A Low Protein Diet Alters Gene Expression in Rat Pancreatic Islets

Journal of Nutrition

Volumn 134, Issue 2, 2004, Pages 321-327

  Delghingaro Augusto, Viviane ^a   Ferreira, Fabiano ^a   Bordin, Silvana ^b   Corezola Do Amaral, Maria Esméria ^a   Toyama, Marcos H ^a   Boschero, Antonio Carlos ^a   Carneiro, Everardo Magalhães ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

cDNA array; Gene expression; Pancreatic islets; Protein restriction

Indexed keywords

CLUSTERIN; GLUCOSE TRANSPORTER; INITIATION FACTOR 2; NEUROTRANSMITTER RECEPTOR; PHOSPHOLIPASE A2; PROTEIN PRECURSOR; SECRETOGRANIN II;

ANIMAL EXPERIMENT; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION REGULATION; INSULIN RELEASE; MALE; METABOLIC DISORDER; NONHUMAN; NUTRITIONAL DISORDER; PANCREAS DISEASE; PANCREAS ISLET; PROTEIN RESTRICTION; PROTEIN TARGETING; PROTEIN TRANSPORT; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALIA; EUKARYOTA;

EID: 0942279597     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.2.321     Document Type: Article

References (65)

1. Fowden, A. L. & Hill, D. J. (2001) Intra-uterine programming of the endocrine pancreas. Br. Med. Bull. 60: 123-142.
2. Vaulont, S. & Kahn, A. (1994) Transcriptional control of metabolic regulation genes by carbohydrates. FASEB J. 8: 28-35.
3. Towle, H. C. (1995) Metabolic regulation of gene transcription in mammals. J. Biol. Chem. 270: 23235-23238.
4. Foufelle, F., Girard, J. & Ferre, P. (1998) Glucose regulation of gene expression. Curr. Opin. Clin. Nutr. Metab. Care 1: 323-328.
5. Pegorier, J. P. (1998) Regulation of gene expression by fatty acids. Curr. Opin. Clin. Nutr. Metab. Care 1: 329-334.
6. Srinivasan, M., Song, F., Aalinkeel, R. & Patel, M. L. (2001) Molecular adaptations in islets from neonatal rats reared artificially on a high carbohydrate milk formula. J. Nutr. Biochem. 12: 575-584.
7. Harper, A. E. & Rogers, Q. R. (1965) Amino acid imbalance. Proc. Nutr. Soc. 24: 173-190.
8. Richardson, L. R., Hale, F. & Ritchey, S. J. (1965) Effect of fasting and level of dietary protein on free amino acids in pig plasma. J. Anim. Sci. 24: 368-379.
9. Peng, Y., Meliza, L. L., Vavich, M. G. & Kemmerer, A. R. (1975) Effects of amino acid imbalance and protein content of diets on food intake and preference of young, adult, and diabetic rats. J. Nutr. 105: 1395-1404.
10. Reusens, B., Dahri, S., Snoeck, A., Bennis-Taleb, N., Remacle, C. & Hoet, J. J. (1995) Long term consequences of diabetes and its complications may have a fetal origin: experimental and epidemiological evidence. In: Diabetes (Cowett, R. M., ed.), vol. 35, pp. 187-198. Nestle Nutrition Workshop Series, Raven Press, New York, NY.
11. Cetin, I. (2001) Amino acid interconversions in the fetal-placental unit: the animal model and human studies in vivo. Pediatr. Res. 49: 148-154.
12. Kilberg, M. S., Hutson, R. G. & Laine, R. O. (1994) Amino acid-regulated gene expression in eukaryotic cells. FASEB J. 8: 13-19.
13. Jousse, C., Bruhat, A. & Fafournoux, P. (1999) Amino acid regulation of gene expression. Curr. Opin. Clin. Nutr. Metab. Care 2: 297-301.
14. Fafournoux, P., Bruhat, A. & Jousse, C. (2000) Amino acid regulation of gene expression. Biochem. J. 351: 1-12.
15. Snoeck, A., Remacle, C., Reusens, B. & Hoet, J. J. (1990) Effect of a low protein diet during pregnancy on the fetal rat endocrine pancreas. Biol. Neonate 57: 107-118.
16. Dahri, S., Snoeck, A., Reusens-Billen, B., Remacle, C. & Hoet, J. J. (1991) Islet function in offspring of mothers on low-protein diet during gestation. Diabetes 40 (suppl. 2): 115-120.
17. Hoet, J. J., Dahri, S., Snoeck, A., Reusens-Billen, B. & Remacle, C. (1992) Importance of diets and their effect on fetal development: function and structure of the endocrine pancreas following protein deficiency during intrauterine life. Bull. Mem. Acad. R. Med. Belg. 147: 174-181.
18. Latorraca, M. Q., Cameiro, E. M., Mello, M. A. & Boschero, A. C. (1999) Reduced insulin secretion in response to nutrients in islets from malnourished young rats is associated with a diminished calcium uptake. J. Nutr. Biochem. 10: 37-43.
