A comparative study of cardiovascular, endocrine and behavioural effects of betamethasone and dexamethasone administration to fetal sheep

Journal of Physiology

Volumn 499, Issue 1, 1997, Pages 217-226

  Derks, Jan B ^b   Giussani, Dino A ^a   Jenkins, Susan L ^a   Wentworth, Richard A ^a   Visser, Gerard H A ^b   Padbury, James F ^c   Nathanielsz, Peter W ^a  

^a Department of Population Medicine and Diagnostic Sciences   (United States)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; BETAMETHASONE; CATECHOLAMINE; DEXAMETHASONE; GLUCOCORTICOID; NORADRENALIN;

ADRENALIN BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; CATECHOLAMINE BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; ENDOCRINE FUNCTION; FETUS; FETUS BREATHING; HEMODYNAMICS; HYPERTENSION; NONHUMAN; NORADRENALIN BLOOD LEVEL; PRIORITY JOURNAL; SHEEP; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 0031050041     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1997.sp021922     Document Type: Article

References (38)

1. ANDERSON, A. B. M., FLINT, A. P. F. & TURNBULL, A. C. (1975). Mechanisms of action of glucocorticoids in induction of ovine parturition: Effect of placental steroid metabolism. Journal of Endocrinology 66, 61-70.
2. AXELROD, L. (1983). Inhibition of prostacyclin production mediates permissive effect of glucocorticoids on vascular tone. Lancet i, 904-906.
3. BENEDIKTSSON, R., LINDSAY, R. S., NOBLE, J., SECKL, J. R. & EDWARDS, C. R. W. (1993). Glucocorticoid exposure in utero: new model for adult hypertension. Lancet 341, 339-341.
4. BIAN, X. P., SEIDLER, F. J. & SLOTKIN, T. A. (1992). Promotional role for glucococorticoids in the development of intracellular signalling: enhanced cardiac and renal adenylate cyclase reactivity to β-adrenergic and non-adrenergic stimuli after low-dose fetal dexamethasone exposure. Journal of Developmental Physiology 17, 289-297.
5. CHALLIS, J. R. G. & BROOKS, A. N. (1989). Maturation and activation of hypothalamic-pituitary-adrenal function in fetal sheep. Endocrine Reviews 10, 182-204.
6. CROWLEY, P., CHALMERS, I. & KEIRSE, M. J. (1990). The effects of corticosteroid administration before preterm delivery: an overview of the evidence from controlled trials. British Journal of Obstetrics and Gynaecology 97, 11-25.
7. DAWES, G. S., SERRA-SERRA, V., MOULDEN, M. & REDMAN, C. W. G. (1994). Dexamethasone and fetal heart rate variation. British Journal of Obstetrics and Gynaecology 101, 675-679.
8. DERKS, J. B., JENKINS, S. L., WENTWORTH, R. A., GIUSSANI, D. A., VAN DAM, L. M., VISSER, G. H. A. & NATHANIELSZ, P. W. (1995a). The effect of betamethasone (BETA) and dexamethasone (DEX) administration to fetal sheep at 125 days gestation (dGA) on fetal blood pressure (FBP), heart rate (FHR), and heart rate variation (FHRvar). Journal of Physiology 483.P, 113P.
9. DERKS, J. B., MULDER, E. J. H. & VISSER, G. H. A. (1995b). The effects of maternal betamethasone administration on the fetus. British Journal of Obstetrics and Gynaecology 102, 40-46.
10. DODIC, M. & WINTOUR, E. M. (1994). Effects of prolonged (48 h) infusion of cortisol on blood pressure, renal function and fetal fluids in the immature ovine foetus. Clinical and Experimental Pharmacology and Physiology 21, 971-980.
11. GIUSSANI, D. A., RIQUELME, R. A., MORAGA, F. A., MCGARRIGLE, H. H. G., GAETE, C. R., SANHUEZA, E. M., HANSON, M. A. & LLANOS, A. J. (1996). Chemoreflex and endocrine components of the cardiovascular responses to acute hypoxemia in the llama fetus. American Journal of Physiology 40, R73-83.
12. GIUSSANI, D. A., SPENCER, J. A. D., MOORE, P. J., BENNET, L. & HANSON, M. A. (1993). Afferent and efferent components of the cardiovascular reflex responses to acute hvpoxia in term fetal sheep. Journal of Physiology 461, 431-449.
13. HAIGH, R. M. & JONES, C. T. (1990). Effect of glucocorticoids on alpha I-adrenergic receptor binding in rat vascular smooth muscle. Journal of Molecular Endocrinology 5, 41-48.
14. HAYNES, R. C. (1990). Adrenocorticotropic hormone, adrenocortical steroids and their synthetic analogs, inhibitors of adrenal steroid biosynthesis. In Goodman and Gilman's the Pharmacological Basis of Therapeutics, 8th edn, ed. GOODMAN GILMAN, A., RALL, T. W., NIES, A. S. & TAYLOR, P., pp. 1431-1459. Pergamon Press, New York.
15. JOELS, M. & DE KLOET, E. R. (1995). Corticosteroid hormones: Endocrine messengers in the brain. News in Physiological Sciences 10, 71-76.
16. KARI, M. A., HALLMAN, M., ERONEN, M., TERAMO, K., VIRTANEN, M., KOIVISTO, M. & IKONEN, R. S. (1994). Prenatal dexamethasone treatment in conjunction with rescue therapy of human surfactant: A randomized placebo-controlled multicenter study. Pediatrics 93, 730-736.
