Modulation of rat and human cytochromes P450 involved in PhIP and 4-ABP activation by an aqueous extract of Phyllanthus orbicularis

Journal of Ethnopharmacology

Volumn 90, Issue 2-3, 2004, Pages 273-277

  Ferrer, Mirle ^a   Cristófol, Carles ^b   Sánchez Lamar, Angel ^c   Fuentes, Jorge Luís ^d   Barbé, Jordi ^a   Llagostera, Montserrat ^a  

^a Dpt de Genet i de Microbiol   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c UNIVERSITY OF HAVANA   (Cuba)

^d Ctro Aplicaciones Tecnologicas D   (Cuba)

Author keywords

4 ABP; Antimutagenesis; CYP1A; Cytochromes P450; PhIP; Phyllanthus orbicularis

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 4 BIPHENYLAMINE; ANTIMUTAGENIC AGENT; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 1A2; PHYLLANTHUS ORBICULARIS EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG; WATER;

ARTICLE; ASSAY; CHEMICAL MUTAGENESIS; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME REGULATION; HUMAN; LIVER MICROSOME; MEDICINAL PLANT; MUTAGENICITY; NONHUMAN; PHYLLANTHUS; PHYLLANTHUS ORBICULARIS; TOXICOKINETICS;

PHYLLANTHUS ORBICULARIS; SALMONELLA;

EID: 0842283184     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2003.10.005     Document Type: Article

References (33)

