-
1
-
-
0025336149
-
Effects of n-3 fatty acids on lipid metabolism
-
Nestel PJ. Effects of n-3 fatty acids on lipid metabolism. Annu Rev Nutr 1990; 10:149-167.
-
(1990)
Annu Rev Nutr
, vol.10
, pp. 149-167
-
-
Nestel, P.J.1
-
2
-
-
0029915914
-
Polyunsaturated fatty acid regulation of hepatic gene transcription
-
Clarke SD, Jump DB. Polyunsaturated fatty acid regulation of hepatic gene transcription. J Nutr 1996; 126 (symposium):1105-1109.
-
(1996)
J Nutr
, vol.126
, Issue.SYMPOSIUM
, pp. 1105-1109
-
-
Clarke, S.D.1
Jump, D.B.2
-
3
-
-
0030027709
-
Cyclic AMP and fatty acids increase carnitine palmitoyltransferase I transcription in cultured fetal rat hepatocytes
-
Chatelain F, Kohl C, Esser V, McGarry JD, Girard J, Pégorier JP. Cyclic AMP and fatty acids increase carnitine palmitoyltransferase I transcription in cultured fetal rat hepatocytes. Eur J Biochem 1996; 235:789-798.
-
(1996)
Eur J Biochem
, vol.235
, pp. 789-798
-
-
Chatelain, F.1
Kohl, C.2
Esser, V.3
McGarry, J.D.4
Girard, J.5
Pégorier, J.P.6
-
4
-
-
0030841936
-
Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulator of lipid metabolism
-
Latruffe N, Vamecq J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulator of lipid metabolism. Biochimie 1997; 79:81-94. This paper represents a recent and exhaustive overview of the effect of PP and PPARs in the control of transcription of several genes involved in the regulation of mitochondrial or peroxisomal β-oxidation and lipoprotein metabolism.
-
(1997)
Biochimie
, vol.79
, pp. 81-94
-
-
Latruffe, N.1
Vamecq, J.2
-
5
-
-
0029294531
-
Peroxisome proliferator activated receptors: Transcriptional regulators of adipogenesis, lipid metabolism and more
-
Wahli W, Braissant O, Desvergne B. Peroxisome proliferator activated receptors: transcriptional regulators of adipogenesis, lipid metabolism and more. Chem Biol 1995; 2:261-266.
-
(1995)
Chem Biol
, vol.2
, pp. 261-266
-
-
Wahli, W.1
Braissant, O.2
Desvergne, B.3
-
6
-
-
0030691810
-
Fatty acid regulation of gene expression. Its role in fuel partitioning and insulin resistance
-
Clarke SD, Baillie R, Jump DB, Nakamura MT. Fatty acid regulation of gene expression. Its role in fuel partitioning and insulin resistance. Ann NY Acad Sci 1997; 827:178-187.
-
(1997)
Ann NY Acad Sci
, vol.827
, pp. 178-187
-
-
Clarke, S.D.1
Baillie, R.2
Jump, D.B.3
Nakamura, M.T.4
-
7
-
-
0028789164
-
Effect of germfree state on the capacities of isolated rat colonocytes to metabolize n-butyrate, glucose and glutamine
-
Cherbuy C, Darcy-Vrillon B, Morel MT, Pégorier JP, Duée PH. Effect of germfree state on the capacities of isolated rat colonocytes to metabolize n-butyrate, glucose and glutamine. Gastroenterology 1995; 109:1890-1899.
-
(1995)
Gastroenterology
, vol.109
, pp. 1890-1899
-
-
Cherbuy, C.1
Darcy-Vrillon, B.2
Morel, M.T.3
Pégorier, J.P.4
Duée, P.H.5
-
8
-
-
0030772026
-
Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line
-
Nakano K, Mizuno T, Sowa Y, Orita T, Yoshino T, Okuyama Y, et al. Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line. J Biol Chem 1997; 272:22199-22206. The authors demonstrate that butyrate, a SCFA, directly induces the transcription of WAF1/Cip1 gene in human colon adenocarcinoma cells.
