NR2A induction and NMDA receptor-dependent neuronal death by neurotrophin-4/5 in cortical cell culture

Journal of Neurochemistry

Volumn 88, Issue 3, 2004, Pages 708-716

  Choi, So Young ^a   Hwang, Jung Jin ^a   Koh, Jae Young ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

Egr 1; Erk; Excitotoxicity; Necrosis; Src; TrkB

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; 4 (2 AMINOETHYL)BENZENESULFONYL FLUORIDE; ANTISENSE OLIGODEOXYNUCLEOTIDE; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CELL PROTEIN; DIZOCILPINE; EARLY GROWTH RESPONSE FACTOR 1; GLUTAMIC ACID; GLYCINE; K 252A; MITOGEN ACTIVATED PROTEIN KINASE 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROTROPHIN 4; NITRIC OXIDE SYNTHASE; PROTEIN KINASE P60; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SERINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ATTENUATION; BRAIN CORTEX; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; FETUS; INHIBITION KINETICS; MOUSE; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

ANIMALS; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; MICE; NERVE GROWTH FACTORS; NEURONS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, N-METHYL-D-ASPARTATE;

ANIMALIA;

EID: 0942298554     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.02187.x     Document Type: Article

References (36)

1. Beckmann A. M. and Wilce P. A. (1997) Egr transcription factors in the nervous system. Neurochem. Int. 31, 477-510.
2. Casaccia-Bonnefil P., Gu C. and Chao M. V. (1999) Neurotrophins in cell survival/death decisions. Adv. Exp. Med. Biol. 468, 275-282.
3. Castellanos-Ortega M. R., Cruz-Aguado R. and Martinez-Marti L. (1999) Nerve growth factor: possibilities and limitations of its clinical application. Rev. Neurol. 29, 439-447.
4. Cheung H. H. and Hurd J. W. (2001) Tyrosine phosphorylation of the N-methyl-D-aspartate receptor by exogenous and postsynaptic density-associated Src-family tyrosine kinases. J. Neurochem. 78, 524-534.
5. Choi D. W. (1992) Excitotoxic cell death. J. Neurobiol. 23, 1261-1276.
6. Choi W., Kim H. J., Ahn Y. H., Hong S. H. and Koh J. Y. (2000) Mediation by TrkB of BDNF-induced oxidative neuronal necrosis in cortical culture. Soc. Neurosci. Abstract 26, 1884.
7. Connor B. and Dragunow M. (1998) The role of neuronal growth factors in neurodegenerative disorders of the human brain. Brain Res. Brain Res. Rev. 27, 1-39.
8. Eggert A., Ikegaki N., Liu X., Chou T. T., Lee V. M., Trojanowski J. Q. and Brodeur G. M. (2000) Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells. Oncogene 19, 2043-2051.
9. Gwag B. J., Koh J. Y., Chen M. M., Dugan L. L., Behrens M. M., Lobner D. and Choi D. W. (1995) BDNF or IGF-I potentiates free radical-mediated injury in cortical cell cultures. Neuroreport 7, 93-96.
10. Gwag B. J., Koh J. Y., DeMaro J. A., Ying H. S., Jacquin M. and Choi D. W. (1997) Slowly triggered excitotoxicity occurs by necrosis in cortical cultures. Neuroscience 77, 393-401.
11. Hanke J. H., Gardner J. P., Dow R. L., Changelian P. S., Brissette W. H., Weringer E. J., Pollok B. A. and Connelly P. A. (1996) Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J. Biol. Chem. 271, 695-701.
12. Hetman M., Kanning K., Cavanaugh J. E. and Xia Z. (1999) Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. J. Biol. Chem. 274, 22569-22580.
13. Hodge C., Liao J., Stofega M., Guan K., Carter-Su C. and Schwart Z. J. (1998) Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, Egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2. J. Biol. Chem. 273, 31327-31336.
14. Hsieh C. Y., Leslie F. M. and Metherate R. (2002) Nicotine exposure during a postnatal critical period alters NR2A and NR2B mRNA expression in rat auditory forebrain. Brain Res. Dev. Brain Res. 133, 19-25.
15. Hughes P. E., Alexi T., Walton M., Williams C. E., Dragunow M., Clark R. G. and Gluckman P. D. (1999) Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system. Prog. Neurobiol. 57, 421-450.
