Structural, thermodynamic, and kinetic analyses of tetrahydrooxazine- derived inhibitors bound to β-glucosidases

Journal of Biological Chemistry

Volumn 279, Issue 47, 2004, Pages 49236-49242

  Gloster, Tracey M ^a   Macdonald, James M ^b,c   Tarling, Chris A ^c   Stick, Robert V ^b   Withers, Stephen G ^c   Davies, Gideon J ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DERIVATIVES; ENTHALPY; ENTROPY; HYDROLYSIS; THERMODYNAMICS; X RAY ANALYSIS;

ENZYME FUNCTIONS; TRANSITION STATE MIMICRY;

ENZYMES;

1 DEOXYNOJIRIMYCIN; AMINE; BETA GLUCOSIDASE; GLYCOSIDASE INHIBITOR; ISOFAGOMINE; OXAZINE DERIVATIVE; TETRAHYDROOXAZINE; UNCLASSIFIED DRUG;

ARTICLE; CALORIMETRY; CRYSTAL STRUCTURE; ENTHALPY; ENZYME ACTIVITY; ENZYME INHIBITION; KINETICS; MICHAELIS CONSTANT; PRIORITY JOURNAL; STRUCTURE ANALYSIS; THERMODYNAMICS;

BACILLUS; CALORIMETRY; CELLULASE; CELLULASES; CRYSTALLOGRAPHY, X-RAY; ENTROPY; ENZYME INHIBITORS; HEAT; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; OXAZINES; PROTEIN BINDING; PROTEIN CONFORMATION; THERMODYNAMICS; THERMOTOGA MARITIMA;

EID: 10344249935     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M407195200     Document Type: Article

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