-
(1997)
J Biol Chem
, vol.272
, pp. 22199-22206
-
-
Nakano, K.1
Mizuno, T.2
Sowa, Y.3
Orita, T.4
Yoshino, T.5
Okuyama, Y.6
-
9
-
-
0030731946
-
Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels
-
Gremlich S, Bonny C, Waeber G, Thorens B. Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels. J Biol Chem 1997; 272:30261-30269.
-
(1997)
J Biol Chem
, vol.272
, pp. 30261-30269
-
-
Gremlich, S.1
Bonny, C.2
Waeber, G.3
Thorens, B.4
-
11
-
-
0029144018
-
Induction of the acyl-coenzyme a synthetase gene by fibrates and fatty acids is mediated by peroxisome proliferator response element in the C promoter
-
Schoonjans K, Watanabe M, Suzuki H, Mahfoudi A, Krey G, Wahli W, et al. Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by peroxisome proliferator response element in the C promoter. J Biol Chem 1995; 270:1-8.
-
(1995)
J Biol Chem
, vol.270
, pp. 1-8
-
-
Schoonjans, K.1
Watanabe, M.2
Suzuki, H.3
Mahfoudi, A.4
Krey, G.5
Wahli, W.6
-
12
-
-
0030774420
-
Fatty acid regulation of fatty acid-binding protein expression in the small intestine
-
Poirier H, Niot I, Degrace P, Monnot M-C, Bernard A, Besnard P. Fatty acid regulation of fatty acid-binding protein expression in the small intestine. Am J Physiol 1997; 273:289-295.
-
(1997)
Am J Physiol
, vol.273
, pp. 289-295
-
-
Poirier, H.1
Niot, I.2
Degrace, P.3
Monnot, M.-C.4
Bernard, A.5
Besnard, P.6
-
13
-
-
0028058149
-
Molecular and biochemical analyses of fatty acid transport, metabolism and gene regulation in Escherichia coli
-
Black PN, DiRusso CC. Molecular and biochemical analyses of fatty acid transport, metabolism and gene regulation in Escherichia coli. Biochim Biophys Acta 1994; 1210:123-145.
-
(1994)
Biochim Biophys Acta
, vol.1210
, pp. 123-145
-
-
Black, P.N.1
DiRusso, C.C.2
-
14
-
-
0031197036
-
Peroxisome proliferator-activated receptor agonists
-
Willson TM, Wahli W. Peroxisome proliferator-activated receptor agonists. Curr Opin Chem Biol 1997; 1:235-241. This review focuses on the recent identification of synthetic and natural ligands for PPARs and the role of these transcriptional factors in the regulation of gene expression.
-
(1997)
Curr Opin Chem Biol
, vol.1
, pp. 235-241
-
-
Willson, T.M.1
Wahli, W.2
-
15
-
-
0028860254
-
Analysis of acyl coenzyme a binding to the transcription factor FadR and identification of amino acid residues in the carboxyl terminus required for ligand binding
-
Raman N, DiRusso CC. Analysis of acyl coenzyme A binding to the transcription factor FadR and identification of amino acid residues in the carboxyl terminus required for ligand binding. J Biol Chem 1995; 270:1092-1097.
-
(1995)
J Biol Chem
, vol.270
, pp. 1092-1097
-
-
Raman, N.1
DiRusso, C.C.2
-
16
-
-
0029994543
-
Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
-
Schoonjans K, Staels B, Auwerx J. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 1996; 37:907-925.
-
(1996)
J Lipid Res
, vol.37
, pp. 907-925
-
-
Schoonjans, K.1
Staels, B.2
Auwerx, J.3
-
17
-
-
0030748675
-
Regulation of gene expression by fatty acids: Special reference to fatty acid binding protein
-
Niot I, Poirier H, Besnard P. Regulation of gene expression by fatty acids: special reference to fatty acid binding protein. Biochimie 1997; 79:129-133.