16. Hwang J. J., Choi S. Y. and Koh J. Y. (2002) The role of NADPH oxidase, neuronal nitric oxide synthase and poly-(ADP fibose) polymerase in oxidative neuronal death induced in cortical cultures by brain-derived neurotrophic factor and neurotrophin-4/5. J. Neurochem. 82, 894-902.
17. Hyman C., Hofer M., Barde Y. A., Juhas Z. M., Yancopoulos G. D., Squinto S. P. and Lindsay R. M. (1991) BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350, 230-232.
18. Ishikawa Y., Ikeuchi T. and Hatanaka H. (2000) Brain-derived neurotrophic factor accelerates nitric oxide donor-induced apoptosis of cultured cortical neurons. J. Neurochem. 75, 494-502.
19. Iwasaki Y., Gay B., Wada K. and Koizumi S. (1998) Association of the Src family tyrosine kinase Fyn with TrkB. J. Neurochem. 71, 106-111.
20. Kim H. J., Hwang J. J., Behrens M. M., Snider B. J., Choi D. W. and Koh J. Y. (2003) TrkB mediates BDNF-induced potentiation of neuronal necrosis in cortical culture. Neurobiol. Dis. 14, 110-119.
21. Klesse L. J. and Parada L. F. (1999) Trks: signal transduction and intracellular pathways. Microsc. Res. Techn. 45, 210-216.
22. Koh J. Y. and Choi D. W. (1987) Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J. Neurosci. Methods 20, 83-90.
23. Koh J. Y., Gwag B. J., Lobner D. and Choi D. W. (1995) Potentiated necrosis of cultured cortical neurons by neurotrophins. Science 268, 573-575.
24. Noh K. M. and Koh J. Y. (2000) Induction and activation by NADPH oxidases in cultured cortical neurons and astrocytes. J. Neurosci. 20, RC1-5.
25. Noh K. M., Lee J. C., Ahn Y. H., Hong S. H. and Koh J. Y. (1999) Insulin-induced oxidative neuronal injury in cortical culture: mediation by induced N-methyl-D-aspartate receptors. IUBMB Life 48, 263-269.
26. Park J. A. and Koh J. Y. (1999) Induction of an immediate early gene egr-1 by zinc through extracellular signal-regulated kinase activation in cortical culture: its role in zinc-induced neuronal death. J. Neurochem. 73, 450-456.
27. Reiser C. O., Lan Z. T., Hofmann F., Hofer G., Rupprecht H. D. and Goppelt-Struebe M. (1998) Lysophosphatidic acid-mediated signal-transduction pathways involved in the induction of the early-response genes prostaglandin G/ H synthase-2 and Egr-1: a critical role for the mitogen-activated protein kinase p38 and for Rho proteins. Biochem. J. 330, 1107-1114.
28. Roux P. and Barker P. (2002) Neurotrophin signaling through the p75 neurotrophin receptor. Prog. Neurobiol. 67, 203.
29. Schwachtgen J. L., Houston P., Campbell C., Sukhatme V. and Braddock M. (1998) Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway. J. Clin. Invest. 101, 2540-2549.
30. Seeburger J. L. and Springer J. E. (1993) Experimental rationale for the therapeutic use of neurotrophins in amyotrophic lateral sclerosis. Exp. Neurol. 124, 64-72.
31. Sgambato V., Pages C., Rogard M., Besson M. J. and Caboche J. (1998) Extracellular signal-regulated kinase (ERK) controls immediate early gene induction on corticostriatal stimulation. J. Neurosci. 18, 8814-8825.
32. Small D. L., Murray C. L., Mealing G. A., Poulter M. O., Buchan A. M. and Morley P. (1998) Brain derived neurotrophic factor induction of N-methyl-D-aspartate receptor subunit NR2A expression in cultured rat cortical neurons. Neurosci. Lett. 252, 211-214.
33. Tapley P., Lamballe F. and Barbacid M. (1992) K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors. Oncogene 7, 371-381.
34. Tongiorgi E., Cattaneo A. and Domenici L. (1999) Co-expression of TrkB and the N-methyl-D-aspartate receptor subunits NR1-C1, NR2A and NR2B in the rat visual cortex. Neuroscience 90, 1361-1369.
35. Wong E. H., Kemp J. A., Priestley T., Knight A. R., Woodruff G. N. and Iversen L. L. (1986) The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc. Natl. Acad. Sci. USA 83, 7104-7108.
36. Zhong J., Carrozza D. P., Williams K., Pritchett D. B. and Molinoff P. B. (1995) Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain. J. Neurochem. 64, 531-539.