A role for caveolae in cell migration

FASEB Journal

Volumn 18, Issue 15, 2004, Pages 1801-1811

  Navarro, Angels ^a   Anand Apte, Bela ^a   Parat, Marie Odile ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Angiogenesis; Caveolin 1; Endothelial cell; Motility

Indexed keywords

CAVEOLIN 1;

ANGIOGENESIS; CAVEOLA; CELL ACTIVITY; CELL MEMBRANE; CELL MIGRATION; CHOLESTEROL TRANSPORT; CYTOSKELETON; ENDOTHELIUM CELL; EXTRACELLULAR SPACE; MOLECULE; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CAVEOLAE; CAVEOLIN 1; CAVEOLINS; CELL MOVEMENT; CYTOSKELETON; ENDOTHELIUM, VASCULAR; NEOVASCULARIZATION, PHYSIOLOGIC; RATS;

EID: 10044219518     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.04-2516rev     Document Type: Review

References (129)

1. Palade, G. E. (1953) Fine structure of blood capillaries. J. Appl. Phys. 24, 1424
2. Yamada, E. (1955) The fine structure of the gall bladder epithelium of the mouse. J. Biophys. Biochem. Cytol. 1, 445-458
3. Shaul, P. W., and Anderson, R. G. (1998) Role of plasmalemmal caveolae in signal transduction. Am. J. Physiol. 275, L843-L851
4. Stan, R. V. (2002) Structure and function of endothelial caveolae. Microsc. Res. Tech. 57, 350-364
5. Frank, P. G., Woodman, S. E., Park, D. S., and Lisanti, M. P. (2003) Caveolin, caveolae, and endothelial cell function. Arterioscler. Thromb. Vasc. Biol. 23, 1161-1168
6. Gratton, J. P., Bernatchez, P., and Sessa, W. C. (2004) Caveolae and caveolins in the cardiovascular system. Circ. Res. 94, 1408-1417
7. Lauffenburger, D. A., and Horwitz, A. F. (1996) Cell migration: a physically integrated molecular process. Cell 84, 359-639
8. Hall, A. (1998) Rho GTPases and the actin cytoskeleton. Science 279, 509-514
9. Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., and Hall, A. (1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410
10. Ridley, A. J., and Hall, A. (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399
11. Nobes, C. D., and Hall, A. (1995) Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62
12. Prigozhina, N. L., and Waterman-Storer, C. M. (2004) Protein kinase D-mediated anterograde membrane trafficking is required for fibroblast motility. Curr. Biol. 14, 88-98
13. Schmoranzer, J., Kreitzer, G., and Simon, S. M. (2003) Migrating fibroblasts perform polarized, microtubule-dependent exocytosis towards the leading edge. J. Cell Sci. 116, 4513-4519
14. Raucher, D., and Sheetz, M. P. (2000) Cell spreading and lamellipodial extension rate is regulated by membrane tension. J. Cell Biol. 148, 127-136
15. Vasanji, A., Ghosh, P. K., Graham, L. M., Eppell, S. J., and Fox, P. L. (2004) Polarization of plasma membrane microviscosity during endothelial cell migration. Dev. Cell 6, 29-41
16. Pierini, L. M., Lawson, M. A., Eddy, R. J., Hendey, B., and Maxfield, F. R. (2000) Oriented endocytic recycling of alpha5beta1 in motile neutrophils. Blood 95, 2471-2480
17. Bretscher, M. S. (1996) Moving membrane up to the front of migrating cells. Cell 85, 465-467
18. Bretscher, M. S. (1996) Getting membrane flow and the cytoskeleton to cooperate in moving cells. Cell 87, 601-606
19. Bretscher, M. S., and Aguado-Velasco, C. (1998) EGF induces recycling membrane to form ruffles. Curr. Biol. 8, 721-724
20. Murphy, C., Saffrich, R., Grummt, M., Gournier, H., Rybin, V., Rubino, M., Auvinen, P., Lutcke, A., Parton, R. G., and Zerial, M. (1996) Endosome dynamics regulated by a Rho protein. Nature (London) 384, 427-432
