Overexpression of cyclin e in the HC11 mouse mammary epithelial cell line is associated with growth inhibition and increased expression of p27Kip1

Cancer Research

Volumn 56, Issue 6, 1996, Pages 1389-1399

  Sgambato, Alessandro ^a,b   Han, Edward Kyu Ho ^a   Zhou, Ping ^a   Schieren, Ira ^a   Weinstein, I Bernard ^a,c  

^a The New York Presbyterian Hospital   (United States)

^b CATHOLIC UNIVERSITY   (Italy)

^c New York State Psychiat Inst and New York Presbyterian Hospital Columbia University Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER GROWTH; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL POPULATION; ENZYME ACTIVITY; EPITHELIUM CELL; GENE EXPRESSION; GENETIC TRANSDUCTION; GROWTH INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BREAST; BREAST NEOPLASMS; CASEINS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TRANSFORMED; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA, COMPLEMENTARY; FEMALE; FIBROBLASTS; G0 PHASE; G1 PHASE; G2 PHASE; GENE EXPRESSION; HUMANS; MAMMARY GLANDS, ANIMAL; MICE; MICE, INBRED BALB C; MICROTUBULE-ASSOCIATED PROTEINS; MOLECULAR WEIGHT; RNA, MESSENGER; S PHASE; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0029947215     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (77)

