Expression and phosphorylation of the replication regulator protein geminin

Biochemical and Biophysical Research Communications

Volumn 305, Issue 2, 2003, Pages 412-420

  Kulartz, Monika ^a   Kreitz, Sandra ^a   Hiller, Ekkehard ^a   Damoc, Elena Catalina ^a   Przybylski, Michael ^a   Knippers, Rolf ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

Cell cycle; DNA replication; Geminin; Mass spectrometry; Phosphorylation; Replication regulation; Turnover

Indexed keywords

GEMININ; MESSENGER RNA; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA REPLICATION; HALF LIFE TIME; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; REGULATORY MECHANISM;

METAZOA;

EID: 0038705854     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00773-3     Document Type: Article

References (31)

1. McGarry T.J., Kirschner M.W. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell. 93:1998;1043-1053.
2. Wohlschlegel J.A., Dwyer B.T., Dhar S.K., Cvetic C., Walter J.C., Dutta A. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science. 290:2000;2309-2312.
3. Tada S., Li A., Maiorano D., Mechali M., Blow J.J. Repression of origin assembly in metaphase depends on inhibition of RLF- B/Cdt1 by geminin. Nat. Cell Biol. 3:2001;107-113.
4. Ritzi M., Knippers R. Initiation of genome replication: assembly and disassembly of replication-competent chromatin. Gene. 245:2000;13-20.
5. Tye B.K. MCM proteins in DNA replication. Annu. Rev. Biochem. 68:1999;649-686.
6. Bell S.P., Dutta A. DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71:2002;333-374.
7. Stillman B. DNA replication. Genomic views of genome duplication. Science. 294:2001;2301-2304.
8. Ellison V., Stillman B. Opening of the clamp: an intimate view of an ATP-driven biological machine. Cell. 106:2001;655-660.
9. Nishitani H., Lygerou Z. Control of DNA replication licensing in a cell cycle. Genes Cells. 7:2002;523-534.
10. Ishimi Y., Ichinose S., Omori A., Sato K., Kimura H. Binding of human minichromosome maintenance proteins with histone H3. J. Biol. Chem. 271:1996;24115-24122.
11. Mimura S., Takisawa H. Xenopus Cdc45-dependent loading of DNA polymerase α onto chromatin under the control of S-phase Cdk. EMBO J. 17:1998;5699-5707.
12. Sanchez M., Calzada A., Bueno A. The Cdc6 protein is ubiquitinated in vivo for proteolysis in Saccharomyces cerevisiae. J. Biol. Chem. 274:1999;9092-9097.
13. Calzada A., Sanchez M., Sanchez E., Bueno A. The stability of the Cdc6 protein is regulated by cyclin-dependent kinase/cyclin B complexes in Saccharomyces cerevisiae. J. Biol. Chem. 275:2000;9734-9741.
14. Jiang W., Wells N.J., Hunter T. Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. Proc. Natl. Acad. Sci. USA. 96:1999;6193-6198.
15. Petersen B.O., Lukas J., Sorensen C.S., Bartek J., Helin K. Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. EMBO J. 18:1999;396-410.
16. Nishitani H., Taraviras S., Lygerou Z., Nishimoto T. The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. J. Biol. Chem. 276:2001;44905-44911.
17. Quintana D.G., Dutta A. The metazoan origin recognition complex. Front. Biosci. 4:1999;D805-815.
18. DePamphilis M.L. Replication origins in metazoan chromosomes: fact or fiction? Bioessays. 21:1999;5-16.
19. Kelly T.J., Brown G.W. Regulation of chromosome replication. Annu. Rev. Biochem. 69:2000;829-880.
20. Bastians H., Topper L.M., Gorbsky G.L., Ruderman J.V. Cell cycle-regulated proteolysis of mitotic target proteins. Mol. Biol. Cell. 10:1999;3927-3941.
21. Rialland M., Sola F., Santocanale C. Essential role of human CDT1 in DNA replication and chromatin licensing. J. Cell Sci. 115:2002;1435-1440.
22. Kreitz S., Ritzi M., Baack M., Knippers R. The human origin recognition complex protein 1 dissociates from chromatin during S phase in HeLa cells. J. Biol. Chem. 276:2001;6337-6342.
23. Treuner K., Findeisen M., Strausfeld U., Knippers R. Phosphorylation of replication protein A middle subunit (RPA32) leads to a disassembly of the RPA heterotrimer. J. Biol. Chem. 274:1999;15556-15561.
24. Biermann E., Baack M., Kreitz S., Knippers R. Synthesis and turn-over of the replicative Cdc6 protein during the HeLa cell cycle. Eur. J. Biochem. 269:2002;1040-1046.
25. Strausfeld U.P., Howell M., Rempel R., Maller J.L., Hunt T., Blow J.J. Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases. Curr. Biol. 4:1994;876-883.
26. Posewitz M.C., Tempst P. Immobilized gallium(III) affinity chromatography of phosphopeptides. Anal. Chem. 71:1999;2883-2892.
27. Hodgson B., Li A., Tada S., Blow J.J. Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import. Curr. Biol. 12:2002;678-683.
28. Gillespie P.J., Li A., Blow J.J. Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins. BMC Biochem. 2:2001;15.
29. Wold M.S. Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu. Rev. Biochem. 66:1997;61-92.
30. Falquet L., Pagni M., Bucher P., Hulo N., Sigrist C.J., Hofmann K., Bairoch A. The PROSITE database, its status in 2002. Nucleic Acids Res. 30:2002;235-238.
31. Kennelly P.J., Krebs E.G. Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J. Biol. Chem. 266:1991;15555-15558.