-
(1997)
Biochimie
, vol.79
, pp. 129-133
-
-
Niot, I.1
Poirier, H.2
Besnard, P.3
-
18
-
-
0026757369
-
Specificity of unsaturated fatty acid-regulated expression of the Saccharomyces cerevisiae OLE1 gene
-
McDonough VM, Stukey JE, Martin CE. Specificity of unsaturated fatty acid-regulated expression of the Saccharomyces cerevisiae OLE1 gene. J Biol Chem 1992; 267:5931-5936.
-
(1992)
J Biol Chem
, vol.267
, pp. 5931-5936
-
-
McDonough, V.M.1
Stukey, J.E.2
Martin, C.E.3
-
19
-
-
0030040585
-
Regulatory elements that control transcription activation and unsaturated fatty acid-mediated repression of the Saccharomyces cerevisiae OLE1 gene
-
Choi JY, Stukey J, Hwang SY, Martin CE. Regulatory elements that control transcription activation and unsaturated fatty acid-mediated repression of the Saccharomyces cerevisiae OLE1 gene. J Biol Chem 1996; 271:3581-3589.
-
(1996)
J Biol Chem
, vol.271
, pp. 3581-3589
-
-
Choi, J.Y.1
Stukey, J.2
Hwang, S.Y.3
Martin, C.E.4
-
20
-
-
0029787239
-
Disruption of the gene encoding the acyl-CoA-binding protein (ACB1) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae
-
Schjerling CK, Hummel R, Hansen JK, Borsting C, Mikkelsen JM, Kristiansen K, Knudsen J. Disruption of the gene encoding the acyl-CoA-binding protein (ACB1) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae. J Biol Chem 1996; 271:22514-22521. Using acyl-CoA binding protein knockout in yeast, the authors suggest that LCFAcyl-CoA might be the intracellular metabolite responsible for the regulation of A9-desaturase gene transcription.
-
(1996)
J Biol Chem
, vol.271
, pp. 22514-22521
-
-
Schjerling, C.K.1
Hummel, R.2
Hansen, J.K.3
Borsting, C.4
Mikkelsen, J.M.5
Kristiansen, K.6
Knudsen, J.7
-
21
-
-
2242479945
-
Evidence that acyl-CoA synthetase activity is required for repression of yeast acetyl coenzyme a carboxylase by exogenous fatty acids
-
Kamiryo T, Parthassarathy S, Numa S. Evidence that acyl-CoA synthetase activity is required for repression of yeast acetyl coenzyme A carboxylase by exogenous fatty acids. Proc Natl Acad Sci USA 1976; 73:386-390.
-
(1976)
Proc Natl Acad Sci USA
, vol.73
, pp. 386-390
-
-
Kamiryo, T.1
Parthassarathy, S.2
Numa, S.3
-
22
-
-
0028273806
-
Transcriptional activation by amphipathic carboxylic peroxisomal proliferators is induced by free acid rather than the acyl-CoA derivative
-
Hertz R, Berman I, Bar-Tana J. Transcriptional activation by amphipathic carboxylic peroxisomal proliferators is induced by free acid rather than the acyl-CoA derivative. Eur J Biochem 1994; 221:611-615.
-
(1994)
Eur J Biochem
, vol.221
, pp. 611-615
-
-
Hertz, R.1
Berman, I.2
Bar-Tana, J.3
-
24
-
-
0031798524
-
Role of long-chain fatty acids in the postnatal induction of genes coding for liver mitochondrial β-oxidative enzymes
-
in press
-
Pégorier JP, Chatelain F, Thumelin S, Girard J. Role of long-chain fatty acids in the postnatal induction of genes coding for liver mitochondrial β-oxidative enzymes. Biochem Soc Trans 1998; 26:in press.
-
(1998)
Biochem Soc Trans
, vol.26
-
-
Pégorier, J.P.1
Chatelain, F.2
Thumelin, S.3
Girard, J.4
-
25
-
-
0030047806
-
Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α, -β and -γ in the adult rat
-
Braissant O, Foufelle F, Scotto C, Dauça M, Wahli W. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-α, -β and -γ in the adult rat. Endocrinology 1996; 137:354-366.
