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Volumn 6, Issue 3, 2004, Pages 169-180

Could mitochondrial DNA quantitation be a surrogate marker for drug mitochondrial toxicity?

Author keywords

HIV; Hyperlactatemia; Lipoatrophy; Mitochondrial DNA; Nucleoside reverse transcriptase inhibitors

Indexed keywords

ABACAVIR; ADEFOVIR; ANTIRETROVIRUS AGENT; DIDANOSINE; DNA DIRECTED DNA POLYMERASE GAMMA; EFAVIRENZ; EMTRICITABINE; LAMIVUDINE; MITOCHONDRIAL DNA; NUCLEOSIDE ANALOG; RIBAVIRIN; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; TENOFOVIR; ZALCITABINE; ZIDOVUDINE;

EID: 10044232783     PISSN: 11396121     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (31)

References (96)
  • 1
    • 0034493575 scopus 로고    scopus 로고
    • Symptomatic hyperlactatemia: An emerging complication of antiretroviral therapy
    • Gerard Y, Maulin L, Yazdanpanah Y, et al. Symptomatic hyperlactatemia: an emerging complication of antiretroviral therapy. AIDS 2000;14:2723-30.
    • (2000) AIDS , vol.14 , pp. 2723-2730
    • Gerard, Y.1    Maulin, L.2    Yazdanpanah, Y.3
  • 2
    • 0037045058 scopus 로고    scopus 로고
    • Increased long-term mitochondrial toxicity in combinations of nucleoside analogues reverse transcriptase inhibitors
    • Walker U, Setzer B, Venhoff N. Increased long-term mitochondrial toxicity in combinations of nucleoside analogues reverse transcriptase inhibitors. AIDS 2002;16:2165-73.
    • (2002) AIDS , vol.16 , pp. 2165-2173
    • Walker, U.1    Setzer, B.2    Venhoff, N.3
  • 3
    • 0036235237 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and antiretroviral nucleoside analogues toxicities: What is the evidence?
    • Dagan T, Sable C, Bray J, et al. Mitochondrial dysfunction and antiretroviral nucleoside analogues toxicities: what is the evidence? Mitochondrion 2002;1:397-412.
    • (2002) Mitochondrion , vol.1 , pp. 397-412
    • Dagan, T.1    Sable, C.2    Bray, J.3
  • 4
    • 1342310769 scopus 로고    scopus 로고
    • Antiretroviral nucleoside and nucleotide analogues and mitochondria
    • Cossarizza A, Moyle G. Antiretroviral nucleoside and nucleotide analogues and mitochondria. AIDS 2004;18:137-51.
    • (2004) AIDS , vol.18 , pp. 137-151
    • Cossarizza, A.1    Moyle, G.2
  • 5
    • 0032576724 scopus 로고    scopus 로고
    • Energy transduction in ATP synthase
    • Elston T, Wang H, Oster G. Energy transduction in ATP synthase. Nature 1998;391:510-3.
    • (1998) Nature , vol.391 , pp. 510-513
    • Elston, T.1    Wang, H.2    Oster, G.3
  • 7
    • 0035851098 scopus 로고    scopus 로고
    • Exoruclease proofreading by human mitochondrial DNA polymerase
    • Johnson A, Johnson K. Exoruclease proofreading by human mitochondrial DNA polymerase. J Biol Chem 2001;276:38097-107.
    • (2001) J. Biol. Chem. , vol.276 , pp. 38097-38107
    • Johnson, A.1    Johnson, K.2
  • 8
    • 0037972522 scopus 로고    scopus 로고
    • Mitochondrial respiratory chain diseases
    • Di Mauro S, Schon F. Mitochondrial respiratory chain diseases. N Engl J Med 2003;348:2656-68.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 2656-2668
    • Di Mauro, S.1    Schon, F.2
  • 9
    • 0030917702 scopus 로고    scopus 로고
    • Impaired mitochondrial function in microvesicular steatosis. Effects of drugs, ethanol, hormones and cytokines
    • Fromenty B, Pessayre D. Impaired mitochondrial function in microvesicular steatosis. Effects of drugs, ethanol, hormones and cytokines. J Hepatol 1997;26:43-53.
    • (1997) J. Hepatol. , vol.26 , pp. 43-53
    • Fromenty, B.1    Pessayre, D.2
  • 10
    • 0038025371 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in the elderly: Possible role in insulin resistance
    • Petersen K, Befroy D, Dufour S, et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 2003; 300:1140-2.
    • (2003) Science , vol.300 , pp. 1140-1142
    • Petersen, K.1    Befroy, D.2    Dufour, S.3
  • 11
    • 0032189850 scopus 로고    scopus 로고
    • Adverse effects of reverse transcriptase inhibitors: Mitochondrial toxicity as a common pathway
    • Brinkman K, Ter Hofstede H, Burger D, et al. Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as a common pathway. AIDS 1998;12:1735-44.
    • (1998) AIDS , vol.12 , pp. 1735-1744
    • Brinkman, K.1    Ter Hofstede, H.2    Burger, D.3
  • 12
    • 0033396957 scopus 로고    scopus 로고
    • Fat distribution and metabolic changes in patients with HIV infection
    • Safrin S, Grunfeld C. Fat distribution and metabolic changes in patients with HIV infection. AIDS 1999;13:2493-505.
    • (1999) AIDS , vol.13 , pp. 2493-2505
    • Safrin, S.1    Grunfeld, C.2
  • 13
    • 0034033584 scopus 로고    scopus 로고
    • Mitochondrial toxicity of nucleoside reverse transcriptase inhibitors: A looming obstacle for long-term antiretroviral therapy?
