Antenatal glucocorticoids reset the level of baseline and hypoxemia-induced pituitary-adrenal activity in the sheep fetus during late gestation

American Journal of Physiology - Endocrinology and Metabolism

Volumn 286, Issue 2 49-2, 2004, Pages

  Fletcher, Andrew J W ^a   Ma, Xiao Hong ^c   Wu, Wen X ^c   Nathanielsz, Peter W ^c   McGarrigle, Hugh H G ^b   Fowden, Abigail L ^a   Giussani, Dino A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c Animal Health Diagnostic Center   (United States)

Author keywords

Dexamethasone; Hypoxemia

Indexed keywords

CORTICOTROPIN; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HALOTHANE; HYDROCORTISONE; MESSENGER RNA; SODIUM CHLORIDE;

ACID BASE BALANCE; ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD GAS; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; FEMALE; FETUS; FETUS HYPOXIA; HISTOPATHOLOGY; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOXEMIA; MICROSCOPY; NONHUMAN; NORTHERN BLOTTING; PREGNANCY; PRIORITY JOURNAL; SHEEP;

EID: 0942298241     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00158.2003     Document Type: Article

References (57)

1. Akagi K, Berdusco ET, and Challis JR. Cortisol inhibits ACTH but not the AVP response to hypoxaemia in fetal lambs at days 123-128 of gestation. J Dev Physiol 14: 319-324, 1990.
2. Anwar MA, Schwab M, Poston L, and Nathanielsz PW. Betamethasone-mediated vascular dysfunction and changes in hematological profile in the ovine fetus. Am J Physiol Heart Circ Physiol 276: H1137-H1143, 1999.
3. Armitage P and Berry G. Further analysis of straight line data. In: Statistical Methods in Medical Research. Oxford, UK: Blackwell, 1994, p. 292-305.
4. Bennet L, Kozuma S, McGarrigle HH, and Hanson MA. Temporal changes in fetal cardiovascular, behavioural, metabolic and endocrine responses to maternally administered dexamethasone in the late gestation fetal sheep. Br J Obstet Gynaecol 106: 331-339, 1999.
5. Boddy K, Jones CT, Mantell C, Ratcliffe JG, and Robinson JS. Changes in plasma ACTH and corticosteroid of the maternal and fetal sheep during hypoxia. Endocrinology 94: 588-591, 1974.
6. 2 stimulates adrenocorticotrophin and cortisol secretion via a hypothalamic site of action in fetal sheep. J Dev Physiol 18: 173-177, 1992.
7. Brooks AN, Howe DC, Porter DW, and Naylor AM. Neuropeptide-Y stimulates pituitary-adrenal activity in fetal and adult sheep. J Neuroendocrinol 6: 161-166, 1994.
8. Carr G, Jacobs R, Young I, Schwartz J, White A, Crosby S, and Thorburn G. Development of adrenocorticotropin-(1-39) and precursor peptide secretory responses in the fetal sheep during the last third of gestation. Endocrinology 136: 5020-5027, 1995.
9. Castro MI, Valego NK, Zehnder TJ, and Rose JC. The ratio of plasma bioactive to immunoreactive ACTH-like activity increases with gestational age in the fetal lamb. J Dev Physiol 18: 193-201, 1992.
10. Challis JR, Huhtanen D, Sprague C, Mitchell BF, and Lye SJ. Modulation by cortisol of adrenocorticotropin-induced activation of adrenal function in fetal sheep. Endocrinology 116: 2267-2272, 1985.
11. Coulter CL, Myers DA, Nathanielsz PW, and Bird IM. Ontogeny of angiotensin II type 1 receptor and cytochrome P450(c11) in the sheep adrenal gland. Biol Reprod 62: 714-719, 2000.
12. Darbeida H, Naaman E, and Durand P. Glucocorticoid induction of the maturation of ovine fetal adrenocortical cells. Biochem Biophys Res Commun 145: 999-1005, 1987.
13. Dean F and Matthews SG. Maternal dexamethasone treatment in late gestation alters glucocorticoid and mineralocorticoid receptor mRNA in the fetal guinea pig brain. Brain Res 846: 253-259, 1999.
14. Derks JB, Giussani DA, Jenkins SL, Wentworth RA, Visser GH, Padbury JF, and Nathanielsz PW. A comparative study of cardiovascular, endocrine and behavioural effects of betamethasone and dexamethasone administration to fetal sheep. J Physiol 499: 217-226, 1997.
15. Dodic M, May CN, Wintour EM, and Coghlan JP. An early prenatal exposure to excess glucocorticoid leads to hypertensive offspring in sheep. Clin Sci (Colch) 94: 149-155, 1998.