21. Di Cesare, A., Paris, S., Albertinazzi, C., Dariozzi, S., Andersen, J., Mann, M., de Longhi, R., and de Curtis, I. (2000) p95-APP1 links membrane transport to Rac-mediated reorganization of actin. Nat. Cell Biol. 2, 521-530
22. Fernandez, I., Ying, Y., Albanesi, J., and Anderson, R. G. (2002) Mechanism of caveolin filament assembly. Proc. Natl. Acad. Sci. USA 99, 11193-11198
23. Schlegel, A., Arvan, P., and Lisanti, M. P. (2001) Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the endoplasmic reticulum. J. Biol. Chem. 276, 4398-4408
24. Rothberg, K. G., Heuser, J. E., Donzell, W. C., Ying, Y. S., Glenney, J. R., and Anderson, R. G. (1992) Caveolin, a protein component of caveolae membrane coats. Cell 68, 673-682
25. Wary, K. K., Mariotti, A., Zurzolo, C., and Giancotti, F. G. (1998) A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell 94, 625-634
26. Smart, E. J., Ying, Y., Donzell, W. C., and Anderson, R. G. (1996) A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane. J. Biol. Chem. 271, 29427-29435
27. Rohlich, P., and Allison, A. C. (1976) Oriented pattern of membrane-associated vesicles in fibroblasts. J. Ultrastruct. Res. 57, 94-103
28. Parton, R. G., Joggerst, B., and Simons, K. (1994) Regulated internalization of caveolae. J. Cell Biol. 127, 1199-1215
29. Fujimoto, T., Miyawaki, A., and Mikoshiba, K. (1995) Inositol 1,4,5-trisphosphate receptor-like protein in plasmalemmal caveolae is linked to actin filaments. J. Cell Sci. 108, 7-15
30. Izumi, T., Shibata, Y., and Yamamoto, T. (1988) Striped structures on the cytoplasmic surface membranes of the endothelial vesicles of the rat aorta revealed by quick-freeze, deep-etching replicas. Anat. Rec. 220, 225-232
31. Peters, K. R., Carley, W. W., and Palade, G. E. (1985) Endothelial plasmalemmal vesicles have a characteristic striped bipolar surface structure. J. Cell Biol. 101, 2233-2238
32. 2+ waves preferentially originate at specific loci in caveolin-rich cell edges. Proc. Natl. Acad. Sci. USA 95, 5009-5014
33. Stahlhut, M., and van Deurs, B. (2000) Identification of filamin as a novel ligand for caveolin-1: evidence for the organization of caveolin-1-associated membrane domains by the actin cytoskeleton. Mol. Biol. Cell 11, 325-337
34. 14) via activation of p38 mitogen-activated protein kinase and c-Src kinase. Evidence for caveolae, the actin cytoskeleton, and focal adhesions as mechanical sensors of osmotic stress. J. Biol. Chem. 276, 8094-8103
35. Wei, Y., Lukashev, M., Simon, D. I., Bodary, S. C., Rosenberg, S., Doyle, M. V., and Chapman, H. A. (1996) Regulation of integrin function by the urokinase receptor. Science 273, 1551-1555
36. Preissner, K. T., Kanse, S. M., and May, A. E. (2000) Urokinase receptor: a molecular organizer in cellular communication. Curr. Opin. Cell Biol. 12, 621-628
37. Wei, Y., Yang, X., Liu, Q., Wilkins, J. A., and Chapman, H. A. (1999) A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling. J. Cell Biol. 144, 1285-1294
38. Chapman, H. A., Wei, Y., Simon, D. I., and Waltz, D. A. (1999) Role of urokinase receptor and caveolin in regulation of integrin signaling. Thromb. Haemost. 82, 291-297
39. Wickstrom, S. A., Alitalo, K., and Keski-Oja, J. (2002) Endostatin associates with integrin alpha5beta1 and caveolin-1, and activates Src via a tyrosyl phosphatase-dependent pathway in human endothelial cells. Cancer Res. 62, 5580-5589