    • Brinkman K, Kakuda T. Mitochondrial toxicity of nucleoside reverse transcriptase inhibitors: a looming obstacle for long-term antiretroviral therapy? Curr Opin Infect Dis 2000;13:5-11.
    • (2000) Curr. Opin. Infect. Dis. , vol.13 , pp. 5-11
    • Brinkman, K.1    Kakuda, T.2
  • 14
    • 0043156458 scopus 로고    scopus 로고
    • Polyphenotypic expression of mitochondrial toxicity caused by nucleoside reverse transcriptase inhibitors
    • Miller R, Shahmonesh M, Hanna M, et al. Polyphenotypic expression of mitochondrial toxicity caused by nucleoside reverse transcriptase inhibitors. Antiviral Ther 2003;8:253-7.
    • (2003) Antiviral Ther. , vol.8 , pp. 253-257
    • Miller, R.1    Shahmonesh, M.2    Hanna, M.3
  • 15
    • 0038215451 scopus 로고    scopus 로고
    • Structural determinants in human DNA polymerase y account for mitochondrial toxicity from nucleoside analogs
    • Lim S, Ponamerev M, Longley M, Copeland W. Structural determinants in human DNA polymerase y account for mitochondrial toxicity from nucleoside analogs. J Mol Biol 2003:329;45-57.
    • (2003) J. Mol. Biol. , vol.329 , pp. 45-57
    • Lim, S.1    Ponamerev, M.2    Longley, M.3    Copeland, W.4
  • 16
    • 3042726798 scopus 로고    scopus 로고
    • Treatment for adult HIV infection: 2004 recommendations of the International AIDS Society-USA Panel
    • Yeni P, Hammer S, Hirsch M, et al. Treatment for adult HIV infection: 2004 recommendations of the International AIDS Society-USA Panel. JAMA 2004;292:251-65.
    • (2004) JAMA , vol.292 , pp. 251-265
    • Yeni, P.1    Hammer, S.2    Hirsch, M.3
  • 17
    • 0028148674 scopus 로고
    • Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis
    • Martin J, Brown C, Matthews-Davis N, et al. Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis. Antimicrob Agents Chemother 1994;38: 2743-9.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 2743-2749
    • Martin, J.1    Brown, C.2    Matthews-Davis, N.3
  • 18
    • 0028990381 scopus 로고
    • Mitochondrial toxicity of antiretroviral drugs
    • Lewis W, Dalakas M. Mitochondrial toxicity of antiretroviral drugs. Nat Med 1995;1:417-22.
    • (1995) Nat. Med. , vol.1 , pp. 417-422
    • Lewis, W.1    Dalakas, M.2
  • 19
    • 0033935975 scopus 로고    scopus 로고
    • Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity
    • Kakuda T. Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity. Clin Ther 2000;22:685-708.
    • (2000) Clin. Ther. , vol.22 , pp. 685-708
    • Kakuda, T.1
  • 20
    • 0036174438 scopus 로고    scopus 로고
    • Assessment of mitochondrial toxicity in human cells treated with tenofovir: Comparison with other nucleoside reverse transcriptase inhibitors
    • Birkus G, Hitchcock M, Cihlar T. Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother 2002;46:716-23.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 716-723
    • Birkus, G.1    Hitchcock, M.2    Cihlar, T.3
  • 21
    • 1642420304 scopus 로고    scopus 로고
    • Relationship between antiviral activity and host toxicity: Comparison of the incorporation efficiencies of 2′, 3′-dideoxy-5-fluoro-3′-thiacytidine-triphosphate analogs by HIV-1 reverse transcriptase and human mitochondrial DNA polymerase
    • Feng J, Murakami E, Zorca S, et al. Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2′, 3′-dideoxy-5-fluoro-3′-thiacytidine-triphosphate analogs by HIV-1 reverse transcriptase and human mitochondrial DNA polymerase. Antimicrob Agents Chemother 2004;48:1300-6.
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 1300-1306
    • Feng, J.1    Murakami, E.2    Zorca, S.3
  • 22
    • 0025274663 scopus 로고
    • Mitochondrial myopathy caused by long-term zidovudine toxicity
    • Dalakas M, IIIa I, Pezehkpour G, et al. Mitochondrial myopathy caused by long-term zidovudine toxicity. N Engl J Med 1990; 322:1098-105.
    • (1990) N. Engl. J. Med. , vol.322 , pp. 1098-1105
    • Dalakas, M.1    Illa, I.2    Pezehkpour, G.3
  • 23
    • 0026028226 scopus 로고
    • Depletion of muscle mitochondrial DNA in AIDS patient with zidovudine-induced myopathy
    • Arnudo E, Dalakas M, Shanske S, et al. Depletion of muscle mitochondrial DNA in AIDS patient with zidovudine-induced myopathy Lancet 1991;337:508-10.
    • (1991) Lancet , vol.337 , pp. 508-510
    • Arnudo, E.1    Dalakas, M.2    Shanske, S.3
  • 24
    • 0027417551 scopus 로고
    • Mitochondrial myopathy associated with chronic zidovudine therapy in AIDS
    • Peters B, Winer J, Landon D, et al. Mitochondrial myopathy associated with chronic zidovudine therapy in AIDS. Q J Med 1993;86:5-15.
    • (1993) Q. J. Med. , vol.86 , pp. 5-15
    • Peters, B.1    Winer, J.2    Landon, D.3
  • 25
    • 0043136476 scopus 로고    scopus 로고
    • Lactic acidosis related to nucleoside therapy in HIV-infected patients
    • Falcó V, Crespo M, Ribera E. Lactic acidosis related to nucleoside therapy in HIV-infected patients. Expert Coin Pharmacother 2003;4:1321-9.
