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Volumn 376, Issue 1-2, 1997, Pages 153-160

The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: Functional and localization studies

Author keywords

Aromatic amine; Cytochrome P450; Heterocyclic amine; N acetyltransferase; Sulfotransferase

Indexed keywords

ACYLTRANSFERASE; AROMATIC AMINE; CYTOCHROME P450; DRUG METABOLIZING ENZYME; HETEROCYCLIC AMINE; MESSENGER RNA; SULFOTRANSFERASE;

EID: 0030995728     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00038-9     Document Type: Article
Times cited : (115)

References (44)
  • 2
    • 0023328602 scopus 로고
    • Ranking possible carcinogenic hazards
    • Ames, B.N., R. Magaw and L.S. Gold (1987) Ranking possible carcinogenic hazards, Science, 236, 271-280.
    • (1987) Science , vol.236 , pp. 271-280
    • Ames, B.N.1    Magaw, R.2    Gold, L.S.3
  • 3
    • 84970359089 scopus 로고
    • Lung cancer incidence among Swedish bakers and pastrycooks: Temporal variation
    • Carstensen, J.M., L. Wicksell, G. Eklund and J.-A. Gustafsson (1988) Lung cancer incidence among Swedish bakers and pastrycooks: temporal variation, Scand. J. Soc. Med., 16, 81-85.
    • (1988) Scand. J. Soc. Med. , vol.16 , pp. 81-85
    • Carstensen, J.M.1    Wicksell, L.2    Eklund, G.3    Gustafsson, J.-A.4
  • 4
    • 0025949636 scopus 로고
    • Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: Evidence for species-specific metabolism
    • Czerwinski, M., T.L. McLemore, R.M. Philpot, P.T. Nhamburo, K. Korzekwa, H.V. Gelboin and F.J. Gonzalez (1991) Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism, Cancer Res., 51, 4636-4638.
    • (1991) Cancer Res. , vol.51 , pp. 4636-4638
    • Czerwinski, M.1    McLemore, T.L.2    Philpot, R.M.3    Nhamburo, P.T.4    Korzekwa, K.5    Gelboin, H.V.6    Gonzalez, F.J.7
  • 5
    • 0027163025 scopus 로고
    • Mutagenic activation of IQ, PhIP, and MeIQx by hepatic microsomes from rat, monkey and man: Low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo
    • Davis, C.D., H.A.J. Schut, R.H. Adamson, U.P. Thorgeirsson, S.S. Thorgeirsson and E.G. Snyderwine (1993) Mutagenic activation of IQ, PhIP, and MeIQx by hepatic microsomes from rat, monkey and man: low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo, Carcinogenesis, 14, 61-65.
    • (1993) Carcinogenesis , vol.14 , pp. 61-65
    • Davis, C.D.1    Schut, H.A.J.2    Adamson, R.H.3    Thorgeirsson, U.P.4    Thorgeirsson, S.S.5    Snyderwine, E.G.6
  • 6
    • 0022471888 scopus 로고
    • Xenobiotic metabolism in human alveolar type II cells isolated by centrifugal elutriation and density gradient centrifugation
    • Devereux, T.R., T.E. Massey, M.R. Van Scott, J. Yankaskas and J.R. Fouts (1986) Xenobiotic metabolism in human alveolar type II cells isolated by centrifugal elutriation and density gradient centrifugation, Cancer Res., 46, 5438-5443.
    • (1986) Cancer Res. , vol.46 , pp. 5438-5443
    • Devereux, T.R.1    Massey, T.E.2    Van Scott, M.R.3    Yankaskas, J.4    Fouts, J.R.5
  • 7
    • 0025344378 scopus 로고
    • Cytochrome P-450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues
    • de Waziers, I., P.H. Cugenc, C.S. Yang, J.-P. Leroux and P.H. Beaune (1990) Cytochrome P-450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues, J. Pharmacol. Exp. Ther., 253, 387-394.