40. Wickstrom, S. A., Alitalo, K., and Keski-Oja, J. (2003) Endostatin associates with lipid rafts and induces reorganization of the actin cytoskeleton via down-regulation of RhoA activity. J. Biol. Chem. 278, 37895-37901
41. Hocking, D. C., and Kowalski, K. (2002) A cryptic fragment from fibronectin's III1 module localizes to lipid rafts and stimulates cell growth and contractility. J. Cell Biol. 158, 175-184
42. Stahl, A., and Mueller, B. M. (1995) The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolae. J. Cell Biol. 129, 335-344
43. Annabi, B., Lachambre, M., Bousquet-Gagnon, N., Page, M., Gingras, D., and Beliveau, R. (2001) Localization of membrane-type 1 matrix metalloproteinase in caveolae membrane domains. Biochem. J. 353, 547-553
44. Puyraimond, A., Fridman, R., Lemesle, M., Arbeille, B., and Menashi, S. (2001) MMP-2 colocalizes with caveolae on the surface of endothelial cells. Exp. Cell Res. 262, 28-36
45. Remade, A., Murphy, G., and Roghi, C. (2003) Membrane type I-matrix metalloproteinase (MT1-MMP) is internalised by two different pathways and is recycled to the cell surface. J. Cell Sci. 116, 3905-3916
46. Cavallo-Medved, D., Dosescu, J., Linebaugh, B. E., Sameni, M., Rudy, D., and Sloane, B. F. (2003) Mutant K-ras regulates cathepsin B localization in caveolae of human colorectal carcinoma cells. Neoplasia 5, 507-519
47. Tang, W., and Hemler, M. E. (2004) Caveolin-1 regulates MMP-1 induction and CD147/EMMPRIN cell surface clustering. J. Biol. Chem. 279, 11112-11118
48. Smart, E. J., Graf, G. A., McNiven, M. A., Sessa, W. C., Engelman, J. A., Scherer, P. E., Okamoto, T., and Lisanti, M. P. (1999) Caveolins, liquid-ordered domains, and signal transduction. Mol. Cell. Biol. 19, 7289-7304
49. 2+ wave initiation move with caveolae to the trailing edge of migrating cells. J. Cell Sci. 115, 475-484
50. Isshiki, M., Ying, Y. S., Fujita, T., and Anderson, R. G. (2002) A molecular sensor detects signal transduction from caveolae in living cells. J. Biol. Chem. 277, 43389-43398
51. Isshiki, M., and Anderson, R. G. (1999) Calcium signal transduction from caveolae. Cell Calcium 26, 201-208
52. Lockwich, T. P., Liu, X., Singh, B. B., Jadlowiec, J., Weiland, S., and Ambudkar, I. S. (2000) Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains. J. Biol. Chem. 275, 11934-11942
53. 2+ entry. J. Biol. Chem. 275, 17979-17985
54. 2+ entry and enhances endoplasmic reticulum Ca uptake in bovine vascular endothelial cells. J. Physiol. 539, 77-91
55. 2+ influx channels by regulating plasma membrane localization of TRPC1. J. Biol. Chem. 278, 27208-27215
56. Garcia-Cardena, G., Martasek, P., Masters, B. S., Skidd, P. M., Couet, J., Li, S., Lisanti, M. P., and Sessa, W. C. (1997) Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the NOS caveolin binding domain in vivo. J. Biol. Chem. 272, 25437-25440
57. Lee, P. C., Salyapongse, A. N., Bragdon, G. A., Shears, L. L., Watkins, S. C., Edington, H. D., and Billiar, T. R. (1999) Impaired wound healing and angiogenesis in eNOS-deficient mice. Am. J. Physiol. 277, H1600-H1608
58. Labrecque, L., Royal, I., Surprenant, D. S., Patterson, C., Gingras, D., and Beliveau, R. (2003) Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol. Mol. Biol. Cell 14, 334-347
59. Michel, T. (1999) Targeting and translocation of endothelial nitric oxide synthase. Braz. J. Med. Biol. Res. 32, 1361-1366
60. Fulton, D., Gratton, J. P., and Sessa, W. C. (2001) Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough? J. Pharmacol. Exp. Ther. 299, 818-824