    • (2003) Expert Opin. Pharmacother. , vol.4 , pp. 1321-1329
    • Falcó, V.1    Crespo, M.2    Ribera, E.3
  • 26
    • 3543075654 scopus 로고    scopus 로고
    • Fatal lactic acidosis associated with co-administration of didanosine and tenofovir disoproxil fumarate
    • Guo Y, Fung H. Fatal lactic acidosis associated with co-administration of didanosine and tenofovir disoproxil fumarate. Pharmacotherapy 2004;24:1089-94.
    • (2004) Pharmacotherapy , vol.24 , pp. 1089-1094
    • Guo, Y.1    Fung, H.2
  • 27
    • 0141548239 scopus 로고    scopus 로고
    • Incidence of symptomalic hyperlactatemia in HIV-infected adults on NRTI
    • 9th Conference on Retrovirus and Opportunistic Infections. Seattle [abstract 35]
    • Lonergan J, Havlir D, Barber E, et al. Incidence of symptomalic hyperlactatemia in HIV-infected adults on NRTI. 9th Conference on Retrovirus and Opportunistic Infections. Seattle 2002 [abstract 35].
    • (2002)
    • Lonergan, J.1    Havlir, D.2    Barber, E.3
  • 28
    • 0036152744 scopus 로고    scopus 로고
    • Hyperlactatemia syndromes in people with HIV infection
    • John M, Mallal S. Hyperlactatemia syndromes in people with HIV infection. Curr Opin Infect Dis 2002;15:23-9.
    • (2002) Curr. Opin. Infect. Dis. , vol.15 , pp. 23-29
    • John, M.1    Mallal, S.2
  • 29
    • 10044293668 scopus 로고    scopus 로고
    • Natural history of sustained hyperlactatemia in HIV-infected subjects
    • 43rd ICAAC Chicago [abstract H-1955]
    • McComsey G, Yau L. Natural history of sustained hyperlactatemia in HIV-infected subjects. 43rd ICAAC. Chicago 2003 [abstract H-1955].
    • (2003)
    • McComsey, G.1    Yau, L.2
  • 30
    • 2342425409 scopus 로고    scopus 로고
    • Asymptomatic hyperlactatemia: Predictive value, natural history and correlates
    • McComsey G. Asymptomatic hyperlactatemia: predictive value, natural history and correlates. Antiviral Ther 2004;9:205-12.
    • (2004) Antiviral Ther. , vol.9 , pp. 205-212
    • McComsey, G.1
  • 31
    • 4444325849 scopus 로고    scopus 로고
    • Mitochondrial dysfunction: Patient monitoring and toxicity management
    • McComsey G, Lonergan T, Mitochondrial dysfunction: patient monitoring and toxicity management. J Acquir Immun Defic Syndr 2004;37(Suppl):30-5.
    • (2004) J. Acquir. Immun. Defic. Syndr. , vol.37 , Issue.SUPPL. , pp. 30-35
    • McComsey, G.1    Lonergan, T.2
  • 32
    • 0032493043 scopus 로고    scopus 로고
    • A syndrome of peripheral lipodystrophy, hyperlipidemia and insulin resistance in patients receiving HIV protease inhibitors
    • Carr A, Samaras K, Burton S, et al. A syndrome of peripheral lipodystrophy, hyperlipidemia and insulin resistance in patients receiving HIV protease inhibitors. AIDS 1998;12:51-8.
    • (1998) AIDS , vol.12 , pp. 51-58
    • Carr, A.1    Samaras, K.2    Burton, S.3
  • 33
    • 0033545441 scopus 로고    scopus 로고
    • Redistribution of body fat in HIV-infected women undergoing combined antiretroviral therapy
    • Gervasoni C, Ridolfo A, Trifiro G, et al. Redistribution of body fat in HIV-infected women undergoing combined antiretroviral therapy. AIDS 1999;13:465-72.
    • (1999) AIDS , vol.13 , pp. 465-472
    • Gervasoni, C.1    Ridolfo, A.2    Trifiro, G.3
  • 34
    • 0035951473 scopus 로고    scopus 로고
    • Lipodystrophy in HIV-1 infected patients treated with protease inhibitors: A prospective cohort
    • Heath K, Hogg R, Chan K, et al. Lipodystrophy in HIV-1 infected patients treated with protease inhibitors: a prospective cohort. AIDS 2001;15:231-40.
    • (2001) AIDS , vol.15 , pp. 231-240
    • Heath, K.1    Hogg, R.2    Chan, K.3
  • 35
    • 0038204340 scopus 로고    scopus 로고
    • HIV lipodystrophy: Risk factors, pathogenesis, diagnosis and management
    • Carr A. HIV lipodystrophy: risk factors, pathogenesis, diagnosis and management. AIDS 2003;17(Suppl):141-8.
    • (2003) AIDS , vol.17 , Issue.SUPPL. , pp. 141-148
    • Carr, A.1
  • 36
    • 18044376212 scopus 로고    scopus 로고
    • Lipodystrophy, metabolic disorders, and HIV infection: Aquitaine cohort, France 1999
    • Thiebaut R, Daucourt V, Mercie P, et al. Lipodystrophy, metabolic disorders, and HIV infection: Aquitaine cohort, France 1999. Clin Infect Dis 2000;31:1482-7.
    • (2000) Clin. Infect. Dis. , vol.31 , pp. 1482-1487
    • Thiebaut, R.1    Daucourt, V.2    Mercie, P.3
  • 37
    • 0035134609 scopus 로고    scopus 로고
    • Metabolic abnormalities and cardiovascular disease risk factors in adults with HIV infection and lipodystrophy
    • Hadigan C, Meigs J, Corcoran C, et al. Metabolic abnormalities and cardiovascular disease risk factors in adults with HIV infection and lipodystrophy. Clin Infect Dis 2001;32:1045-52.