1. Bear W.L., Teel R.W. Effects of citrus flavonoids on the mutagenicity of hetrocyclic amines and on cytochrome P450 1A2 activity. Anticancer Research. 20:2000;3609-3614.
2. Burke M.D., Thompson S., Elcombe C.R., Halper J., Haaparanta T., Mayers R.T. Ethoxy-, pentoxy-, and benzyloxyphenoxazones and homologues. Biochemical Pharmacology. 34:1985;3337-3345.
3. Burke M.D., Thompson S., Weaver R.J., Wolf C.R., Mayers R.T. Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver. Biochemical Pharmacology. 48:1994;923-936.
4. Callander R.D., Mackay J.M., Clay P., Elcombe C.R., Elliot B.M. Evaluation of phenobarbital/β-naphthoflavone as an alternative S9-induction regime to Aroclor 1254 in the rat for use in vitro genotoxicity assays. Mutagenesis. 10:1995;517-522.
5. Canivenc-Lavier M.C., Bentejac M., Millar M.L., Leclerc J., Siess M.H., Latruffe N., Suschetet M. Differential effects of nonhydroxylated flavonoids as inducers of cytochrome P4501A and 2B isozymes in rat liver. Toxicology and Applied Pharmacology. 136:1996;348-353.
6. Dang L.V.N., McQueen Ch.A. Mutagenicity of 4-aminobiphenyl and 4-acetylaminobiphenyl in Salmonella typhimurium strains expressing different levels of N-acetyltransferase. Toxicology and Applied Pharmacology. 159:1999;77-82.
7. Dashwood R.H. Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: an 'A to Z' guide to chemopreventive agents, promoters and transgenic models. Mutation Research. 511:2002;89-112.
8. De Flora S. Mechanisms of inhibitors of mutagenesis and carcinogenesis. Mutation Research. 402:1998;151-158.
9. De Flora S., Ramel C. Mechanisms of inhibitors of mutagenesis and carcinogenesis. Classification and overview. Mutation Research. 202:1988;285-306.
10. De Flora S., Izzotti A., D'Agostini F., Balansky R.M., Noonan D., Albini A. Multiple points of intervention in the prevention of cancer and other mutation-related diseases. Mutation Research. 480/481:2001;9-22.
11. del Barrio G., Parra F. Evaluation of the antiviral activity of an aqueous extract from Phyllanthus orbicularis. Journal of Ethnopharmacology. 72:2000;317-322.
12. Ferrer M., Sánchez-Lamar A., Fuentes J.L., Barbé J., Llagostera M. Studies on antimutagenesis of Phyllanthus orbicularis: mechanisms involved against aromatic amines. Mutation Research. 498:2001;99-105.
13. Ferrer M., Sánchez-Lamar A., Fuentes J.L., Barbé J., Llagostera M. Antimutagenic mechanisms of Phyllanthus orbicularis when hydrogen peroxide is tested using Salmonella assay. Mutation Research. 517:2002;251-254.
14. Gooderham N.J., Zhu H., Lauber S., Boyce A., Creton S. Molecular and genetic toxicology of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Mutation Research. 506/507:2002;91-99.
15. Hakura A., Suzuki S., Satoh T. Advantage of the use of human liver S9 in the Ames test. Mutation Research. 438:1999;29-36.
16. Hammons G.J., Fletcher J.V., Stepps K.R., Smith E.A., Balentine D.A., Harboury M.E., Kadlubar F.F. Effects of chemopreventive agents on the metabolic activation of the arylamines PhIP and 4-aminobiphenyl in human and rat liver microsomes. Nutrition and Cancer. 33:1999;46-52.
17. IARC, 1987. International Agency for Cancer Research Monographs on the Evaluation of Carcinogenic Risk to Humans, 4-Aminobiphenyl [92-67-1] 1 (Suppl. 7).
18. IARC, 1993. International Agency for Cancer Research Monographs on the Evaluation of Carcinogenic Risk to Humans, PhIP [105650-23-5] 56 (Suppl. 7).
19. Johnson T.E., Umbenhauer D.R., Galloway S.M. Human liver S9 metabolites activation proficiency in cytogenetic assays and comparison with phenobarbital/β-naphtoflavone or Aroclor 1254 induced rat S9. Environmental and Molecular Mutagenesis. 28:1996;51-59.
20. Kadlubar F.F., Butler M.A., Kaderlik K.R., Chou H.C., Lang N.P. Polymorphisms for aromatic amine metabolism in humans: relevance for human carcinogenesis. Environmental Health Perspectives. 98:1992;69-74.
21. Knize M.G., Salmon C.P., Mehta S.S., Felton J.S. Analysis of cooked muscle meats for heterocyclic aromatic amine carcinogens. Mutation Research. 376:1997;129-134.
22. Maron D.M., Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutation Research. 113:1983;173-215.
23. Nims R.W., Prough R.A., Lubet R.A. Cytosol mediated reduction of resorufin: a method for measuring quinone oxidoreductase. Archives of Biochemistry and Biophysics. 229:1984;459-465.
24. Rose P., Faulkner K., Williamson G., Mithen R. 7-Methyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes. Carcinogenesis. 21:2000;1983-1988.
25. Sánchez-Lamar A., Cozzi R., Cundari E., Fiore M., Ricordy R., De Salvia R. Phyllanthus orbicularis aqueous extract: cytotoxic, genotoxic and antimutagenic effects in the CHO cell line. Toxicology and Applied Pharmacology. 161:1999;231-239.
26. Steinkelner H., Rabot S., Freywald C., Nobis E., Scharf G., Chabicovsky M., Knasmüller S., Kassie F. Effects of cruciferous vegetables and their constituents on drug metabolism enzymes involved in the bioactivation of DNA-reactive dietary carcinogens. Mutation Research. 480/481:2001;285-297.
27. Takahashi E., Fujita K., Kamataki T., Arimoto-Kobayashi S., Okamoto K., Negishi T. Inhibition of human cytochrome P450 1B1, 1A1 and 1A2 by antigenotoxic compounds, purpurin and alizarin. Mutation Research. 508:2002;147-156.
28. Venkatakrishnan K., von Moltke L.L., Greenblatt D.J. Human drug metabolism and the cytochrome P450: application and relevance of in vitro models. Journal of Clinical Pharmacology. 41:2002;1149-1179.
29. Watanabe M., Ishidate M. Jr., Nohmi T. Sensitive method for the detection of mutagenic nitroarenes and aromatic amines: new derivatives of Salmonella typhimurium tester strains possessing elevated O-acetyltranferase levels. Mutation Research. 234:1990;337-348.
30. Weisburguer, J.H., 1988. Past, present and future role of carcinogenic and mutagenic N-substituted aryl compounds in human cancer causation. In: King, C.M., Romano, L.J., Schueltzle, D. (Eds.), Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroarenes. Elsevier, New York, pp. 3-19.
31. Windmill K.F., McKinnon R.A., Zhu X., Gaedigk A., Grant D.M., McManus M.E. The role of xenobiotics metabolizing enzymes in arylamine toxicity and carcinogenesis, functional and localization studies. Mutation Research. 376:1997;153-160.
32. Zhai S., Dai R., Friedman F.K., Vestal R.E. Comparative inhibition of human cytochromes P450 1A1 and 1A2 by flavonoids. Drug Metabolism and Disposition. 26:1998;989-992.
33. Zhao K., Murray S., Davies D.S., Boobis A.R., Gooderham N.J. Metabolism of the food derived mutagen and carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) by human liver microsomes. Carcinogenesis. 15:1994;1285-1288.