-
1
-
-
0031685620
-
TGF-beta signal transduction
-
J. Massague TGF-beta signal transduction Annu Rev Biochem 67 1998 753 791
-
(1998)
Annu Rev Biochem
, vol.67
, pp. 753-791
-
-
Massague, J.1
-
2
-
-
0032529159
-
Smads and early developmental signaling by the TGFbeta superfamily
-
M. Whitman Smads and early developmental signaling by the TGFbeta superfamily Genes Dev 12 1998 2445 2462
-
(1998)
Genes Dev
, vol.12
, pp. 2445-2462
-
-
Whitman, M.1
-
3
-
-
0028953810
-
Transforming growth factor beta and cell cycle regulation
-
M.G. Alexandrow, and H.L. Moses Transforming growth factor beta and cell cycle regulation Cancer Res 55 1995 1452 1457
-
(1995)
Cancer Res
, vol.55
, pp. 1452-1457
-
-
Alexandrow, M.G.1
Moses, H.L.2
-
4
-
-
0031684855
-
Extracellular matrix-associated transforming growth factor-beta: Role in cancer cell growth and invasion
-
J. Taipale, J. Saharinen, and J. Keski-Oja Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion Adv Cancer Res 75 1998 87 134
-
(1998)
Adv Cancer Res
, vol.75
, pp. 87-134
-
-
Taipale, J.1
Saharinen, J.2
Keski-Oja, J.3
-
5
-
-
0030793645
-
Transforming growth factor-beta in breast cancer: A working hypothesis
-
M. Reiss, and M.H. Barcellos-Hoff Transforming growth factor-beta in breast cancer: a working hypothesis Breast Cancer Res Treat 45 1997 81 95
-
(1997)
Breast Cancer Res Treat
, vol.45
, pp. 81-95
-
-
Reiss, M.1
Barcellos-Hoff, M.H.2
-
6
-
-
0032909086
-
Genetic events and the role of TGF beta in epithelial tumour progression
-
R.J. Akhurst, and A. Balmain Genetic events and the role of TGF beta in epithelial tumour progression J Pathol 187 1999 82 90
-
(1999)
J Pathol
, vol.187
, pp. 82-90
-
-
Akhurst, R.J.1
Balmain, A.2
-
7
-
-
0031817391
-
Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: Implications for tumor invasion
-
G. Portella, S.A. Cumming, J. Liddell, W. Cui, H. Ireland, and R.J. Akhurst Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion Cell Growth Differ 9 1998 393 404
-
(1998)
Cell Growth Differ
, vol.9
, pp. 393-404
-
-
Portella, G.1
Cumming, S.A.2
Liddell, J.3
Cui, W.4
Ireland, H.5
Akhurst, R.J.6
-
8
-
-
0035199487
-
Invasion and metastasis of a mammary tumor involves TGF-beta signaling
-
J.A. McEarchern, J.J. Kobie, V. Mack, R.S. Wu, L. Meade-Tollin, and C.L. Arteaga Invasion and metastasis of a mammary tumor involves TGF-beta signaling Int J Cancer 91 2001 76 82
-
(2001)
Int J Cancer
, vol.91
, pp. 76-82
-
-
McEarchern, J.A.1
Kobie, J.J.2
MacK, V.3
Wu, R.S.4
Meade-Tollin, L.5
Arteaga, C.L.6
-
9
-
-
0034575168
-
TGFbeta1 stimulates the secretion of matrix metalloproteinase 2 (MMP2) and the invasive behavior in human ovarian cancer cells, which is suppressed by MMP inhibitor BB3103
-
S.W. Lin, M.T. Lee, F.C. Ke, P.P. Lee, C.J. Huang, and M.M. Ip TGFbeta1 stimulates the secretion of matrix metalloproteinase 2 (MMP2) and the invasive behavior in human ovarian cancer cells, which is suppressed by MMP inhibitor BB3103 Clin Exp Metastasis 18 2000 493 499
-
(2000)
Clin Exp Metastasis
, vol.18
, pp. 493-499
-
-
Lin, S.W.1
Lee, M.T.2
Ke, F.C.3
Lee, P.P.4
Huang, C.J.5
Ip, M.M.6
-
11
-
-
0028291737
-
A matrix metalloproteinase expressed on the surface of invasive tumour cells
-
H. Sato, T. Takino, Y. Okada, J. Cao, A. Shinagawa, and E. Yamamoto A matrix metalloproteinase expressed on the surface of invasive tumour cells Nature 370 1994 61 65
-
(1994)
Nature
, vol.370
, pp. 61-65
-
-
Sato, H.1
Takino, T.2
Okada, Y.3
Cao, J.4
Shinagawa, A.5