    • (2001) Clin. Infect. Dis. , vol.32 , pp. 1045-1052
    • Hadigan, C.1    Meigs, J.2    Corcoran, C.3
  • 39
    • 0030818613 scopus 로고    scopus 로고
    • Protease inhibitors associated hyperglycaemia
    • Dube M, Johnson D, Currier J, Leedom J. Protease inhibitors associated hyperglycaemia. Lancet 1997;350:713-34.
    • (1997) Lancet , vol.350 , pp. 713-734
    • Dube, M.1    Johnson, D.2    Currier, J.3    Leedom, J.4
  • 41
    • 0035941778 scopus 로고    scopus 로고
    • Risk of lipodystrophy in HIV-1 infected patients treated with protease inhibitors: A prospective cohort study
    • Martínez E, Mocroft A, García-Viejo M, et al. Risk of lipodystrophy in HIV-1 infected patients treated with protease inhibitors: a prospective cohort study. Lancet 2001;357:592-8.
    • (2001) Lancet , vol.357 , pp. 592-598
    • Martínez, E.1    Mocroft, A.2    García-Viejo, M.3
  • 42
    • 0033391005 scopus 로고    scopus 로고
    • A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside therapy
    • Saint-Marc T, Partisani M, Poizot-Martin I, et al. A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside therapy. AIDS 1999;13:1659-67.
    • (1999) AIDS , vol.13 , pp. 1659-1667
    • Saint-Marc, T.1    Partisani, M.2    Poizot-Martin, I.3
  • 43
    • 0034008520 scopus 로고    scopus 로고
    • A syndrome of lipoatrophy, lactic academia and liver dysfunction associated with HIV nucleoside analogue therapy: Contribution to protease inhibitor related lipodystrophy syndrome
    • Carr A, Miller J, Law M, Cooper D. A syndrome of lipoatrophy, lactic academia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor related lipodystrophy syndrome. AIDS 2000;14:25-32.
    • (2000) AIDS , vol.14 , pp. 25-32
    • Carr, A.1    Miller, J.2    Law, M.3    Cooper, D.4
  • 44
    • 0037013085 scopus 로고    scopus 로고
    • Lipodystrophy body-shape changes in a patient undergoing zidovudine monotherapy
    • García-Benayas T, Blanco F, Gómez-Viera J, et al. Lipodystrophy body-shape changes in a patient undergoing zidovudine monotherapy. AIDS 2002;16:1087-9.
    • (2002) AIDS , vol.16 , pp. 1087-1089
    • García-Benayas, T.1    Blanco, F.2    Gómez-Viera, J.3
  • 45
    • 2342589533 scopus 로고    scopus 로고
    • Reversibility of lipoatrophy in HIV-infected patients 2 years after switching from a thymidine analogue to abacavir: The MITOX Extension Study
    • Martin A, Smith D, Carr A, et al. Reversibility of lipoatrophy in HIV-infected patients 2 years after switching from a thymidine analogue to abacavir: the MITOX Extension Study. AIDS 2004;18:1029-36.
    • (2004) AIDS , vol.18 , pp. 1029-1036
    • Martin, A.1    Smith, D.2    Carr, A.3
  • 46
    • 0038644532 scopus 로고    scopus 로고
    • A 48-week, randomized, open-label comparison of three abacavir-based substitution approaches in the management of dyslipidemia and peripheral lipoatrophy
    • Moyle G, Baldwin C, Langroudi B, Mandalia S, Gazzard B. A 48-week, randomized, open-label comparison of three abacavir-based substitution approaches in the management of dyslipidemia and peripheral lipoatrophy. J Acquir Immun Defic Syndr 2003; 33:22-8.
    • (2003) J. Acquir. Immun. Defic. Syndr. , vol.33 , pp. 22-28
    • Moyle, G.1    Baldwin, C.2    Langroudi, B.3    Mandalia, S.4    Gazzard, B.5
  • 47
    • 3042734983 scopus 로고    scopus 로고
    • Prevalence of lipoatrophy and mitochondrial DNA content of blood and subcutaneous fat in HIV-1-infected patients randomly allocated to zidovudine- or stavudine-based therapy
    • Van der Valk M, Casula M, Weverling G, et al. Prevalence of lipoatrophy and mitochondrial DNA content of blood and subcutaneous fat in HIV-1-infected patients randomly allocated to zidovudine- or stavudine-based therapy. Antiviral Thor 2004;9:385-93.
    • (2004) Antiviral Ther. , vol.9 , pp. 385-393
    • Van der Valk, M.1    Casula, M.2    Weverling, G.3
  • 48
    • 10044238465 scopus 로고    scopus 로고
    • The role of nucleoside reverse transcriptase inhibitors in the fat redistribution syndrome
    • Nolan D, Mallal S The role of nucleoside reverse transcriptase inhibitors in the fat redistribution syndrome. J HIV Ther 2004;9:34-40.
    • (2004) J. HIV Ther. , vol.9 , pp. 34-40
    • Nolan, D.1    Mallal, S.2
  • 49
    • 0242500956 scopus 로고    scopus 로고
    • First-line therapy and mitochandrial damage: Different nucleosides, different findings
    • Blanco F, García-Benayas T, De la Cruz J, et al. First-line therapy and mitochandrial damage: different nucleosides, different findings. HIV Clin Trials 2003;4:11-9.