16. Edwards AV, Jones CT, and Bloom SR. Reduced adrenal cortical sensitivity to ACTH in lambs with cut splanchnic nerves. J Endocrinol 110: 81-85, 1986.
17. Fletcher AJ, Edwards CM, Gardner DS, Fowden AL, and Giussani DA. Neuropeptide Y in the sheep fetus: effects of acute hypoxaemia and dexamethasone during late gestation. Endocrinology 141: 3976-3982, 2000.
18. Fletcher AJ, Goodfellow MR, Forhead AJ, Gardner DS, McGarrigle HHG, Fowden AL, and Giussani DA. Low doses of dexamethasone suppress pituitary-adrenal function but augment the glycemic response to acute hypoxemia in fetal sheep during late gestation. Pediatr Res 47: 684-691, 2000.
19. Fletcher AJ, McGarrigle HH, Edwards CM, Fowden AL, and Giussani DA. Effects of low dose dexamethasone treatment on basal cardiovascular and endocrine function in fetal sheep during late gestation. J Physiol 545: 649-660, 2002.
20. Ford LR, Willi SM, Hollis BW, and Wright NM. Suppression and recovery of the neonatal hypothalamic-pituitary-adrenal axis after prolonged dexamethasone therapy. J Pediatr 131: 722-726, 1997.
21. Fowden AL, Li J, and Forhead AJ. Glucocorticoids and the preparation for life after birth: are there long-term consequences of the life insurance? Proc Nutr Soc 57: 113-122, 1998.
22. Giussani DA, McGarrigle HH, Moore PJ, Bennet L, Spencer JA, and Hanson MA. Carotid sinus nerve section and the increase in plasma cortisol during acute hypoxia in fetal sheep. J Physiol 477: 75-80, 1994.
23. Giussani DA, Spencer JA, Moore PJ, Bennet L, and Hanson MA. Afferent and efferent components of the cardiovascular reflex responses to acute hypoxia in term fetal sheep. J Physiol 461: 431-449, 1993.
24. Hollenberg SM, Weinberger C, Ong ES, Cerelli G, Oro A, Lebo R, Thompson EB, Rosenfeld MG, and Evans RM. Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 318: 635-641, 1985.
25. Huch A, Huch R, Schneider H, and Roth G. Continuous transcutaneous monitoring of fetal oxygen tension during labour. Br J Obstet Gynaecol 84: 1-39, 1977.
26. Jackson BT, Morrison SH, Cohn HE, and Piasecki GJ. Adrenal secretion of glucocorticoids during hypoxemia in fetal sheep. Endocrinology 125: 2751-2757, 1989.
27. Kream J, Mulay S, Fukushima DK, and Solomon S. Determination of plasma dexamethasone in the mother and the newborn after administration of the hormone in a clinical trial. J Clin Endocrinol Metab 56: 127-133, 1983.
28. Levitt NS, Lindsay RS, Holmes MC, and Seckl JR. Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat. Neuroendocrinology 64: 412-418, 1996.
29. Liggins GC. The role of cortisol in preparing the fetus for birth. Reprod Fertil Dev 6: 141-150, 1994.
30. 2. Nature 264: 797-799, 1976.
31. Low SC, Moisan MP, Noble JM, Edwards CR, and Seckl JR. Glucocorticoids regulate hippocampal 11 beta-hydroxysteroid dehydrogenase activity and gene expression in vivo in the rat. J Neuroendocrinol 6: 285-290, 1994.
32. Matthews SG. Antenatal glucocorticoids and programming of the developing CNS. Pediatr Res 47: 291-300, 2000.
33. Matthews SG and Challis JR. Regulation of CRH and AVP mRNA in the developing ovine hypothalamus: effects of stress and glucocorticoids. Am J Physiol Endocrinol Metab 268: E1096-E1107, 1995.
34. Matthews SG, Yang K, and Challis JR. Changes in glucocorticoid receptor mRNA in the developing ovine pituitary and the effects of exogenous cortisol. J Endocrinol 144: 483-490, 1995.
35. McDonald TJ, Hoffmann GE, Myers DA, and Nathanielsz PW. Hypothalamic glucocorticoid implants prevent fetal ovine adrenocorticotropin secretion in response to stress. Endocrinology 127: 2862-2868, 1990.
36. Mitchell MD, Lytton FD, and Varticovski L. Paradoxical stimulation of both lipocortin and prostaglandin production in human amnion cells by dexamethasone. Biochem Biophys Res Commun 151: 137-141, 1988.
37. Mokuda O, Ubukata E, and Sakamoto Y. Glucocorticoids potentiate effect of ACTH on cortisol secretion in isolated perfused guinea pig adrenal glands. Exp Clin Endocrinol Diabetes 105: 119-121, 1997.
