in patients with malignant glioma
    • J.S. Yu G. Liu H. Ying W.H. Yong K.L. Black C.J. Wheeler Vaccination with tumor lysate-pulsed dendritic cells elicits antigen specific cytotoxic T-cells in patients with malignant glioma Cancer Res. 64 2003 4973-4979
    • (2003) Cancer Res. , vol.64 , pp. 4973-4979
    • Yu, J.S.1    Liu, G.2    Ying, H.3    Yong, W.H.4    Black, K.L.5    Wheeler, C.J.6
  • 9
    • 0029992327 scopus 로고    scopus 로고
    • Human malignant brain tumor response to herpes simplex thymidine kinase (HSVtk)/ganciclovir gene therapy
    • M. Izquierdo et al. Human malignant brain tumor response to herpes simplex thymidine kinase (HSVtk)/ganciclovir gene therapy Gene Ther. 3 1996 491-495
    • (1996) Gene Ther. , vol.3 , pp. 491-495
    • Izquierdo, M.1
  • 10
    • 0031463632 scopus 로고    scopus 로고
    • Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells
    • Z. Ram et al. Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells Nat. Med. 3 1997 1354-1361
    • (1997) Nat. Med. , vol.3 , pp. 1354-1361
    • Ram, Z.1
  • 11
    • 0034136802 scopus 로고    scopus 로고
    • Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors
    • T.W. Trask et al. Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors Mol. Ther. 1 2000 195-203
    • (2000) Mol. Ther. , vol.1 , pp. 195-203
    • Trask, T.W.1
  • 12
    • 12944315014 scopus 로고    scopus 로고
    • Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: Results of a phase I trial
    • J.M. Markert et al. Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: Results of a phase I trial Gene Ther. 7 2000 867-874
    • (2000) Gene Ther. , vol.7 , pp. 867-874
    • Markert, J.M.1
  • 13
    • 12944272092 scopus 로고    scopus 로고
    • Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma
    • R. Rampling et al. Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma Gene Ther. 7 2000
    • (2000) Gene Ther. , vol.7
    • Rampling, R.1
  • 14
    • 0035256772 scopus 로고    scopus 로고
    • Gliomagenesis: Genetic alterations and mouse models
    • E.C. Holland Gliomagenesis: Genetic alterations and mouse models Nat. Rev. Genet. 2 2001 120-129
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 120-129
    • Holland, E.C.1
  • 15
    • 0029661945 scopus 로고    scopus 로고
    • Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: Multiple dendritic cell subpopulations identified
    • E. Maraskovsky et al. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: Multiple dendritic cell subpopulations identified J. Exp. Med. 184 1996 1953-1962
    • (1996) J. Exp. Med. , vol.184 , pp. 1953-1962
    • Maraskovsky, E.1
  • 16
    • 0031225999 scopus 로고    scopus 로고
    • Developmental pathways of dendritic cells in vivo: Distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice
    • B. Pulendran et al. Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice J. Immunol. 159 1997 2222-2231
    • (1997) J. Immunol. , vol.159 , pp. 2222-2231
    • Pulendran, B.1
  • 17
    • 0030787726 scopus 로고    scopus 로고
    • Ultrastructural and immunohistological evidence for dendritic-like cells within human choroid plexus epithelium
    • J.M. Serot B. Foliguet M.C. Bene G.C. Faure Ultrastructural and immunohistological evidence for dendritic-like cells within human choroid plexus epithelium Neuroreport 8 1997 1995-1998
    • (1997) Neuroreport , vol.8 , pp. 1995-1998
    • Serot, J.M.1    Foliguet, B.2    Bene, M.C.3    Faure, G.C.4
  • 18
    • 10344240632 scopus 로고    scopus 로고
    • Dendritic cells and immune responses in the central nervous system
    • P.R. Lowenstein Dendritic cells and immune responses in the central nervous system Trends Immunol. 23 2002 70
    • (2002) Trends Immunol. , vol.23 , pp. 70
    • Lowenstein, P.R.1
  • 20
    • 0032741719 scopus 로고    scopus 로고
    • Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials
    • R.A. Dewey et al. Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials Nat. Med. 5 1999 1256-1263
    • (1999) Nat. Med. , vol.5 , pp. 1256-1263
    • Dewey, R.A.1
  • 21
    • 0034018533 scopus 로고    scopus 로고
    • Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: Reduced cytotoxicity of a truncated HSV1-TK
    • C. Cowsill et al. Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: Reduced cytotoxicity of a truncated HSV1-TK Gene Ther. 7 2000 679-685
    • (2000) Gene Ther. , vol.7 , pp. 679-685
    • Cowsill, C.1
  • 22
    • 10344219724 scopus 로고    scopus 로고
    • Effects of ectopic decorin in modulating intracranial glioma progression in vivo, in a rat syngeneic model
    • (in press)
    • A. Bigliari et al. Effects of ectopic decorin in modulating intracranial glioma progression in vivo, in a rat syngeneic model Mol. Ther. 2004 (in press)
    • (2004) Mol. Ther.