    • (2003) HIV Clin. Trials , vol.4 , pp. 11-19
    • Blanco, F.1    García-Benayas, T.2    De la Cruz, J.3
  • 50
    • 0037964275 scopus 로고    scopus 로고
    • Replacing stavudine by abacavir reduces lactate levels and may improve lipoatrophy
    • García-Benayas T, Blanco F, De la Cruz J, et al. Replacing stavudine by abacavir reduces lactate levels and may improve lipoatrophy. AIDS 2003;17:921-4.
    • (2003) AIDS , vol.17 , pp. 921-924
    • García-Benayas, T.1    Blanco, F.2    De la Cruz, J.3
  • 51
    • 3042848853 scopus 로고    scopus 로고
    • Efficacy and safety of tenofovir DF vs. stavudine in combination therapy in antiretroviral-naive patients: A 3-year randomized trial
    • Gallant J, Staszewski S, Pozniak A, et al. Efficacy and safety of tenofovir DF vs. stavudine in combination therapy in antiretroviral-naive patients: a 3-year randomized trial. JAMA 2004;292:191-201.
    • (2004) JAMA , vol.292 , pp. 191-201
    • Gallant, J.1    Staszewski, S.2    Pozniak, A.3
  • 52
    • 0037076029 scopus 로고    scopus 로고
    • Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients
    • Cote H, Zabrina D, Brumme L, et al. Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients. N Engl J Med 2002;346:811-20.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 811-820
    • Cote, H.1    Zabrina, D.2    Brumme, L.3
  • 53
    • 0038046118 scopus 로고    scopus 로고
    • Depletion of mitochondrial DNA in HIV-1 infected patients and its amelioration by antiretroviral therapy
    • Miura T, Goto M, Hosoya N, et al. Depletion of mitochondrial DNA in HIV-1 infected patients and its amelioration by antiretroviral therapy. J Med Virol 2003;70:497-505.
    • (2003) J. Med. Virol. , vol.70 , pp. 497-505
    • Miura, T.1    Goto, M.2    Hosoya, N.3
  • 54
    • 1842502612 scopus 로고    scopus 로고
    • Changes in mitochondrial DNA copy number in blood cells from HIV-infected patients undergoing antiretroviral therapy
    • De Mendoza C, De Ronde A, Smolders K, et al. Changes in mitochondrial DNA copy number in blood cells from HIV-infected patients undergoing antiretroviral therapy. AIDS Res Hum Retroviruses 2004;20:271-3.
    • (2004) AIDS Res. Hum. Retroviruses , vol.20 , pp. 271-273
    • De Mendoza, C.1    De Ronde, A.2    Smolders, K.3
  • 57
    • 0037195080 scopus 로고    scopus 로고
    • Cardiomyocytes undergo apoptosis in HIV cardiomyopathy through mitochondrion and death receptor controlled pathways
    • Twu C. Cardiomyocytes undergo apoptosis in HIV cardiomyopathy through mitochondrion and death receptor controlled pathways. Proc Natl Acad Sci USA 2002;24:14386-91.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.24 , pp. 14386-14391
    • Twu, C.1
  • 58
    • 0036848194 scopus 로고    scopus 로고
    • HIV protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation
    • Nie Z. HIV protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation. Cell Death Differ 2002;9:1172-84.
    • (2002) Cell Death Differ. , vol.9 , pp. 1172-1184
    • Nie, Z.1
  • 59
    • 0034854715 scopus 로고    scopus 로고
    • Quantification of mitochondrial DNA in peripheral blood mononuclear cells and subcutaneous fat using real-time dolymerase chain reactions
    • Gahan M, Miller F, Lewin S et al. Quantification of mitochondrial DNA in peripheral blood mononuclear cells and subcutaneous fat using real-time dolymerase chain reactions. J Clin Virol 2001;22:241-7.
    • (2001) J. Clin. Virol. , vol.22 , pp. 241-247
    • Gahan, M.1    Miller, F.2    Lewin, S.3
  • 60
    • 0038298320 scopus 로고    scopus 로고
    • Quantitation of blood lymphocyte mitochondrial DNA for the monitoring of antiretroviral drug-induced mitochondrial DNA depletion
    • Petit C, Mathez D, Barthelemy C, et al. Quantitation of blood lymphocyte mitochondrial DNA for the monitoring of antiretroviral drug-induced mitochondrial DNA depletion. J Acquir Immun Defic Syndr 2003;33:461-9.
    • (2003) J. Acquir. Immun. Defic. Syndr. , vol.33 , pp. 461-469
    • Petit, C.1    Mathez, D.2    Barthelemy, C.3
  • 61
    • 3042587895 scopus 로고    scopus 로고
    • Prospective evaluation of blood concentration of mitochondrial DNA as a marker of toxicity in 157 consecutively recruited untreated or HAART-treated HIV-positive patients
    • Chiappini F, Teicher E, Saffroy R, et al. Prospective evaluation of blood concentration of mitochondrial DNA as a marker of toxicity in 157 consecutively recruited untreated or HAART-treated HIV-positive patients. Lab Invest 2004;84:908-14.