    • (1990) J. Pharmacol. Exp. Ther. , vol.253 , pp. 387-394
    • De Waziers, I.1    Cugenc, P.H.2    Yang, C.S.3    Leroux, J.-P.4    Beaune, P.H.5
  • 8
    • 0025852572 scopus 로고
    • Drug-metabolizing enzyme expression in human normal, peritumoral and tumoral colorectal tissue samples
    • de Waziers, I., P.H. Cugenc, A. Berger, J.-P. Leroux and P.H. Beaune (1991) Drug-metabolizing enzyme expression in human normal, peritumoral and tumoral colorectal tissue samples, Carcinogenesis, 12, 905-909.
    • (1991) Carcinogenesis , vol.12 , pp. 905-909
    • De Waziers, I.1    Cugenc, P.H.2    Berger, A.3    Leroux, J.-P.4    Beaune, P.H.5
  • 9
    • 0019829568 scopus 로고
    • The causes of cancer: Quantitative estimates of avoidable risks of cancer in the United States today
    • Doll, R. and R. Peto (1981) The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today, J. Natl. Cancer Inst., 66, 1191-1308.
    • (1981) J. Natl. Cancer Inst. , vol.66 , pp. 1191-1308
    • Doll, R.1    Peto, R.2
  • 10
    • 0025961475 scopus 로고
    • An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987)
    • Dubach, U.C., B. Rosner and T. Sturmer (1991) An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987), N. Engl. J. Med., 324, 155-160.
    • (1991) N. Engl. J. Med. , vol.324 , pp. 155-160
    • Dubach, U.C.1    Rosner, B.2    Sturmer, T.3
  • 11
    • 0000918297 scopus 로고
    • Heterocyclic-amine mutagens/carcinogens in foods
    • C.S. Cooper and P.L. Grover (Eds.), Springer-Verlag, Berlin
    • Felton, J.S. and M.G. Knize (1990) Heterocyclic-amine mutagens/carcinogens in foods, in: C.S. Cooper and P.L. Grover (Eds.), Handbook of Experimental Pharmacology, Springer-Verlag, Berlin.
    • (1990) Handbook of Experimental Pharmacology
    • Felton, J.S.1    Knize, M.G.2
  • 12
    • 0026511970 scopus 로고
    • Chemical analysis, prevention, and low-level dosimetry of heterocyclic amines from cooked food
    • Felton, J.S., M.G. Knize, M. Roper, E. Fultz, N.H. Shen and K.W. Turteltaub (1992) Chemical analysis, prevention, and low-level dosimetry of heterocyclic amines from cooked food, Cancer. Res., 52, 2103s-2107s.
    • (1992) Cancer. Res. , vol.52
    • Felton, J.S.1    Knize, M.G.2    Roper, M.3    Fultz, E.4    Shen, N.H.5    Turteltaub, K.W.6
  • 13
    • 0019990422 scopus 로고
    • Cytochrome P-450- and flavin-containing monooxygenase-catalyzed formation of the carcinogen N-hydroxy-2-aminofluorene and its covalent binding to nuclear DNA
    • Frederick, C.B., J.B. Mays, D.M. Ziegler, F.P. Guengerich and F.F. Kadlubar (1982) Cytochrome P-450- and flavin-containing monooxygenase-catalyzed formation of the carcinogen N-hydroxy-2-aminofluorene and its covalent binding to nuclear DNA, Cancer Res., 42, 2671-2677.
    • (1982) Cancer Res. , vol.42 , pp. 2671-2677
    • Frederick, C.B.1    Mays, J.B.2    Ziegler, D.M.3    Guengerich, F.P.4    Kadlubar, F.F.5
  • 14
    • 12644292421 scopus 로고
    • Characterization of the human gene for the hepatic flavin-containing monooxygenase (FMO)
    • M. Ingelman-Sundberg, J. Gustaffsson and S. Orrenius (Eds.), Drug Metabolizing Enzymes: Genetics, Regulation and Toxicology, Stockholms Projektgrupp AB
    • Gasser, R., R.M. Philpot and U.A. Meyer (1990) Characterization of the human gene for the hepatic flavin-containing monooxygenase (FMO), in: M. Ingelman-Sundberg, J. Gustaffsson and S. Orrenius (Eds.), Drug Metabolizing Enzymes: Genetics, Regulation and Toxicology, Proc. 8th Int. Symp. Microsomes and Drug Oxidations, Stockholms Projektgrupp AB, p. 43.