61. Zabel, U., Kleinschnitz, C., Oh, P., Nedvetsky, P., Smolenski, A., Muller, H., Kronich, P., Kugler, P., Walter, U., Schnitzer, J. E., et al. (2002) Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide. Nat. Cell Biol. 4, 307-311
62. Dimmeler, S., Dernbach, E., and Zeiher, A. M. (2000) Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration. FEBS Lett. 477, 258-262
63. Ziehe, M., Morbidelli, L., Choudhuri, R., Zhang, H. T., Donnini, S., Granger, H. J., and Bicknell, R. (1997) Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J. Clin. Invest. 99, 2625-2634
64. Sonveaux, P., Martinive, P., DeWever, J., Batova, Z., Daneau, G., Pelat, M., Ghisdal, P., Gregoire, V., Dessy, C., Balligand, J. L., et al. (2004) Caveolin-1 expression Is critical for VEGF-induced ischemic hindlimb collateralization and nitric oxide-mediated angiogenesis. Circ. Res. 95, 154-61
65. Michaely, P. A., Mineo, C., Ying, Y. S., and Anderson, R. G. (1999) Polarized distribution of endogenous Rac1 and RhoA at the cell surface. J. Biol. Chem. 274, 21430-21436
66. Gingras, D., Gauthier, F., Lamy, S., Desrosiers, R. R., and Beliveau, R. (1998) Localization of RhoA GTPase to endothelial caveolae-enriched membrane domains. Biochem. Biophys. Res. Commun. 247, 888-893
67. del Pozo, M. A., Alderson, N. B., Kiosses, W. B., Chiang, H. H., Anderson, R. G., and Schwartz, M. A. (2004) Integrins regulate Rac targeting by internalization of membrane domains. Science 303, 839-842
68. del Pozo, M. A. (2004) Integrin signaling and lipid rafts. Cell Cycle 3, 725-728
69. Guan, J. L. (2004) Cell biology. Integrins, rafts, Rac, and Rho. Science 303, 773-774
70. Senda, T., Horiguchi, Y., Umemoto, M., Sugimoto, N., and Matsuda, M. (1997) Bordetella bronchiseptica dermonecrotizing toxin, which activates a small GTP-binding protein rho, induces membrane organelle proliferation and caveolae formation. Exp. Cell Res. 230, 163-168
71. Spisni, E., Griffoni, C., Santi, S., Riccio, M., Marulli, R., Bartolini, G., Toni, M., Ullrich, V., and Tomasi, V. (2001) Colocalization prostacyclin (PGI2) synthase-caveolin-1 in endothelial cells and new roles for PGI2 in angiogenesis. Exp. Cell Res. 266, 31-43
72. Acevedo, L., Yu, J., Erdjument-Bromage, H., Miao, R. Q., Kim, J. E., Fulton, D., Tempst, P., Strittmatter, S. M., and Sessa, W. C. (2004) A new role for Nogo as a regulator of vascular remodeling. Nat. Med. 10, 382-388
73. Simantov, R., and Silverstein, R. L. (2003) CD36: a critical anti-angiogenic receptor. Front. Biosci. 8, s874-s882
74. Uittenbogaard, A., Shaul, P. W., Yuhanna, I. S., Blair, A., and Smart, E. J. (2000) High density lipoprotein prevents oxidized low density lipoprotein-induced inhibition of endothelial nitric-oxide synthase localization and activation in caveolae. J. Biol. Chem. 275, 11278-11283
75. Murata, M., Peranen, J., Schreiner, R., Wieland, F., Kurzchalia, T. V., and Simons, K. (1995) VIP21/caveolin is a cholesterol-binding protein. Proc. Natl. Acad. Sci. USA 92, 10339-10343
76. Li, H., and Papadopoulos, V. (1998) Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern. Endocrinology 139, 4991-4997
77. Uittenbogaard, A., Ying, Y., and Smart, E. J. (1998) Characterization of a cytosolic heat-shock protein-caveolin chaperone complex. Involvement in cholesterol trafficking. J. Biol. Chem. 273, 6525-6532