Yamamoto, E.6
-
12
-
-
0033168915
-
Regulation of Smad signalling by protein associations and signalling crosstalk
-
Y. Zhang, and R. Derynck Regulation of Smad signalling by protein associations and signalling crosstalk Trends Cell Biol 9 1999 274 279
-
(1999)
Trends Cell Biol
, vol.9
, pp. 274-279
-
-
Zhang, Y.1
Derynck, R.2
-
13
-
-
0034574298
-
How cells read TGF-beta signals
-
J. Massague How cells read TGF-beta signals Nat Rev Mol Cell Biol 1 2000 169 178
-
(2000)
Nat Rev Mol Cell Biol
, vol.1
, pp. 169-178
-
-
Massague, J.1
-
14
-
-
0031035582
-
Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling
-
A. Atfi, S. Djelloul, E. Chastre, R. Davis, and C. Gespach Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling J Biol Chem 272 1997 1429 1432
-
(1997)
J Biol Chem
, vol.272
, pp. 1429-1432
-
-
Atfi, A.1
Djelloul, S.2
Chastre, E.3
Davis, R.4
Gespach, C.5
-
15
-
-
0028937610
-
Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells
-
M.T. Hartsough, and K.M. Mulder Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells J Biol Chem 270 1995 7117 7124
-
(1995)
J Biol Chem
, vol.270
, pp. 7117-7124
-
-
Hartsough, M.T.1
Mulder, K.M.2
-
16
-
-
0033578721
-
Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression
-
H. Hanafusa, J. Ninomiya-Tsuji, N. Masuyama, M. Nishita, J. Fujisawa, and H. Shibuya Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression J Biol Chem 274 1999 27161 27167
-
(1999)
J Biol Chem
, vol.274
, pp. 27161-27167
-
-
Hanafusa, H.1
Ninomiya-Tsuji, J.2
Masuyama, N.3
Nishita, M.4
Fujisawa, J.5
Shibuya, H.6
-
17
-
-
0026026818
-
The GTPase superfamily: Conserved structure and molecular mechanism
-
H.R. Bourne, D.A. Sanders, and F. McCormick The GTPase superfamily: conserved structure and molecular mechanism Nature 349 1991 117 127
-
(1991)
Nature
, vol.349
, pp. 117-127
-
-
Bourne, H.R.1
Sanders, D.A.2
McCormick, F.3
-
18
-
-
0028825531
-
Ras target proteins in eukaryotic cells
-
M.S. Marshall Ras target proteins in eukaryotic cells FASEB J 9 1995 1311 1318
-
(1995)
FASEB J
, vol.9
, pp. 1311-1318
-
-
Marshall, M.S.1
-
19
-
-
0037077272
-
H-Ras/mitogen-activated protein kinase pathway inhibits integrin-mediated adhesion and induces apoptosis in osteoblasts
-
Y. Tanaka, S. Nakayamada, H. Fujimoto, Y. Okada, H. Umehara, and T. Kataoka H-Ras/mitogen-activated protein kinase pathway inhibits integrin-mediated adhesion and induces apoptosis in osteoblasts J Biol Chem 277 2002 21446 21452
-
(2002)
J Biol Chem
, vol.277
, pp. 21446-21452
-
-
Tanaka, Y.1
Nakayamada, S.2
Fujimoto, H.3
Okada, Y.4
Umehara, H.5
Kataoka, T.6
-
20
-
-
0023231242
-
Prognostic significance of the expression of a ras protein with a molecular weight of 21,000 by human breast cancer
-
T. Clair, W.R. Miller, and YS Cho-Chung Prognostic significance of the expression of a ras protein with a molecular weight of 21,000 by human breast cancer Cancer Res 47 1987 5290 5293
-
(1987)
Cancer Res
, vol.47
, pp. 5290-5293
-
-
Clair, T.1
Miller, W.R.2
Cho-Chung, Y.S.3
-
21
-
-
0025637206
-
The H-ras oncogene product p21 and prognosis in human breast cancer
-
D.M. Watson, R.A. Elton, W.J. Jack, J.M. Dixon, U. Chetty, and W.R. Miller The H-ras oncogene product p21 and prognosis in human breast cancer Breast Cancer Res Treat 17 1991 161 169
-
(1991)
Breast Cancer Res Treat
, vol.17
, pp. 161-169
-
-
Watson, D.M.1
Elton, R.A.2
Jack, W.J.3
Dixon, J.M.4
Chetty, U.5
Miller, W.R.6
-
22
-
-
0029002907
-