-
(1996)
Endocrinology
, vol.137
, pp. 354-366
-
-
Braissant, O.1
Foufelle, F.2
Scotto, C.3
Dauça, M.4
Wahli, W.5
-
27
-
-
0028309738
-
Association of the peroxisome proliferator activated receptor and Hsp72
-
Huang G, Alvares K, Chu R, Bradfield CA, Reddy JK. Association of the peroxisome proliferator activated receptor and Hsp72. Biol Chem 1994; 269:8493-8497.
-
(1994)
Biol Chem
, vol.269
, pp. 8493-8497
-
-
Huang, G.1
Alvares, K.2
Chu, R.3
Bradfield, C.A.4
Reddy, J.K.5
-
28
-
-
0029775642
-
Insulin and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor γ
-
Zhang B, Berger J, Zhou G, Elbrecht A, Biswas S, White-Carrington S, et al. Insulin and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor γ. J Biol Chem 1996; 271:31771-31774. This study demonstrates that insulin, through mitogen-activated protein-kinase activation, stimulates the phosphorylation and transcriptional activity of PPARγ in a ligand-dependent fashion.
-
(1996)
J Biol Chem
, vol.271
, pp. 31771-31774
-
-
Zhang, B.1
Berger, J.2
Zhou, G.3
Elbrecht, A.4
Biswas, S.5
White-Carrington, S.6
-
29
-
-
0038776380
-
Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ
-
Hu E, Kim JB, Sarraf P, Spiegelman BM. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ. Science 1996; 274:2100-2103. The authors demonstrate that insulin and phorbol esters stimulate the phosphorylation of PPARy via mitogen-activated protein-kinases. Although the site of phosphorylation of PPARy is distinct from the DNA binding domain, phosphorylation reduces the transcriptional activity of PPARy in contrast to that demonstrated in [28].
-
(1996)
Science
, vol.274
, pp. 2100-2103
-
-
Hu, E.1
Kim, J.B.2
Sarraf, P.3
Spiegelman, B.M.4
-
30
-
-
0030985318
-
Fatty acids, eicosanoids and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
-
Krey G, Braissant O, L'Horset F, Kalkhoven E, Perroud M, Parker MG, Wahli W. Fatty acids, eicosanoids and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol Endocrinol 1997; 11:779-791.
-
(1997)
Mol Endocrinol
, vol.11
, pp. 779-791
-
-
Krey, G.1
Braissant, O.2
L'Horset, F.3
Kalkhoven, E.4
Perroud, M.5
Parker, M.G.6
Wahli, W.7
-
31
-
-
0030952937
-
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator activated receptors α and δ
-
Forman BM, Chen J, Evans RM. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator activated receptors α and δ. Proc Natl Acad Sci USA 1997; 94:4312-4317.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4312-4317
-
-
Forman, B.M.1
Chen, J.2
Evans, R.M.3
-
32
-
-
13144283625
-
Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library
-
Brown PJ, Smith-Oliver TA, Charifson PS, Tomkinson NCO, Fivush AM, Sternbach DD, et al. Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library. Chem Biol 1997; 4:909-918.
-
(1997)
Chem Biol
, vol.4
, pp. 909-918
-
-
Brown, P.J.1
Smith-Oliver, T.A.2
Charifson, P.S.3
Tomkinson, N.C.O.4
Fivush, A.M.5
Sternbach, D.D.6
-
33
-
-
0006132932
-
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
-
Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, et al. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ. Proc Natl Acad Sci USA 1997; 94:4318-4323.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4318-4323
-
-
Kliewer, S.A.1
Sundseth, S.S.2
Jones, S.A.3
Brown, P.J.4
Wisely, G.B.5
Koble, C.S.6
-
34
-
-
0030794057
-
Peroxisome proliferator-activated receptors, orphans with ligands and functions
-
Schoonjans K, Martin G, Staels B, Auwerx J. Peroxisome proliferator-activated receptors, orphans with ligands and functions. Curr Opin Lipidol 1997; 8:159-166.