    • (2004) Lab. Invest. , vol.84 , pp. 908-914
    • Chiappini, F.1    Teicher, E.2    Saffroy, R.3
  • 62
    • 0037999080 scopus 로고    scopus 로고
    • Mitochondrial DNA depletion and morphologic changes in adipocytes associated with nucleoside reverse transcriptase inhibitor therapy
    • Nolan D, Hammond E, Martin A, et al. Mitochondrial DNA depletion and morphologic changes in adipocytes associated with nucleoside reverse transcriptase inhibitor therapy. AIDS 2003;17:1329-38
    • (2003) AIDS , vol.17 , pp. 1329-1338
    • Nolan, D.1    Hammond, E.2    Martin, A.3
  • 63
    • 10744222741 scopus 로고    scopus 로고
    • Depletion of mitochondrial DNA in liver under antiretroviral therapy with didarosine, stavudine, or zalcitabine
    • Walker U, Bauerle J, Laguno M, et al. Depletion of mitochondrial DNA in liver under antiretroviral therapy with didarosine, stavudine, or zalcitabine. Hepatology 2004;39:311-7
    • (2004) Hepatology , vol.39 , pp. 311-317
    • Walker, U.1    Bauerle, J.2    Laguno, M.3
  • 64
    • 0035968164 scopus 로고    scopus 로고
    • Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase γ
    • Lim S, Copeland W. Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase γ. J Biol Chem 2001;276:616-23.
    • (2001) J. Biol. Chem. , vol.276 , pp. 616-623
    • Lim, S.1    Copeland, W.2
  • 65
    • 0036471555 scopus 로고    scopus 로고
    • Evidence of nucleoside analogue reverse transcriptase inhibitor associated genetic and structural defects of mitochondria in adipose tissue of HIV-infected patients
    • Walker U, Bickel M, Volksbeck S, et al. Evidence of nucleoside analogue reverse transcriptase inhibitor associated genetic and structural defects of mitochondria in adipose tissue of HIV-infected patients. J Acquir Immun Defic Syndr 2002;29:117-21.
    • (2002) J. Acquir. Immun. Defic. Syndr. , vol.29 , pp. 117-121
    • Walker, U.1    Bickel, M.2    Volksbeck, S.3
  • 66
    • 0033831315 scopus 로고    scopus 로고
    • Respiratory chain dysfunction associated with multiple mitochondrial DNA deletions in antiretroviral therapy related lipodystrophy
    • Miró O, Gómez M, Pedrol E, et al. Respiratory chain dysfunction associated with multiple mitochondrial DNA deletions in antiretroviral therapy related lipodystrophy. AIDS 2000;14:1855-7.
    • (2000) AIDS , vol.14 , pp. 1855-1857
    • Miró, O.1    Gómez, M.2    Pedrol, E.3
  • 67
    • 0034622993 scopus 로고    scopus 로고
    • Is there a relationship between hepatitis C virus infection and anti retroviral-associated lipoatrophy?
    • Zylberberg H, Nalpas B, Pol S, et al. Is there a relationship between hepatitis C virus infection and anti retroviral-associated lipoatrophy? AIDS 2000;14:2055.
    • (2000) AIDS , vol.14 , pp. 2055
    • Zylberberg, H.1    Nalpas, B.2    Pol, S.3
  • 68
    • 0035360859 scopus 로고    scopus 로고
    • Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus associated hepatocarcinogenesis
    • Moriya K, Nakagawa K, Santa T, et al. Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus associated hepatocarcinogenesis. Cancer Res 2001;61:4365-70.
    • (2001) Cancer Res. , vol.61 , pp. 4365-4370
    • Moriya, K.1    Nakagawa, K.2    Santa, T.3
  • 69
    • 2942746646 scopus 로고    scopus 로고
    • Quantitative detection of common deletion of mitochondrial DNA in hepatocellular carcinoma and hepatocellular nodular hyperplasic
    • Shao J, Gao H, Li H, et al. Quantitative detection of common deletion of mitochondrial DNA in hepatocellular carcinoma and hepatocellular nodular hyperplasic. World J Gastroenterol 2004; 10:1560-4.
    • (2004) World J. Gastroenterol. , vol.10 , pp. 1560-1564
    • Shao, J.1    Gao, H.2    Li, H.3
  • 70
    • 10744222741 scopus 로고    scopus 로고
    • Depletion of mitochondrial DNA in liver under antiretroviral therapy with didanosine, stavudine, or zalcitabine
    • Walker U, Bauerle J, Laguno M, et al. Depletion of mitochondrial DNA in liver under antiretroviral therapy with didanosine, stavudine, or zalcitabine. Hepatology 2004;39:311-7.
    • (2004) Hepatology , vol.39 , pp. 311-317
    • Walker, U.1    Bauerle, J.2    Laguno, M.3
  • 71
    • 10044221447 scopus 로고    scopus 로고
    • Mitochondrial DNA depletion in HIV-infected patients is enhanced with chronic hepatitis C and treatment with pegylated interferon plus ribavirin
    • XV International AIDS Conference Bangkok, July [abstract MoPeB3313]
    • De Mendoza C, Sánchez-Conde M, Timmermans E, et al. Mitochondrial DNA depletion in HIV-infected patients is enhanced with chronic hepatitis C and treatment with pegylated interferon plus ribavirin. XV International AIDS Conference Bangkok, July 2004 [abstract MoPeB3313].
    • (2004)
    • De Mendoza, C.1    Sánchez-Conde, M.2    Timmermans, E.3
  • 72
    • 0035956691 scopus 로고    scopus 로고
    • Increased mitochondrial toxicity with ribavirin in HIV/HCV coinfection
    • Lafeuillade A, Hittinger G, Chadapaud S. Increased mitochondrial toxicity with ribavirin in HIV/HCV coinfection. Lancet 2001; 357:280-1.
    • (2001) Lancet , vol.357 , pp. 280-281
    • Lafeuillade, A.1    Hittinger, G.2    Chadapaud, S.3
  • 74
    • 12144286456 scopus 로고    scopus 로고
    • High rate of didanosine-related mitochondrial toxicity in HIV/HCV coinfected patients receiving ribavirin
    • Moreno A, Quereda C, Moreno L, et al. High rate of didanosine-related mitochondrial toxicity in HIV/HCV coinfected patients receiving ribavirin. Antiviral Ther 2004;9:133-8.