    • (1990) Proc. 8th Int. Symp. Microsomes and Drug Oxidations , pp. 43
    • Gasser, R.1    Philpot, R.M.2    Meyer, U.A.3
  • 15
    • 0024519596 scopus 로고
    • Immunohistochemical localization of NADPH-cytochrome P450 reductase in human tissues
    • Hall, P.M., I. Stupans, W. Burgess, D.J. Birkett and M.E. McManus (1989) Immunohistochemical localization of NADPH-cytochrome P450 reductase in human tissues, Carcinogenesis, 10, 521-530.
    • (1989) Carcinogenesis , vol.10 , pp. 521-530
    • Hall, P.M.1    Stupans, I.2    Burgess, W.3    Birkett, D.J.4    McManus, M.E.5
  • 16
    • 0027281895 scopus 로고
    • Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases
    • Hein, D.W., M.A. Doll, T.D. Rustan, K. Gray, Y. Feng, R.J. Ferguson and D.M. Grant (1993) Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases, Carcinogenesis, 14, 1633-1638.
    • (1993) Carcinogenesis , vol.14 , pp. 1633-1638
    • Hein, D.W.1    Doll, M.A.2    Rustan, T.D.3    Gray, K.4    Feng, Y.5    Ferguson, R.J.6    Grant, D.M.7
  • 17
    • 0025768966 scopus 로고
    • A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
    • Ito, N., R. Hasegawa, M. Sano, S. Tamano, H. Esumi, S. Takayama and T. Sugimura (1991) A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), Carcinogenesis, 12, 1503-1506.
    • (1991) Carcinogenesis , vol.12 , pp. 1503-1506
    • Ito, N.1    Hasegawa, R.2    Sano, M.3    Tamano, S.4    Esumi, H.5    Takayama, S.6    Sugimura, T.7
  • 18
    • 0028108024 scopus 로고
    • Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues
    • Kaderlik, K.R., R.F. Minchin, G.J. Mulder, K.F. Ilett, M. Daugaard-Jenson, C.H. Teitel and F.F. Kadlubar (1994) Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues, Carcinogenesis, 15, 1703-1709.
    • (1994) Carcinogenesis , vol.15 , pp. 1703-1709
    • Kaderlik, K.R.1    Minchin, R.F.2    Mulder, G.J.3    Ilett, K.F.4    Daugaard-Jenson, M.5    Teitel, C.H.6    Kadlubar, F.F.7
  • 20
    • 0021690880 scopus 로고
    • Role of cytochrome P-450 and flavin-containing monooxygenase in the N-hydroxylation of N-methyl-4-aminoazobenzene in rat liver: Analysis with purified enzymes and antibodies
    • Kimura, T., M. Kodama and C. Nagata (1984) Role of cytochrome P-450 and flavin-containing monooxygenase in the N-hydroxylation of N-methyl-4-aminoazobenzene in rat liver: analysis with purified enzymes and antibodies, Gann, 75, 895-904.
    • (1984) Gann , vol.75 , pp. 895-904
    • Kimura, T.1    Kodama, M.2    Nagata, C.3
  • 22
    • 0026464753 scopus 로고
    • Comparison of mouse and human colon tumors with regard to phase I and phase II drug-metabolizing enzyme systems
    • Massaad, L., I. de Waziers, V. Ribrag, F. Janot, P.H. Beaune, J. Morizet, A. Gouyette and G.G. Chabot (1992) Comparison of mouse and human colon tumors with regard to phase I and phase II drug-metabolizing enzyme systems, Cancer Res., 52, 6567-6575.
    • (1992) Cancer Res. , vol.52 , pp. 6567-6575
    • Massaad, L.1    De Waziers, I.2    Ribrag, V.3    Janot, F.4    Beaune, P.H.5    Morizet, J.6    Gouyette, A.7    Chabot, G.G.8
  • 23
    • 0025790577 scopus 로고
    • Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization
    • McKinnon, R.A., P.M. Hall, L.C. Quattrochi, R.H. Tukey and M.E. McManus (1991) Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization, Hepatology, 14, 848-856.