    • Bigliari, A.1
  • 23
    • 0036152214 scopus 로고    scopus 로고
    • Immunology of viral-vector-mediated gene transfer into the brain: An evolutionary and developmental perspective
    • P.R. Lowenstein Immunology of viral-vector-mediated gene transfer into the brain: An evolutionary and developmental perspective Trends Immunol. 23 2002 23-30
    • (2002) Trends Immunol. , vol.23 , pp. 23-30
    • Lowenstein, P.R.1
  • 24
    • 0033636254 scopus 로고    scopus 로고
    • Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis
    • B. Serafini S. Columba-Cabezas F. Di Rosa F. Aloisi Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis Am. J. Pathol. 157 2000 1991-2002
    • (2000) Am. J. Pathol. , vol.157 , pp. 1991-2002
    • Serafini, B.1    Columba-Cabezas, S.2    Di Rosa, F.3    Aloisi, F.4
  • 25
    • 2442708947 scopus 로고    scopus 로고
    • Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis
    • B. Serafini B. Rosicarelli R. Magliozzi E. Stigliano F. Aloisi Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis Brain Pathol. 14 2004 164-174
    • (2004) Brain Pathol. , vol.14 , pp. 164-174
    • Serafini, B.1    Rosicarelli, B.2    Magliozzi, R.3    Stigliano, E.4    Aloisi, F.5
  • 26
    • 0033999887 scopus 로고    scopus 로고
    • Regulation of T-cell responses by CNS antigen-presenting cells: Different roles for microglia and astrocytes
    • F. Aloisi F. Ria L. Adorini Regulation of T-cell responses by CNS antigen-presenting cells: Different roles for microglia and astrocytes Immunol. Today 21 2000 141-147
    • (2000) Immunol. Today , vol.21 , pp. 141-147
    • Aloisi, F.1    Ria, F.2    Adorini, L.3
  • 27
    • 0035865406 scopus 로고    scopus 로고
    • Brain dendritic cells and macrophages/microglia in central nervous system inflammation
    • H.G. Fischer G. Reichmann Brain dendritic cells and macrophages/microglia in central nervous system inflammation J. Immunol. 166 2001 2717-2726
    • (2001) J. Immunol. , vol.166 , pp. 2717-2726
    • Fischer, H.G.1    Reichmann, G.2
  • 28
    • 0034193965 scopus 로고    scopus 로고
    • Phenotype and functions of brain dendritic cells emerging during chronic infection of mice with Toxoplasma gondii
    • H.G. Fischer U. Bonifas G. Reichmann Phenotype and functions of brain dendritic cells emerging during chronic infection of mice with Toxoplasma gondii J. Immunol. 164 2000 4826-4834
    • (2000) J. Immunol. , vol.164 , pp. 4826-4834
    • Fischer, H.G.1    Bonifas, U.2    Reichmann, G.3
  • 29
    • 0242643750 scopus 로고    scopus 로고
    • The brain as an immune privileged site: Dendritic cells of the central nervous system inhibit T cell activation
    • T. Suter et al. The brain as an immune privileged site: Dendritic cells of the central nervous system inhibit T cell activation Eur. J. Immunol. 33 2003 2998-3006
    • (2003) Eur. J. Immunol. , vol.33 , pp. 2998-3006
    • Suter, T.1
  • 30
    • 11144357340 scopus 로고    scopus 로고
    • Expression of CCR7 in multiple sclerosis: Implications for CNS immunity
    • P. Kivisakk et al. Expression of CCR7 in multiple sclerosis: implications for CNS immunity Ann. Neurol. 55 2004 627-638
    • (2004) Ann. Neurol. , vol.55 , pp. 627-638
    • Kivisakk, P.1
  • 31
    • 0037246792 scopus 로고    scopus 로고
    • Inflammation in the central nervous system: The role for dendritic cells
    • M. Pashenkov N. Teleshova H. Link Inflammation in the central nervous system: The role for dendritic cells Brain Pathol. 13 2003 23-33
    • (2003) Brain Pathol. , vol.13 , pp. 23-33
    • Pashenkov, M.1    Teleshova, N.2    Link, H.3
  • 32
    • 0036298188 scopus 로고    scopus 로고
    • Uncoupling of virus-induced inflammation and anti-viral immunity in the brain parenchyma
    • P.G. Stevenson J.M. Austyn S. Hawke Uncoupling of virus-induced inflammation and anti-viral immunity in the brain parenchyma J. Gen. Virol. 83 2002 1735-1743
    • (2002) J. Gen. Virol. , vol.83 , pp. 1735-1743
    • Stevenson, P.G.1    Austyn, J.M.2    Hawke, S.3
  • 33
    • 0032964119 scopus 로고    scopus 로고
