Cortisol infusion depresses the ratio of bioactive to immunoreactive ACTH in adrenalectomized sheep fetuses

American Journal of Physiology - Endocrinology and Metabolism

Volumn 274, Issue 3 37-3, 1998, Pages

  Zehnder, Timothy J ^a   Valego, Nancy K ^a   Schwartz, Jeffrey ^a   Green, Jennifer ^a   Rose, James C ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Adrenalectomy; Adrenocorticotropic hormone; Adrenocorticotropin; Bioactive adrenocorticotropic hormone; Immunoreactive adrenocorticotropic hormone; Ovine; Pituitary

Indexed keywords

ADRENALECTOMY; AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTERIAL GAS; ARTICLE; CORTICOTROPIN RELEASE; FETUS MATURITY; HEMATOCRIT; HYPOPHYSIS ADRENAL SYSTEM; IMMUNOREACTIVITY; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; SHEEP; STEM CELL;

EID: 0031968142     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.274.3.e391     Document Type: Article

References (29)

1. Apostolakis, E. M., L. D. Longo, J. D. Veldhuis, and S. M. Yellow. Dissociation of pulsatile cortisol and adrenocorticotropin secretion in fetal sheep during late gestation. Endocrinology 130: 2571-2578, 1992.
2. Bennett, H. P., and C. McMartin. Peptide hormones and their analogues: distribution, clearance from the circulation, and inactivation in vivo. Pharmacol. Rev. 30: 247-292, 1979.
3. Carr, G. A., R. A. Jacobs, I. R. Young, J. Schwartz, A. White, S. Crosby, and G. D. Thorburn. Development of adrenocorticotropin-(1-39) and precursor peptide secretory responses in the fetal sheep during the last third of gestation. Endocrinology 136: 5020-5027, 1995.
4. Castro, M. I., N. K. Valego, T. J. Zehnder, and J. C. Rose. The ratio of plasma bioactive to immunoreactive ACTH-like activity increases with gestational age in the fetal lamb. J. Dev. Physiol. 18: 193-201, 1992.
5. Castro, M. I., N. K. Valego, T. J., Zehnder, and J. C. Rose. Bioactive-to-immunoreactive ACTH activity changes with severity of stress in late-gestation ovine fetus. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E68-E73, 1993.
6. Challis, J. R., and A. N. Brooks. Maturation and activation of hypothalamic-pituitary-adrenal function in fetal sheep. Endocr. Rev. 10: 182-204, 1989.
7. Eipper, B. A., and R. E. Mains. Structure and biosynthesis of pro-adrenocorticotropin/endorphin and related peptides. Endocr. Rev. 1: 1-27, 1980.
8. Engeland, W. C., P. Miller, and D. S. Cann. Dissociation between changes in plasma bioactive and immunoreactive adrenocorticotropin after hemorrhage in awake dogs. Endocrinology 124: 2978-2985, 1989.
9. Gasson, J. C. Steroidogenic activity of high molecular weight forms of corticotropin. Biochemistry 18: 4215-4224, 1979.
10. Goverde, H. J. M., G. J. Pesman, and A. G. H. Smals. The bioactivity of immunoreactive adrenocorticotrophin in human blood is dependent on the secretory state of the pituitary gland. Clin. Endocrinol. (Oxf.) 31: 255-265, 1989.
11. Jobert, D. M. Astudy of prenatal growth and development in the sheep. J. Agric. Sci. 47: 382-427, 1956.
12. Jones, C. T. Normal fluctuations in the concentration of corticosteroid and adrenocorticotrophin in the plasma of foetal and pregnant sheep. Horm. Metab. Res. 11: 237-241, 1979.
13. Jones, C. T., and M. M. Roebuck. ACTH peptides and the development of the fetal adrenal. J. Steroid Biochem. 12: 77-82, 1980.
14. McMillen, I. C., J. J. Merei, A. White, S. Crosby, and J. Schwartz. Increasing gestational age and cortisol alter the ratio of ACTH precursors: ACTH secreted from the anterior pituitary of the fetal sheep. J. Endocrinol. 144: 569-576, 1995.