38. Myers DA, Robertshaw D, and Nathanielsz PW. Effect of bilateral splanchnic nerve section on adrenal function in the ovine fetus. Endocrinology 127: 2328-2335, 1990.
39. Narasaka T, Suzuki T, Moriya T, and Sasano H. Temporal and spatial distribution of corticosteroidogenic enzymes immunoreactivity in developing human adrenal. Mol Cell Endocrinol 174: 111-120, 2001.
40. 2 infusion in the fetal lamb on fetal plasma ACTH, prolactin and cortisol concentrations. Prostaglandins 18: 101-116, 1979.
41. Robinson PM, Comline RS, Fowden AL, and Silver M. Adrenal cortex of fetal lamb: changes after hypophysectomy and effects of Synacthen on cytoarchitecture and secretory activity. Q J Exp Physiol 68: 15-27, 1983.
42. Ross JT, McMillen IC, Adams MB, and Coulter CL. A premature increase in circulating cortisol suppresses expression of 11beta hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid in the adrenal of the fetal sheep. Biol Reprod 62: 1297-1302, 2000.
43. Saoud CJ and Wood CE. Developmental changes and molecular weight of immunoreactive glucocorticoid receptor protein in the ovine fetal hypothalamus and pituitary. Biochem Biophys Res Commun 229: 916-921, 1996.
44. Seckl JR. Glucocorticoid programming of the fetus; adult phenotypes and molecular mechanisms. Mol Cell Endocrinol 185: 61-71, 2001.
45. Simmonds PJ, Phillips ID, Poore KR, Coghill ID, Young IR, and Canny BJ. The role of the pituitary gland and ACTH in the regulation of mRNAs encoding proteins essential for adrenal steroidogenesis in the late-gestation ovine fetus. J Endocrinol 168: 475-485, 2001.
46. Sloboda DM, Moss TJ, Gurrin LC, Newnham JP, and Challis JR. The effect of prenatal betamethasone administration on postnatal ovine hypothalamic-pituitary-adrenal function. J Endocrinol 172: 71-81, 2002.
47. Sloboda DM, Newnham JP, and Challis JR. Effects of repeated maternal betamethasone administration on growth and hypothalamic-pituitary-adrenal function of the ovine fetus at term. J Endocrinol 165: 79-91, 2000.
48. Terrone DA, Rinehart BK, Rhodes PG, Roberts WE, Miller RC, and Martin JN Jr. Multiple courses of betamethasone to enhance fetal lung maturation do not suppress neonatal adrenal response. Am J Obstet Gynecol 180: 1349-1353, 1999.
49. Terrone DA, Smith LG Jr, Wolf EJ, Uzbay LA, Sun S, and Miller RC. Neonatal effects and serum cortisol levels after multiple courses of maternal corticosteroids. Obstet Gynecol 90: 819-823, 1997.
50. Uno H, Eisele S, Sakai A, Shelton S, Baker E, DeJesus O, and Holden J. Neurotoxicity of glucocorticoids in the primate brain. Horm Behav 28: 336-348, 1994.
51. Welberg LA, Seckl JR, and Holmes MC. Inhibition of 11beta-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring. Eur J Neurosci 12: 1047-1054, 2000.
52. Wood CE. Sinoaortic denervation attenuates the reflex responses to hypotension in fetal sheep. Am J Physiol Regul Integr Comp Physiol 256: R1103-R1110, 1989.
53. Wood CE and Chen HG. Acidemia stimulates ACTH, vasopressin, and heart rate responses in fetal sheep. Am J Physiol Regul Integr Comp Physiol 257: R344-R349, 1989.
54. Wood CE, Chen HG, and Bell ME. Role of vagosympathetic fibers in the control of adrenocorticotropic hormone, vasopressin, and renin responses to hemorrhage in fetal sheep. Circ Res 64: 515-523, 1989.
55. Yang K, Berdusco ET, and Challis JR. Opposite effects of glucocorticoid on hepatic 11 beta-hydroxysteroid dehydrogenase mRNA and activity in fetal and adult sheep. J Endocrinol 143: 121-126, 1994.
56. Yang K, Jones SA, and Challis JR. Changes in glucocorticoid receptor number in the hypothalamus and pituitary of the sheep fetus with gestational age and after adrenocorticotropin treatment. Endocrinology 126: 11-17, 1990.
57. Zehnder TJ, Valego NK, Schwartz J, Green J, and Rose JC. Cortisol infusion depresses the ratio of bioactive to immunoreactive ACTH in adrenalectomized sheep fetuses. Am J Physiol Endocrinol Metab 274: E391-E396, 1998.