    • (2004) Antiviral Ther. , vol.9 , pp. 133-138
    • Moreno, A.1    Quereda, C.2    Moreno, L.3
  • 75
    • 0025880937 scopus 로고
    • Mechanism of the potentiating effect of ribavirin on the activity of 2′3′-dideoxyrosine against HIV
    • Balzarini J, Lee C, Herdewijn P, De Clercq E. Mechanism of the potentiating effect of ribavirin on the activity of 2′3′-dideoxyrosine against HIV. J Biol Chem 1991; 266:21509-14.
    • (1991) J. Biol. Chem. , vol.266 , pp. 21509-21514
    • Balzarini, J.1    Lee, C.2    Herdewijn, P.3    De Clercq, E.4
  • 77
    • 0035393683 scopus 로고    scopus 로고
    • Association between insulin resistance and hepatitis C virus chronic infection in HIV-hepatitis C virus coinfected patients undergoing antiretroviral therapy
    • Duong M, Petit J, Piroth L, et al. Association between insulin resistance and hepatitis C virus chronic infection in HIV-hepatitis C virus coinfected patients undergoing antiretroviral therapy. J Acquir Immun Defic Syndr 2001;27:245-50.
    • (2001) J. Acquir. Immun. Defic. Syndr. , vol.27 , pp. 245-250
    • Duong, M.1    Petit, J.2    Piroth, L.3
  • 78
    • 0842300373 scopus 로고    scopus 로고
    • Steatosis and hepatitis C virus: Mechanisms and significance for hepatic and extrahepatic disease
    • Lonardo A, Adinolfi L, Loria P, et al. Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease. Gastroenterology 2004;126:586-97.
    • (2004) Gastroenterology , vol.126 , pp. 586-597
    • Lonardo, A.1    Adinolfi, L.2    Loria, P.3
  • 79
    • 0037378552 scopus 로고    scopus 로고
    • Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy
    • Shiramizu B, Shikuma K, Kamemoto L, et al. Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy. J Acquir Immun Defic Syndr 2003;32:370-4.
    • (2003) J. Acquir. Immun. Defic. Syndr. , vol.32 , pp. 370-374
    • Shiramizu, B.1    Shikuma, K.2    Kamemoto, L.3
  • 80
    • 2342613668 scopus 로고    scopus 로고
    • Mitochondrial damage and DNA depletion in cord blood and umbilical cord from infants exposed in utero to Combivir
    • Divi R, Walker V, Wade N, et al. Mitochondrial damage and DNA depletion in cord blood and umbilical cord from infants exposed in utero to Combivir. AIDS 2004;18:1013-21.
    • (2004) AIDS , vol.18 , pp. 1013-1021
    • Divi, R.1    Walker, V.2    Wade, N.3
  • 81
    • 0033604060 scopus 로고    scopus 로고
    • Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues
    • Blanche S, Tardieu M, Rustin P, et al. Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues Lancet 1999;354:1084-9.
    • (1999) Lancet , vol.354 , pp. 1084-1089
    • Blanche, S.1    Tardieu, M.2    Rustin, P.3
  • 82
    • 0042232027 scopus 로고    scopus 로고
    • Persistent mitochondrial dysfunction in HIV-1-exposed but uninfected infants: Clinical screening in a large prospective cohort
    • Barret B, Tardieu M, Rustin P, et al. Persistent mitochondrial dysfunction in HIV-1-exposed but uninfected infants: clinical screening in a large prospective cohort. AIDS 2003;17:1769-85.
    • (2003) AIDS , vol.17 , pp. 1769-1785
    • Barret, B.1    Tardieu, M.2    Rustin, P.3
  • 83
    • 0027931039 scopus 로고
    • Biochemical and molecular investigations in respiratory chain deficiencies
    • Rustin P, Chretien D, Bourgeron T, et al. Biochemical and molecular investigations in respiratory chain deficiencies. Clin Chem Acta 1994;228:35-51.
    • (1994) Clin. Chem. Acta , vol.228 , pp. 35-51
    • Rustin, P.1    Chretien, D.2    Bourgeron, T.3
  • 84
    • 0033040081 scopus 로고    scopus 로고
    • Effects of general anesthetic procedures on mitochondrial function of human skeletal muscle
    • Miró O, Barrientos A, Alonso J, et al. Effects of general anesthetic procedures on mitochondrial function of human skeletal muscle. Eur J Clin Pharmacol 1999;55:35-41.
    • (1999) Eur. J. Clin. Pharmacol. , vol.55 , pp. 35-41
    • Miró, O.1    Barrientos, A.2    Alonso, J.3
  • 85
    • 4644237568 scopus 로고    scopus 로고
    • Enzymatic diagnosis of oxidative phosphorylation defects on muscle biopsy: Better on tissue homogenate or on a mitochondria-enriched suspension?
    • Casademont J, Perea M, López S, et al. Enzymatic diagnosis of oxidative phosphorylation defects on muscle biopsy: better on tissue homogenate or on a mitochondria-enriched suspension? Med Sci Monit 2004;10:49-53.
    • (2004) Med. Sci. Monit. , vol.10 , pp. 49-53
    • Casademont, J.1    Perea, M.2    López, S.3
  • 86
    • 0025832755 scopus 로고
    • Assessment of the mitochondrial respiratory chain
    • Rustin P, Chretien D, Bourgeron T, et al. Assessment of the mitochondrial respiratory chain. Lancet 1991;338:60.