78. Uittenbogaard, A., and Smart, E. J. (2000) Palmitoylation of caveolin-1 is required for cholesterol binding, chaperone complex formation, and rapid transport of cholesterol to caveolae. J. Biol. Chem. 275, 25595-25599
79. Axel, D. I., Riessen, R., Runge, H., Viebahn, R., and Karsch, K. R. (2000) Effects of cerivastatin on human arterial smooth muscle cell proliferation and migration in transfilter cocultures. J. Cardiovasc. Pharmacol. 35, 619-629
80. Vincent, L., Chen, W., Hong, L., Mirshahi, F., Mishal, Z., Mirshahi-Khorassani, T., Vannier, J. P., Soria, J., and Soria, C. (2001) Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: contribution to its antiangiogenic effect. FEBS Lett. 495, 159-166
81. Brouet, A., Sonveaux, P., Dessy, C., Moniotte, S., Balligand, J. L., and Feron, O. (2001) Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins. Circ. Res. 89, 866-873
82. Weis, M., Heeschen, C., Glassford, A.J., and Cooke, J. P. (2002) Statins have biphasic effects on angiogenesis. Circulation 105, 739-745
83. Parton, R. G., and Richards, A. A. (2003) Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms. Traffic 4, 724-738
84. Schnitzer, J. E., Oh, P., and McIntosh, D. P. (1996) Role of GTP hydrolysis in fission of caveolae directly from plasma membranes. Science 274, 239-242
85. Oh, P., McIntosh, D. P., and Schnitzer, J. E. (1998) Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium. J. Cell Biol. 141, 101-114
86. Schnitzer, J. E., Liu J., and Oh, P. (1995) Endothelial caveolae have the molecular transport machinery for vesicle budding, docking, and fusion including VAMP, NSF, SNAP, annexins, and GTPases. J. Biol. Chem. 270. 14399-14404
87. Minshall, R. D., Tiruppathi, C., Vogel, S. M., Niles, W. D., Gilchrist, A., Hamm, H. E., and Malik, A. B. (2000) Endothelial cell-surface gp60 activates vesicle formation and trafficking via G (i) -coupled Src kinase signaling pathway. J. Cell Biol. 150, 1057-1070
88. Pelkmans, L., Puntener, D., and Helenius, A. (2002) Local actin polymerization and dynamin recruitment in SV40-induced internalization of caveolae. Science 296, 535-539
89. Bretscher, M. S., and Aguado-Velasco, C. (1998) Membrane traffic during cell locomotion. Curr. Opin. Cell Biol. 10, 537-541
90. Ridley, A. J., Schwartz, M. A., Burridge, K., Firtel, R. A., Ginsberg, M. H., Borisy, G., Parsons, J. T., and Horwitz, A. R. (2003) Cell migration: integrating signals from front to back. Science 302, 1704-1709
91. Wedlich-Soldner, R., and Li, R. (2003) Spontaneous cell polarization: undermining determinism. Nat. Cell Biol. 5, 267-270
92. Schmidt, C. E., Horwitz, A. F., Lauffenburger, D. A., and Sheetz, M. P. (1993) Integrin-cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulated. J. Cell Biol. 123, 977-991
93. Nabeshima, K., Inoue, T., Shimao, Y., Okada, Y., Itoh, Y., Seiki, M., and Koono, M. (2000) Front-cell-specific expression of membrane-type 1 matrix metalloproteinase and gelatinase A during cohort migration of colon carcinoma cells induced by hepatocyte growth factor/scatter factor. Cancer Res. 60, 3364-3369
94. Lawrence, J. B., and Singer, R. H. (1986) Intracellular localization of messenger RNAs for cytoskeletal proteins. Cell 45, 407-415
95. Kolega, J. (1998) Cytoplasmic dynamics of myosin IIA and IIB: spatial 'sorting' of isoforms in locomoting cells. J. Cell Sci. 111, 2085-2095
96. Totsukawa, G., Wu, Y., Sasaki, Y., Hartshorne, D. J., Yamakita, Y., Yamashiro, S., and Matsumura, F. (2004) Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts. J. Cell Biol. 164, 427-439