19. Reis, M. A., Carneiro, E. M., Mello, M. A., Boschero, A. C., Saad, M. J. & Velloso, L. A. (1997) Glucose-induced insulin secretion is impaired and insulin-induced phosphorylation of the insulin receptor and insulin receptor substrate-1 are increased in protein-deficient rats. J. Nutr. 127: 403-410.
20. Doumus, B. T., Watson, W. A. & Biggs, H. G. (1971) Albumin standards and measurements of serum albumin with bromocresol green. Clin. Chim. Acta 31: 87-96.
21. Heard, C. R., Frangi, S. M., Wright, P. M. & McCartney, P. R. (1997) Biochemical characteristics of different forms of protein-energy malnutrition: an experimental model using young rats. Br. J. Nutr. 37: 1-21.
22. Weinkove, C., Weinkove, E. A. & Pimstone, B. L. (1976) Glucose tolerance and insulin release in malnourished rats. Clin. Sci. Mol. Med. 50: 153-163.
23. Scott, A. M., Atwater, I. & Rojas, E. (1981) A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans. Diabetologia 21: 470-475.
24. Bordin, S., Boschero, A. C., Cameiro, E. M. & Atwater, I. (1995) Ionic mechanisms involved in the regulation of insulin secretion by muscarinic agonists. J. Membr. Biol. 148: 177-184.
25. http://www.bdbiosciences.com/atlas/genelists/index.shtml/7854-1. [Accessed May 02, 2003.]
26. http://www.ncbi.nlm.nih.gov/PubMed. [Accessed June 30, 2003.]
27. http//www.ncbi.nlm.nih.gov/BLAST. [Accessed January 20, 2002.]
28. Eickhoff, B., Korn, B., Schick, M., Poustka, A. & van der Bosch, J. (1999) Normalization of array hybridization experiments in differential gene expression analysis. Nucleic Acids Res. 27: e33.
29. Hales, C. N., Desai, M., Ozanne, S. E. & Crowther, N. J. (1996) Fishing in the stream of diabetes: from measuring insulin to the control of fetal organogenesis. Biochem. Soc. Trans. 24: 341-350.
30. Bemey, D. M., Desai, M., Palmer, D. J., Greenwald, S., Brown, A., Hales, C. N. & Berry, C. L. (1997) The effects of maternal protein deprivation on the fetal rat pancreas: major structural changes and their recuperation. J. Pathol. 183: 109-115.
31. Petrik, J., Reusens, B., Arany, E., Remacle, C., Coelho, C., Hoet, J. J. & Hill, D. J. (1999) A low protein diet alters the balance of islet cell replication and apoptosis in the fetal and neonatal rat and is associated with a reduced pancrelatic expression of insulin-like growth factor-II. Endocrinology 140: 4861-4873.
32. Cherif, H., Reusens, B., Dahri, S. & Remacle, C. (2001) A protein-restricted diet during pregnancy alters in vitro insulin secretion from islets of fetal Wistar rats. J. Nutr. 131: 1555-1559.
33. Ferreira, F., Filiputti, E., Arantes, V. C., Stoppiglia, L. F., Araujo, E. P., Delghingaro-Augusto, V., Latorraca, M. Q., Toyama, M. H., Boschero, A. C. & Carneiro, E. M. (2003) Decreased cholinergic stimulation of insulin secretion by islets from rats fed a low protein diet is associated with reduced protein kinase C α expression. J. Nutr. 133: 695-699.
34. Arantes, V. C., Teixeira, V. P., Reis, M. A., Latorraca, M. Q., Leite, A. R., Carneiro, E. M., Yamada, A. T. & Boschero, A. C. (2002) Expression of PDX-1 is reduced in pancreatic islets from pups of rat dams fed a low protein diet during gestation and lactation. J. Nutr. 132: 2030-2035.
35. Latorraca, M. Q., Cameiro, E. M., Boschero, A. C. & Mello, M. A. (1998) Protein deficiency during pregnancy and lactation impairs glucose-induced insulin secretion but increases the sensitivity to insulin in weaned rats. Br. J. Nutr. 80: 291-297.
36. Rao, R. H. (1988) Diabetes in the undernourished: coincidence or consequence? Endocr. Rev. 9: 67-87.
37. Lake, N., Wright, E. D. & Lapp, W. S. (1992) Effects of taurine deficiency on immune function in mice. Adv. Exp. Med. Biol. 315: 241-243.
38. Eley, D. W., Lake, N. & ter Keurs, H. E. (1994) Taurine depletion and excitation-contraction coupling in rat myocardium. Circ. Res. 74: 1210-1219.
39. Cherif, H., Reusens, B., Ahn, M. T., Hoet, J. J. & Remacle, C. (1998) Effects of taurine on the insulin secretion of rat fetal islets from dams fed a low-protein diet. J. Endocrinol. 159: 341-348.
40. Gao, Z., Young, R. A., Li, G., Najafi, H., Buettger, C., Sukumvanich, S. S., Wong, R. K., Wolf, B. A. & Matschinsky, F. M. (2003) Distinguishing features of leucine and alpha-ketoisocaproate sensing in pancreatic beta-cells. Endocrinology 144: 1949-1957.