    • (1991) Lancet , vol.338 , pp. 60
    • Rustin, P.1    Chretien, D.2    Bourgeron, T.3
  • 87
    • 0035231595 scopus 로고    scopus 로고
    • Assaying mitochondrial respiratory complex activity in mitochondria isolated from human cells and tissues
    • Birch-Machin M, Turnbull D. Assaying mitochondrial respiratory complex activity in mitochondria isolated from human cells and tissues. Methods Cell Biol 2001;65:97-117.
    • (2001) Methods Cell Biol. , vol.65 , pp. 97-117
    • Birch-Machin, M.1    Turnbull, D.2
  • 88
    • 10744226254 scopus 로고    scopus 로고
    • Mitochondrial DNA depletion and respiratory chain enzymatic deficiencies are present in peripheral blood mononuclear cells of HIV-infected patients with HAART-related lipodystrophy
    • Miró O, López S, Pedrol E, et al. Mitochondrial DNA depletion and respiratory chain enzymatic deficiencies are present in peripheral blood mononuclear cells of HIV-infected patients with HAART-related lipodystrophy. Antiviral Ther 2003;8:333-8.
    • (2003) Antiviral Ther. , vol.8 , pp. 333-338
    • Miró, O.1    López, S.2    Pedrol, E.3
  • 89
    • 4544253103 scopus 로고    scopus 로고
    • Mitochondrial effects of antiretroviral therapies in asymptomatic patients
    • López S, Miró O, Martínez E, et al. Mitochondrial effects of antiretroviral therapies in asymptomatic patients. Antiviral Ther 2004;9:47-55.
    • (2004) Antiviral Ther. , vol.9 , pp. 47-55
    • López, S.1    Miró, O.2    Martínez, E.3
  • 90
    • 20844453407 scopus 로고    scopus 로고
    • Mitochondrial effects of HIV infection on the peripheral blood mononuclear cells of HIV-infected patients who were never treated with antiretrovirals
    • Miró O, López S, Martínez E, et al. Mitochondrial effects of HIV infection on the peripheral blood mononuclear cells of HIV-infected patients who were never treated with antiretrovirals. Clin Infect Dis 2004;39:710-6.
    • (2004) Clin. Infect. Dis. , vol.39 , pp. 710-716
    • Miró, O.1    López, S.2    Martínez, E.3
  • 91
    • 0037369839 scopus 로고    scopus 로고
    • Accumulation of mitochondrial DNA mutations in HIV-infected patients treated with nucleoside analogue reverse transcriptase inhibitors
    • Martin A, Hammond E, Nolan D, et al. Accumulation of mitochondrial DNA mutations in HIV-infected patients treated with nucleoside analogue reverse transcriptase inhibitors. Am J Hum Genet 2003;72:549-60.
    • (2003) Am. J. Hum. Genet. , vol.72 , pp. 549-560
    • Martin, A.1    Hammond, E.2    Nolan, D.3
  • 92
    • 2942740986 scopus 로고    scopus 로고
    • Real-time monitoring of RNA and DNA reactions by fluorescence detection
    • Singh K, Hanne A, Krupp G. Real-time monitoring of RNA and DNA reactions by fluorescence detection. Methods Mol Biol 2004; 252:33-48.
    • (2004) Methods Mol. Biol. , vol.252 , pp. 33-48
    • Singh, K.1    Hanne, A.2    Krupp, G.3
  • 93
    • 0141659640 scopus 로고    scopus 로고
    • Decline of mitochondrial DNA during therapy with nucleoside analogue reverse transcriptase inhibitors assessed by a single-tube NASBA simultaneously assaying both mitochondrial and nuclear DNA
    • XIV International AIDS Conference. Barcelona [abstract WeOrB1305]
    • De Ronde A, Van Gemen B, Casula M. Decline of mitochondrial DNA during therapy with nucleoside analogue reverse transcriptase inhibitors assessed by a single-tube NASBA simultaneously assaying both mitochondrial and nuclear DNA. XIV International AIDS Conference. Barcelona 2002 [abstract WeOrB1305].
    • (2002)
    • De Ronde, A.1    Van Gemen, B.2    Casula, M.3
  • 94
    • 0012588801 scopus 로고    scopus 로고
    • Therapy with efavirenz + ritonavir boosted indinavir, with or without stavudine after 24 weeks does not decrease mtDNA and mtRNA content of PBMC assessed by single-tube duplex real time NASBA
    • Casula M, Do Baar M, Van Gemen B, et al. Therapy with efavirenz + ritonavir boosted indinavir, with or without stavudine after 24 weeks does not decrease mtDNA and mtRNA content of PBMC assessed by single-tube duplex real time NASBA. Antiviral Ther 2002;7:16.
    • (2002) Antiviral Ther. , vol.7 , pp. 16
    • Casula, M.1    Do Baar, M.2    Van Gemen, B.3
  • 95
    • 10044258265 scopus 로고    scopus 로고
    • Platelets, a typical source of error in real-time PCR quantification of mitochondrial DNA content in human peripheral blood cells
    • Banas B, Kost B, Goebel F. Platelets, a typical source of error in real-time PCR quantification of mitochondrial DNA content in human peripheral blood cells. Eur J Med Res 2004;9:371-7.
    • (2004) Eur. J. Med. Res. , vol.9 , pp. 371-377
    • Banas, B.1    Kost, B.2    Goebel, F.3
  • 96
    • 0037322036 scopus 로고    scopus 로고
    • Tests for mitochondrial function and DNA: Potentials and pitfalls
    • Cossarizza A. Tests for mitochondrial function and DNA: potentials and pitfalls. Curr Opin Infect Dis 2003;16:5-10.
    • (2003) Curr. Opin. Infect. Dis. , vol.16 , pp. 5-10
    • Cossarizza, A.1


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