-
(1997)
Curr Opin Lipidol
, vol.8
, pp. 159-166
-
-
Schoonjans, K.1
Martin, G.2
Staels, B.3
Auwerx, J.4
-
35
-
-
0029661982
-
The PPAR alpha-leukotriene B4 pathway to inflammation control
-
Devchand PR, Keller H, Peters JM, Vazquez M, Gonzalez FJ, Wahli W. The PPAR alpha-leukotriene B4 pathway to inflammation control. Nature 1996; 384:39-43.
-
(1996)
Nature
, vol.384
, pp. 39-43
-
-
Devchand, P.R.1
Keller, H.2
Peters, J.M.3
Vazquez, M.4
Gonzalez, F.J.5
Wahli, W.6
-
36
-
-
0028802627
-
Differential activation of peroxisome proliferator activated receptors by eicosanoids
-
Yu K, Bayona W, Kallen CB, Harding HP, Ravera CP, McMahon G, et al. Differential activation of peroxisome proliferator activated receptors by eicosanoids. J Biol Chem 1995; 270:23975-23983.
-
(1995)
J Biol Chem
, vol.270
, pp. 23975-23983
-
-
Yu, K.1
Bayona, W.2
Kallen, C.B.3
Harding, H.P.4
Ravera, C.P.5
McMahon, G.6
-
37
-
-
0028972025
-
15-deoxy-D12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARy
-
Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 15-deoxy-D12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARy. Cell 1995; 83:803-812.
-
(1995)
Cell
, vol.83
, pp. 803-812
-
-
Forman, B.M.1
Tontonoz, P.2
Chen, J.3
Brun, R.P.4
Spiegelman, B.M.5
Evans, R.M.6
-
38
-
-
0028972026
-
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
-
Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 1995; 83:813-819.
-
(1995)
Cell
, vol.83
, pp. 813-819
-
-
Kliewer, S.A.1
Lenhard, J.M.2
Willson, T.M.3
Patel, I.4
Morris, D.C.5
Lehmann, J.M.6
-
39
-
-
0028276397
-
Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids
-
Rodriguez JC, Gil-Gomez G, Hegardt FC, Haro D. Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. J Biol Chem 1994; 269:18767-18772.
-
(1994)
J Biol Chem
, vol.269
, pp. 18767-18772
-
-
Rodriguez, J.C.1
Gil-Gomez, G.2
Hegardt, F.C.3
Haro, D.4
-
40
-
-
0028033268
-
The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression
-
Gulick T, Cresci S, Caira T, Moore DD, Kelly DP. The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc Natl Acad Sci USA 1994; 91:11012-11016.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 11012-11016
-
-
Gulick, T.1
Cresci, S.2
Caira, T.3
Moore, D.D.4
Kelly, D.P.5
-
41
-
-
0028997684
-
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
-
Lee SS, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, et al. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 1995; 15:3012-3022.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 3012-3022
-
-
Lee, S.S.1
Pineau, T.2
Drago, J.3
Lee, E.J.4
Owens, J.W.5
Kroetz, D.L.6
-
42
-
-
0030841938
-
Recent update on the PPAR alpha-null mouse
-
Gonzalez FJ. Recent update on the PPAR alpha-null mouse. Biochimie 1997; 79:139-144.
-
(1997)
Biochimie
, vol.79
, pp. 139-144
-
-
Gonzalez, F.J.1
-
43
-
-
0030783119
-
Polyunsaturated fatty acid suppression of hepatic fatty acid synthase and S14 gene expression does not require peroxisome proliferator-activated receptor alpha
-
Ren B, Thelen AP, Peters JM, Gonzalez FJ, Jump DB. Polyunsaturated fatty acid suppression of hepatic fatty acid synthase and S14 gene expression does not require peroxisome proliferator-activated receptor alpha. J Bil/ Chem 1997; 272:26827-26832. Using PPARα null (-/-) mice, the authors demonstrate that the PUFA-induced inhibition of fatty acid synthase and Spot 14 gene expression does not require PPARα. By contrast, the induction of peroxisomal acyl-CoA oxidase and microsornal cytochrome P450A2 gene expression by PP is impaired in PPARα (-/-) mice.