41. Li, C., Najafi, H., Daikhin, Y., Nissim, I. B., Collins, H. W., Yudkoff, M., Matschinsky, F. M. & Stanley, C. A. (2003) Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets. J. Biol. Chem. 278: 2853-2858.
42. Thorens, B. (2003) A gene knockout approach in mice to identify glucose sensors controlling glucose homeostasis. Pflugers. Arch. 445: 482-490.
43. Dunaway, G. A. & Kasten, T. P. (1987) Nature of the subunits of the 6-phosphofructo-1-kinase isoenzymes from rat tissues. Biochem. J. 242: 667-671.
44. Yaney, G. C., Schultz, V., Cunningham, B. A., Dunaway, G. A., Corkey, B. E. & Tornheim, K. (1995) Phosphofructokinase isozymes in pancreatic islets and clonal beta-cells (INS-1). Diabetes 44: 1285-1289.
45. Eto, K., Sakura, H., Yasuda, K., Hayakawa, T., Kawasaki, E., Moriuchi, R., Nagataki, S., Yazaki, Y. & Kadowaki, T. (1994) Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet. Biochem. Biophys. Res. Commun. 198: 990-998.
46. Knobler, H., Weiss, Y., Peled, M. & Groner, Y. (1997) Impaired glucose-induced insulin response in transgenic mice overexpressing the L-phosphofructokinase gene. Diabetes 46: 1414-1418.
47. 45Ca uptake by pancreatic rat islets. Nutr. Biochem. 6: 314-318.
48. + channel in insulin-secreting pancreatic beta-cells. J. Mol. Endocrinol. 22: 113-123.
49. Sogaard, M., Tani, K., Ye, R. R., Geromanos, S., Tempst, P., Kirchhausen, T., Rothman, J. E. & Sollner, T. (1994) A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell 78: 937-948.
50. Johannes, L., Doussau, F., Clabecq, A., Henry, J. P., Darchen, F. & Poulain, B. (1996) Evidence for a functional link between Rab3 and the SNARE complex. J. Cell. Sci. 109: 2875-2884.
51. Lupashin, V. V. & Waters, M. G. (1997) t-SNARE activation through transient interaction with a rab-like guanosine triphosphatase. Science (Washington, DC) 276: 1255-1258.
52. Wagner, A. C., Strowski, M. Z., Goke, B. & Williams, J. A. (1995) Molecular cloning of a new member of the Rab protein family, Rab 26, from rat pancreas. Biochem. Biophys. Res. Commun. 207: 950-956.
53. Easom, R. A. (2000) Beta-granule transport and exocytosis. Semin. Cell. Dev. Biol. 11: 253-266.
54. 2+-dependent association of calmodulin with the Rab3A effector domain inversely correlates with insulin exocytosis. Diabetes 50: 2029-2039.
55. 2+/calmodulin-dependent protein kinase II activity in pancreatic beta-cells. Am. J. Physiol. 274: E708-E715.
56. Coppola, T., Perret-Menoud, V., Luthi, S., Farnsworth, C. C., Glomset, J. A. & Regazzi, R. (1999) Disruption of Rab3-calmodulin interaction, but not other effector interactions, prevents Rab3 inhibition of exocytosis. EMBO J. 18: 5885-5891.
57. Sidyelyeva, G. & Fricker, L. D. (2002) Characterization of Drosophila carboxypeptidase D. J. Biol. Chem. 277: 49613-49620.
58. Rong, Y. P., Liu, F., Zeng, L. C., Ma, W. J., Wei, D. Z. & Han, Z. G. (2002) Cloning and characterization of a novel human secretory protein: secretogranin III. Sheng Wu Hua Hsueh Yu Sheng Wu Wu Li Hsueh Pao 34: 411-417.
59. Taupenot, L., Harper, K. L. & O'Connor, D. T. (2003) Mechanisms of disease: the chromagranin family. N. Engl. J. Med. 348: 1134-1149.
60. Vu, T. H. & Werb, Z. (2000) Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev. 14: 2123-2133.
61. Bromberg, J. & Darnell, J. E., Jr. (2000) The role of STATs in transcriptional control and their impact on cellular function. Oncogene 19: 2468-2473.
62. Jones, P. M. & Persaud, S. J. (1998) Protein kinases, protein phosphorylation, and the regulation of insulin secretion from pancreatic beta-cells. Endocr. Rev. 19: 429-461.
63. Johnson, G. L. & Lapadat, R. (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science (Washington, DC) 298: 1911-1912.
64. Song, F., Srinivasan, M., Aalinkeel, R. & Patel, M. S. (2001) Use of a cDNA array for the identification of genes induced in islets of suckling rats by a high-carbohydrate nutritional intervention. Diabetes 50: 2053-2060.
65. Srinivasan, M., Aalinkeel, R., Song, F., Lee, B., Laychock, S. G. & Patel, M. S. (2000) Adaptive changes in insulin secretion by islets from neonatal rats raised on a high-carbohydrate formula. Am. J. Physiol. 279: E1347-E1357.