Transcriptional suppression of matrix metalloproteinase-9 gene expression by IFN-γ and IFN-β: Critical role of STAT-1α

Journal of Immunology

Volumn 167, Issue 9, 2001, Pages 5150-5159

  Ma, Z ^a   Qin, H ^a   Benveniste, E N ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; GAMMA INTERFERON; GELATINASE B; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; STAT1 PROTEIN;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; ASTROCYTOMA; CANCER INVASION; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FIBROSARCOMA; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; TRANSCRIPTION REGULATION;

EID: 0035500287     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.9.5150     Document Type: Article

References (65)

1. Matrix metalloproteinases: Effectors of development and normal physiology
2. Matrix metalloproteinases: Structures, evolution, and diversification
3. Matrix metalloproteinases and tumor invasion: From correlation and causality to the clinic
4. Matrix metalloproteinases in tumor invasion and metastasis
5. Matrix metalloproteinases: Multifunctional contributors to tumor progression
6. Generation of biologically active IL-1β by matrix metalloproteinases: A novel caspase-1 -independent pathway of IL-1β processing
7. The matrix metalloproteinase-9 regulates the insulin-like growth factor-triggered autocrine response in DU-145 carcinoma cells
8. Matrix metalloproteinase-7-dependent release of tumor necrosis factor-α in a model of herniated disc resorption
9. The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis
10. Expression and localization of 92 kDa type IV collagenase/gelatinase B (MMP-9) in human gliomas
11. Metastatic potential correlates with enzymatic degradation of basement membrane collagen
12. The role of matrix metalloproteinases in autoimmune damage to the central and peripheral nervous system
13. Changes of serum sICAM-1 and MMP-9 induced by rIFNβ-1b treatment in relapsing-remitting MS
14. Serum MMP-9 and TIMP-1 levels are related to MRI activity in relapsing multiple sclerosis
15. Novel regulation of type IV collagenase (matrix metalloproteinase-9 and -2) activities by transforming growth factor-β1 in human prostate cancer cell lines
16. Function of the TIMPs
17. Integrin-mediated signalling of gelatinase B secretion in colon cancer cells
18. Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion
19. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
20. How cells respond to interferons
21. Wherefore interferon?
22. Use of interferon for prevention of hepatocellular carcinoma in cirrhotic patients with hepatitis B or hepatitis C virus infection
23. Inhibition of angiogenesis and vascular tumor growth by interferon-producing cells: A gene therapy approach
24. The treatment of established intracranial tumors by in situ retroviral IFN-γ transfer
25. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
26. STATs and gene regulation
27. Complex roles of Statl in regulating gene expression
28. Regulation of c-myc expression by IFN-γ through Statl-dependent and -independent pathways
29. Transcriptional suppression of matrix metalloproteinase-2 gene expression in human astroglionna cells by TNF-α and IFN-γ
30. High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both α and γ interferons
31. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
32. Transcriptional regulation of intercellular adhesion molecule-1 in astrocytes involves NF-κB and C/EBP isoforms
33. Cytokine regulation of CC and CXC chemokine expression by human astrocytes
34. Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-β Eur
35. Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3lets and AP-1 sequences
36. IFN-γ regulation of the type IV class II transactivator promoter in astrocytes
37. Maximal activation of transcription by Statl and Stat3 requires both tyrosine and serine phospborylation
38. The transcription factors Spl, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells
39. Complementation of a mutant cell line: Central role of the 91 kDa polypeptide of ISGF3 in the interferon-a and -γ signal transduction pathways
40. The antiviral state induced by a interferon and γ interferon requires transcriptionally active Statl protein
41. Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion
42. Inhibition of matrix metalloproteinase 9 expression by a ribozyme blocks metastasis in a rat sarcoma model system
43. Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells
44. Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells
45. Transcriptional activation of the matrix metalloproteinase-9 gene in an H-ras and v-myc transformed rat embryo cell line
46. v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements: A mechanism regulating gene expression independent of that by inflammatory cytokines
47. Transcriptional silencing of perlecan gene expression by interferon-γ
48. Interferon-γ-mediated inhibition of cyclin A gene transcription is independent of individual cis-acting elements in the cyclin A promoter
49. CBP/p300 in cell growth, transformation, and development
50. Co-activators and co-repressors in the integration of transcriptional responses
51. Nuclear receptor coactivators
52. Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300
53. CBP-induced stimulation of c-Fos activity is abrogated by EIA
54. 63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro
55. p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter
56. Cooperation of Stat2 and p300/CBP in signalling induced by interferon-α
57. Differential use of CREB binding protein-coactivator complexes
58. Two contact regions between Stat1 and CBP/p300 in interferon γ signaling
59. Immunology of malignant gliomas
60. Gene transfer of IFN-γ into established brain tumors represses growth by antiangiogenesis
61. Treatment of multiple sclerosis with interferon β
62. Interferon-β inhibits activated leukocyte migration through human brain microvascular endothelial cell monolayer
63. Chemokine-enhanced migration of human peripheral blood mononuclear cells is antagonized by interferon β-1b through an effect on matrix metalloproteinase-9
64. Interferon β-1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase-9
65. MMPI demise spotlights target choice