The effects of maternal protein deprivation on the fetal rat pancreas: Major structural changes and their recuperation

Journal of Pathology

Volumn 183, Issue 1, 1997, Pages 109-115

  Berney, D M ^a   Desai, M ^b   Palmer, D J ^a   Greenwald, S ^a   Brown, A ^a   Hales, C N ^b   Berry, C L ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Development; Diabetes; Endocrine; Pancreas; Protein

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; FEMALE; GROWTH RETARDATION; LOW BIRTH WEIGHT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN MALNUTRITION; RAT;

ANIMAL NUTRITION PHYSIOLOGY; ANIMALS; BODY WEIGHT; FEMALE; ISLETS OF LANGERHANS; LACTATION; ORGAN SIZE; PANCREAS; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL EXPOSURE DELAYED EFFECTS; PROTEIN DEFICIENCY; RATS; RATS, WISTAR;

EID: 0030753422     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199709)183:1<109::AID-PATH1091>3.0.CO;2-B     Document Type: Article

References (21)

1. Hales CN, Barker DJP, Clark PMS, et al. Fetal and infant growth and impaired glucose tolerance at age 64 years. Br Med J 1991; 303: 1019-1022.
2. Barker DJP, Hales CN, Fall CHD, Osmond C, Phipps K, Clark PMS. Type 2 (non-insulin dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 1993; 36: 62-67.
3. Barker DJP. Fetal and Infant Origins of Adult Disease. London: British Medical Journal Publications, 1992.
4. Hales CN, Barker DJP. Type 2 (non-insulin dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 192; 35: 595-601.
5. Dahri S, Snoek A, Reusens-Billen B, Remacle C, Hoet JJ. Islet function in offspring of mothers on low protein diet during gestation. Diabetes 1991; 40(Suppl): 2115-2120.
6. Desai M, Crowther NJ, Ozanne SE, Lucas A, Hales CN. Adult glucose and lipid metabolism may be programmed during fetal life. Biochem Soc Trans 1995; 23: 331 335.
7. Perrier BH. Effects of prolonged maternal fast on the pancreas of 18-21 day old foetal rats. Ultrastructural and morphometric study of the beta cells. Cell Tissue Res 1984; 237: 169-179.
8. James WPT, Coore HG. Persistent impairment of insulin secretion and glucose tolerance after malnutrition. Am J Clin Nutr 1970; 23: 386-389.
9. Milner RD. Metabolic and hormonal responses to oral amino acids in infantile malnutrition. Arch Dis Child 1971; 46: 301-305.
10. Desai M, Crowther NJ, Lucas A, Hales CN. Organ-selective growth in the offspring of protein-restricted mothers. Br J Nutr 1996; 76: 591-603.
11. Slack JMW. Developmental biology of the pancreas. Development 1995; 121: 1569-1580.
12. Andrew A. An experimental investigation into the possible neural crest origin of pancreatic APUD (islet) cells. J Embryol Exp Morph 1976; 35: 577-593.
13. Bouwens L, Kloppel G. Islet cell neogenesis in the pancreas. Virchows Arch 1996; 427: 553-560.
14. Deltour L, Leduque P, Paldi A, Ripoche M, Dubois P, Jami J. Polyclonal origin of pancreatic islets in aggregation mouse chimaeras. Development 1991; 112: 1115-1121.
15. Teitelman G, Alpert S, Polak JM, Martinez A, Hanahan D. Mouse endocrine pancreases coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 1993; 118: 1031-1039.
16. Gittes GK, Galante PE, Hanahan D, Rutter WJ, Debas HT. Lineagespecific morphogenesis in the developing pancreas: role of mesenchymal factors. Development 1996; 122: 439-447.
17. Kaung HL. Growth dynamics of pancreatic islet cell populations during fetal and neonatal development of the rat. Dev Dyn 1994; 200: 163 175.
18. Wang RN, Bouwens L, Kloppel G. Beta-cell growth in adolescent and adult rats treated with streptozocin during the neonatal period. Diabetologia 1996; 39: 548-557.
19. Sanvito F, Herrera PL, Huarte J, et al. TGF-beta 1 influences the relative development of the exocrine and endocrine pancreas in vitro. Development 1994; 120: 3451-3462.
20. Snoeck A, Remacle C, Reusens B, Hoet JJ. Effect of a low protein diet during pregnancy on the fetal rat endocrine pancreas. Biol Neonate 1990; 57: 107-118.
21. Ogata ES, Bussey ME, LaBarbera A, Finley S. Altered growth, hypoglycaemia, hypoalaninemia and ketonemia in the young rat: postnatal consequences of intrauterine growth retardation. Pediatr Res 1985; 19: 32-37.