Aberrant function of the Ras signal transduction pathway in human breast cancer
-
G.J. Clark, and C.J. Der Aberrant function of the Ras signal transduction pathway in human breast cancer Breast Cancer Res Treat 35 1995 133 144
-
(1995)
Breast Cancer Res Treat
, vol.35
, pp. 133-144
-
-
Clark, G.J.1
Der, C.J.2
-
23
-
-
0029662049
-
TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
-
M. Oft, J. Peli, C. Rudaz, H. Schwarz, H. Beug, and E. Reichmann TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells Genes Dev 10 1996 2462 2477
-
(1996)
Genes Dev
, vol.10
, pp. 2462-2477
-
-
Oft, M.1
Peli, J.2
Rudaz, C.3
Schwarz, H.4
Beug, H.5
Reichmann, E.6
-
24
-
-
0034612789
-
Role of transforming growth factor-beta signaling in cancer
-
M.P. de Caestecker, E. Piek, and A.B. Roberts Role of transforming growth factor-beta signaling in cancer J Natl Cancer Inst 92 2000 1388 1402
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 1388-1402
-
-
De Caestecker, M.P.1
Piek, E.2
Roberts, A.B.3
-
25
-
-
0034785348
-
TGF-beta signaling in tumor suppression and cancer progression
-
R. Derynck, R.J. Akhurst, and A. Balmain TGF-beta signaling in tumor suppression and cancer progression Nat Genet 29 2001 117 129
-
(2001)
Nat Genet
, vol.29
, pp. 117-129
-
-
Derynck, R.1
Akhurst, R.J.2
Balmain, A.3
-
26
-
-
0034650586
-
H-ras, but not N-ras, induces an invasive phenotype in human breast epithelial cells: A role for MMP-2 in the H-ras-induced invasive phenotype
-
A. Moon, M.S. Kim, T.G. Kim, S.H. Kim, H.E. Kim, and Y.Q. Chen H-ras, but not N-ras, induces an invasive phenotype in human breast epithelial cells: a role for MMP-2 in the H-ras-induced invasive phenotype Int J Cancer 85 2000 176 181
-
(2000)
Int J Cancer
, vol.85
, pp. 176-181
-
-
Moon, A.1
Kim, M.S.2
Kim, T.G.3
Kim, S.H.4
Kim, H.E.5
Chen, Y.Q.6
-
27
-
-
0141482096
-
P38 Kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells
-
M.S. Kim, E.J. Lee, H.R. Kim, and A. Moon p38 Kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells Cancer Res 63 2003 5454 5461
-
(2003)
Cancer Res
, vol.63
, pp. 5454-5461
-
-
Kim, M.S.1
Lee, E.J.2
Kim, H.R.3
Moon, A.4
-
28
-
-
10344255835
-
TGF-β-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERKs signaling in MCF10A human breast epithelial cells
-
E.S Kim, M.S. Kim, and A. Moon TGF-β-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERKs signaling in MCF10A human breast epithelial cells Int J Oncol 25 2004 1375 1382
-
(2004)
Int J Oncol
, vol.25
, pp. 1375-1382
-
-
Kim, E.S.1
Kim, M.S.2
Moon, A.3
-
29
-
-
0024344882
-
Expression of type IV collagenase and procollagen genes and its correlation with the tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells
-
H. Ura, R.D. Bonfil, R. Reich, R. Reddel, A. Pfeifer, and C.C. Harris Expression of type IV collagenase and procollagen genes and its correlation with the tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells Cancer Res 49 1989 4615 4621
-
(1989)
Cancer Res
, vol.49
, pp. 4615-4621
-
-
Ura, H.1
Bonfil, R.D.2
Reich, R.3
Reddel, R.4
Pfeifer, A.5
Harris, C.C.6
-
30
-
-
0030826510
-
Transcriptional activation by p53 of the human type IV collagenase (gelatinase a or matrix metalloproteinase 2) promoter
-
J. Bian, and Y. Sun Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter Mol Cell Biol 17 1997 6330 6338
-
(1997)
Mol Cell Biol
, vol.17
, pp. 6330-6338
-
-
Bian, J.1
Sun, Y.2
-
31
-
-
0035500287
-
Transcriptional suppression of matrix metalloproteinase-9 gene expression by IFN-gamma and IFN-beta: Critical role of STAT-1alpha
