Phytoestrogens may improve the pregnancy rate in in vitro fertilization-embryo transfer cycles: A prospective, controlled, randomized trial

Fertility and Sterility

Volumn 82, Issue 6, 2004, Pages 1509-1513

  Unfer, Vittorio ^a   Casini, Maria Luisa ^b   Gerli, Sandro ^c   Costabile, Loredana ^a   Mignosa, Marcella ^c   Di Renzo, Gian Carlo ^c  

^a AGUNCO Obstet and Gynecol Ctr   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c Department of Gynecological   (Italy)

Author keywords

IVF ET cycles; luteal phase support; Phytoestrogens; progesterone

Indexed keywords

CHORIONIC GONADOTROPIN; GONADORELIN AGONIST; PHYTOESTROGEN; PLACEBO; PROGESTERONE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOWN REGULATION; ECHOGRAPHY; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HEART BEAT; HUMAN; INFERTILITY; LUTEAL PHASE; MAJOR CLINICAL STUDY; OOCYTE; OUTCOMES RESEARCH; PREGNANCY RATE; PREGNANCY TEST; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; UNIVERSITY HOSPITAL;

ADULT; DELIVERY, OBSTETRIC; DRUG THERAPY, COMBINATION; EMBRYO IMPLANTATION; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HUMANS; INFERTILITY, FEMALE; INJECTIONS, INTRAMUSCULAR; LUTEAL PHASE; PHYTOESTROGENS; PREGNANCY; PREGNANCY RATE; PROGESTERONE; PROSPECTIVE STUDIES; TABLETS;

EID: 10044248766     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2004.07.934     Document Type: Article

References (38)