-
(1997)
J Bil/ Chem
, vol.272
, pp. 26827-26832
-
-
Ren, B.1
Thelen, A.P.2
Peters, J.M.3
Gonzalez, F.J.4
Jump, D.B.5
-
44
-
-
0030766476
-
Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor 2-deficient mice
-
Peters JM, Hennuyers N, Staels B, Fruchart JC, Fievet C, Gonzalez FJ, Auwerx J. Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor 2-deficient mice. J Biol Chem 1997; 272:27307-27312.
-
(1997)
J Biol Chem
, vol.272
, pp. 27307-27312
-
-
Peters, J.M.1
Hennuyers, N.2
Staels, B.3
Fruchart, J.C.4
Fievet, C.5
Gonzalez, F.J.6
Auwerx, J.7
-
45
-
-
0032489437
-
Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα)
-
Aoyama T, Peters JM, Iritani N, Nakajima T, Furihata K, Hashimoto T, Gonzalez FJ. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα). J Biol Chem 1998; 273:5678-5684. The authors show that the constitutive expression of genes encoding several mitochondrial and peroxisomal enzymes is lower and not inducible by PP in the liver of PPARα null (-/-) mice compared with control wild-type mice.
-
(1998)
J Biol Chem
, vol.273
, pp. 5678-5684
-
-
Aoyama, T.1
Peters, J.M.2
Iritani, N.3
Nakajima, T.4
Furihata, K.5
Hashimoto, T.6
Gonzalez, F.J.7
-
46
-
-
0030035696
-
Peroxisome proliferator-activated receptor-α inhibits hepatic S14 gene transcription. Evidence against the peroxisome proliferator-activated receptor-α as the mediator of polyunsaturated fatty acid regulation of S14 gene transcription
-
Ren B, Thelen A, Jump DB. Peroxisome proliferator-activated receptor-α inhibits hepatic S14 gene transcription. Evidence against the peroxisome proliferator-activated receptor-α as the mediator of polyunsaturated fatty acid regulation of S14 gene transcription. J Biol Chem 1996; 271:17167-17173. PPARα and PP inhibit the Spot 14 promoter activity when transfected in primary hepatocytes. The authors suggest that PUFA inhibition of Spot 14 gene transcription is not mediated by PPARα because PP/PPARα and PUFA cis-regulatory elements are functionally and spatially distinct.
-
(1996)
J Biol Chem
, vol.271
, pp. 17167-17173
-
-
Ren, B.1
Thelen, A.2
Jump, D.B.3
-
47
-
-
0031560238
-
Localization of polyunsaturated fatty acid response region in stearoyl-CoA desaturase gene 1
-
Waters KM, Miller CW, Ntambi JM. Localization of polyunsaturated fatty acid response region in stearoyl-CoA desaturase gene 1. Biochim Biophys Acta 1997; 1349:33-42.
-
(1997)
Biochim Biophys Acta
, vol.1349
, pp. 33-42
-
-
Waters, K.M.1
Miller, C.W.2
Ntambi, J.M.3
-
48
-
-
0029784760
-
The peroxisome proliferator-activated receptor alpha is a phosphoprotein: Regulation by insulin
-
Shalev A, Siegrist-Kaiser CA, Yen PM, Wahli W, Burger AG, Chin WW, Meier CA. The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin. Endocrinology 1996; 137:4499-4502. The authors report that PPARa is a phosphoprotein in vivo. Insulin enhances the phosphorylation of PPARα and increases its transcription in HepG2 transfected cells.
-
(1996)
Endocrinology
, vol.137
, pp. 4499-4502
-
-
Shalev, A.1
Siegrist-Kaiser, C.A.2
Yen, P.M.3
Wahli, W.4
Burger, A.G.5
Chin, W.W.6
Meier, C.A.7
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