1. Draetta, G. F Mammalian G1 cyclins Curr Opin. Cell Biol , 6: 842-846, 1994
2. Hunter, T., and Pines, J. Cyclins and cancer II: cyclin D and Cdk inhibitors come of age. Cell, 79: 573-582, 1994.
3. Sherr, C. J. G1 phase progression: cycling on cue. Cell, 79: 551-555, 1994.
4. Heichman, K. A , and Roberts, J. M Rules to replicate by Cell, 79: 557-562, 1994.
5. King, R. W., Jackson, P. K., and Kirschner, M. W. Mitosis in transition. Cell, 79 563-571, 1994.
6. Nurse, P Ordering S phase and M phase in the cell cycle Cell, 79. 547-550, 1994
7. D'Urso, G., Marracino, R., Marshak, D., and Roberts, J. M. Cell cycle control of DNA replication by a homologue from human cells of the p34cdc2 protein kinase Science (Washington DC), 250: 786-791, 1990.
8. Koff, A., Giordano, A., Desai, D., Yamashita, K., Harper, J W., Elledge, S., Nishimoto, T., Morgan, D. O., Franza, B. R., and Roberts, J. M Formation and activation of a cyclin E-Cdk2 complex during the G1 phase of the human cell cycle. Science (Washington DC), 257: 1689-1693, 1992.
9. Jiang, W , Khan, S. M., Zhou, P., Zhang, Y-J., Cacace, A. M., Infante, A. S., Doi, S., Santella, R M., and Weinstein, I. B. Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression. Oncogene, 8: 3447-3457, 1993.
10. Ohtsubo, M., and Roberts, J. M. Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science (Washington DC), 259: 1908-1912, 1993.
11. Quelle, D. E., Ashmun, R A , Shurtleff, S. A., Kato, J Y., Bar-Sagi, D., Roussel, M. F., and Sherr, C. J. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes & Dev , 7: 1559-1571, 1993.
12. Resnitzky, D., Gossen, M , Bujard, H , and Reed, S. 1 Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol. Cell. Biol., 14. 1669-1679, 1994.
13. Wimmel, A , Lucibello, F. C., Sewing, A., Adolph, S., and Muller, R Inducible acceleration of G1 progression through tetracycline-regulated expression of human cyclin E. Oncogene, 9: 995-997, 1994.
14. Baldin, V., Lukas, J., Marcote, M. J., Pagano, M , and Draetta, G. Cyclin D1 is a nuclear protein required for cell cycle progression in G1 Genes & Dev., 7, 101-108, 1993.
15. Lukas, J., Pagano, M., Staskova, Z., Draetta, G., and Bartek, J. Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumor cell lines. Oncogene. 9: 707-718, 1994.
16. Lukas, J., Bartkova, J., Welcker, M., Peterson, O. W., Peters, G., Strauss, M., and Bartek, J. Cyclin D2 is a moderately oscillating nucleoprotein required for G1 phase progression in specific cell types Oncogene, 10: 2125-2134, 1993
17. Ohtsubo, M., Theodoras, A. M , Schumacher, J., Roberts, J. M., and Pagano, M. Human cyclin E. a nuclear protein essential for the G1-to-S phase transition Mol Cell. Biol , 15: 2612-2624, 1995
18. Resnitzky, D., and Reed, S. I. Different roles for cyclins D1 and E in regulation of the G1-to-S transition. Mol. Cell. Biol., 15: 3463-3469, 1995
19. Lukas, J., Muller, H., Bartkova, J , Spitkovsky, D , Kjerulff, A., Jansen-Durr, P , Strauss, M., and Bartek, J. DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1. J. Cell Biol., 125: 625-638, 1994.
20. Tam, S. W , Theodoras, A. M., Shay, J. W., Draetta, G. F., and Pagano. M Differential expression and regulation of cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for cyclin D1 function in G1 progression Oncogene, 9: 2663-2674, 1994
21. Beijersbergen, R. L , Carlee, L., Kerkhoven, R M., and Bernards, R Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes. Genes & Dev. 9 1340-1353, 1995.
22. Li, Y , Graham, C., Lacy, S., Duncan, A. M V., and Whyte, P. The adenovirus E1A-associaied 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. Genes & Dev., 7: 2366-2377, 1993.
23. Koff, A., Cross, F., Fisher, A., Schumacher, J., Leguellec, K., Philippe, M., and Roberts, J. M. Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell, 66: 1217-1228, 1991.
24. Lew, D. J , Dulic, V., and Reed, S. I Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast. Cell, 66: 1197-1206, 1991.
25. Dulic, V., Lees, E., and Reed, S. I Association of human cyclin E with a periodic G1-S phase protein kinase. Science (Washington DC), 257: 1958-1961, 1992.
26. Hatakeyama, M., Brill, J. A., Fink, G. R., and Weinberg, R. A Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein. Genes & Dev., 8: 1759-1771, 1994
27. Hinds, P W , Mittnacht, S., Dulic, V., Arnold, A., Reed, S I., and Weinberg, R. A Regulation of retinoblastoma protein functions by ectopic expression of human cyclins Cell, 70: 993-1006, 1992
