Improved bioconversion of 15-fluoro-6-deoxyerythronolide B to 15-fluoro-erythromycin A by overexpression of the eryK gene in Saccharopolyspora erythraea

Biotechnology Progress

Volumn 20, Issue 6, 2004, Pages 1660-1665

  Desai, Ruchir P ^a   Rodriguez, Eduardo ^a   Galazzo, Jorge L ^a   Licari, Peter ^a  

^a KOSAN BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOREACTORS; CHROMOSOMES; DRUG PRODUCTS; ENZYME KINETICS; FEEDING; STRAIN;

BRANCH POINTS; FEED RATES; KETOSYNTHASE; MOLAR RATIO;

BIOCONVERSION;

BACTERIAL PROTEIN; CYTOCHROME P450; DRUG DERIVATIVE; ERYK PROTEIN, SACCHAROPOLYSPORA ERYTHRAEA; ERYTHROMYCIN; ERYTHRONOLIDE B; MIXED FUNCTION OXIDASE; RECOMBINANT PROTEIN;

ARTICLE; BIOSYNTHESIS; BIOTRANSFORMATION; CLASSIFICATION; COMPARATIVE STUDY; EVALUATION; GENE EXPRESSION REGULATION; GENETIC ENHANCEMENT; GENETICS; METABOLISM; METHODOLOGY; PHYSIOLOGY; SACCHAROPOLYSPORA; SPECIES DIFFERENCE;

BACTERIAL PROTEINS; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; ERYTHROMYCIN; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC ENHANCEMENT; MIXED FUNCTION OXYGENASES; RECOMBINANT PROTEINS; SACCHAROPOLYSPORA; SPECIES SPECIFICITY;

SACCHAROPOLYSPORA; SACCHAROPOLYSPORA ERYTHRAEA;

EID: 10044258574     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp0497435     Document Type: Article

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