-
Z. Ma, H. Qin, and E.N. Benveniste Transcriptional suppression of matrix metalloproteinase-9 gene expression by IFN-gamma and IFN-beta: critical role of STAT-1alpha J Immunol 167 2001 5150 5159
-
(2001)
J Immunol
, vol.167
, pp. 5150-5159
-
-
Ma, Z.1
Qin, H.2
Benveniste, E.N.3
-
32
-
-
0024263087
-
Loss of growth factor dependence and conversion of transforming growth factor-beta 1 inhibition to stimulation in metastatic H-ras-transformed murine fibroblasts
-
L.C. Schwarz, M.C. Gingras, G. Goldberg, A.H. Greenberg, and J.A. Wright Loss of growth factor dependence and conversion of transforming growth factor-beta 1 inhibition to stimulation in metastatic H-ras-transformed murine fibroblasts Cancer Res 48 1988 6999 7003
-
(1988)
Cancer Res
, vol.48
, pp. 6999-7003
-
-
Schwarz, L.C.1
Gingras, M.C.2
Goldberg, G.3
Greenberg, A.H.4
Wright, J.A.5
-
33
-
-
0032918414
-
TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
-
J.J. Yin, K. Selander, J.M. Chirgwin, M. Dallas, B.G. Grubbs, and R. Wieser TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development J Clin Invest 103 1999 197 206
-
(1999)
J Clin Invest
, vol.103
, pp. 197-206
-
-
Yin, J.J.1
Selander, K.2
Chirgwin, J.M.3
Dallas, M.4
Grubbs, B.G.5
Wieser, R.6
-
34
-
-
0035501062
-
TGF-beta signaling in cancer a double-edged sword
-
R.J. Akhurst, and R. Derynck TGF-beta signaling in cancer a double-edged sword Trends Cell Biol 11 2001 S44 S51
-
(2001)
Trends Cell Biol
, vol.11
-
-
Akhurst, R.J.1
Derynck, R.2
-
35
-
-
0036304111
-
Metastasis is driven by sequential elevation of H-ras and Smad2 levels
-
M. Oft, R.J. Akhurst, and A. Balmain Metastasis is driven by sequential elevation of H-ras and Smad2 levels Nat Cell Biol 4 2002 487 494
-
(2002)
Nat Cell Biol
, vol.4
, pp. 487-494
-
-
Oft, M.1
Akhurst, R.J.2
Balmain, A.3
-
36
-
-
0036086409
-
Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases
-
R.S. Muraoka, N. Dumont, C.A. Ritter, T.C. Dugger, D.M. Brantley, and J. Chen Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases J Clin Invest 109 2002 1551 1559
-
(2002)
J Clin Invest
, vol.109
, pp. 1551-1559
-
-
Muraoka, R.S.1
Dumont, N.2
Ritter, C.A.3
Dugger, T.C.4
Brantley, D.M.5
Chen, J.6
-
37
-
-
0026612306
-
Activation of p21ras by transforming growth factor beta in epithelial cells
-
K.M. Mulder, and S.L. Morris Activation of p21ras by transforming growth factor beta in epithelial cells J Biol Chem 267 1992 5029 5031
-
(1992)
J Biol Chem
, vol.267
, pp. 5029-5031
-
-
Mulder, K.M.1
Morris, S.L.2
-
38
-
-
0028361791
-
Two different signal transduction pathways can be activated by transforming growth factor beta 1 in epithelial cells
-
Z. Yan, S. Winawer, and E. Friedman Two different signal transduction pathways can be activated by transforming growth factor beta 1 in epithelial cells J Biol Chem 269 1994 13231 13237
-
(1994)
J Biol Chem
, vol.269
, pp. 13231-13237
-
-
Yan, Z.1
Winawer, S.2
Friedman, E.3
-
39
-
-
0036674213
-
P38 Mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration
-
A.V. Bakin, C. Rinehart, A.K. Tomlinson, and C.L. Arteaga p38 Mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration J Cell Sci 115 2002 3193 3206
-
(2002)
J Cell Sci
, vol.115
, pp. 3193-3206
-
-
Bakin, A.V.1
Rinehart, C.2
Tomlinson, A.K.3
Arteaga, C.L.4
-
40
-
-
0033588216
-
A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration
-