17. KITTERMAN, J. A., LIGGINS, G. C., FEWELL, J. E. & TOOLEY, W. H. (1983). Inhibition of breathing movements in fetal sheep by prostaglandins. Journal of Applied Physiology 54, 687-692.
18. KNOWLES, R. G., SALTER, M., BROOKS, S. L. & MONCADA, S. (1990). Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the liver, lung, and aorta of the rat. Biochemical and Biophysical Research Communications 172, 1042-1048.
19. KORNEL, L. (1993). The role of vascular steroid receptors in the control of vascular contractility and peripheral vascular resistance. Journal of Biochemical and Molecular Biology 43, 195-203.
20. KREAM, J., MULAY, S., FUKUSHIMA, D. K. & SOLOMON, S. (1983). Determination of plasma dexamethasone in the mother and the newborn after administration of the hormone in a clinical trial. Journal of Clinical Endocrinology and Metabolism 56, 127-133.
21. LEVITT, N. S., HOLMES, M. C., LINDSAY, R. S. & SECKL, J. R. (1995). Prenatal dexamethasone programmes blood pressure, basal corticosterone and hippocampal glucocorticoid receptor gene expression in the rat. Proceedings of the 77th Annual Meeting of the Endocrine Society P451, 225.
22. LIGGINS, G. C. (1969). Premature delivery of foetal lambs infused with glucocorticoids. Journal of Endocrinology 45, 515-523.
23. LIU, J., HAIGH, R. M. & JONES, C. T. (1990). Glucocorticoid increases noradrenaline-induced inositol phosphate formation in vascular smooth muscle cells. Journal of Endocrinology 127 (abstract), 83.
24. MAGYAR, D. M., FRIDSHAL, D., ELSNER, C. W., GLATZ, T., ELIOT, J., KLEIN, A. H., LOWE, K. C., BUSTER, J. E. & NATHANIELSZ, P. W. (1980). Time-trend analysis of plasma cortisol concentrations in the fetal sheep in relation to parturition. Endocrinology 107, 155-159.
25. MATTHEWS, J. N. S., ALTMAN, D. G., CAMPBELL, M. J. & ROYSTON, P. (1990). Analysis of serial measurements in medical research. British Medical Journal 300, 230-235.
26. MULDER, E. J. H., DERKS, J. B. & VISSER, G. H. A. (1995). Effects of maternal dexamethasone administration on human fetal behaviour and heart rate. Proceedings of the Society for the Study of Fetal Physiology, A10, Sweden.
27. MULDER, E. J. H., DERKS, J. B., ZONNEVELD, M. F., BRUINSE, H. W. & VISSER, G. H. A. (1994). Transient reduction in fetal activity and heart rate variation after maternal betamethasone administration. Early Human Development 36, 49-60.
28. NATHANIELSZ, P. W., BAILEY, A., POORE, E. R., THORNBURN, G. D. & HARDING, R. (1980). The relationship between myometrial activity and sleep state and breathing in fetal sheep throughout the last third of gestation. American Journal of Obstetrics and Gynecology 138, 653-659.
29. NIH CONSENSUS DEVELOPMENT CONFERENCE. (1995). Effect of corticosteroids for fetal maturation on perinatal outcomes. American Journal of Obstetrics and Gynecology 173 suppl., 253-344.
30. OLSON, D. M., LYE, S. J., SKINNER, K. & CHALLIS, J. R. G. (1985). Prostanoid concentrations in maternal/fetal plasma and amniotic fluid and intra-uterine tissue prostanoid output in relation to myometrial contractility during the onset of adrenocorticotrophin-induced preterm labor in sheep. Endocrinology 116, 389-397.
31. PETERSEN, M. C., NATION, R. L., ASHLEY, J. J. & MCBRIDE, W. G. (1980). The placental transfer of betamethasone. European Journal of Clinical Pharmacology 18, 245-247.
32. PEULER, J. D. & JOHNSON, G. A. (1977). Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. Life Sciences 21, 625-636.
33. SATO, A., SUZUKI, H., NAKAZATO, Y., SHIBATA, H., INAGAMI, T. & SARUTA, T. (1994). Increased expression of vascular angiotensin II type 1A receptor gene in glucocorticoid-induced hypertension. Journal of Hypertension 12, 511-516.
34. TANGALAKIS, K., LUMBERS, E. R., MORITZ, K. M., TOWSTOLESS, M. K. & WINTOUR, E. M. (1992). Effect of cortisol on blood pressure and vascular reactivity in the ovine fetus. Experimental Physiology 77, 709-717.
35. TOBIAN, L. (1960). Interrelationship of electrolytes, juxtaglomerular cells and hypertension. Physiological Reviews 40, 280-312.
36. TSUEI, S. E. & ASHLEY, J. J. (1978). Quantification of dexamethasone in biological fluids using high performance liquid chromatography. Journal of Chromatography 145, 213-220.
37. WALKER, B. R. & WILLIAMS, B. C. (1992). Corticosteroids and vascular tone: Mapping the messenger maze. Clinical Sciences 82, 597-605.
38. WOOD, C. E., CHEUNG, C. Y. & BRACE, R. A. (1987). Fetal heart rate, arterial pressure, and blood volume responses to cortisol infusion. American Journal of Physiology 253, R904-909.