    • (1991) Hepatology , vol.14 , pp. 848-856
    • McKinnon, R.A.1    Hall, P.M.2    Quattrochi, L.C.3    Tukey, R.H.4    McManus, M.E.5
  • 24
    • 0026514642 scopus 로고
    • Metabolism of food-derived heterocyclic amines in human and rabbit tissues by P4503A proteins in the presence of flavonoids
    • McKinnon, R.A., W.M. Burgess, P. M. Hall, Z. Abdul-Aziz and M.E. McManus (1992) Metabolism of food-derived heterocyclic amines in human and rabbit tissues by P4503A proteins in the presence of flavonoids, Cancer Res., 52, 2108s-2113s.
    • (1992) Cancer Res. , vol.52
    • McKinnon, R.A.1    Burgess, W.M.2    Hall, P.M.3    Abdul-Aziz, Z.4    McManus, M.E.5
  • 25
    • 0028116354 scopus 로고
    • Species-specific expression of CYP4B1 expression in rabbit and human gastrointestinal tissues
    • McKinnon, R.A., W.M. Burgess, F.J. Gonzalez, R. Gasser and M.E. McManus (1994) Species-specific expression of CYP4B1 expression in rabbit and human gastrointestinal tissues, Pharmacogenetics, 4, 260-270.
    • (1994) Pharmacogenetics , vol.4 , pp. 260-270
    • McKinnon, R.A.1    Burgess, W.M.2    Gonzalez, F.J.3    Gasser, R.4    McManus, M.E.5
  • 27
    • 0025296345 scopus 로고
    • Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450
    • McManus, M.E., W.M. Burgess, M.E. Veronese, A. Huggett, L.C. Quattrochi and R.H. Tukey (1990) Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450, Cancer Res., 50, 3367-3376.
    • (1990) Cancer Res. , vol.50 , pp. 3367-3376
    • McManus, M.E.1    Burgess, W.M.2    Veronese, M.E.3    Huggett, A.4    Quattrochi, L.C.5    Tukey, R.H.6
  • 28
    • 0026650976 scopus 로고
    • N- and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells
    • Minchin, R.F., P.T. Reeves, C.H. Teitel, M.E. McManus, B. Mojarrabi, K.F. Ilett and F.F. Kadlubar (1992). N- and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells, Biochem. Biophys. Res. Commun., 185, 839-844.
    • (1992) Biochem. Biophys. Res. Commun. , vol.185 , pp. 839-844
    • Minchin, R.F.1    Reeves, P.T.2    Teitel, C.H.3    McManus, M.E.4    Mojarrabi, B.5    Ilett, K.F.6    Kadlubar, F.F.7
  • 29
    • 0023898817 scopus 로고
    • The immunocytochemical localization and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450
    • Murray, G.I., T.S. Barnes, H.F. Sewell, S.W.B. Ewen, W.T. Melvin and M.D. Burke (1988) The immunocytochemical localization and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450, Br. J. Clin. Pharmacol., 25, 465-475.
    • (1988) Br. J. Clin. Pharmacol. , vol.25 , pp. 465-475
    • Murray, G.I.1    Barnes, T.S.2    Sewell, H.F.3    Ewen, S.W.B.4    Melvin, W.T.5    Burke, M.D.6
  • 30
    • 0027504348 scopus 로고
    • Isolation and expression of a cDNA encoding a male-specific rat sulfotransferase that catalyses activation of N-hydroxy-2-acetylaminofluorene
    • Nagata, K., S. Ozawa, M. Miyata, M. Shimada, D.W. Gong, Y. Yamazoe and R. Kato (1993) Isolation and expression of a cDNA encoding a male-specific rat sulfotransferase that catalyses activation of N-hydroxy-2-acetylaminofluorene, J. Biol. Chem., 268, 24720-24725.
    • (1993) J. Biol. Chem. , vol.268 , pp. 24720-24725
    • Nagata, K.1    Ozawa, S.2    Miyata, M.3    Shimada, M.4    Gong, D.W.5    Yamazoe, Y.6    Kato, R.7
  • 31
    • 0002671950 scopus 로고
    • Pharmacogenetics
    • W.B. Pratt and P. Taylor (Eds.), Churchill Livingstone, New York
    • Nebert, D.W. and W.W. Weber (1990) Pharmacogenetics, in: W.B. Pratt and P. Taylor (Eds.), Principles of Drug Action. The Basis of Pharmacology, Churchill Livingstone, New York, pp. 469-531.