    • +T cells into the central nervous system by professional antigen-presenting cells
    • +T cells into the central nervous system by professional antigen-presenting cells Am. J. Pathol. 154 1999 481-494
    • (1999) Am. J. Pathol. , vol.154 , pp. 481-494
    • Carson, M.J.1    Reilly, C.R.2    Sutcliffe, J.G.3    Lo, D.4
  • 34
    • 0030593433 scopus 로고    scopus 로고
    • The potential role of dendritic cells in immune-mediated inflammatory diseases in the central nervous system
    • M.K. Matyszak V.H. Perry The potential role of dendritic cells in immune-mediated inflammatory diseases in the central nervous system Neuroscience 74 1996 599-608
    • (1996) Neuroscience , vol.74 , pp. 599-608
    • Matyszak, M.K.1    Perry, V.H.2
  • 36
    • 84890579118 scopus 로고    scopus 로고
    • Immune system regulation of transgene expression in the brain. 2. Differential increase of mRNAs encoding for interferon-regulated, chemokine, and T-cell genes during either innate acute or chronic systemic adaptive immune responses to first generation adenoviral viral vectors
    • J.M. Zirger et al. Immune system regulation of transgene expression in the brain. 2. Differential increase of mRNAs encoding for interferon-regulated, chemokine, and T-cell genes during either innate acute or chronic systemic adaptive immune responses to first generation adenoviral viral vectors Mol. Ther. 9 Suppl. 1 2004 1019
    • (2004) Mol. Ther. , vol.9 , Issue.SUPPL. 1 , pp. 1019
    • Zirger, J.M.1
  • 37
    • 10344224292 scopus 로고    scopus 로고
    • Immune system regulation of transgene expression in the brain. 1. Systemically activated immune responses silence adenoviral vector-encoded transgene expression in the brain through both noncytolytic and cytotoxic mechanisms
    • C. Barcia et al. Immune system regulation of transgene expression in the brain. 1. Systemically activated immune responses silence adenoviral vector-encoded transgene expression in the brain through both noncytolytic and cytotoxic mechanisms Mol. Ther. 9 Suppl. 1 2004 459
    • (2004) Mol. Ther. , vol.9 , Issue.SUPPL. 1 , pp. 459
    • Barcia, C.1
  • 38
    • 0032903599 scopus 로고    scopus 로고
    • Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo
    • N.C. Fernandez et al. Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo Nat. Med. 5 1999 405-411
    • (1999) Nat. Med. , vol.5 , pp. 405-411
    • Fernandez, N.C.1
  • 40
    • 0030690356 scopus 로고    scopus 로고
    • Induction of dendritic cells (DC) by Flt3 Ligand (FL) promotes the generation of tumor-specific immune responses in vivo
    • D.H. Lynch Induction of dendritic cells (DC) by Flt3 Ligand (FL) promotes the generation of tumor-specific immune responses in vivo Crit. Rev. Immunol. 18 1998 99-107
    • (1998) Crit. Rev. Immunol. , vol.18 , pp. 99-107
    • Lynch, D.H.1
  • 42
    • 0034868843 scopus 로고    scopus 로고
    • The immune anti-tumor effects of GM-CSF and B7-1 gene transfection are enhanced by surgical debulking of tumor
    • S. Mukherjee et al. The immune anti-tumor effects of GM-CSF and B7-1 gene transfection are enhanced by surgical debulking of tumor Cancer Gene Ther. 8 2001 580-588
    • (2001) Cancer Gene Ther. , vol.8 , pp. 580-588
    • Mukherjee, S.1
  • 43
    • 0026597986 scopus 로고
    • Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector
    • G.W. Wilkinson A. Akrigg Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector Nucleic Acids Res. 20 1992 2233-2239
    • (1992) Nucleic Acids Res. , vol.20 , pp. 2233-2239
    • Wilkinson, G.W.1    Akrigg, A.2
  • 44
    • 0031029226 scopus 로고    scopus 로고
    • Cell type-specific expression in brain cell cultures from a short human cytomegalovirus major immediate early promoter depends on whether it is inserted into herpesvirus or adenovirus vectors
    • A.F. Shering et al. Cell type-specific expression in brain cell cultures from a short human cytomegalovirus major immediate early promoter depends on whether it is inserted into herpesvirus or adenovirus vectors J. Gen. Virol. 78 1997 445-459
    • (1997) J. Gen. Virol. , vol.78 , pp. 445-459