97. Kupfer, A., Louvard, D., and Singer, S. J. (1982) Polarization of the Golgi apparatus and the microtubule-organizing center in cultured fibroblasts at the edge of an experimental wound. Proc. Natl. Acad. Sci. USA 79, 2603-2607
98. Nobes, C. D., and Hall, A. (1999) Rho GTPases control polarity, protrusion, and adhesion during cell movement. J. Cell Biol. 144, 1235-1244
99. del Pozo, M. A., Vicente-Manzanares, M., Tejedor, R., Serrador, J. M., and Sanchez-Madrid, F. (1999) Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes. Eur. J. Immunol. 29, 3609-3620
100. Cox, E. A., Sastry, S. K., and Huttenlocher, A. (2001) Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases. Mol. Biol. Cell 12, 265-277
101. Parent, C. A., and Devreotes, P. N. (1999) A cell's sense of direction. Science 284, 765-770
102. Devreotes, P., and Janetopoulos, C. (2003) Eukaryotic chemotaxis: distinctions between directional sensing and polarization. J. Biol. Chem. 278, 20445-20448
103. Servant, G., Weiner, O. D., Herzmark, P., Balla, T., Sedat, J. W., and Bourne, H. R. (2000) Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science 287, 1037-1040
104. Mañes, S., Mira, E., Gomez-Mouton, C., Lacalle, R. A., Keller, P., Labrador, J. P., and Martinez, A. C. (1999) Membrane raft microdomains mediate front-rear polarity in migrating cells. EMBO J. 18, 6211-6220
105. Manes, S., Lacalle, R. A., Gomez-Mouton, C., del Real, G., Mira, E., and Martinez, A. C. (2001) Membrane raft microdomains in chemokine receptor function. Semin. Immunol. 13, 147-157
106. Gómez-Moutón, C., Abad, J. L., Mira, E., Lacalle, R. A., Gallardo, E., Jimenez-Baranda, S., Illa, I., Bernad, A., Mañes, S., and Martinez, A. C. (2001) Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization. Proc. Natl. Acad. Sci. USA 98, 9642-9647
107. Gomez-Mouton, C., Lacalle, R. A., Mira, E., Jimenez-Baranda, S., Barber, D. F., Carrera, A. C., Martinez, A., and Manes, S. (2004) Dynamic redistribution of raft domains as an organizing platform for signaling during cell chemotaxis. J. Cell Biol. 164, 759-768
108. Seveau, S., Eddy, R. J., Maxfield, F. R., and Pierini, L. M. (2001) Cytoskeleton-dependent membrane domain segregation during neutrophil polarization. Mol. Biol. Cell 12, 3550-3562
109. Kabouridis, P. S., Janzen, J., Magee, A. L., and Ley, S. C. (2000) Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes. Eur. J. Immunol. 30, 954-963
110. Rizzo, V., Sung, A., Oh, P., and Schnitzer, J. E. (1998) Rapid mechanotransduction in situ at the luminal cell surface of vascular endothelium and its caveolae. J. Biol. Chem. 273, 26323-26329
111. Boyd, N. L., Park, H., Yi, H., Boo, Y. C., Sorescu, G. P., Sykes, M., and Jo, H. (2003) Chronic shear induces caveolae formation and alters ERK and Akt responses in endothelial cells. Am. J. Physiol. 285, H1113-H1122
112. Rizzo, V., McIntosh, D. P., Oh, P., and Schnitzer, J. E. (1998) In situ flow activates endothelial nitric oxide synthase in luminal caveolae of endothelium with rapid caveolin dissociation and calmodulin association. J. Biol. Chem. 273, 34724-34729
113. Rizzo, V., Morton, C., DePaola, N., Schnitzer, J. E., and Davies, P. F. (2003) Recruitment of endothelial caveolae into mechanotransduction pathways by flow conditioning in vitro. Am. J. Physiol. 285, H1720-H1729
