Specific COX-2 inhibitors in arthritis, oncology, and beyond: Where is the science headed?

Journal of Rheumatology

Volumn 26, Issue SUPPL. 56, 1999, Pages 25-30

  Lipsky, Peter E ^a,b,c,d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b Department of Arthritis Research ^*  (United States)

^c Rheumatic Diseases Division   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; Analgesia; Colorectal cancer; Cyclooxygenase; Inflammation; Ulcer

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR;

ALZHEIMER DISEASE; ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; COLORECTAL CANCER; CONFERENCE PAPER; DRUG EFFECT; HUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION;

ANIMALS; ARTHRITIS; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RESEARCH;

EID: 0032933934     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (9)

1. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for the aspirin-like drugs. Nature 1971;231:232-5.
2. Davies P, Bailey PJ, Goldenberg MM, Ford-Hutchinson AW. The role of arachidonic oxygenation products in pain and inflammation. Annu Rev Immunol 1984;2:335-57.
3. Needleman P, Turk J, Jakschik BA, Morrison AR, Lefkowith JB. Arachidonic acid metabolism. Annu Rev Biochem 1986;55:69-102.
4. Davies, N. Toxicity of nonsteroidal anti-inflammatory drugs in the large intestine. Dis Colon Rectum 1995;38:1311-21.
5. Gutthann SP. Nonsteroidal antiinflammatory drugs and the risk of hospitalization for acute renal failure. Arch Intern Med 1996;156:2433-9.
6. Herschman HR, Xie W, Reddy S. Inflammation, reproduction, cancer and all that.... The regulation and role of the inducible prostaglandin synthase. Bioessays 1995;17:1031-7.
7. Raz A, Wyche A, Siegel N, Needleman P. Regulation of fibroblast cyclooxygenase synthesis by interleukin-1. J Biol Chem 1988;263:3022-8.
8. Raz A, Wyche A, Siegel N, Needleman P. Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases. Proc Natl Acad Sci U S A 1989;86:1657-61.
9. Herschman, H. Prostaglandin synthase 2. Biochim Biophys Acta 1996; 1299:125-40.