    • (1990) Principles of Drug Action. The Basis of Pharmacology , pp. 469-531
    • Nebert, D.W.1    Weber, W.W.2
  • 32
    • 0024425342 scopus 로고
    • Identification of a new P450 expressed in human lung: Complete cDNA sequence, cDNA directed expression, and chromosome mapping
    • Nhamburo, P.T., F.J. Gonzalez, O.W. McBride, H.V. Gelboin and S. Kimura (1989) Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA directed expression, and chromosome mapping, Biochemistry, 28, 8060-8066.
    • (1989) Biochemistry , vol.28 , pp. 8060-8066
    • Nhamburo, P.T.1    Gonzalez, F.J.2    McBride, O.W.3    Gelboin, H.V.4    Kimura, S.5
  • 33
    • 0026701773 scopus 로고
    • The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)
    • Probst, M.R., M. Blum, I. Fasshauer, D. D'Orazio, U.A. Meyer and D. Wild (1992) The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), Carcinogenesis, 13, 1713-1717.
    • (1992) Carcinogenesis , vol.13 , pp. 1713-1717
    • Probst, M.R.1    Blum, M.2    Fasshauer, I.3    D'Orazio, D.4    Meyer, U.A.5    Wild, D.6
  • 35
    • 0027151873 scopus 로고
    • Localization of genes encoding three distinct flavin-containing monooxygenases to human chromosome 1q
    • Shephard, E.A., C.T. Dolphin, M.F. Fox, S. Povey, R. Smith and I.R. Phillips (1993) Localization of genes encoding three distinct flavin-containing monooxygenases to human chromosome 1q, Genomics, 16, 85-89.
    • (1993) Genomics , vol.16 , pp. 85-89
    • Shephard, E.A.1    Dolphin, C.T.2    Fox, M.F.3    Povey, S.4    Smith, R.5    Phillips, I.R.6
  • 36
    • 0026457950 scopus 로고
    • Multistep carcinogenesis: A 1992 perspective
    • Sugimura, T. (1992) Multistep carcinogenesis: a 1992 perspective, Science, 258, 603-607.
    • (1992) Science , vol.258 , pp. 603-607
    • Sugimura, T.1
  • 40
    • 0008749286 scopus 로고
    • Human N-acetyltransferases: Genetic polymorphism and metabolic profiles of the major isoforms
    • G.M. Pacifici and G.N. Fracchia (Eds.), European Commission, Luxembourg
    • Weber, W.W. and K.P. Vatsis (1995) Human N-acetyltransferases: genetic polymorphism and metabolic profiles of the major isoforms, in: G.M. Pacifici and G.N. Fracchia (Eds.), Advances in Drug Metabolism in Man, European Commission, Luxembourg, pp. 351-405.
    • (1995) Advances in Drug Metabolism in Man , pp. 351-405
    • Weber, W.W.1    Vatsis, K.P.2
  • 41
    • 0025977415 scopus 로고
    • Expression of two cytochromes P450 involved in carcinogen activation in a human colon cell line
    • White, T.B., D.K. Hammond, H. Vasquez and H.W. Strobel (1991) Expression of two cytochromes P450 involved in carcinogen activation in a human colon cell line, Mol. Cell. Biochem., 102, 61-69.
    • (1991) Mol. Cell. Biochem. , vol.102 , pp. 61-69
    • White, T.B.1    Hammond, D.K.2    Vasquez, H.3    Strobel, H.W.4
  • 42
    • 0027993436 scopus 로고
    • Characterization and expression of hepatic sulfotransferase involved in the metabolism of N-substituted aryl compounds
    • Yamazoe, Y., S. Ozawa, K. Nagata, D.W. Gong and R. Kato (1994) Characterization and expression of hepatic sulfotransferase involved in the metabolism of N-substituted aryl compounds, Environ. Health Perspect., 102, 99-103.
    • (1994) Environ. Health Perspect. , vol.102 , pp. 99-103
    • Yamazoe, Y.1    Ozawa, S.2    Nagata, K.3    Gong, D.W.4    Kato, R.5


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