28. Pagano, M., Peppertok, R , Verde, F., Ansorge, W , and Draetta, G. Regulation of the human cell cycle by the Cdk2 protein kinase. J. Cell Biol., 121: 101-111, 1993.
29. Tsai, L-H., Lees, E., Faha, B., Harlow, E., and Riabowol, K. The Cdk2 kinase is required for the G1-to-S transition in mammalian cells. Oncogene, 8: 1593-1602, 1993.
30. Weinberg, R. The retinoblastoma protein and cell cycle control. Cell, 81: 323-330, 1995.
31. Elledge, S. J., and Harper, J. W. Cdk inhibitors: on the threshold of checkpoints and development Curr. Opin Cell Biol , 6: 847-852, 1994.
32. Sherr, C. J., and Roberts, J. M Inhibitors of mammalian G1 cyclin-dependent kinases. Genes & Dev., 9: 1149-1163, 1995.
33. MacLachlan, T. K., Sang, N., and Giordano, A. Cyclins, cyclin-dependent kinases and cdk inhibitors implication in cell cycle control and cancer. Crit. Rev. Eukaryotic Gene Expression, 5: 127-156, 1995.
34. Buckley, M. F , Sweeney, K. J , Hamilton, J. A , Sini, R. L., Manning, D. L., Nicholson, R. I , deFazio, A , Watts, C. K. Musgrove, E A., and Sutherland, R. L. Expression and amplification of cyclin genes in human breast cancer. Oncogene, 8: 2127-2133, 1993.
35. Jiang, W., Khan, S. M., Tomita, N., Zhang, Y-J., Lu, S. H , and Weinstein, I. B. Amplification and expression of the human cyclin D gene in esophageal cancer. Cancer Res., 52. 2980-2983, 1992.
36. Jiang, W., Zhang, Y-J., Kahn, S. M., Hollstein, M., Santella, M., Lu, S., Harris, C C., Montesano, R., and Weinstein, I. Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc Natl Acad. Sci. USA. 90: 9026-9030, 1993.
37. Keyomarsi, K , and Pardee, A. B. Redundant cyclin overexpression and gene amplification in breast cancer cells. Proc. Natl. Acad. Sci. USA, 90: 1112-1116, 1993.
38. Leach, F. S., Elledge, S. J., Sherr, C. J., Willson, J. K., Markowitz, S., Kinzler, K. W., and Vogelstein, B. Amplification of cyclin genes in colorectal carcinomas. Cancer Res., 53:, 1986-1989, 1993.
39. Gong, J., Ardelt, B., Traganos, F., and Darzynkiewicz, Z. Unscheduled expression of cyclin B1 and cyclin E in several leukemic and solid tumor cell lines. Cancer Res., 54:, 4285-4288, 1994.
40. Keyomarsi, K., O'Leary, N , Molnar, G , Lees, E., Fingert, H. J., and Pardee, A. B Cyclin E, a potential prognostic marker for breast cancer. Cancer Res., 54: 380-385, 1994.
41. Ball, R K., Friis, R. R., Schoenenberger, C. A., Doppler, W., and Groner, B. Prolactin regulation of β-casein gene expression and of a cytosolic 120-kd protein in a cloned mouse mammary epithelial cell line. EMBO J., 7: 2089-2095, 1988.
42. Stampfer, M. R , and Bartley, J. C. Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene. Proc. Natl Acad. Sci USA, 82: 2394-2398, 1985
43. Caeace, A M., Guadagno, S N , Krauss, R. S., Fabbro, D., and Weinstein, I. B. The epsilon isofortn of protein kinase C is an oncogene when overexpressed in rat fibroblasts. Oncogene, 8: 2095-2104, 1993.
44. Mann, R., Mulligan, R. C., and Baltimore, D Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell, 33. 153-159, 1983.
45. Housey, G. M., Johnson, M. D., Hsiao, W. L W., O'Brian, C. A., Murphy, J. P., Kirschmeier, P., and Weinstein, I. B Overproduction of protein kinase C causes disordered growth control in rat fibroblasts Cell, 52: 343-354, 1988
46. Han, E. K., Sgambato, A , Jiang, W., Zhang, Y. J , Santella, R M., Doki, Y., Cacace, A. M , Schieren, I., and Weinstein, I. B Stable overexpression of cyclin D1 in a human mammary epithelial cell line prolongs the S-phase and inhibits growth. Oncogene, 10: 953-961, 1995
47. Church, G M., and Gilbert, W. Genomic sequencing. Proc. Natl. Acad. Sci. USA, 81: 1991-1995, 1984.
48. Matsushime, H., Quelle, D E., Shurtleff, S. A , Shibuya, M., Sherr, C. J , and Kato, J-Y. D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell Biol., 14:. 2066-2076, 1994.
49. Merlo, G. R., Venesio, T , Taverna, D., Marte, B. M , Callahan, R., and Hynes, N. E. Growth suppression of normal mammary epithelial cells by wild-type p53. Oncogene, 9: 443-453, 1994.
50. Robbins, J., Blondel, B. J., Callahan, D., and Callahan, R Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells J Virol., 66. 2594-2599, 1992.
51. Buchkovich, K., Duffy, L. A., and Harlow, E. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell, 58: 1097-1105, 1989.
52. Damjanov, I., Shan, J., Wang, R. F , Damjanov, A , and DeLoia, J. A. Molecular cloning and characterization of murine cyclin E. Biochem. Biophys. Res. Commun., 201, 994-1000, 1994.