15. Myers, D. A., T. J. McDonald, T. G. Dunn, G. E. Moss, and P. W. Nathanielsz. Effect of implantation of dexamethasone adjacent to the paraventricular nucleus on messenger ribonucleic acid for corticotropin-releasing hormone and proopiomelanocortin during late gestation in fetal sheep. Endocrinology 130: 2167-2172, 1992.
16. Ozolins, I. Z., G. C. Antolovich, C. A. Browne, P. A. Perry, P. M. Robinson, M. Silver, and I. C. McMillen. Effect of adrenalectomy or long term cortisol or adrenocorticotropin (ACTH)-releasing factor infusion on the concentration and molecular weight distribution of ACTH in fetal sheep plasma. Endocrinology 129: 1942-1950, 1991.
17. Ray, N. D., C. S. Turner, N. M. Rawashdeh, and J. C. Rose. Ovine fetal adrenal gland and cardiovascular function. Am. J. Physiol. 254 (Regulatory Integrative Comp. Physiol. 23): R2707-R2710, 1988.
18. Rose, J. C., P. J. Meis, and M. Morris. Ontogeny of endocrine (ACTH, vasopressin, cortisol) responses to hypotension in lamb fetuses. Am. J. Physiol. 240 (Endocrinol. Metab. 3): E656-E661, 1981.
19. Rose, J. C., M. Morris, and P. J. Meis. Hemorrhage in newborn lambs: effects on arterial blood pressure, ACTH, cortisol, and vasopressin. Am. J. Physiol. 240 (Endocrinol. Metab. 3): E585-E590, 1981.
20. Schwartz, J., P. Ash, V. Ford, H. Raff, S. Crosby, and A. White. Secretion of adrenocorticotrophin (ACTH) and ACTH precursors in ovine anterior pituitary cells: actions of corticotrophin-releasing hormone, arginine vasopressin, and glucocorticoids. J. Endocrinol. 140: 189-195, 1994.
21. Schwartz, J., F. Kleftogiannis, R. Jacobs, G. D. Thorburn, S. R. Crosby, and A. White. Biological activity of adrenocorticotropic hormone precursors on ovine adrenal cells. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E623-E629, 1995.
22. Tanaka, S., M. Nomizu, and K. Kurosumi. Intracellular sites of proteolytic processing of pro-opiomelanocortin in melanotrophs and corticotrophs in rat pituitary. J. Histochem. Cytochem. 39: 809-821, 1991.
23. White, A., H. Smith, M. Hoadley, S. H. Dobson, and J. G. Ratcliffe. Clinical evaluation of a two-site immunoradiometric assay for adrenocorticotrophin in unextracted human plasma using monoclonal antibodies. Clin. Endocrinol. (Oxf.) 26: 41-52, 1987.
24. Wintour, E. M., J. P. Coghlan, K. H. Hardy, D. P. Hennessy, B. E. Lingwood, and B. A. Scoggins. Adrenal corticosteroids and immunoreactive ACTH in chronically cannulated ovine foetuses with bilateral adrenalectomy. Acta Endocrinol. 96: 546-552, 1980.
25. Wood, C. E. Sensitivity of cortisol-induced inhibition of ACTH and renin in fetal sheep. Am. J. Physiol. 250 (Regulatory Integrative Comp. Physiol. 19): R795-R802, 1986.
26. Wood, C. E. Does a decrease in cortisol negative feedback efficacy precede ovine parturition? Am. J. Physiol. 252 (Regulatory Integrative Comp. Physiol. 21): R624-R627, 1987.
27. Wood, C. E. Insensitivity of near-term fetal sheep to cortisol: possible relation to the control of parturition. Endocrinology 122: 1565-1572, 1988.
28. Zehnder, T. J., N. K. Valego, and J. C. Rose. The effects of chronically elevated plasma cortisol on the bioactive and immunoreactive corticotropin responses to hemorrhage in the fetal sheep at 0.70 gestation. Am. J. Obstet. Gynecol. 171: 1251-1256, 1994.
29. Zehnder, T. J., N. K. Valego, J. Schwartz, A. White, and J. C. Rose. Regulation of bioactive and immunoreactive ACTH secretion by CRF and AVP in sheep fetuses. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E1076-E1082, 1995.