1. R.J. Paulson, M.V. Sauer, R.A. Lobo Factors affecting embryo implantation after human in vitro fertilization: a hypothesis Am J Obstet Gynecol 163 1990 2020 2023
2. D. Valbuena, M. Jasper, J. Remohi, A. Pellicer, C. Simon Ovarian stimulation and endometrial receptivity Hum Reprod 14 Suppl 2 1999 107 111
3. J. Bongaarts A method for the estimation of fecundability Demography 12 1975 645 660
4. A. Abate, A. Brigand, L. Costabile, F.G. Abate, E. Balzano, M. Perino 17-alpha-hydroxyprogesyerone caproate and natural progesterone in assisted reproduction: a comparative study Clin Exp Obstet Gynecol 24 1997 190 192
5. T.C. Li, I.D. Cooke Evaluation of the luteal phase Hum Reprod 6 1991 484 499
6. M.C. Macnamee, R.G. Edwards, C.M. Howles The influence of stimulation regimes and luteal phase support on the outcome of IVF Hum Reprod 3 Suppl 2 1988 43 52
7. E.A. Pritts, A.K. Atwood Luteal phase support in infertility treatment: a meta-analysis of the randomized trials Hum Reprod 17 2002 2287 2299
8. M. Ludwig, K. Diedrich Evaluation of an optimal luteal phase support protocol in IVF Acta Obstet Gynecol Scand 80 2001 452 466
9. C. Posaci, J. Smitz, M. Camus, K. Osmanagaoglu, P. Devroey Progesterone for the luteal support of assisted reproductive technologies: clinical options Hum Reprod 15 Suppl 1 2000 129 148
10. A. Tavaniotou, J. Smitz, C. Bourgain, P. Devroey Comparison between different routes of progesterone administration as luteal phase support in infertility treatments Hum Reprod Update 6 2000 139 148
11. P.G. Artini, A. Volpe, S. Angioni, M.C. Galassi, C. Battaglia, A.R. Genazzani A comparative, randomized study of three different progesterone support of the luteal phase following IVF/ET program J Endocrinol Invest 18 1995 51 56
12. K.A. Hutchinson-Williams, B. Lunenfeld, M.P. Diamond, G. Lavy, S.P. Boyers, A.H. DeCherney Human chorionic gonadotropin, estradiol, and progesterone profiles in conception and nonconception cycles in an in vitro fertilization program Fertil Steril 52 1989 441 445
13. A. Herman, A. Raziel, D. Strassburger, Y. Soffer, I. Bukovsky, R. Ron-El The benefits of mid-luteal addition of human chorionic gonadotrophin in in-vitro fertilization using a down-regulation protocol and luteal support with progesterone Hum Reprod 11 1996 1552 1557
14. J.S. Younis, V.Y. Ezra, Y. Sherman, A. Simon, J.G. Schenker, N. Laufer The effect of estradiol depletion during the luteal phase on endometrial development Fertil Steril 62 1994 103 107
15. D.H. Edgar Oestrogen and human implantation Hum Reprod 10 1995 2 4
16. D.D. Baird, A.J. Wilcox, C.R. Weinberg, F. Kamel, D.R. McConnaoughey, P.I. Musey Preimplantation hormonal differences between the conception and non-conception menstrual cycles of 32 normal women Hum Reprod 12 1997 2607 2613
17. D.R. Stewart, J.W. Overstreet, S.T. Nakajima, B.L. Lasley Enhanced ovarian steroid secretion before implantation in early human pregnancy J Clin Endocrinol Metab 76 1993 1470 1476
18. S.F. Lipson, P.T. Ellison Comparison of salivary steroid profiles in naturally occurring conception and non-conception cycles Hum Reprod 11 1996 2090 2096
19. J.S. Younis, A. Simon, N. Laufer Endometrial preparation: lessons from oocyte donation Fertil Steril 66 1996 873 884
20. K.A. Hutchinson-Williams, B. Lunenfeld, M.P. Diamond, G. Lavy, S.P. Boyers, A.H. DeCherney Human chorionic gonadotropin, estradiol, and progesterone profiles in conception and nonconception cycles in an in vitro fertilization program Fertil Steril 52 1989 441 445
21. K. Hutchinson-Williams, A. Decherney, G. Lavy, M.P. Diamond, F. Naftolin, B. Lunenfeld Luteal rescue in in vitro fertilization-embryo transfer Fertil Steril 3 1990 495 501
22. J.C. Emperaire, A. Ruffie, A.J. Audebert, A. Verdauger Early prognosis for IVF pregnancies through plasma estrogen Lancet 2 1984 1151 1155
23. N. Laufer, D. Navot, J.G. Schenker The pattern of luteal phase plasma progesterone and estradiol in fertile cycles Am J Obstet Gynecol 143 1982 808 813
24. X. Xu, H.J. Wang, P.A. Murphy, S. Hendrich Neither background diet nor type of soy food affects short-term isoflavone bioavailability in women J Nutr 130 2000 798 801
25. H. Adlercreutz Phyto-oestrogens and cancer Lancet Oncol 3 2002 364 373
26. S. Barnes, T.G. Peterson, L. Coward Rationale for the use of genistein-containing soy matrices in chemoprevention trials for breast and prostate cancer J Cell Biochem Suppl 22 1995 181 187
27. K. Morito, T. Aomori, T. Hirose, J. Kinjo, J. Hasegawa, S. Ogawa Interaction of phytoestrogens with estrogen receptors alpha and beta (II) Biol Pharm Bull 25 2002 48 52
28. V. Unfer, M.L. Casini, L. Costabile, M. Mignosa, S. Gerli, G.C. Di Renzo High dose of phytoestrogens can reverse the antiestrogenic effects of clomiphene citrate on the endometrium in patients undergoing intrauterine insemination: a randomized trial J Soc Gynecol Invest 11 2004 323 328
29. J.L. Balk, D.A. Whiteside, G. Naus, E. DeFerrari, J.M. Roberts A pilot study of the effects of phytoestrogen supplementation on postmenopausal endometrium J Soc Gynecol Investig 9 2002 238 242
30. M. Penotti, E. Fabio, A.B. Modena, M. Rinaldi, U. Omodei, P. Vigano Effect of soy-derived isoflavones on hot flushes, endometrial thickness, and the pulsatility index of the uterine and cerebral arteries Fertil Steril 79 2003 1112 1117
31. D.H. Upmalis, R. Lobo, L. Bradley, M. Warren, F.L. Cone, C.A. Lamia Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study [erratum in: Menopause 2000;7:422] Menopause 7 2000 236 242
32. V. Unfer, M.L. Casini, L. Costabile, M. Mignosa, S. Gerli, G.C. Di Renzo Endometrial effects of long term treatment with phytoestrogens: a randomized, double blind, placebo controlled study Fertil Steril 82 2004 145 148
33. A.C. Pike, A.M. Brzozowski, R.E. Hubbard, T. Bonn, A.G. Thorsell, O. Engstrom Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist EMBO J 18 1999 4608 4618
34. T. Barkhem, B. Carlsson, Y. Nilsson, E. Enmark, J. Gustafsson, S. Nilsson Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists Mol Pharmacol 54 1998 105 112
35. B.S. Katzenellenbogen, J.A. Katzenellenbogen Estrogen receptor transcription and transactivation: estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer Breast Cancer Res 2 2000 335 344
36. S.O. Mueller Overview of in vitro tools to assess the estrogenic and antiestrogenic activity of phytoestrogens J Chromatogr B Analyt Technol Biomed Life Sci 777 2002 155 165
37. V. Krishnan, H. Heath, H.U. Bryant Mechanism of action of estrogens and selective estrogen receptor modulators Vitam Horm 60 2000 123 147
38. K.C. Reinhart, R.K. Dubey, P.J. Keller, U. Lauper, M. Rosselli Xeno-oestrogens and phyto-oestrogens induce the synthesis of leukaemia inhibitory factor by human and bovine oviduct cells Mol Hum Reprod 5 1999 899 907