J.C. Hedges, M.A. Dechert, I.A. Yamboliev, J.L. Martin, E. Hickey, and L.A. Weber A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration J Biol Chem 274 1999 24211 24219
-
(1999)
J Biol Chem
, vol.274
, pp. 24211-24219
-
-
Hedges, J.C.1
Dechert, M.A.2
Yamboliev, I.A.3
Martin, J.L.4
Hickey, E.5
Weber, L.A.6
-
41
-
-
0037099745
-
TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses
-
L. Yu, M.C. Hebert, and Y.E. Zhang TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses EMBO J 21 2002 3749 3759
-
(2002)
EMBO J
, vol.21
, pp. 3749-3759
-
-
Yu, L.1
Hebert, M.C.2
Zhang, Y.E.3
-
42
-
-
0035879867
-
TGF-beta-induced invasiveness of pancreatic cancer cells is mediated by matrix metalloproteinase-2 and the urokinase plasminogen activator system
-
V. Ellenrieder, S.F. Hendler, C. Ruhland, W. Boeck, G. Adler, and T.M. Gress TGF-beta-induced invasiveness of pancreatic cancer cells is mediated by matrix metalloproteinase-2 and the urokinase plasminogen activator system Int J Cancer 93 2001 204 211
-
(2001)
Int J Cancer
, vol.93
, pp. 204-211
-
-
Ellenrieder, V.1
Hendler, S.F.2
Ruhland, C.3
Boeck, W.4
Adler, G.5
Gress, T.M.6
-
43
-
-
0033981730
-
Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase
-
N. Johansson, R. Ala-aho, V. Uitto, R. Grenman, N.E. Fusenig, and C. Lopez-Otin Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase J Cell Sci 113 2000 227 235
-
(2000)
J Cell Sci
, vol.113
, pp. 227-235
-
-
Johansson, N.1
Ala-Aho, R.2
Uitto, V.3
Grenman, R.4
Fusenig, N.E.5
Lopez-Otin, C.6
-
44
-
-
0036386902
-
Transforming growth factor-beta1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes
-
J.F. Santibanez, J. Guerrero, M. Quintanilla, A. Fabra, and J. Martinez Transforming growth factor-beta1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes Biochem Biophys Res Commun 296 2002 267 273
-
(2002)
Biochem Biophys Res Commun
, vol.296
, pp. 267-273
-
-
Santibanez, J.F.1
Guerrero, J.2
Quintanilla, M.3
Fabra, A.4
Martinez, J.5
-
45
-
-
0039552125
-
Transforming growth factor-beta induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase
-
L. Ravanti, L. Hakkinen, H. Larjava, U. Saarialho-Kere, M. Foschi, and J. Han Transforming growth factor-beta induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase J Biol Chem 274 1999 37292 37300
-
(1999)
J Biol Chem
, vol.274
, pp. 37292-37300
-
-
Ravanti, L.1
Hakkinen, L.2
Larjava, H.3
Saarialho-Kere, U.4
Foschi, M.5
Han, J.6
-
46
-
-
0035914334
-
Transforming growth factor-beta-induced osteoblast elongation regulates osteoclastic bone resorption through a p38 mitogen-activated protein kinase-and matrix metalloproteinase-dependent pathway
-
M.A. Karsdal, M.S. Fjording, N.T. Foged, J.M. Delaisse, and A. Lochter Transforming growth factor-beta-induced osteoblast elongation regulates osteoclastic bone resorption through a p38 mitogen-activated protein kinase-and matrix metalloproteinase-dependent pathway J Biol Chem 276 2001 39350 39358
-
(2001)
J Biol Chem
, vol.276
, pp. 39350-39358
-
-
Karsdal, M.A.1
Fjording, M.S.2
Foged, N.T.3
Delaisse, J.M.4
Lochter, A.5
-
47
-
-
0032918016
-
Novel regulation of type IV collagenase (matrix metalloproteinase-9 and -2) activities by transforming growth factor-beta1 in human prostate cancer cell lines
-
I. Sehgal, and T.C. Thompson Novel regulation of type IV collagenase (matrix metalloproteinase-9 and -2) activities by transforming growth factor-beta1 in human prostate cancer cell lines Mol Biol Cell 10 1999 407 416
-
(1999)
Mol Biol Cell
, vol.10
, pp. 407-416
-
-
Sehgal, I.1
Thompson, T.C.2
|