114. Sun, R. J., Muller, S., Stoltz, J. F., and Wang, X. (2002) Shear stress induces caveolin-1 translocation in cultured endothelial cells. Eur. Biophys. J. 30, 605-611
115. Parat, M. O., Anand-Apte, B., and Fox, P. L. (2003) Differential caveolin-1 polarization in endothelial cells during migration in two and three dimensions. Mol. Biol. Cell 14, 3156-3168
116. Liu, J., Wang, X. B., Park, D. S., and Lisanti, M. P. (2002) Caveolin-1 expression enhances endothelial capillary tubule formation. J. Biol. Chem. 227, 10661-10668
117. Smart, E. J., and Anderson, R. G. (2002) Alterations in membrane cholesterol that affect structure and function of caveolae. Methods Enzymol. 353, 131-139
118. Galvez, B. G., Matias-Roman, S., Yanez-Mo, M., Vicente-Manzanares, M., Sanchez-Madrid, F., and Arroyo, A. G. (2003) Caveolae are a novel pathway for MT1-MMP traffic in human endothelial cells. Mol. Biol. Cell 15, 678-687
119. Griffoni, C., Spisni, E., Santi, S., Riccio, M., Guarnieri, T., and Tomasi, V. (2000) Knockdown of caveolin-1 by antisense oligonucleotides impairs angiogenesis in vitro and in vivo. Biochem. Biophys. Res. Commun. 276, 756-761
120. Ge, S., and Pachter, J. S. (2003) Caveolin-1 knockdown by small interfering RNA suppresses responses to the chemokine MCP-1 by human astrocytes. J. Biol. Chem. 279, 6688-6695
121. Park, D. S., Cohen, A. W., Frank, P. G., Razani, B., Lee, H., Williams, T. M., Chandra, M., Shirani, J., De Souza, A. P., Tang, B., et al. (2003) Caveolin-1 null (-/-) mice show dramatic reductions in life span. Biochemistry 42, 15124-15131
122. Woodman, S. E., Ashton, A. W., Schubert, W., Lee, H., Williams, T. M., Medina, F. A., Wyckoff, J. B., Combs, T. P., and Lisanti, M. P. (2003) Caveolin-1 knockout mice show an impaired angiogenic response to exogenous stimuli. Am. J. Pathol. 162, 2059-2068
123. Zhang, W., Razani, B., Altschuler, Y., Bouzahzah, B., Mostov, K. E., Pestell, R. G., and Lisanti, M. P. (2000) Caveolin-1 inhibits epidermal growth factor-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3). Transformation suppressor effects of adenovirus-mediated gene delivery of caveolin-1. J. Biol. Chem. 275, 20717-20725
124. Liu, J., Razani, B., Tang, S., Terman, B. I., Ware, J. A., and Lisanti, M. P. (1999) Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angrogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1. J. Biol. Chem. 274, 15781-15785
125. Li, S., Couet, J., and Lisanti, M. P. (1996) Src tyrosine kinases Galpha subumts, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases J. Biol. Chem. 271, 29182-29190
126. Bucci, M., Gratton, J. P., Rudic, R. D., Acevedo, L., Roviezzo F., Cirino, G., and Sessa, W. C. (2000) In vivo delivery of the caveolm-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation. Nat. Med. 6, 1362-1367
127. Gratton J. P., Lin, M. I., Yu, J., Weiss, E. D., Jiang, Z. L., Fairchild, T. A., Iwakiri, Y., Groszmann, R., Claffey, K. P., Cheng, Y. C., et al. (2003) Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progresin mice. Cancer Cell 4, 31-39
128. Galbiati, F., Volonte, D., Engelman, J. A., Watanabe, G., Burk, R., Pestell, R. G., and Lisanti, M. P. (1998) Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. EMBO J. 17, 6633-6648
129. Regina, A., Jodoin, J., Khoueir, P., Rolland, Y., Berthelet F., Moumdjian, R., Fenart, L., Cecchelli, R., Demeule, M., and Beliveau, R. (2004) Down-regulation of caveolin-1 in glioma vasculature: Modulation by radiotherapy. J. Neurosci. Res. 75, 291-299