    • Shering, A.F.1
  • 45
    • 0034294843 scopus 로고    scopus 로고
    • Strong promoters are the key to highly efficient, noninflammatory and noncytotoxic adenoviral-mediated transgene delivery into the brain in vivo
    • C.A. Gerdes M.G. Castro P.R. Lowenstein Strong promoters are the key to highly efficient, noninflammatory and noncytotoxic adenoviral-mediated transgene delivery into the brain in vivo Mol. Ther. 2 2000 330-338
    • (2000) Mol. Ther. , vol.2 , pp. 330-338
    • Gerdes, C.A.1    Castro, M.G.2    Lowenstein, P.R.3
  • 46
    • 0033032347 scopus 로고    scopus 로고
    • Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity
    • A.E. Morelli et al. Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity J. Gen. Virol. 80 1999 571-583
    • (1999) J. Gen. Virol. , vol.80 , pp. 571-583
    • Morelli, A.E.1
  • 47
    • 0034691208 scopus 로고    scopus 로고
    • Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: Toward realistic long-term neurological gene therapy for chronic diseases
    • C.E. Thomas G. Schiedner S. Kochanek M.G. Castro P.R. Lowenstein Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: Toward realistic long-term neurological gene therapy for chronic diseases Proc. Natl. Acad. Sci. USA. 97 2000 7482-7487
    • (2000) Proc. Natl. Acad. Sci. USA. , vol.97 , pp. 7482-7487
    • Thomas, C.E.1    Schiedner, G.2    Kochanek, S.3    Castro, M.G.4    Lowenstein, P.R.5
  • 48
    • 0034986065 scopus 로고    scopus 로고
    • Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain
    • C.E. Thomas D. Birkett I. Anozie M.G. Castro P.R. Lowenstein Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain Mol. Ther. 3 2001 36-46
    • (2001) Mol. Ther. , vol.3 , pp. 36-46
    • Thomas, C.E.1    Birkett, D.2    Anozie, I.3    Castro, M.G.4    Lowenstein, P.R.5
  • 49
    • 0003026143 scopus 로고    scopus 로고
    • Gene transfer into neural cells in vivo using adenoviral vectors
    • C.R. Gerfen R. McKay M.A. Rogawski D.R. Sibley P. Skolnick (Eds.) Wiley New York
    • T. Southgate P. Kingston Gene transfer into neural cells in vivo using adenoviral vectors In: C.R. Gerfen R. McKay M.A. Rogawski D.R. Sibley P. Skolnick (Eds.) Current Protocols in Neuroscience 2000 Wiley New York 4.23.1-4.23.40
    • (2000) Current Protocols in Neuroscience
    • Southgate, T.1    Kingston, P.2
  • 50
    • 0032814774 scopus 로고    scopus 로고
    • Instability of adenoviral vectors during transport and its implication for clinical studies
    • C. Nyberg-Hoffman E. Aguilar-Cordova Instability of adenoviral vectors during transport and its implication for clinical studies Nat. Med. 5 1999 955-957
    • (1999) Nat. Med. , vol.5 , pp. 955-957
    • Nyberg-Hoffman, C.1    Aguilar-Cordova, E.2
  • 51
    • 0029981799 scopus 로고    scopus 로고
    • Supernatant rescue assay vs. polymerase chain reaction for detection of wild type adenovirus contaminating recombinant adenovirus stocks
    • L.D. Dion J. Fang R.I. Garver Jr. Supernatant rescue assay vs. polymerase chain reaction for detection of wild type adenovirus contaminating recombinant adenovirus stocks J. Virol. Methods 56 1996 99-107
    • (1996) J. Virol. Methods , vol.56 , pp. 99-107
    • Dion, L.D.1    Fang, J.2    Garver Jr., R.I.3
  • 52
    • 0028466386 scopus 로고
    • Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary human cells in the presence of adenovirus
    • M. Cotten A. Baker M. Saltik E. Wagner M. Buschle Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary human cells in the presence of adenovirus Gene Ther. 1 1994 239-246
    • (1994) Gene Ther. , vol.1 , pp. 239-246
    • Cotten, M.1    Baker, A.2    Saltik, M.3    Wagner, E.4    Buschle, M.5
  • 53
    • 0034933604 scopus 로고    scopus 로고
    • Dendritic cells in models of tumor immunity. Role Flt3 ligand
    • C. Maliszewski et al. Dendritic cells in models of tumor immunity. Role Flt3 ligand Pathol. Biol. (Paris) 49 2001 481-483
    • (2001) Pathol. Biol. (Paris) , vol.49 , pp. 481-483
    • Maliszewski, C.1


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