53. Harper, J. W., Adami, G , Wei, N , Keyomarsi, K., and Elledge, S. J. The p21kd Cdk interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 75: 805-816, 1993
54. Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell, 79: 59-66, 1994.
55. Toyoshima, H., and Hunter, T. p27, a novel inhibitor of G1-cyclin-cdk protein kinase activity, is related to p21. Cell, 78: 67-74, 1994.
56. Xiong, Y., Hannon, G. J., Zhang, G. J., Casso, D., Kobayashi, R., and Beach, D. p21 is a universal inhibitor of cyclin kinases Nature (Lond.), 366: 701-704, 1993.
57. Slingerland, J. M , Hengst, L., Pan, C. H., Alexander, D., Stampfer, M. R., and Reed, S. I. A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor β-arrested epithelial cells. Mol. Cell Biol., 14: 3683-3694, 1994.
58. CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes & Dev., 9: 650-662, 1995
59. kip2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes & Dev., 9: 639-649, 1995.
60. Soule, H. D., Maloney, T. M., Wolman, S. R., Peterson, W. D , Brenz, R., McGrath, C. M , Russo, J , Pauly, R J., Jones, R. F., and Brooks, S. C. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. Cancer Res., 50: 6075-6086, 1990.
61. Hackett, A J., Smith, H. S., Springer, E. L., Nelson-Rees, R. B. O. A., Riggs, J. L., and Gardner, M. B. Two syngeneic cell lines from human breast tissue: the aneuploid mammary epithelial (Hs578T) and the diploid myoepithehal (Hs578Bst) cell lines J. Natl Cancer Inst., 58, 1795-1806, 1977.
62. Caron de Fromentel, C., Nardeux, P. C., Soussi, T , Lavialle, C , Estrade, S., Carloni, G., Chandrasekaran, K., and Cassingena, R. Epithelial HBL-100 cell line derived from milk of an apparently healthy woman harbours SV40 genetic information. Exp. Cell Res., 160: 83-94, 1985
63. Happ, B., Hynes, N. E., and Groner, B. Ha-ras and v-raf oncogenes, but not int-2 and c-myc, interfere with the lactogenic hormone dependent activation of the mammary gland specific transcription factor. Cell Growth & Differ., 4: 9-15, 1993.
64. Sewing, A., Ronicke, V., Burger, C., Funk, M., and Muller, R. Alternative splicing of human cyclin E. J. Cell Sci., 107: 581-588, 1994
65. Nakagawa, T., Mabry, M , de Brustos, A., Ihle, J. N., Nelkin, B. D., and Baylin, S B. Introduction of the v-Ha-rus oncogene induces differentiation of cultured human medullary thyroid carcinoma cells. Proc Natl. Acad. Sci. USA, 84: 5923-5927, 1987.
66. Noda, M., Minoru, K., Ogura, A., Liu, D., Amano, T., Takano, T., and Ikawa, Y. Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line. Nature (Lond.), 318: 73-75, 1985
67. Garrido, C., Plaza, S., Gospodarowicz, D., and Saule, S Fos expression induces growth arrest in tumorigenic neuroretina cells Oncogene, 8: 2713-2720, 1993.
68. Balsalobre, A., and Johcoeur, P. Fos proteins can act as negative regulators of cell growth independently of the fos transforming pathway. Oncogene, 11. 455-465, 1995
69. Tsang, T. C , Chang, Y-W., Powell, M. B , Kittelson, J , Meade-Tollin, L., Hendrix, M. J. C , and Bowden, G. T. v-jun oncogene suppresses both phorbol ester-induced cell invasion and stromelysin gene expression in a mouse papilloma cell line. Cancer Res., 54: 882-886, 1994
70. Pietenpol, J. A., Papadopoulos, N., Markowitz, S , Willson, J. K. V , Kinzler, K W , and Vogelstein, B. Paradoxical inhibition of solid tumor cell growth by bcl2. Cancer Res., 54. 3714-3717, 1994.
71. Choi, P., Tchou-Wong, K-M , and Weinstein, I. B. Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression Mol. Cell. Biol., 10: 4650-4657, 1990.
72. Poon, R Y C , Toyoshima, H , and Hunter, T. Redistribution of the CDK inhibitor p27 between different cyclin/CDK complexes in the mouse fibroblasts cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. Mol. Biol. Cell, 6, 1197-1213, 1995.
73. Kip1 in C3H 10T1/2 mouse fibroblasts. Cancer Res , 55. 1413-1416, 1995
74. Firpo, E J , Koff, A., Solomon, M. J., and Roberts, J. M. Inactivation of a Cdk2 inhibitor during Interleukin 2-induced proliferation of human T lymphocytes Mol. Cell Biol., 14: 4889-4901, 1994.
75. p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature (Lond), 372: 570-573, 1994.
76. Koff, A , Ohtsuki, M , Polyak, K , Roberts, J M., and Massagué, J. Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-β. Science (Washington DC), 260: 536-539, 1993.
77. Kip1, a cyclin-cdk inhibitor, links transforming growth factor-β and contact inhibition 10 cell cycle arrest Genes & Dev., 8. 9-22, 1994.